메뉴 건너뛰기




Volumn 14, Issue 5, 2015, Pages 2322-2330

Discovery and validation of plasma biomarkers for major depressive disorder classification based on liquid chromatography-mass spectrometry

Author keywords

diagnosis biomarker; LC MS; major depressive disorder; metabolomics

Indexed keywords

ACYL CARNITINE; BIOLOGICAL MARKER; CARNITINE; DEOXYCHOLIC ACID; ETHER LIPID; ETHER PHOSPHOLIPID; FATTY ACID; GLYCEROPHOSPHOLIPID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LITHOCHOLIC ACID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LYSOPHOSPHATIDYLETHANOLAMINE; METHIONINE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHOLIPASE A2; TRIACYLGLYCEROL; TRYPTOPHAN; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL; LYSOPHOSPHATIDYLCHOLINE; LYSOPHOSPHOLIPID;

EID: 84929660342     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/acs.jproteome.5b00144     Document Type: Article
Times cited : (152)

References (59)
  • 1
    • 84898921742 scopus 로고    scopus 로고
    • Proteomics, metabolomics, and protein interactomics in the characterization of the molecular features of major depressive disorder
    • Martins-de-Souza, D. Proteomics, metabolomics, and protein interactomics in the characterization of the molecular features of major depressive disorder Dialogues Clin. Neurosci. 2014, 16 (1) 63-73
    • (2014) Dialogues Clin. Neurosci. , vol.16 , Issue.1 , pp. 63-73
    • Martins-De-Souza, D.1
  • 2
    • 50549092885 scopus 로고    scopus 로고
    • The HPA axis in major depression: Classical theories and new developments
    • Pariante, C. M.; Lightman, S. L. The HPA axis in major depression: classical theories and new developments Trends Neurosci. 2008, 31 (9) 464-468
    • (2008) Trends Neurosci. , vol.31 , Issue.9 , pp. 464-468
    • Pariante, C.M.1    Lightman, S.L.2
  • 4
    • 11344249233 scopus 로고    scopus 로고
    • The role of the hippocampus in the pathophysiology of major depression
    • Campbell, S.; MacQueen, G. The role of the hippocampus in the pathophysiology of major depression J. Psychiatry Neurosci. 2004, 29 (6) 417-426
    • (2004) J. Psychiatry Neurosci. , vol.29 , Issue.6 , pp. 417-426
    • Campbell, S.1    Macqueen, G.2
  • 5
    • 0032573166 scopus 로고    scopus 로고
    • Glial reduction in the subgenual prefrontal cortex in mood disorders
    • Ongur, D.; Drevets, W. C.; Price, J. L. Glial reduction in the subgenual prefrontal cortex in mood disorders Proc. Natl. Acad. Sci. U.S.A. 1998, 95 (22) 13290-13295
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , Issue.22 , pp. 13290-13295
    • Ongur, D.1    Drevets, W.C.2    Price, J.L.3
  • 6
    • 68849088976 scopus 로고    scopus 로고
    • Clinical diagnosis of depression in primary care: A meta-analysis
    • Mitchell, A. J.; Vaze, A.; Rao, S. Clinical diagnosis of depression in primary care: a meta-analysis Lancet 2009, 374 (9690) 609-619
    • (2009) Lancet , vol.374 , Issue.9690 , pp. 609-619
    • Mitchell, A.J.1    Vaze, A.2    Rao, S.3
  • 7
    • 84870933754 scopus 로고    scopus 로고
    • The diagnosis of depression: Current and emerging methods
