Tissue distribution and histopathological effects of titanium dioxide nanoparticles after intravenous or subcutaneous injection in mice

Journal of Applied Toxicology

Volumn 32, Issue 5, 2012, Pages 350-357

  Umbreit, T H ^a   Francke Carroll, S ^b   Weaver, J L ^b,c   Miller, T J ^b,c   Goering, P L ^a   Sadrieh, N ^b,c   Stratmeyer, M E ^a  

^a CENTER FOR DEVICES AND RADIOLOGICAL HEALTH   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c OPS   (United States)

Author keywords

Distribution; In vivo; Mouse; Nanoparticles; TiO 2; Titanium dioxide

Indexed keywords

NANOPARTICLE; TITANIUM DIOXIDE; TITANIUM DIOXIDE NANOPARTICLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CELL COUNT; CONTROLLED STUDY; FEMALE; FILTRATION; HEART; HISTOPATHOLOGY; INGUINAL LYMPH NODE; KIDNEY; LIVER; LUNG; MACROPHAGE; MICROSCOPY; MOUSE; NONHUMAN; ORTHOPEDIC EQUIPMENT; PRIORITY JOURNAL; SAFETY; SPLEEN; TISSUE DISTRIBUTION; TISSUE INJURY;

ANIMALS; FEMALE; INJECTIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; LIVER; LUNG; LYMPH NODES; MICE; MICE, INBRED BALB C; NANOPARTICLES; SPLEEN; TIME FACTORS; TISSUE DISTRIBUTION; TITANIUM;

ANIMALIA; MUS;

EID: 84858863841     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1700     Document Type: Article

References (14)

1. Archibeck MJ, Jacobs JJ, Roebuck KA, Glant TT. 2000. The basic science of periprosthetic osteolysis. J. Bone Joint Surg. 82-A: 1478-1489.
2. Choi J, Zhang Q, Reipa V, Wang NS, Stratmeyer ME, Hitchins VM, Goering PL. 2009. Comparison of cytotoxic and inflammatory responses of photoluminescent silicon nanoparticles with silicon micron-sized particles in RAW 264.7 macrophages. J. Appl. Toxicol. 29(1): 52-60.
3. Duan Y, Liu J, Ma L, Li N, Liu H, Wang J, Zheng L, Liu C, Wang X, Zhao X, Yan J, Wang S, Wang H, Zhang X, Hong F. 2010. Toxicological characteristics of nanoparticulate anatase titanium dioxide in mice. Biomaterials. 31(5): 894-899.
4. Fabian E, Landsiedel R, Ma-Hock L, Wiench K, Wohlleben W, van Ravenzwaay B. 2008. Tissue distribution and toxicity of intravenously administered titanium dioxide nanoparticles in rats. Arch. Toxicol. 82: 151-157.
5. Geiser M, Rothen-Rutishauser B, Kapp N, Schurch S, Kreyling W, Schulz H, Semmler M, Im Hof V, Heyder J, Gehr P. 2005. Ultrafine particles cross cellular membranes by nonphagocyctic mechanisms in lungs and in cultured cells. Environ. Health Perspect. 113(11): 1555-1560.
6. Huggins CB, Froehlich J. 1966. High concentration of injected titanium dioxide in abdominal lymph nodes. J Experimental Medicine 124: 1099-1106.
7. Oberdoerster G, Oberdoerster E, Oberdoerster, J. 2005. Nanotechnology: an emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect. 113: 823-839.
8. Olmedo DG, Tasat D, Guglielmotti MB, Cabrini RL. 2003. Titanium transport through the blood stream. An experimental study on rats. J. Mater. Sci. Mater. Med. 14: 1099-1103.
9. Olmedo DG, Tasat D, Evelson P, Guglielmott MB, Cabrini RL. 2007. Biological response of tissues with macrophagic activity to titanium dioxide. J. Biomed. Mater. Res. 84A: 1087-1093.
10. Olmedo DG, Tasat D, Guglielmotti MB, Cabrini RL. 2008. Biodistribution of titanium dioxide from biologic compartments. J. Mater. Sci. Mater. Med.; 19: 3049-3056 doi: 10.1007/s10856-008-3438-x.
11. Patri A, Umbreit T, Zheng J, Nagashima K, Goering P, Francke-Carroll S, Gordon E, Weaver J, Miller T, Sadrieh N, Stratmeyer M. 2009. Energy dispersive X-ray analysis of titanium dioxide nanoparticle distribution after intravenous and subcutaneous injection in mice. J. Appl. Toxicol. 29: 667-672.
12. Reimschuessel R, Evans ER, Stine CB, Hasbrouck N, Mayer TD, Nochetto C, Geiseker CM. 2010. Renal crystal formation after combined or sequential oral administration of melamine and cyanuric acid. Food Chem. Toxicol. 48: 2898-2906.
13. 2, and quartz. Toxicol. Lett. 186: 152-159.
14. Wang J, Zhou G, Chen C, Yu H, Wang T, Ma Y, Jia G, Gao Y, Sun J, Yi L, Jiao F, Zhao Y, Chia S. 2007. Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. Toxicol. Lett. 168: 176-185.