-
2
-
-
85028226154
-
-
Gemcitabine HCL Drug Label [Accessed May 2014]
-
Gemcitabine HCL Drug Label. Available at: http://dailymed.nlm.nih.gov/ dailymed/lookup.cfm?setid=7a753acb-5061-4d34-bc42-c2c7a9512e7a [Accessed May 2014].
-
-
-
-
3
-
-
33745686698
-
Cellular pharmacology of gemcitabine
-
Mini E, Nobili S, Caciagli B, Landini I, Mazzei T. Cellular pharmacology of gemcitabine. Ann Oncol 2006; 17 (Suppl 5):v7-v12.
-
(2006)
Ann Oncol
, vol.17
, pp. v7-v12
-
-
Mini, E.1
Nobili, S.2
Caciagli, B.3
Landini, I.4
Mazzei, T.5
-
4
-
-
0025049372
-
Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2′,2′-difluorodeoxycytidine
-
Heinemann V, Xu YZ, Chubb S, Sen A, Hertel LW, Grindey GB, Plunkett W. Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2′,2′-difluorodeoxycytidine. Mol Pharmacol 1990; 38: 567-572.
-
(1990)
Mol Pharmacol
, vol.38
, pp. 567-572
-
-
Heinemann, V.1
Xu, Y.Z.2
Chubb, S.3
Sen, A.4
Hertel, L.W.5
Grindey, G.B.6
Plunkett, W.7
-
5
-
-
0026571795
-
Cellular elimination of 2′,2′-difluorodeoxycytidine 5′-triphosphate: A mechanism of self-potentiation
-
Heinemann V, Xu YZ, Chubb S, Sen A, Hertel LW, Grindey GB, Plunkett W. Cellular elimination of 2′,2′-difluorodeoxycytidine 5′-triphosphate: a mechanism of self-potentiation. Cancer Res 1992; 52: 533-539.
-
(1992)
Cancer Res
, vol.52
, pp. 533-539
-
-
Heinemann, V.1
Xu, Y.Z.2
Chubb, S.3
Sen, A.4
Hertel, L.W.5
Grindey, G.B.6
Plunkett, W.7
-
6
-
-
0028799108
-
Gemcitabine: Metabolism, mechanisms of action, and self-potentiation
-
Plunkett W, Huang P, Xu YZ, Heinemann V, Grunewald R, Gandhi V. Gemcitabine: metabolism, mechanisms of action, and self-potentiation. Semin Oncol 1995; 22:3-10.
-
(1995)
Semin Oncol
, vol.22
, pp. 3-10
-
-
Plunkett, W.1
Huang, P.2
Xu, Y.Z.3
Heinemann, V.4
Grunewald, R.5
Gandhi, V.6
-
7
-
-
0026324313
-
Action of 2′,2′-difluorodeoxycytidine on DNA synthesis
-
Huang P, Chubb S, Hertel LW, Grindey GB, Plunkett W. Action of 2′,2′-difluorodeoxycytidine on DNA synthesis. Cancer Res 1991; 51:6110-6117.
-
(1991)
Cancer Res
, vol.51
, pp. 6110-6117
-
-
Huang, P.1
Chubb, S.2
Hertel, L.W.3
Grindey, G.B.4
Plunkett, W.5
-
8
-
-
73949130114
-
Cytidine deaminase residual activity in serum is a predictive marker of early severe toxicities in adults after gemcitabine-based chemotherapies
-
Ciccolini J, Dahan L, André N, Evrard A, Duluc M, Blesius A, et al. Cytidine deaminase residual activity in serum is a predictive marker of early severe toxicities in adults after gemcitabine-based chemotherapies. J Clin Oncol 2010; 28:160-165.
-
(2010)
J Clin Oncol
, vol.28
, pp. 160-165
-
-
Ciccolini, J.1
Dahan, L.2
André, N.3
Evrard, A.4
Duluc, M.5
Blesius, A.6
-
9
-
-
84862777507
-
Identification of NME5 as a contributor to innate resistance to gemcitabine in pancreatic cancer cells
-
Li F, Hu G, Jiang Z, Guo J, Wang K, Ouyang K, et al. Identification of NME5 as a contributor to innate resistance to gemcitabine in pancreatic cancer cells. FEBS J 2012; 279:1261-1273.
-
(2012)
FEBS J
, vol.279
, pp. 1261-1273
-
-
Li, F.1
Hu, G.2
Jiang, Z.3
Guo, J.4
Wang, K.5
Ouyang, K.6
-
10
-
-
84886793850
-
Nm23/ nucleoside diphosphate kinase-A as a potent prognostic marker in invasive pancreatic ductal carcinoma identified by proteomic analysis of laser micro-dissected formalin-fixed paraffin-embedded tissue
-
Takadate T, Onogawa T, Fujii K, Motoi F, Mikami S, Fukuda T, et al. Nm23/ nucleoside diphosphate kinase-A as a potent prognostic marker in invasive pancreatic ductal carcinoma identified by proteomic analysis of laser micro-dissected formalin-fixed paraffin-embedded tissue. Clin Proteomics 2012; 9:8.
