Attuning hydroxypropyl methylcellulose phthalate to oral delivery vehicle for effective and selective delivery of protein vaccine in ileum

Biomaterials

Volumn 59, Issue , 2015, Pages 144-159

  Singh, Bijay ^a,b   Maharjan, Sushila ^a,b   Jiang, Tao ^a,b   Kang, Sang Kee ^a,c   Choi, Yun Jaie ^a,b   Cho, Chong Su ^a,b  

^a Seoul National University   (South Korea)

^b Seoul National University   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

M cells; Microparticles; Mucoadhesive; PH responsive; Targeted delivery; Thiolated HPMCP

Indexed keywords

ANTIGENS; CELLS; CYTOLOGY; ESTERS; MAMMALS; RAPID TRANSIT; VACCINES;

M CELLS; MICRO-PARTICLES; MUCOADHESIVE; PH-RESPONSIVE; TARGETED DELIVERY; THIOLATED HPMCP;

PROTEINS;

ANTIGEN; GAMMA INTERFERON; HYDROXYPROPYLMETHYLCELLULOSE PHTHALATE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 4; THIOL GROUP; VACCINE; METHYLCELLULOSE;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY BLOOD LEVEL; ANTIBODY DETECTION; ANTIBODY RESPONSE; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SOLUBILITY; DRUG UPTAKE; DUODENUM PH; ENZYMATIC DEGRADATION; EX VIVO STUDY; FEMALE; HUMORAL IMMUNITY; ILEUM; IMMUNIZATION; INTESTINE TRANSIT TIME; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PEYER PATCH; PH; PRIORITY JOURNAL; PROTEIN SECRETION; SPLEEN; STOMACH PH; ANALOGS AND DERIVATIVES; ANIMAL; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOLOGY; METABOLISM; ORAL DRUG ADMINISTRATION;

MUS;

ADMINISTRATION, ORAL; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; ENZYME-LINKED IMMUNOSORBENT ASSAY; ILEUM; METHYLCELLULOSE; MICE; PEYER'S PATCHES; VACCINES;

EID: 84930176282     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2015.04.017     Document Type: Article

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