    • Smith, K. M.; Renshaw, P. F.; Bilello, J. The diagnosis of depression: current and emerging methods Compr. Psychiatry 2013, 54 (1) 1-6
    • (2013) Compr. Psychiatry , vol.54 , Issue.1 , pp. 1-6
    • Smith, K.M.1    Renshaw, P.F.2    Bilello, J.3
  • 12
    • 84882632229 scopus 로고    scopus 로고
    • Metabolic characterization of hepatocellular carcinoma using nontargeted tissue metabolomics
    • Huang, Q.; Tan, Y.; Yin, P.; Ye, G.; Gao, P.; Lu, X.; Wang, H.; Xu, G. Metabolic characterization of hepatocellular carcinoma using nontargeted tissue metabolomics Cancer Res. 2013, 73 (16) 4992-5002
    • (2013) Cancer Res. , vol.73 , Issue.16 , pp. 4992-5002
    • Huang, Q.1    Tan, Y.2    Yin, P.3    Ye, G.4    Gao, P.5    Lu, X.6    Wang, H.7    Xu, G.8
  • 15
    • 84871643020 scopus 로고    scopus 로고
    • A (1)H-NMR plasma metabonomic study of acute and chronic stress models of depression in rats
    • Shi, B.; Tian, J.; Xiang, H.; Guo, X.; Zhang, L.; Du, G.; Qin, X. A (1)H-NMR plasma metabonomic study of acute and chronic stress models of depression in rats Behav. Brain Res. 2013, 241, 86-91
    • (2013) Behav. Brain Res. , vol.241 , pp. 86-91
    • Shi, B.1    Tian, J.2    Xiang, H.3    Guo, X.4    Zhang, L.5    Du, G.6    Qin, X.7
  • 17
    • 80051665642 scopus 로고    scopus 로고
    • 1H NMR and UPLC-MS-based plasma metabonomic study to investigate the biochemical changes in chronic unpredictable mild stress model of depression
    • 1H NMR and UPLC-MS-based plasma metabonomic study to investigate the biochemical changes in chronic unpredictable mild stress model of depression Metabolomics 2010, 7 (3) 413-423
    • (2010) Metabolomics , vol.7 , Issue.3 , pp. 413-423
    • Zheng, S.1    Zhang, S.2    Yu, M.3    Tang, J.4    Lu, X.5    Wang, F.6    Yang, J.7    Li, F.8
  • 18
    • 84877869228 scopus 로고    scopus 로고
    • Integration of (1)H NMR and UPLC-Q-TOF/MS for a comprehensive urinary metabonomics study on a rat model of depression induced by chronic unpredictable mild stress
    • Jia, H. M.; Feng, Y. F.; Liu, Y. T.; Chang, X.; Chen, L.; Zhang, H. W.; Ding, G.; Zou, Z. M. Integration of (1)H NMR and UPLC-Q-TOF/MS for a comprehensive urinary metabonomics study on a rat model of depression induced by chronic unpredictable mild stress PLoS One 2013, 8 (5) e63624
    • (2013) PLoS One , vol.8 , Issue.5 , pp. 63624
    • Jia, H.M.1    Feng, Y.F.2    Liu, Y.T.3    Chang, X.4    Chen, L.5    Zhang, H.W.6    Ding, G.7    Zou, Z.M.8
  • 19
    • 46749154158 scopus 로고    scopus 로고
    • Metabolic profiling reveals disorder of amino acid metabolism in four brain regions from a rat model of chronic unpredictable mild stress
    • Ni, Y.; Su, M.; Lin, J.; Wang, X.; Qiu, Y.; Zhao, A.; Chen, T.; Jia, W. Metabolic profiling reveals disorder of amino acid metabolism in four brain regions from a rat model of chronic unpredictable mild stress FEBS Lett. 2008, 582 (17) 2627-2636
    • (2008) FEBS Lett. , vol.582 , Issue.17 , pp. 2627-2636
    • Ni, Y.1    Su, M.2    Lin, J.3    Wang, X.4    Qiu, Y.5    Zhao, A.6    Chen, T.7    Jia, W.8
  • 20
    • 66749153176 scopus 로고    scopus 로고
    • Metabonomics Approach to Understanding Acute and Chronic Stress in Rat Models