-
(2012)
Clin Proteomics
, vol.9
, pp. 8
-
-
Takadate, T.1
Onogawa, T.2
Fujii, K.3
Motoi, F.4
Mikami, S.5
Fukuda, T.6
-
11
-
-
33947430594
-
The role of nucleoside transporters in cancer chemotherapy with nucleoside drugs
-
Zhang J, Visser F, King KM, Baldwin SA, Young JD, Cass CE. The role of nucleoside transporters in cancer chemotherapy with nucleoside drugs. Cancer Metastasis Rev 2007; 26:85-110.
-
(2007)
Cancer Metastasis Rev
, vol.26
, pp. 85-110
-
-
Zhang, J.1
Visser, F.2
King, K.M.3
Baldwin, S.A.4
Young, J.D.5
Cass, C.E.6
-
12
-
-
84899919032
-
Prognostic value of human equilibrative nucleoside transporter1 in pancreatic cancer receiving gemcitabine-based chemotherapy: A meta-analysis
-
Liu ZQ, Han YC, Zhang X, Chu L, Fang JM, Zhao HX, et al. Prognostic value of human equilibrative nucleoside transporter1 in pancreatic cancer receiving gemcitabine-based chemotherapy: a meta-analysis. PLoS One 2014; 9: e87103.
-
(2014)
PLoS One
, vol.9
, pp. e87103
-
-
Liu, Z.Q.1
Han, Y.C.2
Zhang, X.3
Chu, L.4
Fang, J.M.5
Zhao, H.X.6
-
13
-
-
84892633020
-
European Study Group for Pancreatic Cancer. Pancreatic cancer hENT1 expression and survival from gemcitabine in patients from the ESPAC-3 trial
-
Greenhalf W, Ghaneh P, Neoptolemos JP, Palmer DH, Cox TF, Lamb RF, et al. European Study Group for Pancreatic Cancer. Pancreatic cancer hENT1 expression and survival from gemcitabine in patients from the ESPAC-3 trial. J Natl Cancer Inst 2014; 106:djt347.
-
(2014)
J Natl Cancer Inst
, vol.106
, pp. djt347
-
-
Greenhalf, W.1
Ghaneh, P.2
Neoptolemos, J.P.3
Palmer, D.H.4
Cox, T.F.5
Lamb, R.F.6
-
14
-
-
84865474189
-
Levels of gemcitabine transport and metabolism proteins predict survival times of patients treated with gemcitabine for pancreatic adenocarcinoma
-
Maréchal R, Bachet JB, Mackey JR, Dalban C, Demetter P, Graham K, et al. Levels of gemcitabine transport and metabolism proteins predict survival times of patients treated with gemcitabine for pancreatic adenocarcinoma. Gastroenterology 2012; 143:664-74.e1-6.
-
(2012)
Gastroenterology
, vol.143
, pp. 664-74e16
-
-
Maréchal, R.1
Bachet, J.B.2
MacKey, J.R.3
Dalban, C.4
Demetter, P.5
Graham, K.6
-
15
-
-
6044267987
-
The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma
-
Spratlin J, Sangha R, Glubrecht D, Dabbagh L, Young JD, Dumontet C, et al. The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma. Clin Cancer Res 2004; 10:6956-6961.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 6956-6961
-
-
Spratlin, J.1
Sangha, R.2
Glubrecht, D.3
Dabbagh, L.4
Young, J.D.5
Dumontet, C.6
-
16
-
-
79952976406
-
A Phase II trial of gemcitabine and mitoxantrone for patients with acute myeloid leukemia in first relapse
-
Advani AS, Shadman M, Ali-Osman F, Barker A, Rybicki L, Kalaycio M, et al. A Phase II trial of gemcitabine and mitoxantrone for patients with acute myeloid leukemia in first relapse. Clin Lymphoma Myeloma Leuk 2010; 10:473-476.
-
(2010)
Clin Lymphoma Myeloma Leuk
, vol.10
, pp. 473-476
-
-
Advani, A.S.1
Shadman, M.2
Ali-Osman, F.3
Barker, A.4
Rybicki, L.5
Kalaycio, M.6
-
17
-
-
0034804359
-
Differential expression of human nucleoside transporters in normal and tumor tissue
-
Pennycooke M, Chaudary N, Shuralyova I, Zhang Y, Coe IR. Differential expression of human nucleoside transporters in normal and tumor tissue. Biochem Biophys Res Commun 2001; 280:951-959.
-
(2001)
Biochem Biophys Res Commun
, vol.280
, pp. 951-959
-
-
Pennycooke, M.1
Chaudary, N.2
Shuralyova, I.3
Zhang, Y.4
Coe, I.R.5
-
18
-
-
79952221881
-
CNT1 expression influences proliferation and chemosensitivity in drug-resistant pancreatic cancer cells
-
Bhutia YD, Hung SW, Patel B, Lovin D, Govindarajan R. CNT1 expression influences proliferation and chemosensitivity in drug-resistant pancreatic cancer cells. Cancer Res 2011; 71:1825-1835.
