Plasma irisin in runners and nonrunners: No favorable metabolic associations in humans

Physiological Reports

Volumn 3, Issue 1, 2015, Pages

  Hew Butler, Tamara ^a   Landis Piwowar, Kristin ^a   Byrd, Gregory ^a   Seimer, Max ^a   Seigneurie, Nicole ^a   Byrd, Brigid ^b   Muzik, Otto ^b  

^a OAKLAND UNIVERSITY   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

Author keywords

Brown fat; Energy expenditure; Running

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; FLUORODEOXYGLUCOSE F 18; GLUCOSE; HIGH DENSITY LIPOPROTEIN; IRISIN; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ADULT; ARTICLE; BODY COMPOSITION; BODY HEIGHT; BODY MASS; BODY WEIGHT; BROWN ADIPOSE TISSUE; COLD STRESS; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; FEMALE; HORMONE BLOOD LEVEL; HUMAN; MALE; METABOLISM; NORMAL HUMAN; OXYGEN CONSUMPTION; POSITRON EMISSION TOMOGRAPHY; REFRACTOMETER; RESPIRATORY QUOTIENT; RESTING ENERGY EXPENDITURE; RUNNING; TRAINING; WHITE ADIPOSE TISSUE;

EID: 84929648290     PISSN: None     EISSN: 2051817X     Source Type: Journal    
DOI: 10.14814/phy2.12262     Document Type: Article

References (33)

