Health effects of selected nanoparticles in vivo: Liver function and hepatotoxicity following intravenous injection of titanium dioxide and Na-oleate-coated iron oxide nanoparticles in rodents

Nanotoxicology

Volumn 9, Issue S1, 2015, Pages 95-105

  Volkovova, Katarina ^a   Handy, Richard D ^c   Staruchova, Marta ^a   Tulinska, Jana ^a   Kebis, Anton ^a   Pribojova, Jana ^a   Ulicna, Olga ^b   Kucharská, Jarmila ^b   Dusinska, Maria ^d  

^a SLOVAK MEDICAL UNIVERSITY   (Slovakia)

^b Physics and Informatics   (Slovakia)

^c UNIVERSITY OF PLYMOUTH   (United Kingdom)

^d NORWEGIAN INSTITUTE FOR AIR RESEARCH   (Norway)

Author keywords

in vivo nanotoxicology; Liver toxicity; Na oleate coated Fe3O4; TiO2 nanoparticles

Indexed keywords

CHOLESTEROL; GLUTATHIONE TRANSFERASE; IRON OXIDE; NANOPARTICLE; TITANIUM DIOXIDE NANOPARTICLE; TRIACYLGLYCEROL; ANTIOXIDANT; FERRIC ION; FERRIC OXIDE; GLUTATHIONE PEROXIDASE; OLEIC ACID; TITANIUM; TITANIUM DIOXIDE;

ACUTE TOXICITY; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; HEALTH HAZARD; LD50; LIPIDOSIS; LIVER FUNCTION; LIVER HISTOLOGY; LIVER HOMOGENATE; LIVER STRUCTURE; LIVER TOXICITY; MITOCHONDRIAL RESPIRATION; NECROSIS; NONHUMAN; ORGANISATION FOR ECONOMIC CO-OPERATION AND DEVELOPMENT; PRIORITY JOURNAL; RAT; SURVIVAL TIME; TISSUE SECTION; ANIMAL; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; INTRAVENOUS DRUG ADMINISTRATION; LIVER; MALE; METABOLISM; MITOCHONDRION; OXIDATIVE STRESS; PATHOLOGY;

ANIMALIA; RATTUS; RATTUS NORVEGICUS; RODENTIA;

ANIMALS; ANTIOXIDANTS; FERRIC COMPOUNDS; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; INJECTIONS, INTRAVENOUS; LIVER; MALE; MITOCHONDRIA; NANOPARTICLES; NECROSIS; OLEIC ACID; OXIDATIVE STRESS; RATS; TITANIUM;

EID: 84930007124     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.3109/17435390.2013.815285     Document Type: Article

References (52)