-
(2011)
Cancer Res
, vol.71
, pp. 1825-1835
-
-
Bhutia, Y.D.1
Hung, S.W.2
Patel, B.3
Lovin, D.4
Govindarajan, R.5
-
19
-
-
57649112390
-
Distribution of gemcitabine pathway genotypes in ethnic Asians and their association with outcome in non-small cell lung cancer patients
-
Soo RA, Wang LZ, Ng SS, Chong PY, Yong WP, Lee SC, et al. Distribution of gemcitabine pathway genotypes in ethnic Asians and their association with outcome in non-small cell lung cancer patients. Lung Cancer 2009; 63:121-127.
-
(2009)
Lung Cancer
, vol.63
, pp. 121-127
-
-
Soo, R.A.1
Wang, L.Z.2
Ng, S.S.3
Chong, P.Y.4
Yong, W.P.5
Lee, S.C.6
-
20
-
-
84864408425
-
Effect of genetic polymorphisms on therapeutic response and clinical outcomes in pancreatic cancer patients treated with gemcitabine
-
Woo HI, Kim KK, Choi H, Kim S, Jang KT, Yi JH, et al. Effect of genetic polymorphisms on therapeutic response and clinical outcomes in pancreatic cancer patients treated with gemcitabine. Pharmacogenomics 2012; 13:1023-1035.
-
(2012)
Pharmacogenomics
, vol.13
, pp. 1023-1035
-
-
Woo, H.I.1
Kim, K.K.2
Choi, H.3
Kim, S.4
Jang, K.T.5
Yi, J.H.6
-
21
-
-
84894040367
-
Genetic polymorphisms of SLC28A3, SLC29A1 and RRM1 predict clinical outcome in patients with metastatic breast cancer receiving gemcitabine plus paclitaxel chemotherapy
-
Lee SY, Im SA, Park YH, Woo SY, Kim S, Choi MK, et al. Genetic polymorphisms of SLC28A3, SLC29A1 and RRM1 predict clinical outcome in patients with metastatic breast cancer receiving gemcitabine plus paclitaxel chemotherapy. Eur J Cancer 2014; 50:698-705.
-
(2014)
Eur J Cancer
, vol.50
, pp. 698-705
-
-
Lee, S.Y.1
Im, S.A.2
Park, Y.H.3
Woo, S.Y.4
Kim, S.5
Choi, M.K.6
-
22
-
-
78449305536
-
Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer
-
Tanaka M, Javle M, Dong X, Eng C, Abbruzzese JL, Li D. Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer. Cancer 2010; 116:5325-5335.
-
(2010)
Cancer
, vol.116
, pp. 5325-5335
-
-
Tanaka, M.1
Javle, M.2
Dong, X.3
Eng, C.4
Abbruzzese, J.L.5
Li, D.6
-
23
-
-
84892937547
-
SLC28A3 genotype and gemcitabine rate of infusion affect dFdCTP metabolite disposition in patients with solid tumours
-
Khatri A, Williams BW, Fisher J, Brundage RC, Gurvich VJ, Lis LG, et al. SLC28A3 genotype and gemcitabine rate of infusion affect dFdCTP metabolite disposition in patients with solid tumours. Br J Cancer 2014; 110:304-312.
-
(2014)
Br J Cancer
, vol.110
, pp. 304-312
-
-
Khatri, A.1
Williams, B.W.2
Fisher, J.3
Brundage, R.C.4
Gurvich, V.J.5
Lis, L.G.6
-
24
-
-
34447329337
-
Pharmacogenomics of gemcitabine: Can genetic studies lead to tailor-made therapy?
-
Ueno H, Kiyosawa K, Kaniwa N. Pharmacogenomics of gemcitabine: can genetic studies lead to tailor-made therapy? Br J Cancer 2007; 97:145-151.
-
(2007)
Br J Cancer
, vol.97
, pp. 145-151
-
-
Ueno, H.1
Kiyosawa, K.2
Kaniwa, N.3
-
25
-
-
41549095093
-
Correlation of CDA, ERCC1, and XPD polymorphisms with response and survival in gemcitabine/cisplatin-treated advanced non-small cell lung cancer patients
-
Tibaldi C, Giovannetti E, Vasile E, Mey V, Laan AC, Nannizzi S, et al. Correlation of CDA, ERCC1, and XPD polymorphisms with response and survival in gemcitabine/cisplatin-treated advanced non-small cell lung cancer patients. Clin Cancer Res 2008; 14:1797-1803.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 1797-1803
-
-
Tibaldi, C.1
Giovannetti, E.2
Vasile, E.3
Mey, V.4
Laan, A.C.5
Nannizzi, S.6
-
26
-
-
84874029063
-
Pharmacogenomics of gemcitabine metabolism: Functional analysis of genetic variants in cytidine deaminase and deoxycytidine kinase
-
Baker JA, Wickremsinhe ER, Li CH, Oluyedun OA, Dantzig AH, Hall SD, et al. Pharmacogenomics of gemcitabine metabolism: functional analysis of genetic variants in cytidine deaminase and deoxycytidine kinase. Drug Metab Dispos 2013; 41:541-545.
