The cardioprotectant 3′,4′-dihydroxyflavonol inhibits opening of the mitochondrial permeability transition pore after myocardial ischemia and reperfusion in rats

Pharmacological Research

Volumn 81, Issue , 2014, Pages 26-33

  Woodman, O L ^a   Long, R ^b,c   Pons, S ^b,c   Eychenne, N ^b,c   Berdeaux, A ^b,c   Morin, D ^b,c  

^a RMIT UNIVERSITY   (Australia)

^b INSERM U955   (France)

^c FACULTÉ DE MÉDECINE   (France)

Author keywords

3 ,4 Dihydroxyflavonol; Cardiac ischemia and reperfusion; Mitochondrial permeability transition pore (mPTP); Mitochondrial respiration; Reactive oxygen species

Indexed keywords

3',4' DIHYDROXYFLAVONOL; CALCIUM ION; FLAVONOL; HYDROGEN PEROXIDE; MALIC ACID; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PYRUVIC ACID; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; 3',4'-DIHYDROXYFLAVONOL; CARDIOTONIC AGENT; CARRIER PROTEIN; FLAVONOL DERIVATIVE; MALIC ACID DERIVATIVE; ROTENONE; SUCCINIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CELL ISOLATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORONARY ARTERY OCCLUSION; HEART MITOCHONDRION; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; IN VIVO STUDY; MALE; MITOCHONDRIAL FUNCTION; MITOCHONDRIAL RESPIRATION; NONHUMAN; OSMOSIS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; ANIMAL; DRUG EFFECTS; METABOLISM; REPERFUSION INJURY; WISTAR RAT;

ANIMALS; CARDIOTONIC AGENTS; FLAVONOLS; MALATES; MALE; MITOCHONDRIA, HEART; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MYOCARDIAL REPERFUSION INJURY; OXYGEN CONSUMPTION; PYRUVIC ACID; RATS, WISTAR; REACTIVE OXYGEN SPECIES; ROTENONE; SUCCINIC ACID;

EID: 84895789278     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2014.01.004     Document Type: Article

References (36)

