Differentiation of Bone Marrow-derived Mesenchymal Stem Cells into Hepatocyte-like Cells on Nanofibers and Their Transplantation into a Carbon Tetrachloride-Induced Liver Fibrosis Model

Stem Cell Reviews and Reports

Volumn 7, Issue 1, 2011, Pages 103-118

  Piryaei, Abbas ^a   Valojerdi, Mojtaba Rezazadeh ^a   Shahsavani, Mansoureh ^b   Baharvand, Hossein ^b,c  

^a TARBIAT MODARES UNIVERSITY   (Iran)

^b ROYAN INSTITUTE FOR REPRODUCTIVE BIOMEDICINE   (Iran)

^c UNIVERSITY OF SCIENCE AND CULTURE   (Iran)

Author keywords

Differentiation; Hepatocyte like cells; Liver fibrosis; Mesenchymal stem cells; Nanofibers

Indexed keywords

ANIMALIA; MUS;

EID: 78751643138     PISSN: 15508943     EISSN: 15586804     Source Type: Journal    
DOI: 10.1007/s12015-010-9126-5     Document Type: Article

References (45)

1. Sancho-Bru, P., Najimi, M., Caruso, M., et al. (2009). Stem and progenitor cells for liver repopulation: can we standardise the process from bench to bedside? Gut, 58, 594-603.
2. Yan, Y., Xu, W., Qian, H., et al. (2009). Mesenchymal stem cells from human umbilical cords ameliorate mouse hepatic injury in vivo. Liver International, 29, 356-365.
3. Banas, A., Teratani, T., Yamamoto, Y., et al. (2009). Rapid hepatic fate specification of adipose-derived stem cells and their therapeutic potential for liver failure. Journal of Gastroenterology and Hepatology, 24, 70-77.
4. Liang, L., Ma, T., Chen, W., et al. (2009). Therapeutic potential and related signal pathway of adipose-derived stem cell transplantation for rat liver injury. Hepatology Research, 39, 822-832.
5. Kuo, T. K., Hung, S. P., Chuang, C. H., et al. (2008). Stem cell therapy for liver disease: parameters governing the success of using bone marrow mesenchymal stem cells. Gastroenterology, 134, 2111-2121.
6. Russo, F. P., Alison, M. R., Bigger, B. W., et al. (2006). The bone marrow functionally contributes to liver fibrosis. Gastroenterology, 130, 1807-1821.
7. di Bonzo, L. V., Ferrero, I., Cravanzola, C., et al. (2008). Human mesenchymal stem cells as a two-edged sword in hepatic regenerative medicine: engraftment and hepatocyte differentiation versus profibrogenic potential. Gut, 57, 223-231.
8. Discher, D. E., Mooney, D. J., & Zandstra, P. W. (2009). Growth factors, matrices, and forces combine and control stem cells. Science, 324, 1673-1677.
9. Dalby, M. J., Gadegaard, N., Tare, R., et al. (2007). The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder. Nature Materials, 6, 997-1003.
10. Baharvand, H., & Mehrjardi, N. Z. (2008). Nanotechnology in Stem Cell Biology and Technology. In: D. E. Reisner, J. D. Bronzino (Eds.), Bionanotechnology (pp. 1-23). Global Prospects Taylor & Francis, Inc.
11. Brophy, C. M., Luebke-Wheeler, J. L., Amiot, B. P., Remmel, R. P., Rinaldo, P., & Nyberg, S. L. (2009). Gene expression and functional analyses of primary rat hepatocytes on nanofiber matrices. Cells Tissues Organs. doi: 10. 1159/000223235. Epub ahead of print.
12. Schindler, M., Ahmed, I., Kamal, J., et al. (2005). A synthetic nanofibrillar matrix promotes in vivo-like organization and morphogenesis for cells in culture. Biomaterials, 26, 5624-5631.
13. Eslaminejad, M. B., Nikmahzar, A., Taghiyar, L., Nadri, S., & Massumi, M. (2006). Murine mesenchymal stem cells isolated by low density primary culture system. Development, Growth & Differentiation, 48, 361-370.
14. Lee, K. D., Kuo, T. K., Whang-Peng, J., et al. (2004). In vitro hepatic differentiation of human mesenchymal stem cells. Hepatology, 40, 1275-1284.
15. Page, J. L., Johnson, M. C., Olsavsky, K. M., Strom, S. C., Zarbl, H., & Omiecinski, C. J. (2007). Gene expression profiling of extracellular matrix as an effector of human hepatocyte phenotype in primary cell culture. Toxicological Sciences, 97, 384-397.
16. Schwartz, R. E., Reyes, M., Koodie, L., et al. (2002). Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. Journal of Clinical Investigation, 109, 1291-1302.
17. Livak, K. J., & Schmittgen, T. D. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods, 25, 402-408.
18. Tzanakakis, E. S., Hsiao, C. C., Matsushita, T., Remmel, R. P., & Hu, W. S. (2001). Probing enhanced cytochrome P450 2B1/2 activity in rat hepatocyte spheroids through confocal laser scanning microscopy. Cell Transplantation, 10, 329-342.
19. Figliuzzi, M., Cornolti, R., Perico, N., et al. (2009). Bone marrow-derived mesenchymal stem cells improve islet graft function in diabetic rats. Transplantation Proceedings, 41, 1797-1800.
20. Oyagi, S., Hirose, M., Kojima, M., et al. (2006). Therapeutic effect of transplanting HGF-treated bone marrow mesenchymal cells into CCl4-injured rats. Journal of Hepatology, 44, 742-748.
