Inulin and oligofructose: Review of experimental data on immune modulation

Journal of Nutrition

Volumn 137, Issue 11, 2007, Pages

  Seifert, Stephanie ^a   Watz, Bernhard ^a  

^a FEDERAL RESEARCH INSTITUTE OF NUTRITION AND FOOD   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; FRUCTOSE OLIGOSACCHARIDE; IMMUNOGLOBULIN A; INULIN; PREBIOTIC AGENT; RECEPTOR; SHORT CHAIN FATTY ACID;

BACTERIAL METABOLISM; CLINICAL TRIAL; CONFERENCE PAPER; DIET SUPPLEMENTATION; ENTERITIS; EXPERIMENTAL STUDY; FECES ANALYSIS; HUMAN; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; IMMUNOREGULATION; INTESTINE EPITHELIUM CELL; INTESTINE FLORA; INTESTINE LYMPHATIC TISSUE; METABOLITE; NONHUMAN; OUTCOME ASSESSMENT; PEYER PATCH; POSTNATAL DEVELOPMENT; REGULATORY MECHANISM; TISSUE SPECIFICITY;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 35848931665     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/137.11.2563s     Document Type: Conference Paper

References (62)

1. Furrie E, MacFarlane S, Kennedy A, Cummings JH, Walsh SV, O'Neil DA, MacFarlane GT. Synbiotic therapy (Bifidobacterium longum/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomised controlled pilot trial. Gut. 2005;54:242-9.
2. Lindsay JO, Whelan K, Stagg AJ, Gobin P, Al-Hassi HO, Rayment N, Kamm MA, Knight SC, Forbes A. Clinical, microbiological, and immunological effects of fructo-oligosaccharide in patients with Crohn's disease. Gut. 2006;55:348-55.
3. Roller M, Clune Y, Collins K, Rechkemmer G, Watzl B. Consumption of prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis has minor effects on selected immune parameters in polypectomised and colon cancer patients. Br J Nutr. 2007;97:676-84.
4. Moro G, Arslanoglu S, Stahl B, Jelinek J, Wahn U, Boehm G. A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age. Arch Dis Child. 2006;91:814-9.
5. Bakker-Zierikzee AM, van Tol EAF, Kroes H, Alles MS, Kok FJ, Bindels JG. Faecal SIgA secretion in infants fed on pre- or probiotic infant formula. Pediatr Allergy Immunol. 2006;17:134-40.
6. Colomina J, Gil MT, Codoner P, Buesa J. Viral proteins VP2, VP6, and NSP2 are strongly precipitated by serum and fecal antibodies from children with rotavirus symptomatic infection. J Med Virol. 1998;56:58-65.
7. Duggan C, Penny ME, Hibberd P, Gil A, Huapaya A, Cooper A, Coletta F, Emenhiser C, Kleinman RE. Oligofructose-supplemented infant cereal: 2 randomized, blinded, community-based trials in Peruvian infants. Am J Clin Nutr. 2003;77:937-42.
8. Guigoz Y, Rochat F, Perruisseau-Carrier G, Rochat I, Schiffrin EJ. Effects of oligosaccharide on the faecal flora and non-specific immune system in elderly people. Nutr Res. 2002;22:13-25.
9. Bunout D, Hirsch S, de la Maza MP, Muñoz C, Haschke F, Steenhout Ph, Klassen P, Barrera G, Gattas V, Peterman M. Effects of prebiotics on the immune response to vaccination in the elderly. JPEN J Parenter Enteral Nutr. 2002;26:372-6.
10. Bunout D, Barrera G, Hirsch S, Gattas V, de la Maza MP, Haschke F, Steenhout P, Klassen P, Hager C, et al. Effects of a nutritional supplement on the immune response and cytokine production in free-living Chilean elderly. JPEN J Parenter Enteral Nutr. 2004;28:348-54.
11. Watzl B, Bub A, Blockhaus M, Herbert BM, Lührmann PM, Neuhäuser-Berthold M, Rechkemmer G. Prolonged tomato juice consumption has no effect on cell-mediated immunity of well-nourished elderly men and women. J Nutr. 2000;130:1719-23.