1. Abell LL, Levey BD, Brodie BB, Kendall FF. 1952. A simplified method for the estimation of total cholesterol in serum and demonstration of its specificity. J Biol Chem 195:357-366.
2. Aisen P, Enns C, Wessling-Resnick M. 2001. Chemistry andbiology of eukaryotic iron metabolism. Int J Biochem Cell Biol 33:940-959.
3. Al-Bairuty GA, Shaw BJ, Handy RD, Henry TB. 2013. Histopathological effects of waterborne copper nanoparticles and copper sulphate on the organs of rainbow trout (Oncorhynchus mykiss). Aquat Toxicol 126: 104-115.
4. Belyaeva EA, Korotkov SM. 2003. Mechanism of primary Cd2+-induced rat liver mitochondria dysfunction: discrete modes of Cd2+ action on calcium and thiol-dependent domains. Toxicol App Pharm 192:56-68.
5. Bhagavan HN, Chopra RK. 2006. Coenzyme Q10: Absorption, tissue uptake, metabolism andpharmacokinetics. Free Rad Res 40:445-453.
6. Boveris A, Chance B. 1973. The mitochondrial generation of hydrogen peroxide: general properties and effect of hyperbaric oxygen. Biochem J 134:707-716.
7. Brookes PS, Buckingham JA, Tenreiro AM, Hulbert AJ, Brand MD. 1998. The proton permeability of the inner membrane of liver mitochondria from ectothermic and endothermic vertebrates and from obese rats: correlations with standard metabolic rate and phospholipid fatty acid composition. Comp Biochem Physiol B 119: 325-334.
8. Brookes PS, Yoon Y, Robotham JL, Anders MW, Sheu SS. 2004. Calcium, ATP and ROS: a mitochondrial love-hate triangle. Am J Physiol 287:C817-C833.
9. Bury NC, Handy RD. 2010. Copper and iron uptake in teleost fish. In: Bury N, Handy RD, editors. Surface chemistry, bioavailability and metal homeostasis in aquatic organisms: an integrated approach. Vol. 2. London: Essential Reviews in Experimental Biology, Society for Experimental Biology Press. pp. 107-127.
10. Carriquiriborde P, Handy RD, Davies SJ. 2004. Physiological modulation of iron metabolism in rainbow trout (Oncorhynchus mykiss) fed low and high iron diets. J Exp Biol 207:75-86.
11. Cavarocchi NC, England MD, O'Brien JF, Solis E, Russo P, Schaff HV, et al. 1986. Superoxide generation during cardiopulmonary bypass: is there a role for vitamin E? J Surg Res 40:519-527.
12. Eaton JW, Qian M. 2002. Molecular bases of cellular iron toxicity. Free Radical Biol Med 32:833-840.
13. Federici G, Shaw BJ, Handy RD. 2007. Toxicity of titanium dioxide nanoparticles to rainbow trout, (Oncorhynchus mykiss): gill injury, oxidative stress, and other physiological effects. Aquat Toxicol 84: 415-430.
14. Feng J, Liu H, Bhakoo KK, Lu L, Chen Z. 2011. A metabonomic analysis of organ specific response to USPIO administration. Biomaterials 32(27):6558-6569.
15. Gajdošíkova A, Gajdošík A, Koneracká A, Závišová A, Stvrtina S, Krchnárová V, et al. 2006. Acute toxicity of magnetic nanoparticles in mice. Neuro Endocrinol Lett 27(Suppl2):96-99.
16. Guadagnini R, Halamoda B, Walker L, Pojana G, Magdolenova Z, Bilanicova D, et al. 2015. Toxicity screenings of nanomaterials: challenges due to interference with assay processes and components of classic in vitro tests. Nanotoxicology 9(S1):13-24.
17. Habig WH, Pabst MJ, Jakoby WB. 1974. Glutathione Stransferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 249: 7130-7139.
18. Hayes JD, Pulford DJ. 1995. The glutathione s-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprevention and drug resistance. Crit Rev Biochem Mol Biol 30:445-600.
19. Hogeboom GH. 1955. Fractionation of cell components of animal tissues. In: Colowick SP, Kaplan NO, editors. Methods in enzymology. Vol. 1. New York: Academic Press Inc. pp. 16-19.
20. Hussain SM, Hess KL, Gearhart JM, Geiss KT, Schlager JJ. 2005. In vitro toxicity of nanoparticles in BRL 3A rat liver cells. Toxicol In Vitro 19: 975-983.
21. Cheremisina ZP, Vladimirov A. 1975. Effect of endogenous lipid peroxides on respiration in rat liver mitochondria. Biokhimiia 40: 242-247.
22. 3 nanoparticles do not affect kidney function but cause acute effect on the cardiovascular function in healthy mice. Toxicol Appl Pharm 266:276-288.
23. Jeng HA, Swanson J. 2006. Toxicity of metal oxide nanoparticles in mammalian cells. J Environ Sci Health A Tox Hazard Subst Environ Eng 41(12):2699-2711.
24. Jover A. 1963. Technique for the determination of serum glycerides. J Lipid Res 4:228-230.
25. Khan MI, Mohammad A, Patila G, Naqvi SAH, Chauhan LKS, Ahmad I. 2012. Induction of ROS, mitochondrial damage and autophagy in lung epithelial cancer cells by iron oxide nanoparticles. Biomaterials 33: 1477-1488.
26. Kim DK, Zhang Y, Voit W, Roa KV, Kehr J, Bjelke B, et al. 2001. Superparamagnetic iron oxide nanoparticles for bio-medical applications.Scripta mater. 44:1713-1717.
