Role of Vitamin D Deficiency in Extraskeletal Complications: Predictor of Health Outcome or Marker of Health Status?

BioMed Research International

Volumn 2015, Issue , 2015, Pages

  Guessous, Idris ^a,b,c  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CALCIDIOL 1 MONOOXYGENASE; CALCITRIOL; VITAMIN D RECEPTOR; VITAMIN D;

ARTERIAL STIFFNESS; AUTOIMMUNE DISEASE; CARDIOVASCULAR DISEASE; CHRONIC KIDNEY DISEASE; COMPLICATION; EXTRASKELETAL COMPLICATION; HEALTH STATUS; HORMONE SUBSTITUTION; HUMAN; HYPERTENSION; ISCHEMIC HEART DISEASE; MALIGNANT NEOPLASTIC DISEASE; MEASUREMENT ERROR; MENDELIAN RANDOMIZATION ANALYSIS; META ANALYSIS (TOPIC); METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OUTCOME ASSESSMENT; PREDICTOR VARIABLE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SYSTEMATIC REVIEW (TOPIC); VITAMIN D DEFICIENCY; AUTOIMMUNE DISEASES; CARDIOVASCULAR DISEASES; METABOLISM;

AUTOIMMUNE DISEASES; CARDIOVASCULAR DISEASES; HUMANS; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84929646305     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2015/563403     Document Type: Review

References (124)

