Feasibility study on the retention of superporous hydrogel composite polymer in the intestinal tract of man using scintigraphy

Journal of Controlled Release

Volumn 99, Issue 2, 2004, Pages 199-206

  Dorkoosh, F A ^a   Stokkel, M P M ^b   Blok, D ^b   Borchard, G ^a   Rafiee Tehrani, M ^a   Verhoef, J C ^a   Junginger, H E ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Intestinal tract; Man; Residence time; Scintigraphy; SPH composite; Superporous hydrogels (SPH)

Indexed keywords

GAMMA CAMERA; MECHANICAL FIXATION; SCINTIGRAPHY; SUPERPOROUS HYDROGEL;

ABSORPTION; DRUG INTERACTIONS; HYDROGELS; POLYMERS;

DRUG PRODUCTS;

3 SULFOPROPYLACRYLATE; ACRYLAMIDE; ACRYLAMIDE DERIVATIVE; ACRYLIC ACID; ACRYLIC ACID DERIVATIVE; AMMONIUM DERIVATIVE; BICARBONATE; CAPSUGEL; CROSSCARMELLOSE SODIUM; DIAMINE DERIVATIVE; GELATIN; N,N' METHYLENEBISACRYLAMIDE; N,N,N',N' TETRAMETHYLETHYLENEDIAMINE; PERSULFATE AMMONIUM; POLOXAMER; POLYMER; SODIUM DERIVATIVE; TECHNETIUM 99M; UNCLASSIFIED DRUG;

ADULT; ARTICLE; DIET RESTRICTION; DRUG DELIVERY SYSTEM; DRUG SAFETY; ENTERIC COATED TABLET; FEASIBILITY STUDY; FEMALE; GASTROINTESTINAL TRACT SCINTISCANNING; HUMAN; HYDROGEL; INTESTINE; INTESTINE SCINTISCANNING; ISOTOPE LABELING; MALE; MONITORING; NORMAL HUMAN; PRIORITY JOURNAL; SCINTILLATION CAMERA; SITTING; SMALL INTESTINE; STOMACH;

ADMINISTRATION, ORAL; ADULT; CAPSULES; DELAYED-ACTION PREPARATIONS; EXCIPIENTS; FEASIBILITY STUDIES; FEMALE; GELATIN; HUMANS; HYDROGELS; INDIUM RADIOISOTOPES; INTESTINE, SMALL; MALE; POLYMERS; POROSITY; RADIONUCLIDE IMAGING; STOMACH; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS;

EID: 4544270352     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2004.06.012     Document Type: Article

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