    • Wang, X.; Zhao, T.; Qiu, Y.; Su, M.; Jiang, T.; Zhou, M.; Zhao, A.; Jia, W. Metabonomics Approach to Understanding Acute and Chronic Stress in Rat Models J. Proteome Res. 2009, 8 (5) 2511-2518
    • (2009) J. Proteome Res. , vol.8 , Issue.5 , pp. 2511-2518
    • Wang, X.1    Zhao, T.2    Qiu, Y.3    Su, M.4    Jiang, T.5    Zhou, M.6    Zhao, A.7    Jia, W.8
  • 21
    • 84875484742 scopus 로고    scopus 로고
    • Metabolomic identification of molecular changes associated with stress resilience in the chronic mild stress rat model of depression
    • Shao, W. H.; Fan, S. H.; Lei, Y.; Yao, G. E.; Chen, J. J.; Zhou, J.; Xu, H. B.; Liu, H. P.; Wu, B.; Zheng, P.; Fang, L.; Xie, P. Metabolomic identification of molecular changes associated with stress resilience in the chronic mild stress rat model of depression Metabolomics 2013, 9, 433-443
    • (2013) Metabolomics , vol.9 , pp. 433-443
    • Shao, W.H.1    Fan, S.H.2    Lei, Y.3    Yao, G.E.4    Chen, J.J.5    Zhou, J.6    Xu, H.B.7    Liu, H.P.8    Wu, B.9    Zheng, P.10    Fang, L.11    Xie, P.12
  • 23
    • 83055186403 scopus 로고    scopus 로고
    • Liquid chromatography-mass spectrometry based global metabolite profiling: A review
    • Theodoridis, G. A.; Gika, H. G.; Want, E. J.; Wilson, I. D. Liquid chromatography-mass spectrometry based global metabolite profiling: a review Anal. Chim. Acta 2012, 711, 7-16
    • (2012) Anal. Chim. Acta , vol.711 , pp. 7-16
    • Theodoridis, G.A.1    Gika, H.G.2    Want, E.J.3    Wilson, I.D.4
  • 24
    • 84877122175 scopus 로고    scopus 로고
    • Liquid chromatography-mass spectrometry in metabolomics research: Mass analyzers in ultra high pressure liquid chromatography coupling
    • Forcisi, S.; Moritz, F.; Kanawati, B.; Tziotis, D.; Lehmann, R.; Schmitt-Kopplin, P. Liquid chromatography-mass spectrometry in metabolomics research: mass analyzers in ultra high pressure liquid chromatography coupling J. Chromatogr., A 2013, 1292, 51-65
    • (2013) J. Chromatogr., A , vol.1292 , pp. 51-65
    • Forcisi, S.1    Moritz, F.2    Kanawati, B.3    Tziotis, D.4    Lehmann, R.5    Schmitt-Kopplin, P.6
  • 25
    • 84897083718 scopus 로고    scopus 로고
    • UPLC-MS(E) application in disease biomarker discovery: The discoveries in proteomics to metabolomics
    • Zhao, Y. Y.; Lin, R. C. UPLC-MS(E) application in disease biomarker discovery: The discoveries in proteomics to metabolomics Chem. Biol. Interact. 2014, 215, 7-16
    • (2014) Chem. Biol. Interact. , vol.215 , pp. 7-16
    • Zhao, Y.Y.1    Lin, R.C.2
  • 26
    • 84902486234 scopus 로고    scopus 로고
    • Major depressive disorder in DSM-5: Implications for clinical practice and research of changes from DSM-IV
    • Uher, R.; Payne, J. L.; Pavlova, B.; Perlis, R. H. Major depressive disorder in DSM-5: implications for clinical practice and research of changes from DSM-IV Depression Anxiety 2014, 31 (6) 459-471
    • (2014) Depression Anxiety , vol.31 , Issue.6 , pp. 459-471
    • Uher, R.1    Payne, J.L.2    Pavlova, B.3    Perlis, R.H.4
  • 27
    • 78649682499 scopus 로고    scopus 로고
    • Not as golden as standards should be: Interpretation of the Hamilton Rating Scale for Depression