12. Nakamura Y, Nosaka S, Suzuki M, Nagafuchi S, Takahashi T, Yajima T, Takenouchi-Ohkubo N. Dietary fructooligosaccharides up-regulate immunoglobulin A response and polymeric immunoglobulin receptor expression in intestines of infant mice. Clin Exp Immunol. 2004;137:52-8.
13. Hosono A, Ozawa A, Kato R, Ohnishi Y, Nakanishi Y, Kimura T, Nakamura R. Dietary fructooligosaccharides induce immunoregulation of intestinal IgA secretion by murine Peyer's patch cells. Biosci Biotechnol Biochem. 2003;67:758-64.
14. Roller M, Rechkemmer G, Watzl B. Prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis modulates intestinal immune functions in rats. J Nutr. 2004;134:153-6.
15. Roller M, Femia AP, Caderni G, Rechkemmer G, Watzl B. Intestinal immunity of rats with azoxymethane-induced colon cancer is modulated by inulin enriched with oligofructose combined with Lactobacillus rhamnosus and Bifidobacterium lactis. Br J Nutr. 2004;92:931-38.
16. Femia AP, Luceri C, Dolara P, Giannini A, Biggeri A, Salvadoir M, Clune Y, Collins KJ, Paglierani M, Caderni G. Antitumorigenic activity of the prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxymethane-induced colon carcinogenesis in rats. Carcinogenesis. 2002;23:1953-60.
17. Manhart N, Spittler A, Bergmeister H, Mittlböck M, Roth E. Influence of fructooligosaccharides on Peyer's patch lymphocyte numbers in healthy and endotoxemic mice. Nutrition. 2003;19:657-60.
18. Tumbleson ME, Schook LB. Advances in swine biomedical research. In: Tumbleson ME, Schook LB, editors. Advances in swine biomedical research. New York: Plenum Press; 1996. p. 1-3.
19. Girrbach S, Schröder B, Breves G, Rechkemmer G, Watzl B. Short and long-term supplementation of pre- and probiotics modulate T-cell mediated immunity of the porcine GALT. FASEB J. 2005;19:A444-5.
20. Hoentjen F, Welling GW, Harmsen HJ, Zhang X, Snart J, Tannock GW, Lien K, Churchill TA, Lupicki M, Dieleman LA. Reduction of colitis by prebiotics in HLA-B27 transgenic rats is associated with microflora changes and immunomodulation. Inflamm Bowel Dis. 2005;11:977-85.
21. Osman N, Adawi D, Molin G, Ahrne S, Berggren A, Jeppsson B. Bifidobacterium infantis strains with and without a combination of oligofructose and inulin attenuate inflammation in DSS-induced colitis in rats. BMC Gastroenterol. 2006;6:31.
22. Herich R, Révajová V, Levkut M, Bomba A, Nemcová R, Guba P, Gancarčiková S. The effect of Lactobacillus paracasei and raftilose P95 upon the non-specific immune response of piglets. Food Agric Immunol. 2002;14:171-9.
23. Buddington KK, Donahoo JB, Buddington RK. Dietary oligofructose and inulin protect mice from enteric and systemic pathogens and tumor inducers. J Nutr. 2002;132:472-7.
24. Kelly-Quagliana KA, Nelson PD, Buddington RK. Dietary oligofructose and inulinmodulate immune functions in mice. Nutr Res. 2003;23:257-67.
25. Pierre F, Perrin P, Champ M, Bornet F, Meflah K, Menanteau J. Short-chain fructo-oligosaccharides reduce the occurrence of colon tumors and develop gut-associated lymphoid tissue in Min mice. Cancer Res. 1997;57:225-8.
26. Pierre F, Perrin P, Bassonga E, Bornet F, Meflah K, Menanteau J. T cell status influences colon tumor occurrence in Min mice fed short chain fructooligosaccharides as a diet supplement. Carcinogenesis. 1999;20:1953-6.
27. Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol. 2001;2:675-80.