27. Kwong LK, Kamzalov S, Rebrin I, Bayne ACV, Jana CK, Morris P, et al. 2002. Effects of coenzyme Q(10) administration on its tissue concentrations, mitochondrial oxidant generation, and oxidative stress in the rat. Free Rad Biol Med 33:627-638.
28. Lambert AJ, Brand MD. 2004. Inhibitors of the quinone binding site allow rapid superoxide production from mitochondrial NADH: ubiquinone oxidoreductase (complex I). J Biol Chem 279: 39414-39420.
29. Lang JK, Gohil K, Packer L. 1986. Simultaneous determination of tocopherols, ubiquinols, and ubiquinones in blood, plasma, tissue homogenates, and subcellular fractions. Anal Biochem 157: 106-116.
30. Lowry OH, Rosenbrough UJ, Farr AL, Randall RJ. 1951. Protein measurement with the folin phenol reagent. J Biol Chem 193:265-275.
31. 4-nanoparticle induces hepatic and renal tissue injury via oxidative stress in mice. Int J Nanomedicine 7: 4809-4818.
32. Moody AJ, Mitchell R, Jeal AE, Rich PR. 1997. Comparison of the ligand-binding properties of native and copper-less cytochromes bo from Escherichia coli. Biochem J 324:743-752.
33. OECD. 2008. Acute oral toxicity - up and down procedure. OECD test guideline 425 adopted 3rd October 2008. Paris: Organisation for Economic Cooperation and Development.
34. Paglia DE, Valentine WN. 1967. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70:158-169.
35. Porter RK, Hulbert AJ, Brand MD. 1996. Allometry of mitochondrial proton leak: influence of membrane surface area and fatty acid composition. Am J Physiol 271:R1550-R1560.
36. Rømert P, Quistorff B, Bhenke O. 1993. Histological evaluation of the zonation of colloidal gold uptake by the rat liver. Tissue Cell 25:19-32.
37. Rouslin W, Millard RW. 1980. Canine myocardial ischemia: Defct in mitochondrial electron transfer complex I. J Mol Cell Cardiol 12: 639-645.
38. Sadauskas E, Wallin H, Stoltenberg M, Vogel U, Doering P, Larsen A, et al. 2007. Kupffer cells are central in the removal of nanoparticles from the organism. Part Fibre Toxicol 4:10.
39. Sammut IA, Thorniley MS, Simpkin S, Fuller BJ, Bates TE, Green CJ. 1998. Impairment of hepatic mitochondrial respiratory function following storage and orthotopic transplantation of rat livers. Cryobiology 36:49-60.
40. Scown TM, van Aerle R, Johnston BD, Cumberland S, Lead JR, Owen R, et al. 2009. High doses of intravenously administered titanium dioxidenanoparticles accumulate in the kidneys of rainbow trout but with no observableimpairment of renal function. Toxicol Sci 109: 372-380.
41. Sebekova K, Dusinska M, Simon Klenovics K, Kollarova R, Boor P, Kebis A, et al. 2014. Comprehensive assessment of nephrotoxicity of intravenously administered sodium-oleate-coated ultrasmall superpar-amagnetic iron oxide (USPIO) and titanium dioxide (TiO2) nanopar-ticles in rats. Nanotoxicology 8:142-57.
42. Schrand AM, Rahman MF, Hussain SM, Schlager JJ, Smith DA, Syed AF. 2010. Metal-based nanoparticles and their toxicity assessment. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2(5):544-568.
43. Toblli JE, Cao G, Oliveri L, Angerosa M. 2011. Assessment of the extent of oxidative stress induced by intravenous ferumoxytol, ferric carboxymaltose, iron sucrose and iron dextran in a nonclinical model. Arzneimittelforschung 61(7):399-410.
44. Turrens J. 1997. Superoxide production by the mitochondrial respiratory chain. Biosci Rep 17:3-8.
45. Umbreit TH, Francke-Carroll S, Weaver JL, Miller TJ, Goering PL, Sadrieh N, et al. 2012. Tissue distribution and histopathological effects of titanium dioxide nanoparticles after intravenous or subcutaneous injection in mice. J Appl Toxicol 32:350-357.
46. 2 and quartz. Toxicol Lett 186:152-159.
47. Villalba JM, Navarro F, Cordoba F, Serrano A, Arrayo A, Crane FL, et al. 1995. Coenzyme Q reductase from liver plasma membrane: Purificationand role in trans-plasma-membrane electron transport. Proc Natl Acad Sci USA 92:4887-4891.
48. Wang J, Zhou G, Chen C, Yu H, Wang T, Ma Y, et al. 2007. Acute toxicity andbiodistribution of different sized titanium dioxide particles in mice after oral administration. Toxicol Lett 168:176-185.
49. Watts JA, Ford MD, Leonova E. 1999. Iron-mediated cardiotoxicity develops independently of extracellular hydroxyl radicals in isolated rat hearts. J Toxicol 37:19-28.
50. Weibel ER, Kistler GS, Scherle WF. 1966. Practical steriological methods formorphometric cytology. J Cell Biol 30:23-38.
51. Whittaker P, Hines FA, Robl MG, Dunkel VC. 1996. Histopathological evaluation of liver, pancreas, spleen, and heart from iron-overloaded Sprague-Dawley rats. Toxicol Path 24:558-563.
52. Wong SH, Knight JA, Hopfer SM, Zaharia O, Leach CN, Sunderman FW. 1987. Lipoperoxides in plasma as measured by liquid-chromatographic separation of malondialdehyde-thiobarbituric acid adduct. Clin Chem 33:214-220.