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Volumn , Issue , 2013, Pages 75-84

Ion channels as novel pancreatic cancer biomarkers and targets

Author keywords

Biomarker; Calcium; Cellular sensor; Ion channel; Magnesium; Melastatin; Molecular target; Pancreatic cancer; Proliferation; Targeted therapy; Transient receptor potential; TRP; TRPM7; TRPM8

Indexed keywords


EID: 84929921251     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-62703-456-2_5     Document Type: Chapter
Times cited : (5)

References (52)
  • 1
    • 80051580618 scopus 로고    scopus 로고
    • Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths
    • Siegel R, Ward E, Brawley O, Jemal A (2011) Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 61:212-236
    • (2011) CA Cancer J Clin , vol.61 , pp. 212-236
    • Siegel, R.1    Ward, E.2    Brawley, O.3    Jemal, A.4
  • 2
    • 77957128497 scopus 로고    scopus 로고
    • Zebrafish as a biological system for identifying and evaluating therapeutic targets and compounds
    • Han H, Grippo PJ eds, Springer, New York
    • Yee NS (2010) Zebrafish as a biological system for identifying and evaluating therapeutic targets and compounds. In: Han H, Grippo PJ (eds) Drug discovery in pancreatic cancer: models and techniques. Springer, New York, pp 95-112
    • (2010) Drug Discovery in Pancreatic Cancer: Models and Techniques , pp. 95-112
    • Yee, N.S.1
  • 3
    • 77951755278 scopus 로고    scopus 로고
    • Pancreatic cancer
    • Hidalgo M (2010) Pancreatic cancer. N Engl J Med 362:1605-1617
    • (2010) N Engl J Med , vol.362 , pp. 1605-1617
    • Hidalgo, M.1
  • 5
    • 79952341316 scopus 로고    scopus 로고
    • Transient receptor potential ion channel Trpm7 mediates control of exocrine pancreatic growth via Mg 2+-sensitive Socs3a signaling in development and cancer
    • Yee NS, Zhou W, Liang I-C (2011) Transient receptor potential ion channel Trpm7 mediates control of exocrine pancreatic growth via Mg 2+-sensitive Socs3a signaling in development and cancer. Dis Model Mech 4:240-254
    • (2011) Dis Model Mech , vol.4 , pp. 240-254
    • Yee, N.S.1    Zhou, W.2    Liang, I.-C.3
  • 6
    • 77956229134 scopus 로고    scopus 로고
    • Transient receptor potential channel TRPM8 is over-expressed and required for cellular proliferation in pancreatic adenocarcinoma
    • Yee NS, Zhou W, Lee M (2010) Transient receptor potential channel TRPM8 is over-expressed and required for cellular proliferation in pancreatic adenocarcinoma. Cancer Lett 297:49-55
    • (2010) Cancer Lett , vol.297 , pp. 49-55
    • Yee, N.S.1    Zhou, W.2    Lee, M.3
  • 7
    • 79952683619 scopus 로고    scopus 로고
    • The transient receptor potential family of ion channels
    • Nilius B, Owsianik G (2011) The transient receptor potential family of ion channels. Genome Biol 12:218
    • (2011) Genome Biol , vol.12 , pp. 218
    • Nilius, B.1    Owsianik, G.2
  • 8
    • 77955093253 scopus 로고    scopus 로고
    • Cellular functions of transient receptor potential channels
    • Dadon D, Minke B (2010) Cellular functions of transient receptor potential channels. Int J Biochem Cell Biol 42:1430-1445
    • (2010) Int J Biochem Cell Biol , vol.42 , pp. 1430-1445
    • Dadon, D.1    Minke, B.2
  • 9
    • 7644238945 scopus 로고    scopus 로고