    • Kriston, L.; von Wolff, A. Not as golden as standards should be: interpretation of the Hamilton Rating Scale for Depression J. Affective Disord. 2011, 128 (1-2) 175-177
    • (2011) J. Affective Disord. , vol.128 , Issue.12 , pp. 175-177
    • Kriston, L.1    Von Wolff, A.2
  • 28
    • 0035089858 scopus 로고    scopus 로고
    • Serum Lipid Concentrations in Patients with Comorbid Generalized Anxiety Disorder and Major Depressive Disorder
    • Sevincok, L.; Buyukozturk, A.; Dereboy, F. Serum Lipid Concentrations in Patients With Comorbid Generalized Anxiety Disorder and Major Depressive Disorder Can. J. Psychiatry. 2001, 46 (1) 68-71
    • (2001) Can. J. Psychiatry. , vol.46 , Issue.1 , pp. 68-71
    • Sevincok, L.1    Buyukozturk, A.2    Dereboy, F.3
  • 30
    • 0035666723 scopus 로고    scopus 로고
    • Standardizing the Hamilton Depression Rating Scale: Past, present, and future
    • Williams, J. B. Standardizing the Hamilton Depression Rating Scale: past, present, and future Eur. Arch. Psychiatry Clin. Neurosci. 2001, 251 (Suppl 2) II6-II12
    • (2001) Eur. Arch. Psychiatry Clin. Neurosci. , vol.251 , pp. 6-II12
    • Williams, J.B.1
  • 31
    • 84872875141 scopus 로고    scopus 로고
    • Dynamic monitoring of carnitine and acetylcarnitine in the trimethylamine signal after exercise in human skeletal muscle by 7T 1H-MRS
    • Ren, J.; Lakoski, S.; Haller, R. G.; Sherry, A. D.; Malloy, C. R. Dynamic monitoring of carnitine and acetylcarnitine in the trimethylamine signal after exercise in human skeletal muscle by 7T 1H-MRS Magn. Reson. Med. 2013, 69 (1) 7-17
    • (2013) Magn. Reson. Med. , vol.69 , Issue.1 , pp. 7-17
    • Ren, J.1    Lakoski, S.2    Haller, R.G.3    Sherry, A.D.4    Malloy, C.R.5
  • 32
    • 79951687182 scopus 로고    scopus 로고
    • Noninvasive assessment of exercise-related intramyocellular acetylcarnitine in euglycemia and hyperglycemia in patients with type 1 diabetes using (1)H magnetic resonance spectroscopy: A randomized single-blind crossover study
    • Boss, A.; Kreis, R.; Jenni, S.; Ith, M.; Nuoffer, J. M.; Christ, E.; Boesch, C.; Stettler, C. Noninvasive assessment of exercise-related intramyocellular acetylcarnitine in euglycemia and hyperglycemia in patients with type 1 diabetes using (1)H magnetic resonance spectroscopy: a randomized single-blind crossover study Diabetes Care 2011, 34 (1) 220-222
    • (2011) Diabetes Care , vol.34 , Issue.1 , pp. 220-222
    • Boss, A.1    Kreis, R.2    Jenni, S.3    Ith, M.4    Nuoffer, J.M.5    Christ, E.6    Boesch, C.7    Stettler, C.8
  • 33
    • 0037379314 scopus 로고    scopus 로고
    • Bioenergetic approaches for neuroprotection in Parkinson's disease
    • discussion S47-S48
    • Beal, M. F. Bioenergetic approaches for neuroprotection in Parkinson's disease Ann. Neurol. 2003, 53 (Suppl 3) S39-S47 discussion S47-S48
    • (2003) Ann. Neurol. , vol.53 , pp. 39-S47
    • Beal, M.F.1
  • 36
    • 0033653231 scopus 로고    scopus 로고
    • Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties relevance for its mode of action in Alzheimer's disease and geriatric depression
