PDE1C negatively regulates growth factor receptor degradation and promotes VSMC proliferation

Circulation Research

Volumn 116, Issue 7, 2015, Pages 1098-1100

  Satoh, Kimio ^a   Kikuchi, Nobuhiro ^a   Kurosawa, Ryo ^a   Shimokawa, Hiroaki ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cyclic nucleotide phosphodiesterases type 1; Editorials; Endosomes; Lysosomes; Platelet derived growth factor

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; GROWTH FACTOR RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; NITRIC OXIDE; PHOSPHODIESTERASE; PHOSPHODIESTERASE 1C; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROSTACYCLIN; RHO KINASE; UNCLASSIFIED DRUG; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1; PDE1C PROTEIN, HUMAN;

AORTA ANEURYSM; ATHEROSCLEROSIS; CELL MIGRATION; CELL PROLIFERATION; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; HUMAN; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT MOUSE; LIPOPROTEIN METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN HYDROLYSIS; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; REVIEW; VASCULAR SMOOTH MUSCLE CELL; ANIMAL; CYTOLOGY; ENZYMOLOGY; MALE; NEOINTIMA; PHYSIOLOGY; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

ANIMALS; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 1; HUMANS; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NEOINTIMA;

EID: 84929938617     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.115.306139     Document Type: Review

References (25)

