Mono-(2-ethylhexyl) phthalate (MEHP) induces testicular alterations in male guinea pigs at prepubertal stage

Tissue and Cell

Volumn 37, Issue 3, 2005, Pages 167-175

  Awal, M A ^a,b   Kurohmaru, M ^b   Andriana, B B ^b   Kanai, Y ^b   Hayashi, Y ^b  

^a BANGLADESH AGRICULTURAL UNIVERSITY   (Bangladesh)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Apoptosis; Guinea pig; Mono (2 ethylhexyl) phthalate (MEHP); Prepubertal stage; Testicular toxicity

Indexed keywords

CORN OIL; DRUG VEHICLE; PHTHALIC ACID 2 ETHYLHEXYL MONOESTER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; GUINEA PIG; HISTOPATHOLOGY; MALE; NONHUMAN; PREPUBERTY; REPRODUCTIVE TOXICITY; SEMINIFEROUS TUBULE; SERTOLI CELL; SPERMATOGENESIS; SPERMATOZOON; TESTIS DEVELOPMENT; VETERINARY ANATOMY;

EID: 20344380154     PISSN: 00408166     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tice.2004.12.005     Document Type: Article

References (44)

1. P.W. Albro The biochemical toxicology of di-(2-ethylhexyl) phthalate and related phthalates: Testicular atrophy and hepatocarcinogenesis Rev. Biochem. Toxicol. 8 1987 73-119
2. D.J. Allan B.V. Harmon S.A. Roberts Spermatogonial apoptosis has three morphologically recognizable phases and shows no circadian rhythm during normal spermatogenesis in the rat Cell Prolif. 25 1992 241-250
3. J. Bianco-Rodriguez C. Martinez-Garcia Spontaneous germ cell death in the testis of the adult rat takes the form of apoptosis: Reevaluation of cell types that exhibit the ability to die during spermatogenesis Cell Prolif. 29 1996 13-31
4. S. Bardon F. Vignon P. Montcourrier H. Rochefort Steroid receptor-mediated cytotoxicity of an antiestrogen and an antiprogestin in breast cancer cells Cancer Res. 47 1987 1441-1448
5. L. Cai B.F. Hales B. Robaire Induction of apoptosis in the germ cells of adult male rats after exposure to cyclophosphamide Biol. Reprod. 55 1997 1368-1376
6. R.S. Cole M. Tocchi E. Wye D.C. Villeneuve G. Rock Contamination of commercial blood products by mono-(2-ethylhexyl) phthalate Vox Sang. 40 1981 317-322
7. T. Colborn F.S. vom Sail A.M. Soto Developmental effects of endocrine disrupting chemicals in wildlife and humans Environ. Health Perspect. 101 1993 378-384
8. G.B. Corcoran L. Fix D.P. Jones M.T. Moslen P. Nicotera F.A. Oberhammer R. Buttyan Apoptosis: Molecular control point in toxicity Toxicol. Appl. Pharmacol. 128 1994 169-181
9. E.C. Coucouvanis S.W. Sherwood C. Carswell-Crumpton E.G. Spack P.P. Jones Evidence that the mechanism of prenatal germ cell death in the mouse is apoptosis Exp. Cell Res. 209 1993 238-247
10. D.M. Creasy L.M. Beech T.J.B. Gray Effects of mono-(2-ethylhexyl) phthalate and mono-n-pentyl phthalate on the ultrastructural morphology of rat Sertoli cells in Sertoli/germ cell co-cultures: Correlation with the in vivo effects of di-n-pentyl phthalate Toxicol. In vitro 2 1988 83-95
11. T.M. Crisp E.D. Clegg R.L. Cooper W.P. Wood D.G. Anderson K.P. Baetcke J.L. Hoffmann M.S. Morrow D.J. Rodier J.E. Schaeffer L.W. Touart M.G. Zeeman Y.M. Patel Environmental endocrine disruption: An effects assessment and analysis Environ. Health Perspect. 106 1998 11-65
12. M. Dalgaard C. Nellemann H.R. Lam I.K. Sorensen O. Ladefoged The acute effects of mono-(2-ethylhexyl) phthalate (MEHP) on testes of prepubertal Wistar rats Toxicol. Lett. 122 2001 69-79
13. D.G. De Rooji D. Lok Regulation of the density of spermatogenesis in the seminiferous epithelium of the Chinese hamster. II. Differentiating spermatogenesis Anat. Rec. 217 1987 131-136
14. C.S. Giam H.S. Chan G.S. Neff E.C. Atlas Phthalate ester plasticizers: A new class of marine pollutants Science 199 1978 419-421
15. C.J. Giammona P. Sawhney Y. Chandrasekarana J.H. Richburg Death receptor response in rodent testis after mono-(2-ethylhexyl) phthalate exposure Toxicol. Appl. Pharmacol. 185 2002 119-127
16. P. Grasso J.J. Heindel C.J. Powell J. Reichert Effects of mono-(2-ethylhexyl) phthalate, a testicular toxicant, on follicle-stimulating hormone binding to membranes from cultured rat Sertoli cells Biol. Reprod. 48 1993 454-459
17. T.J.B. Gray K.R. Butterworth Testicular atrophy produced by phthalate esters Arch. Toxicol. (Suppl.) 4 1980 452-455
18. T.J.B. Gray I.R. Rowland P.M.W. Foster S.D. Gangolli Species differences in the testicular toxicity of phthalate esters Toxicol. Lett. 11 1982 141-147