-
(2013)
Drug Metab Dispos
, vol.41
, pp. 541-545
-
-
Baker, J.A.1
Wickremsinhe, E.R.2
Ch, L.3
Oluyedun, O.A.4
Dantzig, A.H.5
Hall, S.D.6
-
27
-
-
79955540073
-
Variability in transport and biotransformation of cytarabine is associated with its toxicity in peripheral blood mononuclear cells
-
Parmar S, Seeringer A, Denich D, Gärtner F, Pitterle K, Syrovets T, et al. Variability in transport and biotransformation of cytarabine is associated with its toxicity in peripheral blood mononuclear cells. Pharmacogenomics 2011; 12:503-514.
-
(2011)
Pharmacogenomics
, vol.12
, pp. 503-514
-
-
Parmar, S.1
Seeringer, A.2
Denich, D.3
Gärtner, F.4
Pitterle, K.5
Syrovets, T.6
-
28
-
-
84877670338
-
CDA gene polymorphisms and enzyme activity: Genotype-phenotype relationship in an Italian-Caucasian population
-
Carpi FM, Vincenzetti S, Ubaldi J, Pucciarelli S, Polzonetti V, Micozzi D, et al. CDA gene polymorphisms and enzyme activity: genotype-phenotype relationship in an Italian-Caucasian population. Pharmacogenomics 2013; 14:769-781.
-
(2013)
Pharmacogenomics
, vol.14
, pp. 769-781
-
-
Carpi, F.M.1
Vincenzetti, S.2
Ubaldi, J.3
Pucciarelli, S.4
Polzonetti, V.5
Micozzi, D.6
-
29
-
-
46749134759
-
Correlation between cytidine deaminase genotype and gemcitabine deamination in blood samples
-
Giovannetti E, Laan AC, Vasile E, Tibaldi C, Nannizzi S, Ricciardi S, et al. Correlation between cytidine deaminase genotype and gemcitabine deamination in blood samples. Nucleosides Nucleotides Nucleic Acids 2008; 27:720-725.
-
(2008)
Nucleosides Nucleotides Nucleic Acids
, vol.27
, pp. 720-725
-
-
Giovannetti, E.1
Laan, A.C.2
Vasile, E.3
Tibaldi, C.4
Nannizzi, S.5
Ricciardi, S.6
-
30
-
-
84866743985
-
Cytidine deaminase single-nucleotide polymorphism is predictive of toxicity from gemcitabine in patients with pancreatic cancer: RTOG 9704
-
Farrell JJ, Bae K, Wong J, Guha C, Dicker AP, Elsaleh H. Cytidine deaminase single-nucleotide polymorphism is predictive of toxicity from gemcitabine in patients with pancreatic cancer: RTOG 9704. Pharmacogenomics J 2012; 12:395-403.
-
(2012)
Pharmacogenomics J
, vol.12
, pp. 395-403
-
-
Farrell, J.J.1
Bae, K.2
Wong, J.3
Guha, C.4
Dicker, A.P.5
Elsaleh, H.6
-
31
-
-
83655164249
-
The influence of gemcitabine pathway polymorphisms on treatment outcome in patients with malignant mesothelioma
-
Erculj N, Kovac V, Hmeljak J, Franko A, Dodic-Fikfak M, Dolan V. The influence of gemcitabine pathway polymorphisms on treatment outcome in patients with malignant mesothelioma. Pharmacogenet Genomics 2012; 22:58-68.
-
(2012)
Pharmacogenet Genomics
, vol.22
, pp. 58-68
-
-
Erculj, N.1
Kovac, V.2
Hmeljak, J.3
Franko, A.4
Dodic-Fikfak, M.5
Dolan, V.6
-
32
-
-
84861330349
-
High incidence of severe neutropenia after gemcitabine-based chemotherapy in Chinese cancer patients with CDA 79A C mutation
-
Xu J, Zhou Y, Zhang J, Chen Y, Zhuang R, Liu T, Cai W. High incidence of severe neutropenia after gemcitabine-based chemotherapy in Chinese cancer patients with CDA 79A C mutation. Clin Chim Acta 2012; 413:1284-1287.
-
(2012)
Clin Chim Acta
, vol.413
, pp. 1284-1287
-
-
Xu, J.1
Zhou, Y.2
Zhang, J.3
Chen, Y.4
Zhuang, R.5
Liu, T.6
Cai, W.7
-
33
-
-
34648847288
-
Toxic death case in a patient undergoing gemcitabine-based chemotherapy in relation with cytidine deaminase downregulation
-
Mercier C, Raynal C, Dahan L, Ortiz A, Evrard A, Dupuis C, et al. Toxic death case in a patient undergoing gemcitabine-based chemotherapy in relation with cytidine deaminase downregulation. Pharmacogenet Genomics 2007; 17:841-844.
