Small bowel, celiac disease and adaptive immunity

Digestive Diseases

Volumn 33, Issue 2, 2015, Pages 115-121

  Sollid, Ludvig M ^a   Iversen, Rasmus ^a   Steinsbø, Øyvind ^a   Qiao, Shuo Wang ^a   Bergseng, Elin ^a   Dørum, Siri ^a   Du Pré, M Fleur ^a   Stamnaes, Jorunn ^a   Christophersen, Asbjørn ^a   Cardoso, Inês ^a   Hnida, Kathrin ^a   Chen, Xi ^a   Snir, Omri ^a   Lundin, Knut E A ^a,b  

^a UNIVERSITY OF OSLO   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Adaptive immunity; B cells; Celiac disease; Gluten; MHC genes; T cells

Indexed keywords

ANTIBODY; B LYMPHOCYTE RECEPTOR; CD4 ANTIGEN; EPITOPE; GLUTEN; GLUTEN ANTIBODY; HLA DQ2 ANTIGEN; HLA DQ8 ANTIGEN; IMMUNOGLOBULIN A ANTIBODY; MAJOR HISTOCOMPATIBILITY ANTIGEN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; GUANINE NUCLEOTIDE BINDING PROTEIN; IMMUNOGLOBULIN A; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE;

ADAPTIVE IMMUNITY; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELIAC DISEASE; DEAMINATION; ENDOSOME; HEREDITY; HUMAN; IMMUNE RESPONSE; IMMUNOREGULATION; INNATE IMMUNITY; MAJOR HISTOCOMPATIBILITY COMPLEX; PATHOGENESIS; PRIORITY JOURNAL; T LYMPHOCYTE; IMMUNOLOGY; PATHOLOGY; SMALL INTESTINE;

ADAPTIVE IMMUNITY; CELIAC DISEASE; EPITOPES, T-LYMPHOCYTE; GTP-BINDING PROTEINS; HUMANS; IMMUNOGLOBULIN A; INTESTINE, SMALL; TRANSGLUTAMINASES;

EID: 84930001211     PISSN: 02572753     EISSN: 14219875     Source Type: Journal    
DOI: 10.1159/000369512     Document Type: Article

References (36)