    • Pettegrew, J. W.; Levine, J.; McClure, R. J. Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties relevance for its mode of action in Alzheimer's disease and geriatric depression Mol. Psychiatry 2000, 5 (6) 616-632
    • (2000) Mol. Psychiatry , vol.5 , Issue.6 , pp. 616-632
    • Pettegrew, J.W.1    Levine, J.2    McClure, R.J.3
  • 37
    • 0036047955 scopus 로고    scopus 로고
    • Acetyl-l-carnitine as a possible therapy for Alzheimer's disease
    • Pettegrew, J. W.; McClure, R. J. Acetyl-l-carnitine as a possible therapy for Alzheimer's disease Expert Rev. Neurother. 2002, 2 (5) 647-654
    • (2002) Expert Rev. Neurother. , vol.2 , Issue.5 , pp. 647-654
    • Pettegrew, J.W.1    McClure, R.J.2
  • 40
    • 77952417649 scopus 로고    scopus 로고
    • Metabonomics study of urine and plasma in depression and excess fatigue rats by ultra fast liquid chromatography coupled with ion trap-time of flight mass spectrometry
    • Zhang, F.; Jia, Z.; Gao, P.; Kong, H.; Li, X.; Lu, X.; Wu, Y.; Xu, G. Metabonomics study of urine and plasma in depression and excess fatigue rats by ultra fast liquid chromatography coupled with ion trap-time of flight mass spectrometry Mol. Biosyst 2010, 6 (5) 852-861
    • (2010) Mol. Biosyst , vol.6 , Issue.5 , pp. 852-861
    • Zhang, F.1    Jia, Z.2    Gao, P.3    Kong, H.4    Li, X.5    Lu, X.6    Wu, Y.7    Xu, G.8
  • 42
    • 62149118589 scopus 로고    scopus 로고
    • Lysophosphatidylcholine enhances oxidative stress via the 5-lipoxygenase pathway in rat aorta during aging
    • Zou, Y.; Kim, D. H.; Jung, K. J.; Heo, H. S.; Kim, C. H.; Baik, H. S.; Yu, B. P.; Yokozawa, T.; Chung, H. Y. Lysophosphatidylcholine enhances oxidative stress via the 5-lipoxygenase pathway in rat aorta during aging Rejuvenation Res. 2009, 12 (1) 15-24
    • (2009) Rejuvenation Res. , vol.12 , Issue.1 , pp. 15-24
    • Zou, Y.1    Kim, D.H.2    Jung, K.J.3    Heo, H.S.4    Kim, C.H.5    Baik, H.S.6    Yu, B.P.7    Yokozawa, T.8    Chung, H.Y.9
  • 43
    • 37549004312 scopus 로고    scopus 로고
    • Role of Lysophosphatidylcholine (LPC) in Atherosclerosis
    • Matsumoto, T.; Kobayashi, T.; Kamata, K. Role of Lysophosphatidylcholine (LPC) in Atherosclerosis Curr. Med. Chem. 2007, 14 (30) 3209-3220
    • (2007) Curr. Med. Chem. , vol.14 , Issue.30 , pp. 3209-3220
    • Matsumoto, T.1    Kobayashi, T.2    Kamata, K.3
  • 44
    • 84908568867 scopus 로고    scopus 로고
    • Xanthine oxidoreductase in atherosclerosis pathogenesis: Not only oxidative stress
    • Battelli, M. G.; Polito, L.; Bolognesi, A. Xanthine oxidoreductase in atherosclerosis pathogenesis: Not only oxidative stress Atherosclerosis 2014, 237 (2) 562-567
    • (2014) Atherosclerosis , vol.237 , Issue.2 , pp. 562-567
    • Battelli, M.G.1    Polito, L.2    Bolognesi, A.3
  • 45
    • 67651046067 scopus 로고    scopus 로고
    • Lysophosphatidylcholine induces endothelial cell injury by nitric oxide production through oxidative stress
    • Kim, E. A.; Kim, J. A.; Park, M. H.; Jung, S. C.; Suh, S. H.; Pang, M. G.; Kim, Y. J. Lysophosphatidylcholine induces endothelial cell injury by nitric oxide production through oxidative stress J. Matern. Fetal Neonatal. Med. 2009, 22 (4) 325-331