-
(2007)
Pharmacogenet Genomics
, vol.17
, pp. 841-844
-
-
Mercier, C.1
Raynal, C.2
Dahan, L.3
Ortiz, A.4
Evrard, A.5
Dupuis, C.6
-
34
-
-
84864411377
-
Pathway-based pharmacogenomics of gemcitabine pharmacokinetics in patients with solid tumors
-
Mitra AK, Kirstein MN, Khatri A, Skubitz KM, Dudek AZ, Greeno EW, et al. Pathway-based pharmacogenomics of gemcitabine pharmacokinetics in patients with solid tumors. Pharmacogenomics 2012; 13:1009-1021.
-
(2012)
Pharmacogenomics
, vol.13
, pp. 1009-1021
-
-
Mitra, A.K.1
Kirstein, M.N.2
Khatri, A.3
Skubitz, K.M.4
Dudek, A.Z.5
Greeno, E.W.6
-
35
-
-
84878113857
-
Determination of common genetic variants in cytidine deaminase (CDA) gene in Indian ethnic population
-
Iyer SN, Ankala A, Singhal RS, Hegde MR. Determination of common genetic variants in cytidine deaminase (CDA) gene in Indian ethnic population. Gene 2013; 524:35-39.
-
(2013)
Gene
, vol.524
, pp. 35-39
-
-
Iyer, S.N.1
Ankala, A.2
Singhal, R.S.3
Hegde, M.R.4
-
36
-
-
0037245970
-
A functional single-nucleotide polymorphism in the human cytidine deaminase gene contributing to ara-C sensitivity
-
Yue L, Saikawa Y, Ota K, Tanaka M, Nishimura R, Uehara T, et al. A functional single-nucleotide polymorphism in the human cytidine deaminase gene contributing to ara-C sensitivity. Pharmacogenetics 2003; 13:29-38.
-
(2003)
Pharmacogenetics
, vol.13
, pp. 29-38
-
-
Yue, L.1
Saikawa, Y.2
Ota, K.3
Tanaka, M.4
Nishimura, R.5
Uehara, T.6
-
37
-
-
20244364241
-
Severe drug toxicity associated with a single-nucleotide polymorphism of the cytidine deaminase gene in a Japanese cancer patient treated with gemcitabine plus cisplatin
-
Yonemori K, Ueno H, Okusaka T, Yamamoto N, Ikeda M, Saijo N, et al. Severe drug toxicity associated with a single-nucleotide polymorphism of the cytidine deaminase gene in a Japanese cancer patient treated with gemcitabine plus cisplatin. Clin Cancer Res 2005; 11:2620-2624.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 2620-2624
-
-
Yonemori, K.1
Ueno, H.2
Okusaka, T.3
Yamamoto, N.4
Ikeda, M.5
Saijo, N.6
-
38
-
-
34447303456
-
Pharmacokinetics of gemcitabine in Japanese cancer patients: The impact of a cytidine deaminase polymorphism
-
Sugiyama E, Kaniwa N, Kim SR, Kikura-Hanajiri R, Hasegawa R, Maekawa K, et al. Pharmacokinetics of gemcitabine in Japanese cancer patients: the impact of a cytidine deaminase polymorphism. J Clin Oncol 2007; 25:32-42.
-
(2007)
J Clin Oncol
, vol.25
, pp. 32-42
-
-
Sugiyama, E.1
Kaniwa, N.2
Kim, S.R.3
Kikura-Hanajiri, R.4
Hasegawa, R.5
Maekawa, K.6
-
39
-
-
84860332244
-
DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells
-
Saiki Y, Yoshino Y, Fujimura H, Manabe T, Kudo Y, Shimada M, et al. DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells. Biochem Biophys Res Commun 2012; 421:98-104.
-
(2012)
Biochem Biophys Res Commun
, vol.421
, pp. 98-104
-
-
Saiki, Y.1
Yoshino, Y.2
Fujimura, H.3
Manabe, T.4
Kudo, Y.5
Shimada, M.6
-
40
-
-
5044225419
-
Determinants of sensitivity and resistance to gemcitabine: The roles of human equilibrative nucleoside transporter 1 and deoxycytidine kinase in non-small cell lung cancer
-
Achiwa H, Oguri T, Sato S, Maeda H, Niimi T, Ueda R. Determinants of sensitivity and resistance to gemcitabine: the roles of human equilibrative nucleoside transporter 1 and deoxycytidine kinase in non-small cell lung cancer. Cancer Sci 2004; 95:753-757.
