Pharmacologic Resuscitation: Cell Protective Mechanisms of Histone Deacetylase Inhibition in Lethal Hemorrhagic Shock1

Journal of Surgical Research

Volumn 156, Issue 2, 2009, Pages 290-296

  Butt, Muhammad U ^a   Sailhamer, Elizabeth A ^a   Li, Yongqing ^a   Liu, Baoling ^a   Shuja, Fahad ^a   Velmahos, George C ^a   deMoya, Marc ^a   King, David R ^a   Alam, Hasan B ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

acetylation; hemorrhage; liver; resuscitation; shock; valproic acid

Indexed keywords

CASPASE 3; HISTONE DEACETYLASE; NUCLEAR PROTEIN; STRESS ACTIVATED PROTEIN KINASE; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HEMORRHAGIC SHOCK; LETHALITY; NONHUMAN; PRIORITY JOURNAL; RAT; RESUSCITATION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; CASPASE 3; CELL SURVIVAL; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; HISTONE DEACETYLASES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER; RATS; SHOCK, HEMORRHAGIC; SIGNAL TRANSDUCTION; VALPROIC ACID;

EID: 70349181984     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2009.04.012     Document Type: Article

References (23)

1. Alam H.B., Shults C., Ahuja N., et al. Impact of resuscitation strategies on the acetylation of cardiac histone in a swine model of hemorrhage. Resuscitation 76 (2008) 299
2. Lin T., Chen H., Koustova E., et al. Histone deacetylase as therapeutic target in a rodent model of hemorrhagic shock: Effect of different resuscitation strategies on lung and liver. Surgery 141 (2007) 784
3. Gonzales E.R., Chen H., Munuve R.M., et al. Hepatoprotection and lethality rescue by histone deacetylase inhibitor valproic acid in fatal hemorrhagic shock. J Trauma 65 (2008) 554
4. Shults C., Sailhamer E.A., Li Y., et al. Surviving blood loss without fluid resuscitation. J Trauma 64 (2008) 629
5. Li Y., Yuan Z., Liu B., et al. Prevention of hypoxia induced neuronal apoptosis through histone deacetylase inhibitor. J Trauma 64 (2008) 863
6. Hebbes T.R., Thorne A.W., and Crane-Robinson C. A direct link between core histone acetylation and transcriptionally active chromatin. EMBO J 7 (1988) 1395
7. Glozak M.A., Sengupta N., Zhang X., et al. Acetylation and deacetylation of non-histone proteins. Gene 363 (2005) 15
8. Göttlicher M., Minucci S., Zhu P., et al. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J 20 (2001) 6969
9. Gonzales E., Chen H., Munuve R., et al. Valproic acid prevents hemorrhage-associated lethality and affects the acetylation pattern of cardiac histones. Shock 25 (2006) 395
10. Mollen K.P., McCloskey C.A., Tanaka H., et al. Hypoxia activates c-Jun N-terminal kinase via Rac1-dependent reactive oxygen species production in hepatocytes. Shock 28 (2007) 270
11. Shen H.M., and Liu Z.G. JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species. Free Radic Biol Med 40 (2006) 928
12. Bubici C., Papa S., Dean K., et al. Mutual cross-talk between reactive oxygen species and nuclear factor-κB: Molecular basis and biological significance. Oncogene 25 (2006) 6731
13. Budd R.C. Activation-induced cell death. Curr Opin Immunol 13 (2001) 356
14. Thornberry N.A., and Lazebnik Y. Caspases: Enemies within. Science 281 (1998) 1312
15. Liu Z.G., Hsu H., Goeddel D.V., et al. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell 87 (1996) 565
16. Nakano H., Nakajima A., Sakon-Komazawa S., et al. Reactive oxygen species mediate crosstalk between NF-κB and JNK. Cell Death Differ 13 (2006) 730
17. Gerritsen M.E., Williams A.J., Neish A.S., et al. CREB-binding protein/p300 are transcriptional coactivators of p65. Proc Natl Acad Sci USA 94 (1997) 2927
18. Perkins N.D., Felzien L.K., Betts J.C., et al. Regulation of NF-κB by cyclin-dependent kinases associated with the p300 coactivator. Science 275 (1997) 523
19. Zhong H., May M.J., Jimi E., et al. The phosphorylation status of nuclear NF-κB determines its association with CBP/p300 or HDAC-1. Mol Cell 9 (2002) 625
20. Sheppard K.A., Rose D.W., Haque Z.K., et al. Transcriptional activation by NF-κB requires multiple coactivators. Mol Cell Biol 19 (1999) 6367
21. Chen L., Fischle W., Verdin E., et al. Duration of nuclear NF-κB action regulated by reversible acetylation. Science 293 (2001) 1653
22. Peterson C.L., and Laniel M.A. Histones and histone modifications. Curr Biol 14 (2004) R546
23. Chen H., Yan Y., Davidson T.L., et al. Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells. Cancer Res 66 (2006) 9009