Lysophosphatidylcholine induces endothelial cell injury by nitric oxide production through oxidative stress

Journal of Maternal-Fetal and Neonatal Medicine

Volumn 22, Issue 4, 2009, Pages 325-331

  Kim, Eon A ^a   Kim, Ji Ae ^a   Park, Mi Hye ^a,b   Jung, Sung Chul ^a,b   Suh, Suk Hyo ^a,b   Pang, Myung Geol ^c   Kim, Young Ju ^a,b  

^a Ewha Womans University School of Medicine   (South Korea)

^b Ewha Womans University   (South Korea)

^c Chung Ang University   (South Korea)

Author keywords

Antioxidant; Endothelium; Lysophosphatidylcholine; Nitric oxide; ROS

Indexed keywords

ANTIOXIDANT; LYSOPHOSPHATIDYLCHOLINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; DIACETYLDICHLOROFLUORESCEIN; FLUORESCEIN DERIVATIVE; NITRATE; NITRITE;

ARTICLE; CELL VIABILITY; ENDOTHELIUM CELL; ENDOTHELIUM INJURY; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; UMBILICAL VEIN; BIOSYNTHESIS; CELL CULTURE; CELL SURVIVAL; CYTOLOGY; DRUG EFFECT; METABOLISM;

ANTIOXIDANTS; CELL SURVIVAL; CELLS, CULTURED; ENDOTHELIAL CELLS; FLUORESCEINS; HUMANS; LYSOPHOSPHATIDYLCHOLINES; NG-NITROARGININE METHYL ESTER; NITRATES; NITRIC OXIDE; NITRITES; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; UMBILICAL VEINS;

EID: 67651046067     PISSN: 14767058     EISSN: 14764954     Source Type: Journal    
DOI: 10.1080/14767050802556075     Document Type: Article

References (32)