    • The TRPM ion channel subfamily: Molecular, biophysical and functional features
    • Fleig A, Penner R (2004) The TRPM ion channel subfamily: molecular, biophysical and functional features. Trends Pharmacol Sci 25:633-639
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 633-639
    • Fleig, A.1    Penner, R.2
  • 11
    • 0035131504 scopus 로고    scopus 로고
    • TRP-PLIK, a bifunctional protein with kinase and ion channel activities
    • Runnels LW, Yue L, Clapham DE (2001) TRP-PLIK, a bifunctional protein with kinase and ion channel activities. Science 291:1043-1047
    • (2001) Science , vol.291 , pp. 1043-1047
    • Runnels, L.W.1    Yue, L.2    Clapham, D.E.3
  • 15
    • 0942265537 scopus 로고    scopus 로고
    • Characterization of the protein kinase activity of trpm7/chak1, a protein kinase fused to the transient receptor potential ion channel
    • Ryazanova LV, Dorovkov MV, Ansari A, Ryazanov AG (2004) Characterization of the protein kinase activity of trpm7/chak1, a protein kinase fused to the transient receptor potential ion channel. J Biol Chem 279:3708-3716
    • (2004) J Biol Chem , vol.279 , pp. 3708-3716
    • Ryazanova, L.V.1    Dorovkov, M.V.2    Ansari, A.3    Ryazanov, A.G.4
  • 16
    • 20144366217 scopus 로고    scopus 로고
    • Channel function is dissociated from the intrinsic kinase activity and autophosphorylation of trpm7/chak1
    • Matsushita M, Kozak JA, Shimizu Y, McLachlin DT, Yamaguchi H, Wei FY et al (2005) Channel function is dissociated from the intrinsic kinase activity and autophosphorylation of trpm7/chak1. J Biol Chem 280:20793-20803
    • (2005) J Biol Chem , vol.280 , pp. 20793-20803
    • Matsushita, M.1    Kozak, J.A.2    Shimizu, Y.3    McLachlin, D.T.4    Yamaguchi, H.5    Wei, F.Y.6
  • 17
    • 33645325125 scopus 로고    scopus 로고
    • TRPM7 channel is regulated by magnesium nucleotides via its kinase domain
    • Demeuse P, Penner R, Fleig A (2006) TRPM7 channel is regulated by magnesium nucleotides via its kinase domain. J Gen Physiol 127:421-434
    • (2006) J Gen Physiol , vol.127 , pp. 421-434
    • Demeuse, P.1    Penner, R.2    Fleig, A.3
  • 19
    • 35748972654 scopus 로고    scopus 로고
    • Functional transient receptor potential melastatin 7 channels are critical for human mast cell survival
    • Wykes RC, Lee M, Duffy SM, Yang W, Seward EP, Bradding P (2007) Functional transient receptor potential melastatin 7 channels are critical for human mast cell survival. J Immunol 179:4045-4052
    • (2007) J Immunol , vol.179 , pp. 4045-4052
    • Wykes, R.C.1    Lee, M.2    Duffy, S.M.3    Yang, W.4    Seward, E.P.5    Bradding, P.6
  • 20
    • 36248933061 scopus 로고    scopus 로고
    • Importance of melastatin-like transient receptor potential 7 and cations (magnesium, calcium) in human osteoblast-like cell proliferation
    • Abed E, Moreau R (2007) Importance of melastatin-like transient receptor potential 7 and cations (magnesium, calcium) in human osteoblast-like cell proliferation. Cell Prolif 40:849-865
    • (2007) Cell Prolif , vol.40 , pp. 849-865
    • Abed, E.1    Moreau, R.2
  • 21
    • 68849131636 scopus 로고    scopus 로고
    • Importance of melastatin-like transient receptor potential 7 and magnesium in the stimulation of osteoblast proliferation and migration by platelet-derived growth factor
