Mechanism of primary Cd2+-induced rat liver mitochondria dysfunction: Discrete modes of Cd2+ action on calcium and thiol-dependent domains

Toxicology and Applied Pharmacology

Volumn 192, Issue 1, 2003, Pages 56-68

  Belyaeva, Elena A ^a   Korotkov, Sergey M ^a  

^a SECHENOV INSTITUTE OF EVOLUTIONARY PHYSIOLOGY AND BIOCHEMISTRY   (Russian Federation)

Author keywords

Cd2+ action discrete sites; Cyclosporin A; Dithiothreitol; Mitochondrial permeability transition; Rat liver mitochondrial dysfunction; Respiratory chain components

Indexed keywords

ADENOSINE DIPHOSPHATE; AMMONIUM NITRATE; CADMIUM; CALCIUM ION; CYCLOSPORIN A; DITHIOTHREITOL; EGTAZIC ACID; GLUTAMIC ACID; MALIC ACID; POTASSIUM CHLORIDE; REAGENT; ROTENONE; SUCCINIC ACID; THIOL; CALCIUM; CESIUM; CHELATING AGENT; DIAGNOSTIC AGENT; THIOL DERIVATIVE; UNCOUPLING PROTEIN;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; LIVER MITOCHONDRION; MALE; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; MITOCHONDRION SWELLING; MOLECULAR MECHANICS; NONHUMAN; RAT; RESPIRATORY CHAIN; ANIMAL; CADMIUM POISONING; DRUG EFFECT; ELECTRON TRANSPORT; IN VITRO STUDY; METABOLISM; OXYGEN CONSUMPTION; PATHOLOGY; PHYSIOLOGY;

ADENOSINE DIPHOSPHATE; ANIMALS; CADMIUM; CADMIUM POISONING; CALCIUM; CESIUM RADIOISOTOPES; CHELATING AGENTS; EGTAZIC ACID; ELECTRON TRANSPORT; MALE; MITOCHONDRIA, LIVER; MITOCHONDRIAL SWELLING; OXYGEN CONSUMPTION; RATS; ROTENONE; SULFHYDRYL COMPOUNDS; UNCOUPLING AGENTS;

EID: 0141783760     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-008X(03)00255-2     Document Type: Article

References (67)