1. Lindheimer M, Roberts J, Cunningham F. Chesley's hypertensive disorders in pregnancy. 2nd ed. Stamford, CT; Appleton & Lange; 1999.
2. Kumar CA, Das UN. Oxidant stress in pre-eclampsia and essential hypertension. J Assoc Physicians India 2002;50: 1372-1375.
3. Hubel CA. Oxidative stress in the pathogenesis of preeclampsia. Proc Soc Exp Biol Med 1999;222:222-235.
4. Orhan H, Onderoglu L, Yucel A, Sahin G. Circulating biomarkers of oxidative stress in complicated pregnancies. Arch Gynecol Obstet 2003;267:189-195.
5. Kumar CA, Das UN. Lipid peroxides, anti-oxidants and nitric oxide in patients with pre-eclampsia and essential hypertension. Med Sci Monit 2000;6:901-907.
6. Fleming I, Mohamed A, Galle J, Turchanowa L, Brandes RP, Fisslthaler B, Busse R. Oxidized low-density lipoprotein increases superoxide production by endothelial nitric oxide synthase by inhibiting PKC alpha. Cardiovasc Res 2005; 65:897-906.
7. Gonon AT, Erbas D, Broijersen A, Valen G, Pernow J. Nitric oxide mediates protective effect of endothelin receptor antagonism during myocardial ischemia and reperfusion. Am J Physiol Heart Circ Physiol 2004;286: H1767-H1774.
8. Murugesan G, Fox PL. Role of lysophosphatidylcholine in the inhibition of endothelial cell motility by oxidized LDL. J Clin Invest 1996;97:2736-2744.
9. Chaudhuri P, Colles SM, Damron DS, Graham LM. Lysophosphatidylcholine inhibits endothelial cell migration by increasing intracellular calcium and activating calpain. Arterioscler Thromb Vasc Biol 2003;23:218-223.
10. Hsieh CC, Yen MH, Liu HW, Lau YT. Lysophosphatidylcholine induces apoptotic and non-apoptotic death in vascular smooth muscle cells: in comparison with oxidized LDL. Atherosclerosis 2000;151:481-491.
11. Wang Y, Adair CD, Coe L, Weeks JW, Lewis DF, Alexander JS. Activation of endothelial cells in preeclampsia: increased neutrophil-endothelial adhesion correlates with up-regulation of adhesion molecule P-selectin in human umbilical vein endothelial cells isolated from preeclampsia. J Soc Gynecol Investig 1998;5:237-243.
12. Parthasarathy S, Steinbrecher UP, Barnett J, Witztum JL, Steinberg D. Essential role of phospholipase A2 activity in endothelial cell-induced modification of low density lipoprotein. Proc Natl Acad Sci USA 1985;82:3000-3004.
13. Dimmeler S, Haendeler J, Galle J, Zeiher AM. Oxidized low density lipoprotein induces apoptosis of human endothelial cells by activation of CPP32-like proteases: A mechanistic clue to the ''response to injury'' hypothesis. Circulation 1997;95: 1760-1763.
14. Galle J, Heinloth A, Wanner C, Heermeier K. Dual effect of oxidized LDL on cell cycle in human endothelial cells through oxidative stress. Kidney Int Suppl 2001;78:S120-S123.
15. Kanner J, Harel S, Granit R. Nitric oxide as an antioxidant. Arch Biochem Biophys 1991;289:130-136.
16. Bjorkerud B, Bjorkerud S. Contrary effects of lightly and strongly oxidized LDL with potent promotion of growth versus apoptosis on arterial smooth muscle cells, macrophages, and fibroblasts. Arterioscler Thromb Vasc Biol 1996;16:416-421.
17. Deliconstantinos G, Villiotou V, Stavrides JC, Salemes N, Gogas J. Nitric oxide and peroxynitrite production by human erythrocytes: a causative factor of toxic anemia in breast cancer patients. Anticancer Res 1995;15:1435-1446.
18. Kooy NW, Royall JA. Agonist-induced peroxynitrite production from endothelial cells. Arch Biochem Biophys 1994;310: 352-359.
19. Cominacini L, Rigoni A, Pasini AF, Garbin U, Davoli A, Campagnola M, Pastorino AM, Lo Cascio V, Sawamura T. The binding of oxidized low density lipoprotein (ox-LDL) to ox-LDL receptor-1 reduces the intracellular concentration of nitric oxide in endothelial cells through an increased production of superoxide. J Biol Chem 2001;276:13750-13755.
20. Nishioka H, Horiuchi H, Arai H, Kita T. Lysophosphatidylcholine generates superoxide anions through activation of phosphatidylinositol 3-kinase in human neutrophils. FEBS Lett 1998;441:63-66.
21. Ohara Y, Peterson TE, Zheng B, Kuo JF, Harrison DG. Lysophosphatidylcholine increases vascular superoxide anion production via protein kinase C activation. Arterioscler Thromb 1994;14:1007-1013.
22. Safaya R, Chai H, Kougias P, Lin P, Lumsden A, Yao Q, Chen C. Effect of lysophosphatidylcholine on vasomotor functions of porcine coronary arteries. J Surg Res 2005; 126:182-188.
23. Heinloth A, Heermeier K, Raff U, Wanner C, Galle J. Stimulation of NADPH oxidase by oxidized low-density lipoprotein induces proliferation of human vascular endothelial cells. J Am Soc Nephrol 2000;11:1819-1825.
24. Hamilton JA, Myers D, Jessup W, Cochrane F, Byrne R, Whitty G, Moss S. Oxidized LDL can induce macrophage survival, DNA synthesis, and enhanced proliferative response to CSF-1 and GM-CSF. Arterioscler Thromb Vasc Biol 1999;19:98-105.
25. Ji Y, Han Y, Jianxin D, Huang Y, Chen Q, Ferro A. Inhibition of endothelial nitric oxide generation by low-density lipoprotein is partially prevented by L-arginine and L-ascorbate. Atherosclerosis 2004;176:345-353.
26. Halliwell B. Gutteridge JM. The antioxidant of human extracellular fluids. Arch Biochem Biophys 1990;280:1-8.
27. Kaneko T, Kaji K, Matsuo M. Protective effect of lipophilic derivatives of ascorbic acid on lipid peroxide-induced endothelial injury. Arch Biochem Biophys 1993;304: 176-180.
28. Hennig B, Boissonneault GA, Fiscus LJ, Marra ME. Effect of vitamin E on oxysterol- and fatty acid hydroperoxide-induced changes of repair and permeability properties of cultured endothelial cell monolayers. Int J Vitam Nutr Res 1988; 58:41-47.
29. Keaney Jr, Guo Y, Cunningham D, Shwaery GT. Vascular incorporation of alpha-tocopherol prevents endothelial dysfunction due to oxidized LDL by inhibiting protein kinase C stimulation. J Clin Invest 1996;98:386-394.
30. Kuzuya M, Naito M, Funaki C, Hayashi T, Asai K, Kuzuya F. Probucol prevents oxidative injury to endothelial cells. J. Lipid Res 1991;32:197-204.
31. Martin A, Frei B. Both intracellular and extracellular vitamin C inhibits atherogenic modification of LDL by human vascular endothelial cells. Arterioscler Thromb Vasc Bio 1997;17:1583-1590.
32. Nijveldt, RJ, van Nood E, van Hoorn DE, Boelens PG, van Norren K, van Leeuwen PA. Flavonoids: a review of probable mechanisms of action and potential applications.Am J Clin Nutr 2001;74:418-425.