Mechanistic studies reveal similar catalytic strategies for phosphodiester bond hydrolysis by protein-only and RNA-dependent ribonuclease P

Journal of Biological Chemistry

Volumn 290, Issue 21, 2015, Pages 13454-13464

  Howard, Michael J ^a   Klemm, Bradley P ^a   Fierke, Carol A ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CATALYST ACTIVITY; CRYSTAL STRUCTURE; ENZYMES; ESTERS; HYDROLYSIS; IMPACT IONIZATION; IONIZATION OF LIQUIDS; MAGNESIUM; METAL IONS; METALS; PLANTS (BOTANY); PROTEINS; SCAFFOLDS (BIOLOGY);

ARABIDOPSIS THALIANA; CATALYTIC MECHANISMS; ENZYMATIC MECHANISMS; MACROMOLECULAR COMPOSITION; MAGNESIUM CONCENTRATIONS; MECHANISTIC STUDIES; METAL ION AFFINITIES; PHOSPHODIESTER BONDS;

RNA;

ALANINE; ASPARTIC ACID; MAGNESIUM ION; NUCLEASE; PROTEIN NYN; PROTEIN ONLY RIBONUCLEASE P; RIBONUCLEASE P; RNA; TRANSFER RNA; UNCLASSIFIED DRUG; ARABIDOPSIS PROTEIN; BACTERIAL RNA; METAL; PRORP1 PROTEIN, ARABIDOPSIS; RIBOZYME; RNA PRECURSOR;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CATALYSIS; CONTROLLED STUDY; ENZYME MECHANISM; ENZYME METABOLISM; HYDROLYSIS; IONIZATION; NONHUMAN; PH; PHOSPHODIESTER BOND HYDROLYSIS; PRIORITY JOURNAL; PROTON TRANSPORT; RNA CLEAVAGE; ANISOTROPY; ARABIDOPSIS; BINDING SITE; CONFORMATION; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE;

ARABIDOPSIS THALIANA;

ANISOTROPY; ARABIDOPSIS; ARABIDOPSIS PROTEINS; BASE SEQUENCE; BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; KINETICS; METALS; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEIC ACID CONFORMATION; RIBONUCLEASE P; RNA PRECURSORS; RNA, BACTERIAL; RNA, CATALYTIC;

EID: 84929995683     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.644831     Document Type: Article

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