1. M. Holick, "Evolution, biologic functions, and recommended dietary allowances for vitamin D," in Vitamin D: Molecular Biology, Physiology, and Clinical Applications: Nutrition and Health, Nutrition and Health, pp. 1-16, Humana Press, 1999.
2. M. F. Holick, "McCollum Award Lecture, 1994: vitamin D - new horizons for the 21st century," The American Journal of Clinical Nutrition, vol. 60, no. 4, pp. 619-630, 1994.
3. M. Wacker and M. F. Holick, "Sunlight and Vitamin D: a global perspective for health," Dermato-Endocrinology, vol. 5, no. 1, pp. 51-108, 2013.
4. B. A. Gilchrest, "Sun exposure and vitamin D sufficiency," The American Journal of Clinical Nutrition, vol. 88, no. 2, pp. 570S-577S, 2008.
5. A. G. Uitterlinden, Y. Fang, J. B. J. van Meurs, H. A. P. Pols, and J. P. T. M. van Leeuwen, "Genetics and biology of vitamin D receptor polymorphisms," Gene, vol. 338, no. 2, pp. 143-156, 2004.
6. D. Feldman, J. W. Pike, and J. S. Adams, Vitamin D, Academic Press, 2011.
7. T.-T. Wang, L. E. Tavera-Mendoza, D. Laperriere et al., "Largescale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes," Molecular Endocrinology, vol. 19, no. 11, pp. 2685-2695, 2005.
8. I. Schuster, "Cytochromes P450 are essential players in the vitamin D signaling system," Biochimica et Biophysica Acta- Proteins and Proteomics, vol. 1814, no. 1, pp. 186-199, 2011.
9. N. M. van Schoor and P. Lips, "Worldwide vitamin D status," Best Practice & Research: Clinical Endocrinology & Metabolism, vol. 25, no. 4, pp. 671-680, 2011.
10. P. Pludowski, W. B. Grant, H. P. Bhattoa et al., "Vitamin Dstatus in central Europe," International Journal of Endocrinology, vol. 2014, Article ID 589587, 12 pages, 2014.
11. M. F. Holick and T. C. Chen, "Vitamin D deficiency: a worldwide problem with health consequences," The American Journal of Clinical Nutrition, vol. 87, no. 4, pp. 1080S-1086S, 2008.
12. M. F. Holick, "Vitamin D deficiency," The New England Journal of Medicine, vol. 357, no. 3, pp. 266-281, 2007.
13. I. Guessous, V. Dudler, N. Glatz et al., "Vitamin D levels and associated factors: a population-based study in Switzerland," Swiss Medical Weekly, vol. 142, Article ID w13719, 2012.
14. S. Pilz, A. Tomaschitz, W. März et al., "Vitamin D, cardiovascular disease and mortality," Clinical Endocrinology, vol. 75, no. 5, pp. 575-584, 2011.
15. D. Durup, H. L. Jørgensen, J. Christensen, P. Schwarz, A. M. Heegaard, and B. Lind, "A reverse J-shaped association of allcause mortality with serum 25-hydroxyvitamin D in general practice: the CopD study," Journal of Clinical Endocrinology and Metabolism, vol. 97, no. 8, pp. 2644-2652, 2012.
16. A. C. Ross, J. E. Manson, S. A. Abrams et al., "The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know," Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 1, pp. 53-58, 2011.
17. "KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD)," Kidney International Supplements, no. 113, pp. S1-S130, 2009.
18. B. Troesch, B. Hoeft, M. McBurney, M. Eggersdorfer, and P. Weber, "Dietary surveys indicate vitamin intakes below recommendations are common in representative Western countries," British Journal of Nutrition, vol. 108, no. 4, pp. 692-698, 2012.
19. D. de Abreu, I. Guessous, J.-M. Gaspoz, and P. Marques- Vidal, "Compliance with the Swiss society for nutrition's dietary recommendations in the population of Geneva, Switzerland: a 10-year trend study (1999-2009)," Journal of the Academy of Nutrition and Dietetics, vol. 114, no. 5, pp. 774-780, 2014.
20. I. Bendik, A. Friedel, F. F. Roos, P. Weber, and M. Eggersdorfer, "Vitamin D: a critical and essential micronutrient for human health," Frontiers in Physiology, vol. 5, article 248, 2014.
21. H. K. Biesalski, "International congress 'hidden hunger', March 5-9, 2013, Stuttgart-Hohenheim, Germany," Annals of Nutrition and Metabolism, vol. 62, no. 4, pp. 298-302, 2013.
22. M. F. Holick, "Vitamin D: a millenium perspective," Journal of Cellular Biochemistry, vol. 88, no. 2, pp. 296-307, 2003.