    • Abed E, Moreau R (2009) Importance of melastatin-like transient receptor potential 7 and magnesium in the stimulation of osteoblast proliferation and migration by platelet-derived growth factor. Am J Physiol Cell Physiol 297:C360-C368
    • (2009) Am J Physiol Cell Physiol , vol.297 , pp. C360-C368
    • Abed, E.1    Moreau, R.2
  • 22
    • 55349148686 scopus 로고    scopus 로고
    • Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg 2+ homeostasis
    • Jin J, Desai BN, Navarro B, Donovan A, Andrews NC, Clapham DE (2008) Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg 2+ homeostasis. Science 322:756-759
    • (2008) Science , vol.322 , pp. 756-759
    • Jin, J.1    Desai, B.N.2    Navarro, B.3    Donovan, A.4    Andrews, N.C.5    Clapham, D.E.6
  • 24
    • 33846312821 scopus 로고    scopus 로고
    • TRPM7 is a stretch- and swelling-activated cation channel involved in volume regulation in human epithelial cells
    • Numata T, Shimizu T, Okada Y (2007) TRPM7 is a stretch- and swelling-activated cation channel involved in volume regulation in human epithelial cells. Am J Physiol Cell Physiol 292:C460-C467
    • (2007) Am J Physiol Cell Physiol , vol.292 , pp. C460-C467
    • Numata, T.1    Shimizu, T.2    Okada, Y.3
  • 27
    • 34447553455 scopus 로고    scopus 로고
    • Cell death of melanophores in zebrafish trpm7 mutant embryos depends on melanin synthesis
    • McNeill MS, Paulsen J, Bonde G, Burnight E, Hus MY, Cornell RA (2007) Cell death of melanophores in zebrafish trpm7 mutant embryos depends on melanin synthesis. J Invest Dermatol 127L: 2020-2030
    • (2007) J Invest Dermatol , vol.127 L , pp. 2020-2030
    • McNeill, M.S.1    Paulsen, J.2    Bonde, G.3    Burnight, E.4    Hus, M.Y.5    Cornell, R.A.6
  • 28
    • 23244460769 scopus 로고    scopus 로고
    • Exocrine pancreas development in zebrafish
    • Yee NS, Lorent K, Pack M (2005) Exocrine pancreas development in zebrafish. Dev Biol 284:84-101
    • (2005) Dev Biol , vol.284 , pp. 84-101
    • Yee, N.S.1    Lorent, K.2    Pack, M.3
  • 29
    • 4544291511 scopus 로고    scopus 로고
    • Involvement of TRPM7 in cell growth as a spontaneously activated Ca 2+ entry pathway in human retinoblastoma cells
    • Hanano T, Hara Y, Shi J, Morita H, Umebayashi C, Mori E et al (2004) Involvement of TRPM7 in cell growth as a spontaneously activated Ca 2+ entry pathway in human retinoblastoma cells. J Pharm Sci 95:403-419
    • (2004) J Pharm Sci , vol.95 , pp. 403-419
    • Hanano, T.1    Hara, Y.2    Shi, J.3    Morita, H.4    Umebayashi, C.5    Mori, E.6
  • 30
    • 36348964907 scopus 로고    scopus 로고
    • Transient receptor potential melastatin 7-like current in human head and neck carcinoma cells: Role in cell proliferation
    • Jiang J, Li MH, Inoue K, Chu XP, Seeds J, Xiong ZG (2007) Transient receptor potential melastatin 7-like current in human head and neck carcinoma cells: role in cell proliferation. Cancer Res 67:10929-10938
    • (2007) Cancer Res , vol.67 , pp. 10929-10938
    • Jiang, J.1    Li, M.H.2    Inoue, K.3    Chu, X.P.4    Seeds, J.5    Xiong, Z.G.6
  • 31
    • 57349188508 scopus 로고    scopus 로고
    • Suppression of transient receptor potential melastatin 7 channel induces cell death in gastric cancer
