Expression changes of cell‑cell adhesion‑related genes in colorectal tumors

Oncology Letters

Volumn 9, Issue 6, 2015, Pages 2463-2470

  Bujko, Mateusz ^a   Kober, Paulina ^a   Mikula, Michal ^a   Ligaj, Marcin ^a   Ostrowski, Jerzy ^a   Siedlecki, Janusz Aleksander ^a  

^a INSTITUTE OF ONCOLOGY   (Poland)

Author keywords

Cell cell adhesion; Colorectal adenoma; Colorectal cancer; Gene expression

Indexed keywords

CADHERIN; CADHERIN 11; CLAUDIN; CLAUDIN 15; CLAUDIN 2; CLAUDIN 23; CLAUDIN 5; CLAUDIN 8; P CADHERIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER STAGING; CELL ADHESION RELATED GENE; CELL INTERACTION; COLORECTAL TUMOR; DOWN REGULATION; FEMALE; GENE EXPRESSION PROFILING; HUMAN TISSUE; LAPAROTOMY; MAJOR CLINICAL STUDY; MALE; ONCOGENE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR LOCALIZATION; UPREGULATION; VERY ELDERLY;

EID: 84930003302     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2015.3107     Document Type: Article

References (51)

1. Ponz de Leon M and Di Gregorio C: Pathology of colorectal cancer. Dig Liver Dis 33: 372-388, 2001.
2. Le Bras GF, Taubenslag KJ and Andl CD: The regulation of cell-cell adhesion during epithelial-mesenchymal transition, motility and tumor progression. Cell Adh Migr 6: 365-373, 2012.
3. Tsanou E, Peschos D, Batistatou A, Charalabopoulos A and Charalabopoulos K. The E-cadherin adhesion molecule and colorectal cancer. A global literature approach. Anticancer Res 28: 3815-3826, 2008.
4. Wang X, Tully O, Ngo B, Zitin M and Mullin JM: Epithelial tight junctional changes in colorectal cancer tissues. ScientificWorldJournal 11: 826-841, 2011.
5. Kańczuga-Koda L: Gap junctions and their role in physiology and pathology of the digestive tract. Postepy Hig Med Dosw (Online) 58: 158-165, 2004 (In Polish).
6. Turksen K and Troy TC: Junctions gone bad: claudins and loss of the barrier in cancer. Biochim Biophys Acta 1816: 73-79, 2011.
7. Brenner H, Kloor M and Pox CP: Colorectal cancer. Lancet 383: 1490-1502, 2014.
8. Sipos F and Galamb O: Epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions in the colon. World J Gastroenterol 18: 601-608, 2012.
9. Skrzypczak M, Goryca K, Rubel T, et al: Modeling oncogenic signaling in colon tumors by multidirectional analyses of microarray data directed for maximization of analytical reliability. PLoS One 5: e13091, 2010.
10. Khan K, Hardy R, Haq A, Ogunbiyi O, Morton D and Chidgey M: Desmocollin switching in colorectal cancer. Br J Cancer 95: 1367-1370, 2006.
11. Shimoyama Y, Yoshida T, Terada M, et al: Molecular cloning of a human Ca2+-dependent cell-cell adhesion molecule homologous to mouse placental cadherin: its low expression in human placental tissues. J Cell Biol 109: 1787-1794, 1989.
12. Hardy RG, Tselepis C, Hoyland J, et al: Aberrant P-cadherin expression is an early event in hyperplastic and dysplastic transformation in the colon. Gut 50: 513-519, 2002.
13. Kamposioras K, Konstantara A, Kotoula V, et al: The prognostic significance of WNT pathway in surgically-treated colorectal cancer: β -catenin expression predicts for disease-free survival. Anticancer Res 33: 4573-4584, 2013.
14. Milicic A, Harrison LA, Goodlad R, et al: Ectopic expression of P-cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in vivo. Cancer Res 68: 7760-7768, 2008.
15. Hibi K, Goto T, Mizukami H, et al: Demethylation of the CDH3 gene is frequently detected in advanced colorectal cancer. Anticancer Res 29: 2215-2217, 2009.
16. Yoshioka H, Yamamoto S, Hanaoka H, et al: In vivo therapeutic effect of CDH3/P-cadherin-targeting radioimmunotherapy. Cancer Immunol Immunother 61: 1211-1220, 2012
17. Kaur H, Phillips-Mason PJ, Burden-Gulley SM, et al: Cadherin-11, a marker of the mesenchymal phenotype, regulates glioblastoma cell migration and survival in vivo. Mol Cancer Res 10: 293-304, 2012.
18. Chu K, Cheng CJ, Ye X, et al: Cadherin-11 promotes the metastasis of prostate cancer cells to bone. Mol Cancer Res 6: 1259-1267, 2008.
19. Tamura D, Hiraga T, Myoui A, Yoshikawa H and Yoneda T: Cadherin-11-mediated interactions with bone marrow stromal/osteoblastic cells support selective colonization of breast cancer cells in bone. Int J Oncol 33: 17-24, 2008.
20. Torres S, Bartolomé RA, Mendes M, et al: Proteome profiling of cancer-associated fibroblasts identifies novel proinflammatory signatures and prognostic markers for colorectal cancer. Clin Cancer Res 19: 6006-6019, 2013.
21. Li L, Ying J, Li H, et al: The human cadherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through Wnt/β-catenin signaling and silenced in common carcinomas. Oncogene 31: 3901-3912, 2012.
22. Carmona FJ, Villanueva A, Vidal A, et al: Epigenetic disruption of cadherin-11 in human cancer metastasis. J Pathol 228:230-240, 2012.