23. M. G. Kimlin, "Geographic location and vitamin D synthesis," Molecular Aspects of Medicine, vol. 29, no. 6, pp. 453-461, 2008.
24. T. J. Wang, M. J. Pencina, S. L. Booth et al., "Vitamin D deficiency and risk of cardiovascular disease," Circulation, vol. 117, no. 4, pp. 503-511, 2008.
25. H. Marti-Soler, C. Gubelmann, S. Aeschbacher et al., "Seasonality of cardiovascular risk factors: an analysis including over 230, 000 participants in 15 countries," Heart, vol. 100, no. 9, pp. 1517-1523, 2014.
26. C. D. Davis, "Vitamin D and cancer: current dilemmas and future research needs," The American Journal of Clinical Nutrition, vol. 88, no. 2, pp. 565S-569S, 2008.
27. C. L. Hanchette and G. G. Schwartz, "Geographic patterns of prostate cancer mortality. Evidence for a protective effect of ultraviolet radiation," Cancer, vol. 70, no. 12, pp. 2861-2869, 1992.
28. M. R. Haussler, "Vitamin D receptors: nature and function," Annual Review of Nutrition, vol. 6, pp. 527-562, 1986.
29. C. Carlberg, "Genome-wide (over)view on the actions of vitamin D," Frontiers in Physiology, vol. 5, article 167, 2014.
30. Y. Wang, J. Zhu, and H. F. DeLuca, "Where is the vitamin D receptor?" Archives of Biochemistry and Biophysics, vol. 523, no. 1, pp. 123-133, 2012.
31. I. Guessous and M. Bochud, "Opposite impacts of dietary versus supplemental calcium on cardiovascular health," Evidence-Based Medicine, vol. 18, no. 3, pp. 113-114, 2013.
32. I. Guessous and M. Bochud, "Effects of calcium and vitamin D supplementations on cardiovascular disease: review article," Revue Médicale Suisse, vol .8, no. 348, pp. 1458-1463, 2012.
33. H. Wasse, F. Cardarelli, C. de Staercke, C. Hooper, E. Veledar, and I. Guessous, "25-hydroxyvitamin D concentration is inversely associated with serum MMP-9 in a cross-sectional study of African American ESRD patients," BMC Nephrology, vol. 12, no. 1, article 24, 2011.
34. I. Guessous, M. Bochud, O. Bonny, and M. Burnier, "Calcium, vitamin D and cardiovascular disease," Kidney and Blood Pressure Research, vol. 34, no. 6, pp. 404-417, 2011.
35. T. A. Pearson and T. A. Manolio, "How to interpret a genomewide association study," The Journal of the American Medical Association, vol. 299, no. 11, pp. 1335-1344, 2008.
36. D. P. McDonnell, D. J. Mangelsdorf, J. W. Pike, M. R. Haussler, and B. W. O'Malley, "Molecular cloning of complementary DNA encoding the avian receptor for vitamin D," Science, vol. 235, no. 4793, pp. 1214-1217, 1987.
37. A. G. Uitterlinden, Y. Fang, J. B. J. van Meurs, H. van Leeuwen, and H. A. P. Pols, "Vitamin D receptor gene polymorphisms in relation to Vitamin D related disease states," Journal of Steroid Biochemistry and Molecular Biology, vol. 89-90, no. 1-5, pp.187-193, 2004.
38. H. Arai, K.-I. Miyamoto, M. Yoshida et al., "Thepolymorphism in the caudal-related homeodomain protein Cdx-2 binding element in the human vitamin D receptor gene," Journal of Bone and Mineral Research, vol. 16, no. 7, pp. 1256-1264, 2001.
39. H. A. Morris and P. H. Anderson, "Autocrine and paracrine actions of vitamin D," The Clinical Biochemist Reviews, vol. 31, no. 4, pp. 129-138, 2010.
40. W. Xiang, J. Kong, S. Chen et al., "Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems," The American Journal of Physiology-Endocrinology and Metabolism, vol. 288, no. 1, pp. E125-E132, 2005.
41. J. Kong, G. Qiao, Z. Zhang, S. Q. Liu, and Y. C. Li, "Targeted vitamin D receptor expression in juxtaglomerular cells suppresses renin expression independent of parathyroid hormone and calcium," Kidney International, vol. 74, no. 12, pp. 1577-1581, 2008.
42. S. Pilz, A. Tomaschitz, E. Ritz, and T. R. Pieber, "Vitamin D status and arterial hypertension: a systematic review," Nature Reviews Cardiology, vol. 6, no. 10, pp. 621-630, 2009.
43. M. S. K. Wong, R. Delansorne, R. Y. K. Man, and P. M. Vanhoutte, "Vitamin D derivatives acutely reduce endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat," The American Journal of Physiology-Heart and Circulatory Physiology, vol. 295, no. 1, pp. H289-H296, 2008.