1. Hunt KA, Zhernakova A, Turner G, Heap GA, et al: Newly identified genetic risk variants for celiac disease related to the immune response. Nat Genet 2008; 40: 395-402.
2. Dubois PC, Trynka G, Franke L, Hunt KA, et al: Multiple common variants for celiac disease influencing immune gene expression. Nat Genet 2010; 42: 295-302.
3. Trynka G, Hunt KA, Bockett NA, Romanos J, et al: Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. Nat Genet 2011; 43: 1193-1201.
4. Sollid LM, Lie BA: Celiac disease genetics: current concepts and practical applications. Clin Gastroenterol Hepatol 2005; 3: 843-851.
5. Lundin KEA, Scott H, Hansen T, Paulsen G, Halstensen TS, Fausa O, Thorsby E, Sollid LM: Gliadin-specific, HLA-DQ(10501, 10201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients. J Exp Med 1993; 178: 187-196.
6. Molberg O, McAdam SN, Körner R, Quarsten H, Kristiansen C, Madsen L, Fugger L, Scott H, Roepstorff P, Lundin KEA, Sjöström H, Sollid LM: Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells. Nat Med 1998; 4: 713-717.
7. van de Wal Y, Kooy Y, van Veelen P, Pena S, Mearin L, Papadopoulos G, Koning F: Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity. J Immunol 1998; 161: 1585-1588.
8. Vader LW, de Ru A, van Der WY, Kooy YM, Benckhuijsen W, Mearin ML, Drijfhout JW, van Veelen P, Koning F: Specificity of tissue transglutaminase explains cereal toxicity in celiac disease. J Exp Med 2002; 195: 643-649.
9. Fleckenstein B, Molberg, Qiao SW, Schmid DG, Von Der MF, Elgstoen K, Jung G, Sollid LM: Gliadin T cell epitope selection by tissue transglutaminase in celiac disease. Role of enzyme specificity and pH influence on the transamidation versus deamidation process. J Biol Chem 2002; 277: 34109-34116.
10. Dieterich W, Ehnis T, Bauer M, Donner P, Volta U, Riecken EO, Schuppan D: Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med 1997; 3: 797-801.
11. Osman AA, Gunnel T, Dietl A, Uhlig HH, Amin M, Fleckenstein B, Richter T, Mothes T: B cell epitopes of gliadin. Clin Exp Immunol 2000; 121: 248-254.
12. Husby S, Koletzko S, Korponay-Szabo IR, Mearin ML, Phillips A, Shamir R, Troncone R, Giersiepen K, Branski D, Catassi C, Lelgeman M, Maki M, Ribes-Koninckx C, Ventura A, Zimmer KP; ESPGHAN Working Group on Coeliac Disease Diagnosis; ESPGHAN Gastroenterology Committee; European Society for Pediatric Gastroenterology, Hepatology, and Nutrition: European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr 2012; 54: 136-160.
13. Bjorck S, Brundin C, Lorinc E, Lynch KF, Agardh D: Screening detects a high proportion of celiac disease in young HLA-genotyped children. J Pediatr Gastroenterol Nutr 2010; 50: 49-53.
14. Baklien K, Brandtzaeg P, Fausa O: Immunoglobulins in jejunal mucosa and serum from patients with adult coeliac disease. Scand J Gastroenterol 1977; 12: 149-159.
15. Siegel M, Strnad P, Watts RE, Choi K, Jabri B, Omary MB, Khosla C: Extracellular transglutaminase is catalytically inactive, but is transiently activated upon tissue injury. PLoS One 2008; 3:e1861.
16. Di Niro R, Mesin L, Zheng NY, Stamnaes J, Morrissey M, Lee JH, Huang M, Iversen R, du Pre MF, Qiao SW, Lundin KE, Wilson PC, Sollid LM: High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions. Nat Med 2012; 18: 441-445.
17. Iversen R, Di Niro R, Stamnaes J, Lundin KE, Wilson PC, Sollid LM: Transglutaminase 2-specific autoantibodies in celiac disease target clustered, N-terminal epitopes not displayed on the surface of cells. J Immunol 2013; 190: 5981-5991.
18. Steinsbo O, Henry Dunand CJ, Huang M, Mesin L, Salgado-Ferrer M, Lundin KE, Jahnsen J, Wilson PC, Sollid LM: Restricted VH/VL usage and limited mutations in glutenspecific IgA of coeliac disease lesion plasma cells. Nat Commun 2014; 5: 4041.
19. Sollid LM, Molberg, McAdam S, Lundin KE: Autoantibodies in coeliac disease: tissue transglutaminase-guilt by association? Gut 1997; 41: 851-852.