28. Abreu MT. Immunologic regulation of toll-like receptors in gut epithelium. Curr Opin Gastroenterol. 2003;19:559-64.
29. Cherayil BJ. How not to get bugged by bugs: mechanisms of cellular tolerance to microorganisms. Curr Opin Gastroenterol. 2003;19:572-7.
30. Takahashi T, Nakagawa E, Nara T, Yajima T, Kuwata T. Effects of orally ingested Bifidobacterium longum on the mucosal IgA response of mice to dietary antigens. Biosci Biotechnol Biochem. 1998;62:10-5.
31. Fukushima Y, Kawata Y, Mizumachi K, Kurisaki J, Mitsuoka T. Effect of bifidobacteria feeding on fecal flora and production of immunoglobulins in lactating mouse. Int J Food Microbiol. 1999;46:193-7.
32. Qiao H, Duffy LC, Griffiths E, Dryja D, Leavens A, Rossman J, Rich G, Riepenhoff-Talty M, Locniskar M. Immune responses in rhesus rotavirus-challenged Balb/c mice treated with bifidobacteria and prebiotic supplements. Pediatr Res. 2002;51:750-5.
33. Swanson KS, Grieshop CM, Flickinger EA, Bauer LL, Healy HP, Dawson KA, Merchen NR, Fahey GC, Jr. Supplemental fructooligosaccharides and mannanoligosaccharides influence immune function, ileal and total tract nutrient digestibilities, microbial populations and concentrations of protein catabolites in the large bowel of dogs. J Nutr. 2002;132:980-9.
34. Engelhardt W, Busche R, Gross G, Rechkemmer G. Absorption of short chain fatty acids: mechanisms and regional differences in the large intestine. In: Cummings JH, Rombeau JL, Sakata T, editors. Physiological and clinical aspects of short-chain fatty acids. Cambridge, UK: Cambridge University Press; 1991. p. 60-62.
35. Wolever TM, Josse RG, Leiter RA, Chiasson JL. Time of day and glucose tolerance status affect serum short-chain fatty acid concentrations in humans. Metabolism. 1997;46:805-11.
36. Loh G, Eberhard M, Brunner RM, Hennig U, Kuhla S, Kleessen B, Metges CC. Inulin alters the intestinal microbiota and short-chain fatty acid concentrations in growing pigs regardless of their basal diet. J Nutr. 2006;136:1198-202.
37. Morrison DJ, Mackay WG, Edwards CA, Preston T, Dodson B, Weaver LT. Butyrate production from oligofructose fermentation by the human faecal flora: what is the contribution of extracellular acetate and lactate? Br J Nutr. 2006;96:570-7.
38. Kripke SA, Fox AD, Berman JM, Settle RG, Rombeau JL. Stimulation of intestinal mucosal growth with intracolonic infusion of short-chain fatty acids. JPEN J Parenter Enteral Nutr. 1989;13:109-16.
39. Ichikawa H, Shineha R, Satomi S, Sakata T. Gastric or rectal instillation of short-chain fatty acids stimulates epithelial cell proliferation of small and large intestine in rats. Dig Dis Sci. 2002;47:1141-6.
40. Säemann MD, Böhmig GA, Österreicher CH, Burtscher H, Parolini O, Diakos Ch, Stöckl J, Hörl WH, Zlabinger GJ. Anti-inflammatory effects of sodium butyrate on human monocytes: potent inhibition of IL-12 and up-regulation of IL-10 production. FASEB J. 2000;14:2380-2.
41. Millard AL, Mertes PM, Ittelet D, Villard F, Jeannesson P, Bernard J. Butyrate affects differentiation, maturation and function of human monocyte-derived dendritic cells and macrophages. Clin Exp Immunol. 2002;130:245-55.
42. Cavaglieri CR, Nishiyama A, Fernandes LC, Curi R, Miles EA, Calder PC. Differential effects of short-chain fatty acids on proliferation and production of pro- and anti-inflammatory cytokines by cultured lymphocytes. Life Sci. 2003;73:1683-90.