1. 2+ effects on isolated rat liver mitochondria. J. Bioenerg. Biomembr. 33:(4):2001;303-318.
2. 2+-induced dysfunction of isolated rat liver mitochondria doubts no more . Arch. Biochem. Biophys. 405:2002;252-264.
3. Bernardi P. Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. Evidence that the pore can be opened by membrane depolarization. J. Biol. Chem. 267:1992;8834-8839.
4. Bernardi P. Mitochondrial transport of cations channels, exchangers, and permeability transition . Physiol. Rev. 79:1999;1127-1155.
5. 2+-binding sites in the avian cytochrome bc(1) complex. Biochim. Biophys. Acta. 1459:2000;440-448.
6. Brand M.D. Regulation analysis of energy metabolism. J. Exp. Biol. 200:1997;193-202.
7. Broekemeier K.M., Klocek C.K., Pfeiffer D.R. Proton selective substate of the mitochondrial permeability transition pore regulation by the redox state of the electron transport chain . Biochemistry. 37:1998;13059-13065.
8. Cameron I., McNamee P.M., Markham A., Morgan R.M., Wood M. The effects of cadmium on succinate and NADH-linked substrate oxidations in rat hepatic mitochondria. J. Appl. Toxicol. 6:1986;325-330.
9. Casalino E., Calzarretti G., Sblano C., Landriscina C. Cadmium-dependent enzyme activity alteration is not imputable to lipid peroxidation. Arch. Biochem. Biophys. 383:2000;288-295.
10. Chan T.S., Teng S., Wilson J.X., Galati G., Khan S., O'Brien P.J. Coenzyme Q cytoprotective mechanisms for mitochondrial complex 1 cytopathies involves NAD(P)H quinone oxidoreductase 1(NQO1) . Free Radical Res. 36:(4):2002;421-427.
11. Chauvin C., De Oliveira F., Ronot X., Mousseau M., Leverve X., Fontaine E. Rotenone inhibits the mitochondrial permeability transition-induced cell death in U937 and KB cells. J. Biol. Chem. 276:2001;41394-41398.
12. Chavez E., Zazueta C., Correa F., Garcia N., Aviles C., Robles S.G., Rodriguez C.D. Modulation by substrates of the protective effect of cyclosporin A on mitochondrial damage. Life Sci. 70:2002;2413-2420.
13. Crompton M. The mitochondrial permeability transition pore and its role in cell death. Biochem. J. 341:1999;233-249.
14. Diamond E.M., Kench J.E. Effects of cadmium on the respiration of rat liver mitochondria. Environ.Physiol. Biochem. 4:1974;280-283.
15. Fontaine E., Ichas F., Bernardi P. A ubiquinone-binding site regulates the mitochondrial permeability transition pore. J. Biol. Chem. 273:1998;25734-25740.
16. Fontaine E., Eriksson O., Ichas F., Bernardi P. Regulation of the permeability transition pore in skeletal muscle mitochondria. Modulation by electron flow through the respiratory chain complex I. J. Biol. Chem. 273:1998;12662-12668.
17. Fontaine E., Bernardi P. Progress on the mitochondrial pore regulation by complex I and ubiquinone analogs . J. Bioenerg. Biomembr. 31:(4):1999;335-345.
18. Halestrap A.P., Woodfield K.Y., Connern C.P. Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase. J. Biol. Chem. 272:1997;3346-3354.
19. 2+ trigger site. Arch. Biochem. Biophys. 195:1979;460-467.
20. 2+-activated non-specific channel of the mitochondrial inner membrane. Fed. Proc. 39:1980;1707.
21. Haworth R.A., Hunter D.R. Control of the mitochondrial permeability transition pore by high-affinity ADP binding at the ADP/ATP translocase in permeabilized mitochondria. J. Bioenerg. Biomembr. 32:(1):2000;91-96.
22. Huang X., Zhai D., Huang Y. Dependence of permeability transition pore opening and cytochrome C release from mitochondria on mitochondria energetic status. Mol. Cell. Biochem. 222:2001;1-7.
23. Hunter D.R., Haworth R.A., Southard J.H. Relationship between configuration, function, and permeability in calcium-treated mitochondria. J. Biol. Chem. 251:1976;5069-5077.
24. 2+-induced membrane transition in mitochondria. I. The protective mechanisms. Arch. Biochem. Biophys. 195:1979;453-459.