    • Kim BJ, Park EJ, Lee JH, Jeon J-H, Kim SJ, So I (2008) Suppression of transient receptor potential melastatin 7 channel induces cell death in gastric cancer. Cancer Sci 99:2502-2509
    • (2008) Cancer Sci , vol.99 , pp. 2502-2509
    • Kim, B.J.1    Park, E.J.2    Lee, J.H.3    Jeon, J.-H.4    Kim, S.J.5    So, I.6
  • 33
    • 77952958037 scopus 로고    scopus 로고
    • TRPM7 regulates the migration of human nasopharyngeal carcinoma cell by mediating Ca 2+ influx
    • Chen J-P, Luan Y, You C-X, Chen X-H, Luo R-C, Li R (2010) TRPM7 regulates the migration of human nasopharyngeal carcinoma cell by mediating Ca 2+ influx. Cell Calcium 47:425-432
    • (2010) Cell Calcium , vol.47 , pp. 425-432
    • Chen, J.-P.1    Luan, Y.2    You, C.-X.3    Chen, X.-H.4    Luo, R.-C.5    Li, R.6
  • 34
    • 0037034931 scopus 로고    scopus 로고
    • Identification of a cold receptor reveals a general role for TRP channels in thermosensation
    • McKemy DD, Neuhausser WM, Julius D (2002) Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416:52-58
    • (2002) Nature , vol.416 , pp. 52-58
    • McKemy, D.D.1    Neuhausser, W.M.2    Julius, D.3
  • 37
    • 38349101323 scopus 로고    scopus 로고
    • Diversity in the neural circuitry of cold sensing revealed by genetic axonal labelling of transient receptor potential melastatin 8 neurons
    • Takishima Y, Daniels RL, Knowlton W, Teng J, Liman ER, McKemy DD (2007) Diversity in the neural circuitry of cold sensing revealed by genetic axonal labelling of transient receptor potential melastatin 8 neurons. J Neurosci 27:14147-14157
    • (2007) J Neurosci , vol.27 , pp. 14147-14157
    • Takishima, Y.1    Daniels, R.L.2    Knowlton, W.3    Teng, J.4    Liman, E.R.5    McKemy, D.D.6
  • 38
    • 0035328671 scopus 로고    scopus 로고
    • Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins
    • Tsavaler L, Shapero MH, Morkowski S, Laus R (2001) Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. Cancer Res 61:3760-3769
    • (2001) Cancer Res , vol.61 , pp. 3760-3769
    • Tsavaler, L.1    Shapero, M.H.2    Morkowski, S.3    Laus, R.4
  • 41
    • 70849085425 scopus 로고    scopus 로고
    • Menthol induces cell death via the TRPM8 channel in the human bladder cancer cell line T24
    • Li Q, Wang X, Yang Z, Wang B, Li S (2009) Menthol induces cell death via the TRPM8 channel in the human bladder cancer cell line T24. Oncology 77:335-341
    • (2009) Oncology , vol.77 , pp. 335-341
    • Li, Q.1    Wang, X.2    Yang, Z.3    Wang, B.4    Li, S.5
  • 43
    • 70350638630 scopus 로고    scopus 로고
    • Menthol increases human glioblastoma intracellular Ca2+, BK channel activity and cell migration
    • Wondergem R, Bartley JW (2009) Menthol increases human glioblastoma intracellular Ca2+, BK channel activity and cell migration. J Biomed Sci 16:90
    • (2009) J Biomed Sci , vol.16 , pp. 90
    • Wondergem, R.1    Bartley, J.W.2
  • 45
    • 0034903133 scopus 로고    scopus 로고
    • Zebrafish pdx1 morphant displays defects in pancreas development and digestive organ chirality, and potentially identifies a multipotent pancreas progenitor cell
    • Yee NS, Yusuff S, Pack M (2001) Zebrafish pdx1 morphant displays defects in pancreas development and digestive organ chirality, and potentially identifies a multipotent pancreas progenitor cell. Genesis 30:137-140
