Radionuclide labeling and evaluation of candidate radioligands for PET imaging of histone deacetylase in the brain

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 24, 2013, Pages 6700-6705

  Seo, Young Jun ^a,b   Muench, Lisa ^c   Reid, Alicia ^d   Chen, Jinzhu ^a   Kang, Yeona ^a   Hooker, Jacob M ^e   Volkow, Nora D ^c,f   Fowler, Joanna S ^a   Kim, Sung Won ^c  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

^b Chonbuk National University   (South Korea)

^c NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^d CITY UNIVERSITY OF NEW YORK   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Brain; Brain permeability; Carbon 11; Epigenetics; Positron emission tomography; SAHA

Indexed keywords

6 (FLUOROACETAMIDO) 1 HEXANOICANILIDE C 11; ACETAMIDE; CARBON 11; ENTINOSTAT; ENTINOSTAT C 11; FLUORINE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; M 344; M 344 C 11; RADIOLIGAND; TRICHOSTATIN A; TRICHOSTATIN A C 11; UNCLASSIFIED DRUG; VORINOSTAT; VORINOSTAT C 11;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN REGION; CONTROLLED STUDY; DEACETYLATION; DRUG CLEARANCE; DRUG METABOLISM; DRUG PENETRATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; EPIGENETICS; IN VIVO STUDY; ISOTOPE LABELING; NEUROIMAGING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY;

PRIMATES;

BRAIN; BRAIN PERMEABILITY; CARBON-11; EPIGENETICS; POSITRON EMISSION TOMOGRAPHY; SAHA;

ANILIDES; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CARBON RADIOISOTOPES; FLUORINE RADIOISOTOPES; FLUOROACETATES; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; PERMEABILITY; POSITRON-EMISSION TOMOGRAPHY; PRIMATES; RADIOPHARMACEUTICALS;

EID: 84888882303     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.10.038     Document Type: Article

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