1. ACSM’s Guidelines for Exercise Testing and Prescription. 2014a. Percentile values for peak oxygen uptake (ml/kg/min) in men. Available via http://www.medicine.virginia.edu/research/cores/exercise-physiology/images-1/VO2%20Chart-men.pdf (accessed October 7, 2014).
2. ACSM’s Guidelines for Exercise Testing and Prescription. 2014b. Percentile values for peak oxygen uptake (ml/kg/min) in women. Available via http://www.medicine.virginia.edu/research/cores/exercise-physiology/images-1/VO2%20Chart%20women.pdf (accessed October 7, 2014).
3. Bostrom, P., J. Wu, M. P. Jedrychowski, A. Korde, L. Ye, J. C. Lo, et al. 2012. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481:463-468.
4. Chakravarty, E. F., H. B. Hubert, V. B. Lingala, and J. F. Fries. 2008. Reduced disability and mortality among aging runners: a 21-year longitudinal study. Arch. Intern. Med. 168:1638-1646.
5. Chondronikola, M., E. Volpi, E. Borsheim, C. Porter, P. Annamalai, S. Enerback, et al. 2014. Brown adipose tissue improves whole body glucose homeostasis and insulin sensitivity in humans. Diabetes 63:4089-4099.
6. Crujeiras, A. B., M. Pardo, R. R. Arturo, S. Navas-Carretero, M. A. Zulet, J. A. Martinez, et al. 2014. Longitudinal variation of circulating irisin after an energy restriction-induced weight loss and following weight regain in obese men and women. Am. J. Hum. Biol. 26:198-207.
7. Cypess, A. M., Y. C. Chen, C. Sze, K. Wang, J. English, O. Chan, et al. 2012. Cold but not sympathomimetics activates human brown adipose tissue in vivo. Proc. Natl Acad. Sci. USA 109:10001-10005.
8. Erickson, H. P. 2013. Irisin and FNDC5 in retrospect: an exercise hormone or a transmembrane receptor? Adipocyte 2:289-293.
9. Fain, J. N., J. M. Company, F. W. Booth, M. H. Laughlin, J. Padilla, N. T. Jenkins, et al. 2013. Exercise training does not increase muscle FNDC5 protein or mRNA expression in pigs. Metabolism 62:1503-1511.
10. Haugen, H. A., E. L. Melanson, Z. V. Tran, J. T. Kearney, and J. O. Hill. 2003. Variability of measured resting metabolic rate. Am. J. Clin. Nutr. 78:1141-1145.
11. Hecksteden, A., M. Wegmann, A. Steffen, J. Kraushaar, A. Morsch, S. Ruppenthal, et al. 2013. Irisin and exercise training in humans-results from a randomized controlled training trial. BMC Med. 11:235.
12. Herring, M. P., M. H. Sailors, and M. S. Bray. 2014. Genetic factors in exercise adoption, adherence and obesity. Obes. Rev. 15:29-39.
13. Huh, J. Y., G. Panagiotou, V. Mougios, M. Brinkoetter, M. T. Vamvini, B. E. Schneider, et al. 2012. FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism 61:1725-1738.
14. Kraemer, R. R., P. Shockett, N. D. Webb, U. Shah, and V. D. Castracane. 2014. A transient elevated irisin blood concentration in response to prolonged,moderate aerobic exercise in youngmen and women.Horm. Metab. Res. 46:150-154.
15. Kurdiova, T., M. Balaz, M. Vician, D. Maderova, M. Vlcek, L. Valkovic, et al. 2014. Effects of obesity, diabetes and exercise on Fndc5 gene expression and irisin release in human skeletal muscle and adipose tissue: in vivo and in vitro studies. J. Physiol. 592:1091-1107.
16. Lecker, S. H., A. Zavin, P. Cao, R. Arena, K. Allsup, K. M. Daniels, et al. 2012. Expression of the irisin precursor FNDC5 in skeletal muscle correlates with aerobic exercise performance in patients with heart failure. Circ. Heart Fail. 5:812-818.
17. Lee, D. C., R. R. Pate, C. J. Lavie, X. Sui, T. S. Church, and S. N. Blair. 2014a. Leisure-time running reduces all-cause and cardiovascular mortality risk. J. Am. Coll. Cardiol. 64:472-481.
18. Lee, P., J. D. Linderman, S. Smith, R. J. Brychta, J. Wang, C. Idelson, et al. 2014b. Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans. Cell Metab. 19:302-309.
19. van Marken Lichtenbelt, W. D., J. W. Vanhommerig, N. M. Smulders, J. M. Drossaerts, G. J. Kemerink, N. D. Bouvy, et al. 2009. Cold-activated brown adipose tissue in healthy men. N. Engl. J. Med. 360:1500-1508.
20. Marti, B., and H. Howald. 1985. Long-term effects of physical training on aerobic capacity: controlled study of former elite athletes. J. Appl. Physiol. 69(1451-1459):1990.
21. Muzik, O., T. J. Mangner, W. R. Leonard, A. Kumar, J. Janisse, and J. G. Granneman. 2013. 15O PET measurement of blood flow and oxygen consumption in cold-activated human brown fat. J. Nucl. Med. 54:523-531.
22. Norheim, F., T. M. Langleite, M. Hjorth, T. Holen, A. Kielland, H. K. Stadheim, et al. 2014. The effects of acute and chronic exercise on PGC-1alpha, irisin and browning of subcutaneous adipose tissue in humans. FEBS J. 281:739-749.
23. Ogden, C. L., M. D. Carroll, B. K. Kit, and K. M. Flegal. 2014. Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA 311:806-814.
24. Ouellet, V., S. M. Labbe, D. P. Blondin, S. Phoenix, B. Guerin, F. Haman, et al. 2012. Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. J. Clin. Invest. 122:545-552.
25. Park, K. H., L. Zaichenko, M. Brinkoetter, B. Thakkar, A. Sahin-Efe, K. E. Joung, et al. 2013. Circulating irisin in relation to insulin resistance and the metabolic syndrome. J. Clin. Endocrinol. Metab. 98:4899-4907.
26. Raschke, S., M. Elsen, H. Gassenhuber, M. Sommerfeld, U. Schwahn, B. Brockmann, et al. 2013. Evidence against a beneficial effect of irisin in humans. PLoS ONE 8:e73680.
27. Roca-Rivada, A., C. Castelao, L. L. Senin, M. O. Landrove, J. Baltar, C. A. Belen, et al. 2013. FNDC5/irisin is not only a myokine but also an adipokine. PLoS ONE 8:e60563.
28. Sanchis-Gomar, F., R. Alis, H. Pareja-Galeano, M. Romagnoli, and C. Perez-Quilis. 2014. Inconsistency in circulating irisin levels: what is really happening? Horm. Metab. Res. 46:591-596.
29. Stengel, A., T. Hofmann, M. Goebel-Stengel, U. Elbelt, P. Kobelt, and B. F. Klapp. 2013. Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity-correlation with body mass index. Peptides 39:125-130.
30. Stricker, E. M. 1968. Some physiological and motivational properties of the hypovolemic stimulus for thirst. Physiol. Behav. 3:379-385.
31. Timmons, J. A., K. Baar, P. K. Davidsen, and P. J. Atherton. 2012. Is irisin a human exercise gene? Nature 488:E9-E10.
32. Wen, M. S., C. Y. Wang, S. L. Lin, and K. C. Hung. 2013. Decrease in irisin in patients with chronic kidney disease. PLoS ONE 8:e64025.
33. Zouhal, H., C. Jacob, P. Delamarche, and A. Gratas-Delamarche. 2008. Catecholamines and the effects of exercise, training and gender. Sports Med. 38:401-423.