    • (2009) J. Matern. Fetal Neonatal. Med. , vol.22 , Issue.4 , pp. 325-331
    • Kim, E.A.1    Kim, J.A.2    Park, M.H.3    Jung, S.C.4    Suh, S.H.5    Pang, M.G.6    Kim, Y.J.7
  • 46
    • 84867696554 scopus 로고    scopus 로고
    • The Role of Oxidative Stress in Depressive Disorders
    • Michel, T. M.; Pülschen, D.; Thome, J. The Role of Oxidative Stress in Depressive Disorders Curr. Pharm. Des. 2012, 18 (36) 5890-5899
    • (2012) Curr. Pharm. Des. , vol.18 , Issue.36 , pp. 5890-5899
    • Michel, T.M.1    Pülschen, D.2    Thome, J.3
  • 47
    • 84909582699 scopus 로고    scopus 로고
    • Prolidase activity and oxidative stress in patients with major depressive disorder
    • Kokacya, M. H.; Bahceci, B.; Bahceci, I.; Dilek, A. R.; Dokuyucu, R. Prolidase activity and oxidative stress in patients with major depressive disorder Psychiatr. Danubina 2014, 26 (4) 314-318
    • (2014) Psychiatr. Danubina , vol.26 , Issue.4 , pp. 314-318
    • Kokacya, M.H.1    Bahceci, B.2    Bahceci, I.3    Dilek, A.R.4    Dokuyucu, R.5
  • 48
    • 10844244082 scopus 로고    scopus 로고
    • The relationship between potency of oxidative stress and severity of depression
    • Yanik, M.; Erel, O.; Kati, M. The relationship between potency of oxidative stress and severity of depression Acta Neuropsychiatrica 2004, 16 (4) 200-203
    • (2004) Acta Neuropsychiatrica , vol.16 , Issue.4 , pp. 200-203
    • Yanik, M.1    Erel, O.2    Kati, M.3
  • 49
    • 0035107838 scopus 로고    scopus 로고
    • Phospholipid Metabolism and Depression: The Possible Roles of Phospholipase A2 and Coenzyme A-Independent Transacylase
    • Horrobin, D. F. Phospholipid Metabolism and Depression: the Possible Roles of Phospholipase A2 and Coenzyme A-Independent Transacylase Hum. Psychopharmacol. 2001, 16 (1) 45-52
    • (2001) Hum. Psychopharmacol. , vol.16 , Issue.1 , pp. 45-52
    • Horrobin, D.F.1
  • 50
    • 0034213298 scopus 로고    scopus 로고
    • Glycerophospholipids in brain: Their metabolism, incorporation into membranes, functions, and involvement in neurological disorders
    • Farooqui, A. A.; Horrocks, L. A.; Farooqui, T. Glycerophospholipids in brain: their metabolism, incorporation into membranes, functions, and involvement in neurological disorders Chem. Phys. Lipids 2000, 106 (1) 1-29
    • (2000) Chem. Phys. Lipids , vol.106 , Issue.1 , pp. 1-29
    • Farooqui, A.A.1    Horrocks, L.A.2    Farooqui, T.3
  • 52
    • 1442333287 scopus 로고    scopus 로고
    • Plasmalogens targets for oxidants and major lipophilic antioxidants
    • Engelmann, B. Plasmalogens targets for oxidants and major lipophilic antioxidants Biochem. Soc. Trans. 2004, 32 (Pt 1) 147-150
    • (2004) Biochem. Soc. Trans. , vol.32 , pp. 147-150
    • Engelmann, B.1
  • 53
    • 84876467985 scopus 로고    scopus 로고
    • Reduced plasmalogen concentration as a surrogate marker of oxidative stress in elderly septic patients
    • Brosche, T.; Bertsch, T.; Sieber, C. C.; Hoffmann, U. Reduced plasmalogen concentration as a surrogate marker of oxidative stress in elderly septic patients Arch. Gerontol. Geriatr. 2013, 57 (1) 66-69
