P53 deficiency-induced Smad1 upregulation suppresses tumorigenesis and causes chemoresistance in colorectal cancers

Journal of Molecular Cell Biology

Volumn 7, Issue 2, 2015, Pages 105-118

  Ruan, Xinsen ^a   Zuo, Qiao ^b   Jia, Hao ^a   Chau, Jenny ^c   Lin, Jinlin ^a   Ao, Junping ^d   Xia, Xuechun ^a   Liu, Huijuan ^a   Habib, Samy L ^e   Fu, Chuangang ^b   Li, Baojie ^a  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^d SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^e University of Texas Health Science Center   (United States)

Author keywords

Chemoresistance; Colorectal cancer; P57Kip2; Smad1, p53

Indexed keywords

ATM PROTEIN; CHECKPOINT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1C; DOXORUBICIN; E1A PROTEIN; PROTEIN P53; RAS PROTEIN; SMAD1 PROTEIN; ANTINEOPLASTIC ANTIBIOTIC; ATM PROTEIN, HUMAN; CHEK2 PROTEIN, HUMAN; SMAD1 PROTEIN, HUMAN; TP53 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL DEATH; CELL PROLIFERATION; CELL TRANSFORMATION; CHEMOSENSITIVITY; COLORECTAL CANCER; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; PARANEOPLASTIC SYNDROME; UPREGULATION; AMINO ACID SEQUENCE; ANIMAL; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; DEFICIENCY; DRUG RESISTANCE; GENE EXPRESSION; GENETICS; METABOLISM; MOLECULAR GENETICS; NUDE MOUSE; PATHOLOGY; RECTAL NEOPLASMS; TUMOR CELL CULTURE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ATAXIA TELANGIECTASIA MUTATED PROTEINS; CARCINOGENESIS; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CHECKPOINT KINASE 2; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION; MICE; MICE, INBRED BALB C; MICE, NUDE; MOLECULAR SEQUENCE DATA; NEOPLASM TRANSPLANTATION; RECTAL NEOPLASMS; SMAD1 PROTEIN; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 84929884780     PISSN: 16742788     EISSN: 17594685     Source Type: Journal    
DOI: 10.1093/jmcb/mjv015     Document Type: Article

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