Quantification of ligand PET studies using a reference region with a displaceable fraction: Application to occupancy studies with 11C-DASB as an example

Journal of Cerebral Blood Flow and Metabolism

Volumn 32, Issue 1, 2012, Pages 70-80

  Turkheimer, Federico E ^a   Selvaraj, Sudhakar ^a,b   Hinz, Rainer ^c   Murthy, Venkatesha ^a   Bhagwagar, Zubin ^a   Grasby, Paul ^a   Howes, Oliver ^a,b   Rosso, Lula ^a   Bose, Subrata K ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

11C DASB; kinetic modelling; occupancy; positron emission tomography; rank shaping spectral analysis; reference region; spectral analysis

Indexed keywords

CITALOPRAM; DASB C 11; RADIOLIGAND; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BINDING AFFINITY; BINDING POTENTIAL; BIOLOGICAL MODEL; BRAIN SIZE; CAUDATE NUCLEUS; CEREBELLUM; CONTROLLED STUDY; HIPPOCAMPUS; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PUTAMEN; RANK SHAPING REGULARIZATION OF EXPONENTIAL SPECTRAL ANALYSIS; RELIABILITY; REPRODUCIBILITY; SIMPLIFIED REFERENCE TISSUE MODEL; THALAMUS;

ADULT; ANILINE COMPOUNDS; BINDING, COMPETITIVE; CARBON RADIOISOTOPES; CEREBELLUM; CITALOPRAM; HUMANS; LIGANDS; LINEAR MODELS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; RADIOLIGAND ASSAY; RADIOPHARMACEUTICALS; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; SULFIDES; TISSUE DISTRIBUTION;

EID: 84855345701     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2011.108     Document Type: Article

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