    • (2013) Arch. Gerontol. Geriatr. , vol.57 , Issue.1 , pp. 66-69
    • Brosche, T.1    Bertsch, T.2    Sieber, C.C.3    Hoffmann, U.4
  • 54
    • 34248191297 scopus 로고    scopus 로고
    • Decreased plasmalogen concentration as a surrogate marker of oxidative stress in patients presenting with acute coronary syndromes or supraventricular tachycardias
    • Brosche, T.; Brueckmann, M.; Haase, K. K.; Sieber, C.; Bertsch, T. Decreased plasmalogen concentration as a surrogate marker of oxidative stress in patients presenting with acute coronary syndromes or supraventricular tachycardias Clin. Chem. Lab. Med. 2007, 45 (5) 689-691
    • (2007) Clin. Chem. Lab. Med. , vol.45 , Issue.5 , pp. 689-691
    • Brosche, T.1    Brueckmann, M.2    Haase, K.K.3    Sieber, C.4    Bertsch, T.5
  • 55
    • 75149124644 scopus 로고    scopus 로고
    • Chronic melatonin treatment and its precursor L-tryptophan improve the monoaminergic neurotransmission and related behavior in the aged rat brain
    • Esteban, S.; Garau, C.; Aparicio, S.; Moranta, D.; Barceló, P.; Fiol, M. A.; Rial, R. Chronic melatonin treatment and its precursor L-tryptophan improve the monoaminergic neurotransmission and related behavior in the aged rat brain J. Pineal Res. 2010, 48 (2) 170-177
    • (2010) J. Pineal Res. , vol.48 , Issue.2 , pp. 170-177
    • Esteban, S.1    Garau, C.2    Aparicio, S.3    Moranta, D.4    Barceló, P.5    Fiol, M.A.6    Rial, R.7
  • 56
    • 0030071206 scopus 로고    scopus 로고
    • Monoaminergic neurotransmitters, their precursors and metabolites in brains of Alzheimer patients
    • Storga, D.; Vrecko, K.; Birkmayer, J. G.; Reibnegger, G. Monoaminergic neurotransmitters, their precursors and metabolites in brains of Alzheimer patients Neurosci. Lett. 1996, 203 (1) 29-32
    • (1996) Neurosci. Lett. , vol.203 , Issue.1 , pp. 29-32
    • Storga, D.1    Vrecko, K.2    Birkmayer, J.G.3    Reibnegger, G.4
  • 57
    • 84925232045 scopus 로고    scopus 로고
    • Modulating the serotonin system in the treatment of major depressive disorder
    • Morrissette, D. A.; Stahl, S. M. Modulating the serotonin system in the treatment of major depressive disorder CNS Spectrums 2014, 19 (Suppl 1) 54-68
    • (2014) CNS Spectrums , vol.19 , pp. 54-68
    • Morrissette, D.A.1    Stahl, S.M.2
  • 58
    • 38049081662 scopus 로고    scopus 로고
    • Mechanisms of disease: Major depressive disorder.
    • Belmaker, R. H.; Agam, G. Mechanisms of disease: Major depressive disorder. New Engl. J. Med. 2008, 358, 55-68
    • (2008) New Engl. J. Med. , vol.358 , pp. 55-68
    • Belmaker, R.H.1    Agam, G.2
  • 59
    • 33745522158 scopus 로고    scopus 로고
    • Relationship of brain tryptophan and serotonin in improving cognitive performance in rats
    • Khaliq, S.; Haider, S.; Ahmed, S. P.; Perveen, T.; Haleem, D. J. Relationship of brain tryptophan and serotonin in improving cognitive performance in rats Pak. J. Pharm. Sci. 2006, 19 (1) 11-15
    • (2006) Pak. J. Pharm. Sci. , vol.19 , Issue.1 , pp. 11-15
    • Khaliq, S.1    Haider, S.2    Ahmed, S.P.3    Perveen, T.4    Haleem, D.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.