23. Hruz T, Laule O, Szabo G, et al: Genevestigator v3: a reference expression database for the meta-analysis of transcriptomes. Adv Bioinformatics 2008: 420747, 2008.
24. Blons H, Laccourreye O, Houllier AM, et al: Delineation and candidate gene mutation screening of the 18q22 minimal region of deletion in head and neck squamous cell carcinoma. Oncogene 21: 5016-5023, 2002.
25. Chernoff J: Protein tyrosine phosphatases as negative regulators of mitogenic signaling. J Cell Physiol 180: 173-81, 1999.
26. Serra-Pagès C, Kedersha NL, Fazikas L, et al: The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions. EMBO J 14: 2827-2838, 1995.
27. Symons JR, LeVea CM and Mooney RA: Expression of the leucocyte common antigen-related (LAR) tyrosine phosphatase is regulated by cell density through functional E-cadherin complexes. Biochem J 365: 513-519, 2002.
28. Bonvini P, An WG, Rosolen A, et al: Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription. Cancer Res 61: 1671-1677, 2001.
29. Wang Z, Shen D, Parsons DW, et al: Mutational analysis of the tyrosine phosphatome in colorectal cancers. Science 304: 1164-1166, 2004.
30. Knösel T, Chen Y, Hotovy S, Settmacher U, Altendorf-Hofmann A and Petersen I: Loss of desmocollin 1-3 and homeobox genes PITX1 and CDX2 are associated with tumor progression and survival in colorectal carcinoma. Int J Colorectal Dis 27: 1391-1399, 2012.
31. Singh AB, Sharma A, Smith JJ, et al: Claudin-1 up-regulates the repressor ZEB-1 to inhibit E-cadherin expression in colon cancer cells. Gastroenterology 141: 2140-2153, 2011.
32. Huo Q, Kinugasa T, Wang L, et al: Claudin-1 protein is a major factor involved in the tumorigenesis of colorectal cancer. Anticancer Res 29: 851-857, 2009.
33. Kinugasa T, Huo Q, Higashi D, et al: Selective up-regulation of claudin-1 and claudin-2 in colorectal cancer. Anticancer Res 27: 3729-3734, 2007.
34. Gröne J, Weber B, Staub E, et al: Differential expression of genes encoding tight junction proteins in colorectal cancer: frequent dysregulation of claudin-1, -8 and -12. Int J Colorectal Dis 22: 651-659, 2007.
35. Pitule P, Vycital O, Bruha J, et al: Differential expression and prognostic role of selected genes in colorectal cancer patients. Anticancer Res 33: 4855-4865, 2013.
36. Rahner C, Mitic LL and Anderson JM: Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut. Gastroenterology 120: 411-422, 2001.
37. Soini Y: Expression of claudins 1, 2, 3, 4, 5 and 7 in various types of tumours. Histopathology 46: 551-560, 2005.
38. Escudero-Esparza A, Jiang WG and Martin TA: Claudin-5 participates in the regulation of endothelial cell motility. Mol Cell Biochem 362: 71-85, 2012.
39. Herr D, Sallmann A, Bekes I, et al: VEGF induces ascites in ovarian cancer patients via increasing peritoneal permeability by downregulation of Claudin 5. Gynecol Oncol 127: 210-216, 2012.
40. Zeissig S, Bürgel N, Günzel D, et al: Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 56: 61-72, 2007.
41. Fujita H, Chiba H, Yokozaki H, et al: Differential expression and subcellular localization of claudin-7, -8, -12, -13, and -15 along the mouse intestine. J Histochem Cytochem 54: 933-944, 2006.
42. Arimura Y, Nagaishi K and Hosokawa M: Dynamics of claudins expression in colitis and colitis-associated cancer in rat. Methods Mol Biol 762: 409-425, 2011.
43. Oster B, Thorsen K, Lamy P, et al: Identification and validation of highly frequent CpG island hypermethylation in colorectal adenomas and carcinomas. Int J Cancer 129: 2855-2866, 2011.
44. Citi S, Amorosi A, Franconi F, Giotti A and Zampi G: Cingulin, a specific protein component of tight junctions is expressed in normal and neoplastic human epithelial tissues. Am J Pathol 138: 781-789, 1991.
45. Guillemot L and Citi S: Cingulin regulates claudin-2 expression and cell proliferation through the small GTPase RhoA. Mol Biol Cell 17: 3569-3577, 2006.
46. Papageorgis P, Lambert AW, Ozturk S, et al: Smad signaling is required to maintain epigenetic silencing during breast cancer progression. Cancer Res 70: 968-978, 2010.
47. Losi L, Parenti S, Ferrarini F, et al: Down-regulation of μ-protocadherin expression is a common event in colorectal carcinogenesis. Hum Pathol 42: 960-971, 2011.
48. Beukers W, Hercegovac A, Vermeij M, et al: Hypermethylation of the polycomb group target gene PCDH7 in bladder tumors from patients of all ages. J Urol 190: 311-316, 2013.
49. Li VS, Yuen ST, Chan TL, et al: Frequent inactivation of axon guidance molecule RGMA in human colon cancer through genetic and epigenetic mechanisms. Gastroenterology 137: 176-187, 2009.
50. Yamauchi M, Morikawa T, Kuchiba A, et al: Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum. Gut 61: 847-854, 2012.
51. Koestler DC, Li J, Baron JA, et al: Distinct patterns of DNA methylation in conventional adenomas involving the right and left colon. Mod Pathol 27: 145-155, 2014.