RNA-Seq-based toxicogenomic assessment of fresh frozen and formalin-fixed tissues yields similar mechanistic insights

Journal of Applied Toxicology

Volumn 35, Issue 7, 2015, Pages 766-780

  Auerbach, Scott S ^a   Phadke, Dhiral P ^b   Mav, Deepak ^b   Holmgren, Stephanie ^c   Gao, Yuan ^d   Xie, Bin ^d   Shin, Joo Heon ^d   Shah, Ruchir R ^b   Merrick, B Alex ^a   Tice, Raymond R ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b SRA International   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d Johns Hopkins University   (United States)

Author keywords

Aflatoxin B1; FFPE; Mechanism; RNA Seq; Toxicogenomics

Indexed keywords

AFLATOXIN B1; FRESH FROZEN PLASMA; RIBOSOME RNA; TRANSCRIPTION FACTOR; TRANSCRIPTOME; FORMALDEHYDE; PHARMACOLOGICAL BIOMARKER;

ANIMAL CELL; ARTICLE; BIOLOGICAL PHENOMENA AND FUNCTIONS CONCERNING THE ENTIRE ORGANISM; CONTROLLED STUDY; EXPOSURE; GENE EXPRESSION; GENE ONTOLOGY; GENETIC ANALYSIS; MALE; NONHUMAN; PATHOLOGY; PHENOTYPE; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RNA ANALYSIS; RNA EXTRACTION; RNA SEQUENCE; TOXICOGENETICS; ANIMAL; DRUG EFFECTS; FISCHER 344 RAT; FREEZING; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; LIVER; PROCEDURES; SEQUENCE ANALYSIS;

ANIMALIA; RATTUS;

AFLATOXIN B1; ANIMALS; BIOMARKERS, PHARMACOLOGICAL; FORMALDEHYDE; FREEZING; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; LIVER; MALE; RATS; RATS, INBRED F344; SEQUENCE ANALYSIS, RNA; TOXICOGENETICS;

EID: 84929662053     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.3068     Document Type: Article

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