19. T.J.B. Gray J.A. Beamand Effect of some phthalate esters and other testicular toxins on primary cultures of testicular cells Food Chem. Toxicol. 22 1984 123-131
20. T.J.B. Gray S.D. Gangolli Aspects of the testicular toxicity of phthalate esters Environ. Health Perspect. 65 1986 229-235
21. S. Iona F.G. Klinger R. Sisti R. Ciccalese A. Nunziata M.De. Felici A comparative study of cytotoxic effects of N-ethyl-N-nitrosourea, adriamycin, and mono-(2-ethylhexyl) phthalate on mouse primordial germ cells Cell Biol. Toxicol. 18 2002 131-145
22. E. Kasahara E.F. Sato M. Miyoshi R. Konaka K. Hiramoto J. Sasaki M. Tokuda Y. Nakano M. Inoue Role of oxidative stress in germ cell apoptosis induced by di-(2-ethylhexyl) phthalate Biochem. J. 365 2002 849-856
23. W. Kloas Amphibians as a model to study endocrine disruptors Int. Rev. Cytol. 216 2002 1-57
24. T. Koji Male germ cell death in mouse testes: Possible involvement of Fas and Fas ligand Med. Electron Microsc. 34 2001 213-222
25. N. Kyprinaou J.T. Isaacs Activation of programmed cell death in the rat ventral prostate after castration Endocrinology 122 1988 552-557
26. J. Lee J. Richburg E.B. Ship M.L. Meistrich K. Boekelheide The Fas system, a regulator of testicular germ cell apoptosis, is differentially up-regulated in Sertoli cell versus germ cell injury of the testis Endocrinology 140 1999 852-858
27. L.H. Li W.F. Jester A.L. Laslett J.M. Orth A single dose of di-(2-ethylhexyl) phthalate in neonatal rats alters gonocytes, reduces Sertoli cell proliferation, and decreases cyclin D2 expression Toxicol. Appl. Pharmacol. 166 2000 222-229
28. J.A. McLachlan Environmental signaling: What embryos and evolution teach us about endocrine disrupting chemicals Endocr. Rev. 22 2001 319-341
29. T.K. Monsees M. Franz S. Gebhardt U. Winterstein W.B. Schill J. Hayatpour Sertoli cells as a target for reproductive hazards Andrologia 32 2000 239-246
30. S. Nandi P.P. Banerjee B.R. Zirkin Germ cell apoptosis in the testes of Sprague Dawley rats following testosterone withdrawal by ethane 1, 2-dimethane sulfonate administration: Relationship to Fas? Biol. Reprod. 61 1999 70-75
31. A.I. Packer P. Besmer R.F. Bachvarova Kit ligand mediates survival of type A spermatogonia and dividing spermatocytes in postnatal mouse testes Mol. Reprod. Dev. 42 1995 303-310
32. C.G. Print K.L. Loveland Germ cell suicide: New insights into apoptosis during spermatogenesis BioEssays 22 2000 423-430
33. M.C. Raff Social controls on cell survival and cell death Nature 356 1992 397-400
34. J.H. Richburg K. Boekelheide Mono-(2-ethylhexyl) phthalate rapidly alters both Sertoli cell vimentin filaments and germ cell apoptosis in young rat testes Toxicol. Appl. Pharmacol. 137 1996 42-50
35. J.H. Richburg The relevance of spontaneous and chemically-induced alterations in testicular germ cell apoptosis to toxicology Toxicol. Lett. 112-113 2000 79-86
36. J.H. Richburg A. Nanez L.R. Williams M.E. Embree K. Boekelheide Sensitivity of testicular germ cells to toxicants induced apoptosis in gld mice that express a nonfunctional form of Fas ligand Endocrinology 14 2000 787-793
37. E. Roosen-Runge Germinal cell loss in normal metazoan spermatogenesis J. Reprod. Fertil. 35 1973 339-348
38. A.P. Sinha-Hikim C. Wang A.S. Leung Involvement of apoptosis in the induction of germ cell degeneration in adult rats after gonadotropin-releasing hormone antagonist treatment Endocrinology 136 1995 2770-2775
39. J.S. Suominen J. Linderborg H. Nikula H. Hakovirta M. Parvinen J. Toppari The effects of mono-(2-ethylhexyl) phthalate, adriamycin and N-ethyl-N-nitrosourea on stage-specific apoptosis and DNA synthesis in the mouse spermatogenesis Toxicol. Lett. 143 2003 163-173
40. J.S. Tapanainen J.L. Tilly K.K. Vihko A.J.W. Hsueh Hormonal control of apoptotic cell death in the testis: Gonadotropins and androgens as testicular cell survival factors Mol. Endocrinol. 7 1993 643-650
41. J.A. Thomas T.D. Darby R.D. Wallin P.J. Garvin L. Martis A review of biological effects of di-(2-ethylhexyl) phthalate Toxicol. Appl. Pharmacol. 45 1978 1-27
42. J.A. Thomas M.J. Thomas Biological effects of di-(2-ethylhexyl) phthalate and other phthalic acid esters Crit. Rev. Toxicol. 13 1984 283-317
43. C.R. Tyler S. Jobling J.P. Sumpter Endocrine disruption in wildlife: A critical review of the evidence Crit. Rev. Toxicol. 28 1998 319-361
44. D.L. Vaux G. Haecker A. Strasser An evolutionary perspective on apoptosis Cell 76 1994 777-779