43. Kurita-Ochiai T, Amano S, Fukushima K, Ochiai K. Cellular events involved in butyric acid-induced T cell apoptosis. J Immunol. 2003;171:3576-84.
44. Pratt VC, Tappenden KA, McBurney MI, Field CJ. Short-chain fatty acid-supplemented total parenteral nutrition improves nonspecific immunity after intestinal resection in rats. JPEN J Parenter Enteral Nutr. 1996;20:264-71.
45. Ishizuka S, Tanaka S, Xu H, Hara H. Fermentable dietary fiber potentiates the localization of immune cells in the rat large intestinal crypts. Exp Biol Med. 2004;229:876-84.
46. Ishizaka S, Kikuchi E, Tsujii T. Effects of acetate on human immune system. Immunopharmacol Immunotoxicol. 1993;15:151-62.
47. Brown AJ, Goldsworthy SM, Barnes AA, Eilert MM, Tcheang L, Daniels D, Muir AI, Wigglesworth MJ, Kinghorn I, et al. The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biol Chem. 2003;278:11312-9.
48. Nilsson NE, Kotarsky K, Owman C, Olde B. Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. Biochem Biophys Res Commun. 2003;303:1047-52.
49. Le Poul E, Loison C, Struyf S, Springael JY, Lannoy V, Decobecq ME, Brezillon S, Dupriez V, Vassart G, et al. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J Biol Chem. 2003;278:25481-9.
50. Karaki S, Mitsui R, Hayashi H, Kato I, Sugiya H, Iwanaga T, Furness JB, Kuwahara A. Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine. Cell Tissue Res. 2006;324:353-60.
51. Bach Knudsen KE, Serena A, Bjørnbak Kjær AK, Jørgensen H, Engberg R. Rye bread enhances the production and plasma concentration of butyrate but not the plasma concentrations of glucose and insulin in pigs. J Nutr. 2005;135:1696-704.
52. Bach Knudsen KE, Serena A, Canibe N, Juntunen KS. New insight into butyrate metabolism. Proc Nutr Soc. 2003;62:81-6.
53. Field CJ, McBurney MI, Massimino S, Hayek MG, Sunvold GD. The fermentable fiber content of the diet alters the function and composition of canine gut associated lymphoid tissue. Vet Immunol Immunopathol. 1999;72:325-41.
54. Ross GD, Větvička V. CR3 (CD11b, CD18): a phagocyte and NK cell membrane receptor with multiple ligand specificities and functions. Clin Exp Immunol. 1993;92:181-4.
55. Brown GD, Gordon S. A new receptor for β-glucans. Nature. 2001;413:36-7.
56. Brown GD. Dectin-1: a signalling non-TLR pattern-recognition receptor. Nat Rev Immunol. 2006;6:33-43.
57. Murosaki S, Muroyama K, Yamamoto Y, Kusaka H, Liu T, Yoshika Y. Immunopotentiating activity of nigerooligosaccharides for the T helper 1-like immune response in mice. Biosci Biotechnol Biochem. 1999;63:373-8.
58. Speert DP, Eftekhar F, Puterman ML. Nonopsonic phagocytosis of strains of Pseudomonas aeruginosa from cystic fibrosis patients. Infect Immun. 1984;43:1006-11.
59. Sehgal G, Zhang K, Todd, 3rd RF, Boxer LA, Petty HR. Lectin-like inhibition of immune complex receptor-mediated stimulation of neutrophils. Effects on cytosolic calcium release and superoxide production. J Immunol. 1993;150:4571-80.
60. 13C]galactose load. Isotopes Environ Health Stud. 1999;35:119-25.
61. Watanabe H, Sonoyama K, Watanabe J, Yamaguchi N, Kikuchi H, Nagura T, Aritsuka T, Fukumoto K, Kasai T. Reduction of allergic airway eosinophilia by dietary raffinose in brown Norway rats. Br J Nutr. 2004;92:247-55.
62. Rice PJ, Adams EL, Ozment-Skelton T, Gonzalez AJ, Goldman MP, Lockhart BE, Barker LA, Breuel KF, DePonti WK, et al. Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge. J Pharmacol Exp Ther. 2005;314:1079-86.