25. Ichas F., Mazat J.P. From calcium signaling to cell death two conformations for the mitochondrial permeability transition pore: switching from low- to high-conductance state . Biochim. Biophys. Acta. 1366:1998;33-50.
26. Isenberg J.S., Klaunig J.E. Role of the mitochondrial membrane permeability transition (MPT) in rotenone-induced apoptosis in liver cells. Toxicol. Sci. 53:2000;340-351.
27. Iwata S., Lee J.W., Okada K., Lee J.K., Iwata M., Rasmussen B., Link T.A., Ramaswamy S., Jap B.K. Complete structure of the 11-subunit bovine mitochondrial cytochrome bc 1 complex. Science. 281:1998;64-71.
28. Jay D., Zamorano R., Munoz E., Gleason R., Boldu J.L. Study of the interaction of cadmium with membrane-bound succinate dehydrogenase. J. Bioenerg. Biomembr. 23:1991;381-389.
29. 2+ ions on mitochondrial electron transport. Arch. Biochem. Biophys. 165:1974;121-125.
30. Koizumi T., Yokota T., Shirakura H., Tatsumoto H., Suzuki K.T. Potential mechanism of cadmium-induced cytotoxicity in rat hepatocytes inhibitory action of cadmium on mitochondrial respiratory activity . Toxicology. 92:1994;115-125.
31. 2+ effects on respiration and swelling of rat liver mitochondria were modified by monovalent cations. J. Inorg. Biochem. 70:1998;17-23.
32. 2+-induced mitochondrial membrane permeabilization: role of coenzyme Q redox state. Am. J. Physiol. 269 (Cell Physiol. 38), C141-C147.
33. 2+ acting at the external side of the inner mitochondrial membrane can stimulate mitochondrial permeability transition induced by phenylarsine oxide. Biochim. Biophys. Acta. 1322:1997;221-229.
34. 2+ correlation with mitochondrial permeability transition . Biochim. Biophys. Acta. 1318:1997;395-402.
35. Lemasters J.J., Qian T., Bradham C.A., Brenner D.A., Cascio W.E., Trost L.C., Nishimura Y., Nieminen A.-L., Herman B. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death. J. Bioenerg. Biomembr. 31:(4):1999;305-319.
36. Link T.A., von Jagow G. Zinc ions inhibit the QP center of bovine heart mitochondrial bc 1 complex by blocking a protonatable group. J. Biol. Chem. 270:1995;25001-25006.
37. Martel J., Marion M., Denizeau F. Effect of cadmium on membrane potential in isolated rat hepatocytes. Toxicology. 60:1990;161-172.
38. 2+-reversible inhibition of the mitochondrial megachannel by ubiquinone analogues. FEBS Lett. 480:2000;89-94.
39. Miccadei S., Floridi A. Sites of inhibition of mitochondrial electron transport by cadmium. Chem.-Biol. Interactions. 89:1993;159-167.
40. Muller L. Consequences of cadmium toxicity in rat hepatocytes mitochondrial dysfunction and lipid peroxidation . Toxicology. 40:1986;285-295.
41. Nicolli A., Petronilli V., Bernardi P. Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by matrix pH. Evidence that the pore open-closed probability is regulated by reversible histidine protonation. Biochemistry. 32:1993;4461-4465.
42. Nigam D., Shukla G.S., Agarwal A.K. Glutathione depletion and oxidative damage in mitochondria following exposure to cadmium in rat liver and kidney. Toxicol. Lett. 106:1999;151-157.
43. Nightingale E.R. Phenomenological theory of ion salvation. Effective radii hydrated ions. J. Physiol. Chem. 63:1959;1381-1387.
44. Nishimura G., Proske R.J., Doyama H., Higuchi M. Regulation of apoptosis by respiration cytochrome c release by respiratory substrates . FEBS Lett. 505:2001;399-404.
45. Novgorodov S.A., Gudz T.I., Milgrom Y.M., Brierley G.P. The permeability transition in heart mitochondria is regulated synergistically by ADP and cyclosporin A. J. Biol. Chem. 267:1992;16274-16282.
46. Novgorodov S.A., Gudz T.I., Brierley G.P., Pfeiffer D.R. Magnesium ion modulates the sensitivity of the mitochondrial permeability transition pore to cyclosporin A and ADP. Arch. Biochem. Biophys. 3111:1994;219-228.
