The prognostic significance of WNT pathway in surgically-treated colorectal cancer: β-catenin expression predicts for disease-free survival

Anticancer Research

Volumn 33, Issue 10, 2013, Pages 4573-4584

  Kamposioras, Konstantinos ^a   Konstantara, Athina ^b   Kotoula, Vassiliki ^b   Lakis, Sotiris ^b   Kouvatseas, George ^c   Akriviadis, Evangelos ^b   Vrettou, Eleni ^b   Dionysopoulos, Dimitrios ^b   Krikelis, Dimitrios ^b   Papadopoulou, Kyriaki ^b   Charalambous, Elpida ^b   Chrisafi, Sofia ^b   Konstantaras, Christos ^b   Fountzilas, George ^b  

^a UNIVERSITY HOSPITAL OF LARISSA   (Greece)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^c Health Data Specialists Ltd   (Greece)

Author keywords

catenin; Colorectal cancer; Ecadherin; Invasive front; Prognosis; SFRP; WNT

Indexed keywords

APC PROTEIN; AXIN; BETA CATENIN; CYCLIN D1; MATRILYSIN; MESSENGER RNA; P CADHERIN; SECRETED FRIZZLED RELATED PROTEIN 1; SECRETED FRIZZLED RELATED PROTEIN 2; SECRETED FRIZZLED RELATED PROTEIN 4; UVOMORULIN; WNT5A PROTEIN;

ADULT; AGED; ARTICLE; CANCER STAGING; CANCER SURVIVAL; COHORT ANALYSIS; COLORECTAL CANCER; DISEASE FREE SURVIVAL; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NUCLEOTIDE SEQUENCE; PERINEURAL INVASION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN DEPLETION; PROTEIN EXPRESSION; RETROSPECTIVE STUDY; VERY ELDERLY; WNT SIGNALING PATHWAY;

Β-CATENIN; COLORECTAL CANCER; E-CADHERIN; INVASIVE FRONT; PROGNOSIS; SFRP; WNT;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; BETA CATENIN; CADHERINS; CHEMORADIOTHERAPY, ADJUVANT; COLORECTAL NEOPLASMS; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM INVASIVENESS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES; TREATMENT OUTCOME; WNT SIGNALING PATHWAY;