1. Shimokawa H, 2014 Williams Harvey Lecture: importance of coronary vasomotion abnormalities-from bench to bedside. Eur Heart J 2014; 35: 3180-3193. doi: 10.1093/eurheartj/ehu427.
2. Shimokawa H, Satoh K, Light and dark of reactive oxygen species for vascular function. J Cardiovasc Pharmacol 2015. In press.
3. Berk BC, Vascular smooth muscle growth: autocrine growth mechanisms. Physiol Rev 2001 81 999 1030
4. Satoh K, Fukumoto Y, Nakano M, Sugimura K, Nawata J, Demachi J, Karibe A, Kagaya Y, Ishii N, Sugamura K, Shimokawa H, Statin ameliorates hypoxia-induced pulmonary hypertension associated with down-regulated stromal cell-derived factor-1. Cardiovasc Res 2009; 81: 226-234. doi: 10.1093/cvr/cvn244.
5. Satoh K, Kagaya Y, Nakano M, Ito Y, Ohta J, Tada H, Karibe A, Minegishi N, Suzuki N, Yamamoto M, Ono M, Watanabe J, Shirato K, Ishii N, Sugamura K, Shimokawa H, Important role of endogenous erythropoietin system in recruitment of endothelial progenitor cells in hypoxia-induced pulmonary hypertension in mice. Circulation 2006 113 1442 1450
6. Satoh K, Berk BC, Circulating smooth muscle progenitor cells: novel players in plaque stability. Cardiovasc Res 2008; 77: 445-447. doi: 10.1093/cvr/cvm088.
7. Nagel DJ, Aizawa T, Jeon KI, Liu W, Mohan A, Wei H, Miano JM, Florio VA, Gao P, Korshunov VA, Berk BC, Yan C, Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival. Circ Res 2006; 98: 777-784. doi: 10.1161/01.RES.0000215576.27615.fd.
8. Satoh K, Godo S, Saito H, Enkhjargal B, Shimokawa H, Dual roles of vascular-derived reactive oxygen species-with a special reference to hydrogen peroxide and cyclophilin A. J Mol Cell Cardiol 2014; 73: 50-56. doi: 10.1016/j.yjmcc.2013.12.022.
9. Enkhjargal B, Godo S, Sawada A, Suvd N, Saito H, Noda K, Satoh K, Shimokawa H, Endothelial AMP-activated protein kinase regulates blood pressure and coronary flow responses through hyperpolarization mechanism in mice. Arterioscler Thromb Vasc Biol 2014; 34: 1505-1513. doi: 10.1161/ATVBAHA.114.303735.
10. Rybalkin SD, Bornfeldt KE, Sonnenburg WK, Rybalkina IG, Kwak KS, Hanson K, Krebs EG, Beavo JA, Calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1C) is induced in human arterial smooth muscle cells of the synthetic, proliferative phenotype. J Clin Invest 1997; 100: 2611-2621. doi: 10.1172/JCI119805.
11. Rybalkin SD, Rybalkina I, Beavo JA, Bornfeldt KE, Cyclic nucleotide PDE1C promotes human arterial smooth muscle cell proliferation. Circ Res 2002 90 151 157
12. Cai Y, Nagel DJ, Zhou Q, Cygnar KD, Zhao H, Li F, Pi X, Knight PA, Yan C, Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia. Circ Res 2015; 116: 1120-1132. doi: 10.1161/CIRCRESAHA.116.304408.
13. Boucher P, Gotthardt M, Li WP, Anderson RG, Herz J, LRP: role in vascular wall integrity and protection from atherosclerosis. Science 2003; 300: 329-332. doi: 10.1126/science.1082095.
14. Cai Y, Miller CL, Nagel DJ, Jeon KI, Lim S, Gao P, Knight PA, Yan C, Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2011; 31: 616-623. doi: 10.1161/ATVBAHA.110.212621.
15. Vandeput F, Wolda SL, Krall J, Hambleton R, Uher L, McCaw KN, Radwanski PB, Florio V, Movsesian MA, Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes. J Biol Chem 2007; 282: 32749-32757. doi: 10.1074/jbc.M703173200.
16. Miller CL, Oikawa M, Cai Y, Wojtovich AP, Nagel DJ, Xu X, Xu H, Florio V, Rybalkin SD, Beavo JA, Chen YF, Li JD, Blaxall BC, Abe J, Yan C, Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy. Circ Res 2009; 105: 956-964. doi: 10.1161/CIRCRESAHA.109.198515.
17. Barst RJ, PDGF signaling in pulmonary arterial hypertension. J Clin Invest 2005; 115: 2691-2694. doi: 10.1172/JCI26593.
18. Chhina MK, Nargues W, Grant GM, Nathan SD, Evaluation of imatinib mesylate in the treatment of pulmonary arterial hypertension. Future Cardiol 2010; 6: 19-35. doi: 10.2217/fca.09.54.
19. Zamanian RT, Kudelko KT, Sung YK, de Jesus Perez V, Liu J, Spiekerkoetter E, Current clinical management of pulmonary arterial hypertension. Circ Res 2014; 115: 131-147. doi: 10.1161/CIRCRESAHA.115.303827.
20. Austin ED, Loyd JE, The genetics of pulmonary arterial hypertension. Circ Res 2014; 115: 189-202. doi: 10.1161/CIRCRESAHA.115.303404.
21. Ryan JJ, Archer SL, The right ventricle in pulmonary arterial hypertension: disorders of metabolism, angiogenesis and adrenergic signaling in right ventricular failure. Circ Res 2014; 115: 176-188. doi: 10.1161/CIRCRESAHA.113.301129.
22. Rabinovitch M, Guignabert C, Humbert M, Nicolls MR, Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension. Circ Res 2014; 115: 165-175. doi: 10.1161/CIRCRESAHA.113.301141.
23. Satoh K, Satoh T, Kikuchi N, Omura J, Kurosawa R, Suzuki K, Sugimura K, Aoki T, Nochioka K, Tatebe S, Miyamichi-Yamamoto S, Miura M, Shimizu T, Ikeda S, Yaoita N, Fukumoto Y, Minami T, Miyata S, Nakamura K, Ito H, Kadomatsu K, Shimokawa H, Basigin mediates pulmonary hypertension by promoting inflammation and vascular smooth muscle cell proliferation. Circ Res 2014 115 738 750
24. Lai YC, Potoka KC, Champion HC, Mora AL, Gladwin MT, Pulmonary arterial hypertension: the clinical syndrome. Circ Res 2014; 115: 115-130. doi: 10.1161/CIRCRESAHA.115.301146.
25. Schermuly RT, Pullamsetti SS, Kwapiszewska G, Dumitrascu R, Tian X, Weissmann N, Ghofrani HA, Kaulen C, Dunkern T, Schudt C, Voswinckel R, Zhou J, Samidurai A, Klepetko W, Paddenberg R, Kummer W, Seeger W, Grimminger F, Phosphodiesterase 1 upregulation in pulmonary arterial hypertension: target for reverse-remodeling therapy. Circulation 2007 115 2331 2339