Design, synthesis and preliminary evaluation of 18F-labelled 1,8-naphthyridin- and quinolin-2-one-3-carboxamide derivatives for PET imaging of CB2 cannabinoid receptor

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 12, 2015, Pages 2532-2535

  Saccomanni, Giuseppe ^a   Pascali, Giancarlo ^b,c   Carlo, Sara Del ^a   Panetta, Daniele ^b   De Simone, Mariarosaria ^b   Bertini, Simone ^a   Burchielli, Silvia ^d   Digiacomo, Maria ^a   Macchia, Marco ^a   Manera, Clementina ^a   Salvadori, Piero A ^b  

^a UNIVERSITY OF PISA   (Italy)

^b CNR   (Italy)

^c AUSTRALIAN NUCLEAR SCIENCE AND TECHNOLOGY ORGANISATION   (Australia)

^d Fondazione Toscana G Monasterio   (Italy)

Author keywords

Cannabinoid; CB2 receptor; Iodonium derivatives; Microfluidic system; Radiofluorination

Indexed keywords

1,8 NAPHTHYRIDINE DERIVATIVE; AMIDE; CANNABINOID 2 RECEPTOR; FLUORINE 18; QUINOLINE DERIVATIVE; TRACER; CANNABINOID 1 RECEPTOR; CB91 COMPOUND; CONTRAST MEDIUM; FLUORINE; NAPHTHYRIDINE DERIVATIVE; QUINOLONE DERIVATIVE; RADIOPHARMACEUTICAL AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG DESIGN; DRUG PENETRATION; DRUG SCREENING; DRUG SYNTHESIS; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; NUCLEOPHILICITY; OXIDATION REDUCTION REACTION; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; SUBSTITUTION REACTION; WHOLE BODY PET; ANIMAL; CHEMISTRY; ISOMERISM; METABOLISM; SYNTHESIS; TISSUE DISTRIBUTION;

AMIDES; ANIMALS; CONTRAST MEDIA; DRUG DESIGN; FLUORINE RADIOISOTOPES; ISOMERISM; MALE; MICE; NAPHTHYRIDINES; POSITRON-EMISSION TOMOGRAPHY; QUINOLONES; RADIOPHARMACEUTICALS; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; TISSUE DISTRIBUTION;

EID: 84929704036     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.04.055     Document Type: Article

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