-
(2004)
Cancer Sci
, vol.95
, pp. 753-757
-
-
Achiwa, H.1
Oguri, T.2
Sato, S.3
Maeda, H.4
Niimi, T.5
Ueda, R.6
-
41
-
-
33646407273
-
Immunohistochemical and genetic evaluation of deoxycytidine kinase in pancreatic cancer: Relationship to molecular mechanisms of gemcitabine resistance and survival
-
Sebastiani V, Ricci F, Rubio-Viqueira B, Kulesza P, Yeo CJ, Hidalgo M, et al. Immunohistochemical and genetic evaluation of deoxycytidine kinase in pancreatic cancer: relationship to molecular mechanisms of gemcitabine resistance and survival. Clin Cancer Res 2006; 12:2492-2497.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 2492-2497
-
-
Sebastiani, V.1
Ricci, F.2
Rubio-Viqueira, B.3
Kulesza, P.4
Yeo, C.J.5
Hidalgo, M.6
-
42
-
-
0002831066
-
Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity
-
Kroep JR, Loves WJ, van der Wilt CL, Alvarez E, Talianidis I, Boven E, et al. Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity. Mol Cancer Ther 2002; 1:371-376.
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 371-376
-
-
Kroep, J.R.1
Loves, W.J.2
Van Der Wilt, C.L.3
Alvarez, E.4
Talianidis, I.5
Boven, E.6
-
43
-
-
9244234326
-
Association between single nucleotide polymorphisms in deoxycytidine kinase and treatment response among acute myeloid leukaemia patients
-
Shi JY, Shi ZZ, Zhang SJ, Zhu YM, Gu BW, Li G, et al. Association between single nucleotide polymorphisms in deoxycytidine kinase and treatment response among acute myeloid leukaemia patients. Pharmacogenetics 2004; 14:759-768.
-
(2004)
Pharmacogenetics
, vol.14
, pp. 759-768
-
-
Shi, J.Y.1
Shi, Z.Z.2
Zhang, S.J.3
Zhu, Y.M.4
Gu, B.W.5
Li, G.6
-
44
-
-
70649100419
-
Genetic factors influencing cytarabine therapy
-
Lamba JK. Genetic factors influencing cytarabine therapy. Pharmacogenomics 2009; 10:1657-1674.
-
(2009)
Pharmacogenomics
, vol.10
, pp. 1657-1674
-
-
Lamba, J.K.1
-
45
-
-
33746434516
-
Novel deoxycytidine kinase gene polymorphisms: A population screening study in Caucasian healthy volunteers
-
Joerger M, Bosch TM, Doodeman VD, Beijnen JH, Smits PH, Schellens JH. Novel deoxycytidine kinase gene polymorphisms: a population screening study in Caucasian healthy volunteers. Eur J Clin Pharmacol 2006; 62:681-684.
-
(2006)
Eur J Clin Pharmacol
, vol.62
, pp. 681-684
-
-
Joerger, M.1
Bosch, T.M.2
Doodeman, V.D.3
Beijnen, J.H.4
Smits, P.H.5
Schellens, J.H.6
-
46
-
-
80051798346
-
Differential effect of polymorphisms of CMPK1 and RRM1 on survival in advanced non-small cell lung cancer patients treated with gemcitabine or taxane/cisplatinum
-
Ryu JS, Shin ES, Nam HS, Yi HG, Cho JH, Kim CS, et al. Differential effect of polymorphisms of CMPK1 and RRM1 on survival in advanced non-small cell lung cancer patients treated with gemcitabine or taxane/cisplatinum. J Thorac Oncol 2011; 6:1320-1329.
-
(2011)
J Thorac Oncol
, vol.6
, pp. 1320-1329
-
-
Ryu, J.S.1
Shin, E.S.2
Nam, H.S.3
Yi, H.G.4
Cho, J.H.5
Kim, C.S.6
-
47
-
-
80053148504
-
Genetic variants in cytosolic 5′-nucleotidase II are associated with its expression and cytarabine sensitivity in HapMap cell lines and in patients with acute myeloid leukemia
-
Mitra AK, Crews KR, Pounds S, Cao X, Feldberg T, Ghodke Y, et al. Genetic variants in cytosolic 5′-nucleotidase II are associated with its expression and cytarabine sensitivity in HapMap cell lines and in patients with acute myeloid leukemia. J Pharmacol Exp Ther 2011; 339:9-23.
-
(2011)
J Pharmacol Exp Ther
, vol.339
, pp. 9-23
-
-
Mitra, A.K.1
Crews, K.R.2
Pounds, S.3
Cao, X.4
Feldberg, T.5
Ghodke, Y.6
-
48
-
-
0036462584
-
Determinants of resistance to 2′,2′-difluorodeoxycytidine (gemcitabine)
-
Bergman AM, Pinedo HM, Peters GJ. Determinants of resistance to 2′,2′-difluorodeoxycytidine (gemcitabine). Drug Resist Updat 2002; 5:19-33.
-
(2002)
Drug Resist Updat
, vol.5
, pp. 19-33
-
-
Bergman, A.M.1
Pinedo, H.M.2
Peters, G.J.3
-
49
-
-
79959548041
-
The ribonucleotide reductase large subunit (RRM1) as a predictive factor in patients with cancer
-
Jordheim LP, Sève P, Trédan O, Dumontet C. The ribonucleotide reductase large subunit (RRM1) as a predictive factor in patients with cancer. Lancet Oncol 2011; 12:693-702.