1. D.M. Yellon, and D.J. Hausenloy Myocardial reperfusion injury N Engl J Med 357 11 2007 1121 1135
2. A.P. Halestrap Mitochondria and reperfusion injury of the heart - a holey death but not beyond salvation J Bioeng Biomembr 41 2 2009 113 121
3. C. Penna, M.G. Perrelli, and P. Pagliaro Mitochondrial pathways, permeability transition pore, and redox signaling in cardioprotection: therapeutic implications Antiox Redox Signal 18 5 2013 556 599
4. A.P. Halestrap, S.J. Clarke, and S.A. Javadov Mitochondrial permeability transition pore opening during myocardial reperfusion - a target for cardioprotection Cardiovasc Res 61 3 2004 372 385 (Pubitemid 38210145)
5. A.M. Walters, G.A. Porter Jr., and P.S. Brookes Mitochondria as a drug target in ischemic heart disease and cardiomyopathy Circ Res 111 9 2012 1222 1236
6. N. Mewton, P. Croisille, G. Gahide, G. Rioufol, E. Bonnefoy, and I. Sanchez et al. Effect of cyclosporine on left ventricular remodeling after reperfused myocardial infarction J Am Coll Cardiol 55 12 2010 1200 1205
7. C. Piot, P. Croisille, P. Staat, H. Thibault, G. Rioufol, and N. Mewton et al. Effect of cyclosporine on reperfusion injury in acute myocardial infarction N Engl J Med 359 5 2008 473 481
8. C.J. Thomas, D.C. Ng, N. Patsikatheodorou, Y. Limengka, M.W. Lee, and I.A. Darby et al. Cardioprotection from ischaemia-reperfusion injury by a novel flavonol that reduces activation of p38 MAPK Eur J Pharmacol 658 2-3 2011 160 167
9. S. Wang, G.J. Dusting, C.N. May, and O.L. Woodman 3′,4′- Dihydroxyflavonol reduces infarct size and injury associated with myocardial ischaemia and reperfusion in sheep Br J Pharmacol 142 3 2004 443 452 (Pubitemid 38869857)
10. S. Wang, K. Fei, Y.W. Xu, L.X. Wang, and Y.Q. Chen Dihydroxyflavonol reduces post-infarction left ventricular remodeling by preventing myocyte apoptosis in the non-infarcted zone in goats Chin Med J 122 1 2009 61 67
11. S. Wang, C.J. Thomas, G.J. Dusting, O.L. Woodman, and C.N. May 3′,4′-Dihydroxyflavonol improves post-ischaemic coronary endothelial function following 7 days reperfusion in sheep Eur J Pharmacol 624 1-3 2009 31 37
12. E.C.H. Chan, G.R. Drummond, and O.L. Woodman 3′,4′- Dihydroxyflavonol enhances nitric oxide bioavailability and improves vascular function after ischemia and reperfusion injury in the rat J Cardiovasc Pharmacol 42 2003 727 735 (Pubitemid 37467094)
13. O.L. Woodman, and E.C.H. Chan Vascular and anti-oxidant actions of flavonols and flavones Clin Exp Pharmacol Physiol 31 11 2004 786 790 (Pubitemid 39556854)
14. C.X. Qin, S.J. Williams, and O.L. Woodman Antioxidant activity contributes to flavonol cardioprotection during reperfusion of rat hearts Free Radic Biol Med 51 7 2011 1437 1444
15. D.J. Hausenloy, and D.M. Yellon Reperfusion injury salvage kinase signalling: taking a RISK for cardioprotection Heart Fail Rev 12 3-4 2007 217 234 (Pubitemid 350176695)
16. N.R. Lim, C.J. Thomas, L.S. Silva, Y.Y. Yeap, S. Yap, and J.R. Bell et al. Cardioprotective 3′,4′-dihydroxyflavonol attenuation of JNK and p38MAPK signalling involves CaMKII inhibition Biochem J 456 2 2013 149 161
17. J. Chen, W. Wang, Q. Zhang, F. Li, T. Lei, and D. Luo et al. Low molecular weight fucoidan against renal ischemia-reperfusion injury via inhibition of the MAPK signaling pathway PLoS ONE 8 2 2013 e56224
18. S.J. Harding, G.J. Browne, B.W. Miller, S.A. Prigent, and M. Dickens Activation of ASK1, downstream MAPKK and MAPK isoforms during cardiac ischaemia Biochim Biophys Acta 1802 9 2010 733 740
19. H.Y. Sun, N.P. Wang, M. Halkos, F. Kerendi, H. Kin, and R.A. Guyton et al. Postconditioning attenuates cardiomyocyte apoptosis via inhibition of JNK and p38 mitogen-activated protein kinase signaling pathways Apoptosis 11 9 2006 1583 1593 (Pubitemid 44253675)
20. P.S. Brookes, S.B. Digerness, D.A. Parks, and V. Darley-Usmar Mitochondrial function in response to cardiac ischemia-reperfusion after oral treatment with quercetin Free Radic Biol Med 32 11 2002 1220 1228 (Pubitemid 34603359)
21. B. Silva, P.J. Oliveira, A. Dias, and J.O. Malva Quercetin, kaempferol and biapigenin from Hypericum perforatum are neuroprotective against excitotoxic insults Neurotox Res 13 3-4 2008 265 279
22. M. Fiorani, A. Guidarelli, M. Blasa, C. Azzolini, M. Candiracci, and E. Piatti et al. Mitochondria accumulate large amounts of quercetin: prevention of mitochondrial damage and release upon oxidation of the extramitochondrial fraction of the flavonoid J Nutr Biochem 21 5 2010 397 404
23. F. Grund, O. Tjomsland, I. Sjaastad, A. Ilebekk, and K.A. Kirkeboen Pentobarbital versus medetomidine-ketamine-fentanyl anaesthesia: effects on haemodynamics and the incidence of ischaemia-induced ventricular fibrillation in swine Lab Anim 38 1 2004 70 78 (Pubitemid 38117448)
24. M. Zorniak, K. Mitrega, S. Bialka, M. Porc, and T.F. Krzeminski Comparison of thiopental, urethane, and pentobarbital in the study of experimental cardiology in rats in vivo J Cardiovasc Pharmacol 56 1 2010 38 44
25. F.N. Obame, C. Plin-Mercier, R. Assaly, R. Zini, J.L. Dubois-Rande, and A. Berdeaux et al. Cardioprotective effect of morphine and a blocker of glycogen synthase kinase 3 beta, SB216763 [3-(2,4-dichlorophenyl)-4(1-methyl-1H-indol-3- yl)-1H-pyrrole-2,5-dione], via inhibition of the mitochondrial permeability transition pore J Pharmacol Exp Ther 326 1 2008 252 258 (Pubitemid 351872117)
26. F.N. Obame, R. Zini, R. Souktani, A. Berdeaux, and D. Morin Peripheral benzodiazepine receptor-induced myocardial protection is mediated by inhibition of mitochondrial membrane permeabilization J Pharmacol Exp Ther 323 1 2007 336 345 (Pubitemid 47443246)
27. 2+-induced mitochondrial permeability transition Cardiovasc Res 61 1 2004 115 122 (Pubitemid 38056687)
28. P. Cos, L. Ying, M. Calomme, J.P. Hu, K. Cimanga, and B. Van Poel et al. Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers J Nat Prod 61 1998 71 76 (Pubitemid 28086977)
29. J. Robak, and R.J. Gryglewski Flavonoids are scavengers of superoxide anions Biochem Pharmacol 37 1988 837 841 (Pubitemid 18058453)
30. 2-induced activation of the intrinsic apoptotic pathway in H9c2 cardiomyocytes through scavenging reactive oxygen species and ERK inactivation J Cell Biochem 113 2012 473 485
31. D.J. Hausenloy, E.A. Boston-Griffiths, and D.M. Yellon Cyclosporin A and cardioprotection: from investigative tool to therapeutic agent Br J Pharmacol 165 5 2012 1235 1245
32. D.J. Dorta, A.A. Pigoso, F.E. Mingatto, T. Rodrigues, I.M. Prado, and A.F. Helena et al. The interaction of flavonoids with mitochondria: effects on energetic processes Chem Biol Interact 152 2-3 2005 67 78 (Pubitemid 40517146)
33. S. Trumbeckaite, J. Bernatoniene, D. Majiene, V. Jakstas, A. Savickas, and A. Toleikis The effect of flavonoids on rat heart mitochondrial function Biomed Pharmacother 60 5 2006 245 248 (Pubitemid 43975717)
34. R. Ortega, and N. Garcia The flavonoid quercetin induces changes in mitochondrial permeability by inhibiting adenine nucleotide translocase J Bioeng Biomembr 41 1 2009 41 47
35. L. Biasutto, N. Sassi, A. Mattarei, E. Marotta, P. Cattelan, and A. Toninello et al. Impact of mitochondriotropic quercetin derivatives on mitochondria Biochim Biophys Acta 1797 2 2010 189 196
36. P.G. Pietta Flavonoids as antioxidants J Nat Prod 63 7 2000 1035 1042