EID: 84891358674     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin 63(1): 11-30, 2013.
2. White BD, Chien AJ and Dawson DW: Dysregulation of Wnt/β-catenin signaling in gastrointestinal cancers. Gastroenterology 142(2): 219-232, 2012.
3. MacDonald BT, Tamai K and He X: Wnt/β-catenin signaling:components, mechanisms, and diseases. Dev Cell 17(1): 9-26, 2009.
4. Brabletz T, Jung A, Dag S, Hlubek F and Kirchner T: β- cateninregulates the expression of the matrix metalloproteinase-7 in human colorectal cancer. Am J Pathol 155(4): 1033-1038, 1999.
5. Matono H, Oda Y, Nakamori M, Tamiya S, Yamamoto H, Yokoyama R, Saito T, Iwamoto Y and Tsuneyoshi M: Correlation between beta-catenin widespread nuclear expression and matrix metalloproteinase-7 overexpression in sporadic desmoid tumors. Hum Pathol 39(12): 1802-1808, 2008.
6. Utsunomiya T, Doki Y, Takemoto H, Shiozaki H, Yano M, Sekimoto M, Tamura S, Yasuda T, Fujiwara Y and Monden M: Correlation of β-catenin and cyclin D1 expression in coloncancers. Oncology 61(3): 226-233, 2001.
7. Bovolenta P, Esteve P, Ruiz JM, Cisneros E and Lopez-Rios J: Beyond Wnt inhibition: New functions of secreted Frizzled-related proteins in development and disease. J Cell Sci 121(Pt 6): 737-746, 2008.
8. Filiz AI, Senol Z, Sucullu I, Kurt Y, Demirbas S and Akin ML: The survival effect of E-cadherin and catenins in colorectal carcinomas. Colorectal Dis 12(12): 1223-1230, 2010.
9. Tóth L, András C, Molnár C, Tanyi M, Csiki Z, Molnár P and Szántó J: Investigation of β-catenin and E-cadherin expression inDukes B2 stage colorectal cancer with tissue microarray method. Is it a marker of metastatic potential in rectal cancer? Pathol Oncol Res 18(2): 429-437, 2012.
10. Sun L, Hu H, Peng L, Zhou Z, Zhao X, Pan J, Sun L, Yang Z and Ran Y: P-Cadherin promotes liver metastasis and is associated with poor prognosis in colon cancer. Am J Pathol 179(1): 380-390, 2011.
11. Van Marck V, Stove C, Jacobs K, Van den Eynden G and Bracke M: P-Cadherin in adhesion and invasion: opposite roles in colon and bladder carcinoma. Int J Cancer 128(5): 1031-1044, 2011.
12. Dejmek J, Dejmek A, Safholm A, Sjolander A and Andersson T: WNT-5a protein expression in primary Dukes B colon cancers identifies a subgroup of patients with good prognosis. Cancer Res 65(20): 9142-9146, 2005.
13. Karamitopoulou E, Zlobec I, Panayiotides I, Patsouris ES, Peros G, Rallis G, Lapas C, Karakitsos P, Terracciano LM and Lugli A: Systematic analysis of proteins from different signaling pathways in the tumor center and the invasive front of colorectal cancer. Hum Pathol 42(12): 1888-1896, 2011.
14. Kahlert C, Lahes S, Radhakrishnan P, Dutta S, Mogler C, Herpel E, Brand K, Steinert G, Schneider M, Mollenhauer M, Reissfelder C, Klupp F, Fritzmann J, Wunder C, Benner A, Kloor M, Huth C, Contin P, Ulrich A, Koch M andWeitz J: Overexpression of ZEB2 at the invasion front of colorectal cancer is an independent prognostic marker and regulates tumor invasion in vitro. Clin Cancer Res 17(24): 7654-7663, 2011.
15. Edge SB and Compton CC: The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol 17(6): 1471-1474, 2010.
16. McShane LM, Altman DG, Sauerbrei W, Taube SE, Gion M, Clark GM; Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics: REporting recommendations for tumour MARKer prognostic studies (REMARK). Eur J Cancer 41(12): 1690-1696, 2005.
17. Wang X, Zhang J, Fan M, Zhou Q, Deng H, Aisharif MJ and Chen X: The expression of E-cadherin at the invasive tumor front of oral squamous cell carcinoma: Immunohistochemical and RT-PCR analysis with clinicopathological correlation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107(4): 547-554, 2009.
18. Cianchi F, Cuzzocrea S, Vinci MC, Messerini L, Comin CE, Navarra G, Perigli G, Centorrino T, Marzocco S, Lenzi E, Battisti N, Trallori G and Masini E: Heterogeneous expression of cyclooxygenase-2 and inducible nitric oxide synthase within colorectal tumors: correlation with tumor angiogenesis. Dig Liver Dis 42(1): 20-27, 2010.
19. Baldus SE, Mönig SP, Huxel S, Landsberg S, Hanisch FG, Engelmann K, Schneider PM, Thiele J, Hölscher AH and Dienes HP: MUC1 and nuclear beta-catenin are coexpressed at the invasion front of colorectal carcinomas and are both correlated with tumor prognosis. Clin Cancer Res 10(8): 2790-2796, 2004.
20. Matsuoka T, Mitomi H, Fukui N, Kanazawa H, Saito T, Hayashi T andYao T: Cluster analysis of claudin-1 and -4, E-cadherin, and β-catenin expression in colorectal cancers. J Surg Oncol 103(7):674-686, 2011.
21. Wang L, Cheng H, Liu Y, Wang L, Yu W, Zhang G, Chen B, Yu Z and Hu S: Prognostic value of nuclear beta-catenin overexpression at invasive front in colorectal cancer for synchronous liver metastasis. Ann Surg Oncol 18(6): 1553-1559, 2011.
22. Suzuki H, Masuda N, Shimura T, Araki K, Kobayashi T, Tsutsumi S, Asao T and Kuwano H: Nuclear β-catenin expression at theinvasive front and in the vessels predicts liver metastasis in colorectal carcinoma. Anticancer Res 28(3B): 1821-1830, 2008.
23. Retterspitz MF, Mönig SP, Schreckenberg S, Schneider PM, Hölscher AH, Dienes HP and Baldus SE: Expression of {β}-catenin, MUC1 and c-met in diffuse-type gastric carcinomas: correlations with tumour progression and prognosis. Anticancer Res 30(11): 4635-4641, 2010.
24. Liu LK, Jiang XY, Zhou XX, Wang DM, Song XL and Jiang H: Upregulation of vimentin and aberrant expression of E-cadherin/β-catenin complex in oral squamous cell carcinomas: correlation with the clinicopathological features and patient outcome. Mod Pathol 23(2): 213-224, 2010.
25. Ogino S, Nosho K, Irahara N, Kure S, Shima K, Baba Y, Toyoda S, Chen L, Giovannucci EL, Meyerhardt JA and Fuchs CS: A cohort study of cyclin D1 expression and prognosis in 602 colon cancer cases. Clin Cancer Res 15(13): 4431-4438, 2009.
26. Myklebust MP, Li Z, Tran TH, Rui H, Knudsen ES, Elsaleh H, Fluge Ø, Vonen B, Myrvold HE, Leh S, Tveit KM, Pestell RG and Dahl O: Expression of cyclin D1a and D1b as predictive factors for treatment response in colorectal cancer. Br J Cancer 107(10):1684-1691, 2012.
27. Aamodt R, Jonsdottir K, Andersen SN, Bondi J, Bukholm G and Bukholm IR: Differences in protein expression and gene amplification of cyclins between colon and rectal adenocarcinomas. Gastroenterol Res Pract 2009: 285830, 2009.
28. Kapiteijn E, Liefers GJ, Los LC, Kranenbarg EK, Hermans J, Tollenaar RA, Moriya Y, van de Velde CJ, van Krieken JH: Mechanisms of oncogenesis in colon versus rectal cancer. J Pathol 195(2): 171-178, 2001.
29. Qi J, Zhu YQ, Luo J and Tao WH: Hypermethylation and expression regulation of secreted frizzled-related protein genes in colorectal tumor. World J Gastroenterol 12(44): 7113-7117, 2006.
30. Hao X, Palazzo JP, Ilyas M, Tomlinson I and Talbot IC: Reduced expression of molecules of the cadherin/catenin complex in the transition from colorectal adenoma to carcinoma. Anticancer Res 17(3C): 2241-2247, 1997.
31. Feng Han Q, Zhao W, Bentel J, Shearwood AM, Zeps N, Joseph D, Iacopetta B and Dharmarajan A: Expression of sFRP-4 and beta-catenin in human colorectal carcinoma. Cancer Lett 231(1):129-137, 2006.
32. Kinoshita T, Nomoto S, Kodera Y, Koike M, Fujiwara M and Nakao A: Decreased expression and aberrant hypermethylation of the SFRP genes in human gastric cancer. Hepatogastro enterology 58(107-108): 1051-1056, 2011.