-
(2011)
Lancet Oncol
, vol.12
, pp. 693-702
-
-
Jordheim, L.P.1
Sève, P.2
Trédan, O.3
Dumontet, C.4
-
50
-
-
80052535410
-
Gene expression analysis for predicting gemcitabine resistance in human cholangiocarcinoma
-
Sato J, Kimura T, Saito T, Anazawa T, Kenjo A, Sato Y, et al. Gene expression analysis for predicting gemcitabine resistance in human cholangiocarcinoma. J Hepatobiliary Pancreat Sci 2011; 18:700-711.
-
(2011)
J Hepatobiliary Pancreat Sci
, vol.18
, pp. 700-711
-
-
Sato, J.1
Kimura, T.2
Saito, T.3
Anazawa, T.4
Kenjo, A.5
Sato, Y.6
-
51
-
-
2542530631
-
An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines
-
Davidson JD, Ma L, Flagella M, Geeganage S, Gelbert LM, Slapak CA. An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines. Cancer Res 2004; 64:3761-3766.
-
(2004)
Cancer Res
, vol.64
, pp. 3761-3766
-
-
Davidson, J.D.1
Ma, L.2
Flagella, M.3
Geeganage, S.4
Gelbert, L.M.5
Slapak, C.A.6
-
52
-
-
3042701602
-
RRM1 and PTEN as prognostic parameters for overall and disease-free survival in patients with non-small-cell lung cancer
-
Bepler G, Sharma S, Cantor A, Gautam A, Haura E, Simon G, et al. RRM1 and PTEN as prognostic parameters for overall and disease-free survival in patients with non-small-cell lung cancer. J Clin Oncol 2004; 22:1878-1885.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1878-1885
-
-
Bepler, G.1
Sharma, S.2
Cantor, A.3
Gautam, A.4
Haura, E.5
Simon, G.6
-
53
-
-
84864536876
-
Silencing of ribonucleotide reductase subunit M1 potentiates the antitumor activity of gemcitabine in resistant cancer cells
-
Wonganan P, Chung WG, Zhu S, Kiguchi K, Digiovanni J, Cui Z. Silencing of ribonucleotide reductase subunit M1 potentiates the antitumor activity of gemcitabine in resistant cancer cells. Cancer Biol Ther 2012; 13:908-914.
-
(2012)
Cancer Biol Ther
, vol.13
, pp. 908-914
-
-
Wonganan, P.1
Chung, W.G.2
Zhu, S.3
Kiguchi, K.4
Digiovanni, J.5
Cui, Z.6
-
54
-
-
33748306343
-
The determinants of sensitivity and acquired resistance to gemcitabine differ in non-small cell lung cancer: A role of ABCC5 in gemcitabine sensitivity
-
Oguri T, Achiwa H, Sato S, Bessho Y, Takano Y, Miyazaki M, et al. The determinants of sensitivity and acquired resistance to gemcitabine differ in non-small cell lung cancer: a role of ABCC5 in gemcitabine sensitivity. Mol Cancer Ther 2006; 5:1800-1806.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 1800-1806
-
-
Oguri, T.1
Achiwa, H.2
Sato, S.3
Bessho, Y.4
Takano, Y.5
Miyazaki, M.6
-
55
-
-
76749122345
-
Potent subunit-specific effects on cell growth and drug sensitivity from optimised siRNA-mediated silencing of ribonucleotide reductase
-
Reid G, Wallant NC, Patel R, Antonic A, Saxon-Aliifaalogo F, Cao H, et al. Potent subunit-specific effects on cell growth and drug sensitivity from optimised siRNA-mediated silencing of ribonucleotide reductase. J RNAi Gene Silencing 2009; 5:321-330.
-
(2009)
J RNAi Gene Silencing
, vol.5
, pp. 321-330
-
-
Reid, G.1
Wallant, N.C.2
Patel, R.3
Antonic, A.4
Saxon-Aliifaalogo, F.5
Cao, H.6
-
56
-
-
84858733250
-
Is there a role for the quantification of RRM1 and ERCC1 expression in pancreatic ductal adenocarcinoma?
-
Valsecchi ME, Holdbrook T, Leiby BE, Pequignot E, Littman SJ, Yeo CJ, et al. Is there a role for the quantification of RRM1 and ERCC1 expression in pancreatic ductal adenocarcinoma? BMC Cancer 2012; 12:104.
-
(2012)
BMC Cancer
, vol.12
, pp. 104
-
-
Valsecchi, M.E.1
Holdbrook, T.2
Leiby, B.E.3
Pequignot, E.4
Littman, S.J.5
Yeo, C.J.6
-
57
-
-
84856576940
-
RRM1 expression and clinical outcome of gemcitabine-containing chemotherapy for advanced non-small-cell lung cancer: A meta-analysis
-
Gong W, Zhang X, Wu J, Chen L, Li L, Sun J, et al. RRM1 expression and clinical outcome of gemcitabine-containing chemotherapy for advanced non-small-cell lung cancer: a meta-analysis. Lung Cancer 2012; 75:374-380.
