Characterization of a novel domain 'GATE' in the ABC protein DrrA and its role in drug efflux by the DrrAB complex

Biochemical and Biophysical Research Communications

Volumn 459, Issue 1, 2015, Pages 148-153

  Zhang, Han ^a   Rahman, Sadia ^a   Li, Wen ^a   Fu, Guoxing ^a   Kaur, Parjit ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

Author keywords

ABC transporter; C terminal domain; Doxorubicin efflux; DrrAB; Drug resistance; Nucleotide binding domain

Indexed keywords

ABC TRANSPORTER DRRA; ABC TRANSPORTER DRRAB; ADENOSINE TRIPHOSPHATE; CARRIER PROTEINS AND BINDING PROTEINS; DOXORUBICIN; GLYCINE; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; ABC TRANSPORTER; BACTERIAL PROTEIN; DNA BINDING PROTEIN; DRRA PROTEIN, BACTERIA; DRRB PROTEIN, ESCHERICHIA COLI; ESCHERICHIA COLI PROTEIN; MALK PROTEIN, E COLI;

ARTICLE; BACTERIAL CELL; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG TRANSPORT; ENERGY TRANSFER; GENE MUTATION; GLYCINE LOOP AND TRANSDUCER ELEMENT; HYDROGEN BOND; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; STABLE EXPRESSION; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; CONSERVED SEQUENCE; GENETICS; METABOLISM; MOLECULAR GENETICS; MULTIDRUG RESISTANCE; PROTEIN STABILITY; PROTEIN TERTIARY STRUCTURE;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ATP-BINDING CASSETTE TRANSPORTERS; BACTERIAL PROTEINS; CATALYSIS; CONSERVED SEQUENCE; DNA-BINDING PROTEINS; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ESCHERICHIA COLI PROTEINS; GLYCINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY;

EID: 84930178436     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.02.086     Document Type: Article

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