20. Arentz-Hansen H, McAdam SN, Molberg, Fleckenstein B, Lundin KE, Jorgensen TJ, Jung G, Roepstorff P, Sollid LM: Celiac lesion T cells recognize epitopes that cluster in regions of gliadins rich in proline residues. Gastroenterology 2002; 123: 803-809.
21. Shan L, Molberg, Parrot I, Hausch F, Filiz F, Gray GM, Sollid LM, Khosla C: Structural basis for gluten intolerance in celiac sprue. Science 2002; 297: 2275-2279.
22. Dørum S, Arntzen MO, Qiao SW, Holm A, Koehler CJ, Thiede B, Sollid LM, Fleckenstein B: The preferred substrates for transglutaminase in a complex wheat gluten digest are peptide fragments harboring celiac disease Tcell epitopes. PLoS One 2010; 5:e14056.
23. Tollefsen S, Arentz-Hansen H, Fleckenstein B, Molberg, Raki M, Kwok WW, Jung G, Lundin KE, Sollid LM: HLA-DQ2 and-DQ8 signatures of gluten T cell epitopes in celiac disease. J Clin Invest 2006; 116: 2226-2236.
24. Qiao SW, Bergseng E, Molberg O, Jung G, Fleckenstein B, Sollid LM: Refining the rules of gliadin T cell epitope binding to the disease-associated DQ2 molecule in celiac disease: importance of proline spacing and glutamine deamidation. J Immunol 2005; 175: 254-261.
25. Vader W, Kooy Y, van Veelen P, de Ru A, Harris D, Benckhuijsen W, Pena S, Mearin L, Drijfhout JW, Koning F: The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides. Gastroenterology 2002; 122: 1729-1737.
26. Fallang LE, Bergseng E, Hotta K, Berg-Larsen A, Kim CY, Sollid LM: Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation. Nat Immunol 2009; 10: 1096-1101.
27. Dørum S, Bodd M, Fallang LE, Bergseng E, Christophersen A, Johannesen MK, Qiao SW, Stamnaes J, de Souza GA, Sollid LM: HLADQ molecules as affinity matrix for identification of gluten T-cell epitopes. J Immunol 2014; 193: 4497-4506.
28. Bodd M, Kim CY, Lundin KE, Sollid LM: Tcell response to gluten in patients with HLADQ2.2 reveals requirement of peptide-MHC stability in celiac disease. Gastroenterology 2012; 142: 552-561.
29. van de Wal Y, Kooy YC, Drijfhout JW, Amons R, Papadopoulos GK, Koning F: Unique peptide binding characteristics of the disease-associated DQ(10501, 10201) vs the nondisease-associated DQ(10201, 10202) molecule. Immunogenetics 1997; 46: 484-492.
30. Qiao SW, Raki M, Gunnarsen KS, Loset GA, Lundin KE, Sandlie I, Sollid LM: Posttranslational modification of gluten shapes TCR usage in celiac disease. J Immunol 2011; 187: 3064-3071.
31. Qiao SW, Christophersen A, Lundin KE, Sollid LM: Biased usage and preferred pairing of and chains of TCRs specific for an immunodominant gluten epitope in coeliac disease. Int Immunol 2014; 26: 13-19.
32. Han A, Newell EW, Glanville J, Fernandez-Becker N, Khosla C, Chien YH, Davis MM: Dietary gluten triggers concomitant activation of CD4+ and CD8+ T cells and T cells in celiac disease. Proc Natl Acad Sci USA 2013; 110: 13073-13078.
33. Petersen J, Montserrat V, Mujico JR, Loh KL, Beringer DX, van Lummel M, Thompson A, Mearin ML, Schweizer J, Kooy-Winkelaar Y, van Bergen J, Drijfhout JW, Kan WT, La Gruta NL, Anderson RP, Reid HH, Koning F, Rossjohn J: T-cell receptor recognition of HLA-DQ2-gliadin complexes associated with celiac disease. Nat Struct Mol Biol 2014; 21: 480-488.
34. Broughton SE, Petersen J, Theodossis A, Scally SW, Loh KL, Thompson A, van Bergen J, Kooy-Winkelaar Y, Henderson KN, Beddoe T, Tye-Din JA, Mannering SI, Purcell AW, McCluskey J, Anderson RP, Koning F, Reid HH, Rossjohn J: Biased T cell receptor usage directed against human leukocyte antigen DQ8-restricted gliadin peptides is associated with celiac disease. Immunity 2012; 37: 611-621.
35. Iversen R, Mysling S, Hnida K, Jørgensen TJ, Sollid LM: Activity-regulating structural changes and autoantibody epitopes in transglutaminase assessed by hydrogen/deuterium exchange. Proc Natl Acad Sci USA 2014;111:17146-17151.
36. Bergseng E, Dørum S, Arntzen MØ, Nielsen M, Nygård S, Buus S, de Souza GA, Sollid LM: Different binding motifs of the celiac diseaseassociated HLA molecules DQ2.5, DQ2.2, and DQ7.5 revealed by relative quantitative proteomics of endogenous peptide repertoires. Immunogenetics 2015;67:73-84.