-
(2012)
Lung Cancer
, vol.75
, pp. 374-380
-
-
Gong, W.1
Zhang, X.2
Wu, J.3
Chen, L.4
Li, L.5
Sun, J.6
-
58
-
-
3042665933
-
Gene expression as a predictive marker of outcome in stage IIB-IIIA-IIIB non-small cell lung cancer after induction gemcitabine-based chemotherapy followed by resectional surgery
-
Rosell R, Felip E, Taron M, Majo J, Mendez P, Sanchez-Ronco M, et al. Gene expression as a predictive marker of outcome in stage IIB-IIIA-IIIB non-small cell lung cancer after induction gemcitabine-based chemotherapy followed by resectional surgery. Clin Cancer Res 2004; 10:4215s-4219s.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 4215s-4219s
-
-
Rosell, R.1
Felip, E.2
Taron, M.3
Majo, J.4
Mendez, P.5
Sanchez-Ronco, M.6
-
59
-
-
62549161737
-
XPG mRNA expression levels modulate prognosis in resected non-small-cell lung cancer in conjunction with BRCA1 and ERCC1 expression
-
Bartolucci R, Wei J, Sanchez JJ, Perez-Roca L, Chaib I, Puma F, et al. XPG mRNA expression levels modulate prognosis in resected non-small-cell lung cancer in conjunction with BRCA1 and ERCC1 expression. Clin Lung Cancer 2009; 10:47-52.
-
(2009)
Clin Lung Cancer
, vol.10
, pp. 47-52
-
-
Bartolucci, R.1
Wei, J.2
Sanchez, J.J.3
Perez-Roca, L.4
Chaib, I.5
Puma, F.6
-
60
-
-
68949154477
-
Significance of RRM1 and ERCC1 expression in resectable pancreatic adenocarcinoma
-
Akita H, Zheng Z, Takeda Y, Kim C, Kittaka N, Kobayashi S, et al. Significance of RRM1 and ERCC1 expression in resectable pancreatic adenocarcinoma. Oncogene 2009; 28:2903-2909.
-
(2009)
Oncogene
, vol.28
, pp. 2903-2909
-
-
Akita, H.1
Zheng, Z.2
Takeda, Y.3
Kim, C.4
Kittaka, N.5
Kobayashi, S.6
-
61
-
-
19944429421
-
Ribonucleotide reductase M1 gene promoter activity, polymorphisms, population frequencies, and clinical relevance
-
Bepler G, Zheng Z, Gautam A, Sharma S, Cantor A, Sharma A, et al. Ribonucleotide reductase M1 gene promoter activity, polymorphisms, population frequencies, and clinical relevance. Lung Cancer 2005; 47:183-192.
-
(2005)
Lung Cancer
, vol.47
, pp. 183-192
-
-
Bepler, G.1
Zheng, Z.2
Gautam, A.3
Sharma, S.4
Cantor, A.5
Sharma, A.6
-
62
-
-
34447137381
-
An association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients
-
Rha SY, Jeung HC, Choi YH, Yang WI, Yoo JH, Kim BS, et al. An association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients. Oncologist 2007; 12:622-630.
-
(2007)
Oncologist
, vol.12
, pp. 622-630
-
-
Rha, S.Y.1
Jeung, H.C.2
Choi, Y.H.3
Yang, W.I.4
Yoo, J.H.5
Kim, B.S.6
-
63
-
-
84887275064
-
A meta-analysis of gemcitabine biomarkers in patients with pancreaticobiliary cancers
-
Wei CH, Gorgan TR, Elashoff DA, Hines OJ, Farrell JJ, Donahue TR. A meta-analysis of gemcitabine biomarkers in patients with pancreaticobiliary cancers. Pancreas 2013; 42:1303-1310.
-
(2013)
Pancreas
, vol.42
, pp. 1303-1310
-
-
Wei, C.H.1
Gorgan, T.R.2
Elashoff, D.A.3
Hines, O.J.4
Farrell, J.J.5
Donahue, T.R.6
-
64
-
-
69249228672
-
FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt
-
Pei H, Li L, Fridley BL, Jenkins GD, Kalari KR, Lingle W, et al. FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt. Cancer Cell 2009; 16:259-266.
-
(2009)
Cancer Cell
, vol.16
, pp. 259-266
-
-
Pei, H.1
Li, L.2
Fridley, B.L.3
Jenkins, G.D.4
Kalari, K.R.5
Lingle, W.6
-
65
-
-
84860711052
-
FKBP5 as a selection biomarker for gemcitabine and Akt inhibitors in treatment of pancreatic cancer
-
Hou J, Wang L. FKBP5 as a selection biomarker for gemcitabine and Akt inhibitors in treatment of pancreatic cancer. PLoS One 2012; 7:e36252.
-
(2012)
PLoS One
, vol.7
, pp. e36252
-
-
Hou, J.1
Wang, L.2
|