    • (2001) Genesis , vol.30 , pp. 137-140
    • Yee, N.S.1    Yusuff, S.2    Pack, M.3
  • 46
    • 0038498340 scopus 로고    scopus 로고
    • Clinicopathologic and molecular features of pancreatic adenocarcinoma associated with Peutz-Jeghers Syndrome
    • Yee NS, Furth EE, Pack M (2003) Clinicopathologic and molecular features of pancreatic adenocarcinoma associated with Peutz-Jeghers Syndrome. Cancer Biol Ther 2:38-47
    • (2003) Cancer Biol Ther , vol.2 , pp. 38-47
    • Yee, N.S.1    Furth, E.E.2    Pack, M.3
  • 47
    • 21644472376 scopus 로고    scopus 로고
    • Zebrafish as a model for pancreatic cancer research
    • Yee NS, Pack M (2005) Zebrafish as a model for pancreatic cancer research. Methods Mol Med 103:273-298
    • (2005) Methods Mol Med , vol.103 , pp. 273-298
    • Yee, N.S.1    Pack, M.2
  • 48
    • 37249019494 scopus 로고    scopus 로고
    • Mutation of RNA pol III subunit rpc2/polr3b leads to deficiency of subunit rpc11 and disrupts zebrafish digestive development
    • Yee NS, Gong W, Huang Y, Lorent K, Maraia R, Pack M (2007) Mutation of RNA pol III subunit rpc2/polr3b leads to deficiency of subunit rpc11 and disrupts zebrafish digestive development. PLoS Biol 5:2484-2492
    • (2007) PLoS Biol , vol.5 , pp. 2484-2492
    • Yee, N.S.1    Gong, W.2    Huang, Y.3    Lorent, K.4    Maraia, R.5    Pack, M.6
  • 49
    • 77957163485 scopus 로고    scopus 로고
    • Werner's syndrome as a hereditary risk factor for exocrine pancreatic cancer: Potential role of WRN in pancreatic tumorigenesis and patient-tailored therapy
    • Chun SG, Yee NS (2010) Werner's syndrome as a hereditary risk factor for exocrine pancreatic cancer: potential role of WRN in pancreatic tumorigenesis and patient-tailored therapy. Cancer Biol Ther 10:430-437
    • (2010) Cancer Biol Ther , vol.10 , pp. 430-437
    • Chun, S.G.1    Yee, N.S.2
  • 50
    • 79953304257 scopus 로고    scopus 로고
    • Histone deacetylase 1 is required for pancreatic epithelial proliferation in development and cancer
    • Zhou W, Liang I-C, Yee NS (2011) Histone deacetylase 1 is required for pancreatic epithelial proliferation in development and cancer. Cancer Biol Ther 11:659-670
    • (2011) Cancer Biol Ther , vol.11 , pp. 659-670
    • Zhou, W.1    Liang, I.-C.2    Yee, N.S.3
  • 51
    • 76249090605 scopus 로고    scopus 로고
    • Combined targeting of histone deacetylases and hedgehog signaling enhances cytotoxicity in pancreatic cancer
    • Chun SG, Zhou W, Yee NS (2009) Combined targeting of histone deacetylases and hedgehog signaling enhances cytotoxicity in pancreatic cancer. Cancer Biol Ther 8:1328-1339
    • (2009) Cancer Biol Ther , vol.8 , pp. 1328-1339
    • Chun, S.G.1    Zhou, W.2    Yee, N.S.3
  • 52
    • 84964865993 scopus 로고    scopus 로고
    • Targeting developmental regulators of zebrafish exocrine pancreas as a therapeutic approach in human pancreatic cancer
    • Yee NS, Zhou W, Chun SG, Liang I-C, Yee RK (2012) Targeting developmental regulators of zebrafish exocrine pancreas as a therapeutic approach in human pancreatic cancer. Biol Open 1(4):295-307
    • (2012) Biol Open , vol.1 , Issue.4 , pp. 295-307
    • Yee, N.S.1    Zhou, W.2    Chun, S.G.3    Liang, I.-C.4    Yee, R.K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.