21. Sato, Y., Araki, H., Kato, J., et al. (2005). Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion. Blood, 106, 756-763.
22. Cao, B. Q., Lin, J. Z., Zhong, Y. S., et al. (2007). Contribution of mononuclear bone marrow cells to carbon tetrachloride-induced liver fibrosis in rats. World J Gastroenterol., 13, 1851-1854. discussion 1854-1856.
23. Fang, H. L., Lai, J. J., Lin, W. L., & Lin, W. C. (2007). A fermented substance from Aspergillus phoenicis reduces liver fibrosis induced by carbon tetrachloride in rats. Bioscience, Biotechnology, and Biochemistry, 71, 1154-1161.
24. Arezzini, B., Lunghi, B., Lungarella, G., & Gardi, C. (2003). Iron overload enhances the development of experimental liver cirrhosis in mice. International Journal of Biochemistry and Cell Biology, 35, 486-495.
25. Marumoto, Y., Terai, S., Urata, Y., et al. (2008). Continuous high expression of XBP1 and GRP78 is important for the survival of bone marrow cells in CCl4-treated cirrhotic liver. Biochemical and Biophysical Research Communications, 367, 546-552.
26. Sakaida, I., Terai, S., Yamamoto, N., et al. (2004). Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice. Hepatology, 40, 1304-1311.
27. Terai, S., Sakaida, I., Yamamoto, N., et al. (2003). An in vivo model for monitoring trans-differentiation of bone marrow cells into functional hepatocytes. Journal of Biochemistry, 134, 551-558.
28. Alison, M. R., Vig, P., Russo, F., et al. (2004). Hepatic stem cells: from inside and outside the liver? Cell Proliferation, 37, 1-21.
29. Baharvand, H., Hashemi, S. M., & Shahsavani, M. (2008). Differentiation of human embryonic stem cells into functional hepatocyte-like cells in a serum-free adherent culture condition. Differentiation, 76, 465-477.
30. Aurich, I., Mueller, L. P., Aurich, H., et al. (2007). Functional integration of hepatocytes derived from human mesenchymal stem cells into mouse livers. Gut, 56, 405-415.
31. Aurich, H., Sgodda, M., Kaltwasser, P., et al. (2009). Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo. Gut, 58, 570-581.
32. Duncan, A. W., Dorrell, C., & Grompe, M. (2009). Stem cells and liver regeneration. Gastroenterology, 137, 466-481.
33. Abdel Aziz, M. T., Atta, H. M., Mahfouz, S., et al. (2007). Therapeutic potential of bone marrow-derived mesenchymal stem cells on experimental liver fibrosis. Clinical Biochemistry, 40, 893-899.
34. Seo, M. J., Suh, S. Y., Bae, Y. C., & Jung, J. S. (2005). Differentiation of human adipose stromal cells into hepatic lineage in vitro and in vivo. Biochemical and Biophysical Research Communications, 328, 258-264.
35. van Poll, D., Parekkadan, B., Cho, C. H., et al. (2008). Mesenchymal stem cell-derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivo. Hepatology, 47, 1634-1643.
36. Caplan, A. I., & Dennis, J. E. (2006). Mesenchymal stem cells as trophic mediators. Journal of Cellular Biochemistry, 98, 1076-1084.
37. Parekkadan, B., van Poll, D., Suganuma, K., et al. (2007). Mesenchymal stem cell-derived molecules reverse fulminant hepatic failure. PLoS ONE, 2, e941.
38. Wang, X., Willenbring, H., Akkari, Y., et al. (2003). Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature, 422, 897-901.
39. Camargo, F. D., Finegold, M., & Goodell, M. A. (2004). Hematopoietic myelomonocytic cells are the major source of hepatocyte fusion partners. Journal of Clinical Investigation, 113, 1266-1270.
40. Jang, Y. Y., Collector, M. I., Baylin, S. B., Diehl, A. M., & Sharkis, S. J. (2004). Hematopoietic stem cells convert into liver cells within days without fusion. Nature Cell Biology, 6, 532-539.
41. Hashemi, S. M., Soleimani, M., Zargarian, S. S., et al. (2008). In vitro differentiation of human cord blood-derived unrestricted somatic stem cells into hepatocyte-like cells on poly(epsilon-Caprolactone) nanofiber scaffolds. Cells Tissues Organs, 190, 135-149.
42. Li, W. J., Tuli, R., Okafor, C., et al. (2005). A three-dimensional nanofibrous scaffold for cartilage tissue engineering using human mesenchymal stem cells. Biomaterials, 26, 599-609.
43. Silva, G. A., Czeisler, C., Niece, K. L., et al. (2004). Selective differentiation of neural progenitor cells by high-epitope density nanofibers. Science, 303, 1352-1355.
44. Biehl, J. K., Yamanaka, S., Desai, T. A., Boheler, K. R., & Russell, B. (2009). Proliferation of mouse embryonic stem cell progeny and the spontaneous contractile activity of cardiomyocytes are affected by microtopography. Developmental Dynamics, 238, 1964-1973.
45. Chai, C., & Leong, K. W. (2007). Biomaterials approach to expand and direct differentiation of stem cells. Molecular Therapy, 15, 467-480.