Mono-2-ethylhexyl phthalate stimulates androgen production but suppresses mitochondrial function in mouse leydig cells with different steroidogenic potential

Toxicological Sciences

Volumn 145, Issue 1, 2015, Pages 149-156

  Savchuk, Iuliia ^a   Söder, Olle ^a   Svechnikov, Konstantin ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Leydig cells; MEHP; Mitochondria; Monophthalates; Mouse genotypes; StAR; Steroidogenesis

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANDROGEN; CHORIONIC GONADOTROPIN; MONO N BENZYL PHTHALATE; MONO N BUTYL PHTHALATE; PHTHALIC ACID 2 ETHYLHEXYL MONOESTER; PHTHALIC ACID DERIVATIVE; SUPEROXIDE; UNCLASSIFIED DRUG; MONO-(2-ETHYLHEXYL)PHTHALATE; PHOSPHOPROTEIN; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; STEROID; STEROIDOGENIC ACUTE REGULATORY PROTEIN;

ANDROGEN SYNTHESIS; ANIMAL CELL; ARTICLE; BIOLOGICAL ACTIVITY; CELL FUNCTION; CONTROLLED STUDY; GENOTYPE; LEYDIG CELL; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; UPREGULATION; ANALOGS AND DERIVATIVES; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CBA MOUSE; DRUG EFFECTS; METABOLISM;

RODENTIA;

ANDROGENS; ANIMALS; DIETHYLHEXYL PHTHALATE; LEYDIG CELLS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MITOCHONDRIA; PHOSPHOPROTEINS; STEROIDS;

EID: 84929665210     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfv042     Document Type: Article

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