Expression of a single siRNA against a conserved region of NP gene strongly inhibits in vitro replication of different Influenza A virus strains of avian and swine origin

Antiviral Research

Volumn 120, Issue , 2015, Pages 16-22

  Stoppani, Elena ^a,b   Bassi, Ivan ^a   Dotti, Silvia ^b   Lizier, Michela ^a,c   Ferrari, Maura ^b   Lucchini, Franco ^a  

^a UNIVERSITÀ CATTOLICA DEL SACRO CUORE   (Italy)

^b ISTITUTO ZOOPROFILATTICO SPERIMENTALE DELLA LOMBARDIA E DELL EMILIA ROMAGNA   (Italy)

^c HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

Author keywords

Influenza; Nucleoprotein; Orthomyxoviridae; RNA interference; siRNA

Indexed keywords

NUCLEOPROTEIN; SMALL INTERFERING RNA; CORE PROTEIN; NP PROTEIN, INFLUENZA A VIRUS; RNA BINDING PROTEIN; VIRUS RNA;

ANIMAL CELL; ARTICLE; AVIAN INFLUENZA VIRUS; CONTROLLED STUDY; GENETIC CONSERVATION; IN VITRO STUDY; MDCK CELL LINE; NONHUMAN; PRIORITY JOURNAL; RNA ANALYSIS; RNA SEQUENCE; SWINE INFLUENZA VIRUS; VIRUS GENOME; VIRUS INHIBITION; VIRUS REPLICATION; VIRUS STRAIN; ANIMAL; ANTAGONISTS AND INHIBITORS; BIRD; DOG; DRUG EFFECTS; GENETICS; HUMAN; INFLUENZA A VIRUS; ISOLATION AND PURIFICATION; METABOLISM; ORTHOMYXOVIRUS INFECTION; PHYSIOLOGY; PIG; REAL TIME POLYMERASE CHAIN REACTION; VETERINARY; VIROLOGY;

ANIMALIA; AVES; INFLUENZA A VIRUS; ORTHOMYXOVIRIDAE; SUIDAE;

ANIMALS; BIRDS; DOGS; HUMANS; INFLUENZA A VIRUS; MADIN DARBY CANINE KIDNEY CELLS; ORTHOMYXOVIRIDAE INFECTIONS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; RNA, VIRAL; RNA-BINDING PROTEINS; SWINE; VIRAL CORE PROTEINS; VIRUS REPLICATION;

EID: 84929646327     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2015.04.017     Document Type: Article

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