Selective histone deacetylase 6 inhibition prolongs survival in a lethal two-hit model

Journal of Surgical Research

Volumn 197, Issue 1, 2015, Pages 39-44

  Cheng, Xin ^a   Liu, Zhengcai ^b   Liu, Baoling ^a   Zhao, Ting ^a   Li, Yongqing ^a   Alam, Hasan B ^a  

^a UNIVERSITY OF MICHIGAN HOSPITALS   (United States)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

HDAC6; Hemorrhagic shock; Mouse; Tubastatin A; Two hit

Indexed keywords

HISTONE DEACETYLASE 6; HISTONE DEACETYLASE INHIBITOR; INTERLEUKIN 6; MESSENGER RNA; MYELOPEROXIDASE; RNA; TUBASTATIN A; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; HDAC6 PROTEIN, MOUSE; HISTONE DEACETYLASE; HYDROXAMIC ACID; INDOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; HEMORRHAGIC SHOCK; LIVER; LONG TERM SURVIVAL; MALE; MOUSE; NONHUMAN; PERITONEAL FLUID; PERITONEUM LAVAGE; POST TREATMENT SURVIVAL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SEPSIS; SURVIVAL TIME; UPREGULATION; ANIMAL; C57BL MOUSE; COMPLICATION; EVALUATION STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; MORTALITY; MULTIPLE ORGAN FAILURE; RANDOMIZATION; SHOCK, HEMORRHAGIC; TREATMENT OUTCOME;

ANIMALS; BIOMARKERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HYDROXAMIC ACIDS; INDOLES; INJECTIONS, INTRAPERITONEAL; MALE; MICE; MICE, INBRED C57BL; MULTIPLE ORGAN FAILURE; RANDOM ALLOCATION; REAL-TIME POLYMERASE CHAIN REACTION; SEPSIS; SHOCK, HEMORRHAGIC; TREATMENT OUTCOME;

EID: 84930178001     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2015.02.070     Document Type: Conference Paper

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