A combination of new screening assays for prioritization of transmission-blocking antimalarials reveals distinct dynamics of marketed and experimental drugs

Journal of Antimicrobial Chemotherapy

Volumn 70, Issue 5, 2014, Pages 1357-1366

  Bolscher, J M ^a   Koolen, K M J ^a   Van Gemert, G J ^b   Van de Vegte Bolmer, M G ^b   Bousema, T ^b   Leroy, D ^c   Sauerwein, R W ^a,b   Dechering, K J ^a  

^a Current affiliation: TropIQ Health Sciences   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c Medicines for Malaria Venture   (Switzerland)

Author keywords

Drug susceptibility testing; Endoperoxides; Gametocytes; Malaria; Plasmodium spp.; Transmission

Indexed keywords

AMODIAQUINE; CHLOROQUINE; CHLORPROGUANIL; LACTATE DEHYDROGENASE; PEROXIDE; ANTIMALARIAL AGENT;

ANIMAL CELL; ANOPHELES; ARTICLE; CONTROLLED STUDY; DISEASE TRANSMISSION; DRUG MARKETING; DRUG SCREENING; ENZYME ACTIVITY; FEMALE; GAMETOCYTE; GAMETOGENESIS; HIGH THROUGHPUT SCREENING; HUMAN; IC50; IMMUNOASSAY; MALARIA; MALARIA CONTROL; NONHUMAN; PLASMODIUM FALCIPARUM; ANIMAL; CELL SURVIVAL; DRUG EFFECTS; ENZYMOLOGY; ISOLATION AND PURIFICATION; PARASITOLOGY; PLASMODIUM; PROCEDURES;

ANIMALS; ANOPHELES; ANTIMALARIALS; CELL SURVIVAL; DRUG EVALUATION, PRECLINICAL; FEMALE; HIGH-THROUGHPUT SCREENING ASSAYS; INHIBITORY CONCENTRATION 50; L-LACTATE DEHYDROGENASE; PLASMODIUM;

EID: 84929749276     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkv003     Document Type: Article

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