47. Ogata M., Hasegawa T., Yamazaki Y., Nogami Y. Effect of cadmium on changes in concentration of adenine nucleotides induced by mitochondria. Acta Med. Okayama. 32:1978;387-392.
48. Okun J.G., Lummen P., Brandt U. Three classes of inhibitors share a common binding domain in mitochondrial complex I (NADH:ubiquinone oxidoreductase). J. Biol. Chem. 274:1999;2625-2630.
49. Palmeira C.M., Wallace K.B. Benzoquinone inhibits the voltage-dependent induction of the mitochondrial permeability transition caused by redox-cycling naphthoquinones. Toxicol. Appl. Pharmacol. 143:1997;338-347.
50. Pastorino J.G., Snyder J.W., Serroni A., Hoek J.B., Farber J.L. Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition. J. Biol. Chem. 268:1993;13791-13798.
51. Pastorino J.G., Simbula G., Gilfor E., Hoek J.B., Farber J.L. Protoporphyrin IX, an endogenous ligand of the peripheral benzodiazepine receptor, potentiates induction of the mitochondrial permeability transition and the killing of cultured hepatocytes by rotenone. J. Biol. Chem. 269:1994;31041-31046.
52. Rasheed B.K.A., Diwan J.J., Sanadi D.R. Activation of potassium ion transport in mitochondria by cadmium ion. Eur. J. Biochem. 1444:1984;643-647.
53. Rikans L.E., Yamano T. Mechanisms of cadmium-mediated acute hepatotoxicity. J. Biochem. Mol. Toxicol. 14:2000;110-117.
54. Sato N., Kamada T., Suematsu T., Abe H., Furuyama F., Hagihara B. Cadmium toxicity and liver mitochondria. II. Protective effect of hepatic soluble fraction against cadmium-induced mitochondrial dysfunction. J. Biochem. 84:1978;127-133.
55. Skulskii I.A., Korotkov S.M., Glazunov V.V., Ivanova T.I., Savina M.V. Effect of cadmium ions on the respiration, cation transport and morphology of the liver mitochondria in the rat and the lamprey. Tsitologiia. 30:1988;956-962. (in Russian).
56. Smith J.L. Secret life of cytochrome bc1. Science. 281:1998;58-60.
57. Stohs S.J., Bagchi D., Hassoun E., Bagchi M. Oxidative mechanisms in the toxicity of chromium and cadmium ions. J. Environ. Pathol. Toxicol. Oncol. 20:2001;77-88.
58. Szabo I., Bernardi P., Zoratti M. Modulation of the mitochondrial megachannel by divalent cations and protons. J. Biol. Chem. 267:1992;2940-2946.
59. Teixeira B.M., Kowaltowski A.J., Castilho R.F., Vercesi A.E. Inhibition of mitochondrial permeability transition by low pH is associated with less extensive membrane protein thiol oxidation. Biosci. Rep. 19:(6):1999;525-533.
60. 2+-treated rats general regression of inner membrane cristae and electron transport impairment . Biol. Cell. 55:1985;71-86.
61. Vainio H.L., Mela L., Chance B. Energy dependent bivalent cation translocation in rat liver mitochondria. Eur. J. Biochem. 12:1970;387-391.
62. Valnot I., Kassis J., Chretien D., de Lonlay P., Parfait B., Munnich A., Kachaner J., Rustin P., Rotig A. A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency. Hum. Genet. 104:(6):1999;460-466.
63. Walter L., Nogueira V., Leverve X., Heitz M.P., Bernardi P., Fontaine E. Three classes of ubiquinone analogs regulate the mitochondrial permeability transition pore through a common site. J. Biol. Chem. 275:2000;29521-29527.
64. Wang Y., Beattie D.S. Molecular modeling studies of the DCCD-treated cyt bc1 complex predicted conformational changes and inhibition of proton translocation . J. Bioenerg. Biomembr. 34:(2):2002;81-88.
65. Wudarczyk J., Debska G., Lenartowicz E. Zinc as an inducer of the membrane permeability transition in rat liver mitochondria. Arch. Biochem. Biophys. 363:1999;1-8.
66. Zhang Z., Huang L., Shulmeister V.M., Chi K.K., Kim K.K., Hung L.W., Crofts A.R., Berry E.A., Kim S.H. Electron transfer by domain movement in cytochrome bc1. Nature. 392:1998;677-684.
67. Zoratti M., Szabo I. The mitochondrial permeability transition. Biochim. Biophys. Acta. 1241:1995;139-176.