44. A. Zittermann, S. S. Schleithoff, and R. Koerfer, "Putting cardiovascular disease and vitamin D insufficiency into perspective," British Journal of Nutrition, vol. 94, no. 4, pp. 483-492, 2005.
45. T. D. O'Connell, J. E. Berry, A. K. Jarvis, M. J. Somerman, and R. U. Simpson, "1,25-dihydroxyvitamin D3 regulation of cardiac myocyte proliferation and hypertrophy," The American Journal of Physiology-Heart and Circulatory Physiology, vol. 272, no. 4, part 2, pp. H1751-H1758, 1997.
46. K. E. Watson, M. L. Abrolat, L. L. Malone et al., "Active serum vitamin D levels are inversely correlated with coronary calcification," Circulation, vol. 96, no. 6, pp. 1755-1760, 1997.
47. S. Penckofer, J. Kouba, D. E. Wallis, and M. A. Emanuele, "Vitamin D and diabetes: let the sunshine in," Diabetes Educator, vol. 34, no. 6, pp. 939-954, 2008.
48. A. G. Pittas, J. Lau, F. B. Hu, and B. Dawson-Hughes, "The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis," Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 6, pp. 2017-2029, 2007.
49. K. Yin and D. K. Agrawal, "Vitamin D and inflammatory diseases," Journal of Inflammation Research, vol. 7, no. 1, pp. 69-87, 2014.
50. T. K. Wobke, B. L. Sorg, and D. Steinhilber, "Vitamin D in inflammatory diseases," Frontiers in Physiology, vol. 5, article 244, 2014.
51. S. Mordan-Mccombs, M. Valrance, G. Zinser, M. Tenniswood, and J. Welsh, "Calcium, vitamin D and the vitamin D receptor: impact on prostate and breast cancer in preclinical models," Nutrition Reviews, vol. 65, no. 8, part 2, pp. S131-S133, 2007.
52. S. Ahmad, T. A. Chowdhury, and B. J. Boucher, "Diabetes and cancer: could vitamin D provide the link?" Journal of Diabetes and Its Complications, vol. 27, no. 2, pp. 184-190, 2013.
53. National Kidney Foundation, "K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification," The American Journal of Kidney Diseases, vol. 39, no. 2, supplement 1, pp. S1-S266, 2002.
54. F. Duranton, M. E. Rodriguez-Ortiz, Y. Duny, M. Rodriguez, J. P. Daurès, and A. Argilés, "Vitamin D treatment and mortality in chronic kidney disease: a systematic review and meta-analysis," The American Journal of Nephrology, vol. 37, no. 3, pp. 239-248, 2013.
55. Z. Zheng, H. Shi, J. Jia, D. Li, and S. Lin, "Vitamin D supplementation and mortality risk in chronic kidney disease: a meta-analysis of 20 observational studies," BMC Nephrology, vol. 14, article 199, 2013.
56. G. Bonizzi and M. Karin, "The two NF-kappaB activation pathways and their role in innate and adaptive immunity," Trends in Immunology, vol. 25, no. 6, pp. 280-288, 2004.
57. C. Guijarro and J. Egido, "Transcription factor-κB(NF-κB) and renal disease," Kidney International, vol. 59, no. 2, pp. 415-424, 2001.
58. E. Giovannucci, Y. Liu, B. W. Hollis, and E. B. Rimm, "25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study," Archives of Internal Medicine, vol. 168, no. 11, pp. 1174-1180, 2008.
59. J. Marniemi, E. Alanen, O. Impivaara et al., "Dietary and serum vitamins and minerals as predictors of myocardial infarction and stroke in elderly subjects," Nutrition, Metabolism and Cardiovascular Diseases, vol. 15, no. 3, pp. 188-197, 2005.
60. W. B. Grant, H. S. Cross, C. F. Garland et al., "Estimated benefit of increased vitamin D status in reducing the economic burden of disease in western Europe," Progress in Biophysics and Molecular Biology, vol. 99, no. 2-3, pp. 104-113, 2009.
61. M. Pfeifer, B. Begerow, H. W. Minne, D. Nachtigall, and C. Hansen, "Effects of a short-term vitamin D3 and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women," Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 4, pp. 1633-1637, 2001.
62. D. P. Trivedi, R. Doll, and K. T. Khaw, "Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial," The British Medical Journal, vol. 326, no. 7387, pp. 469-472, 2003.
63. A. Z. LaCroix, J. Kotchen, G. Anderson et al., "Calcium plus vitamin D supplementation and mortality in postmenopausal women: the women's health initiative calcium-vitamin D randomized controlled trial," Journals of Gerontology A: Biological Sciences and Medical Sciences, vol. 64, no. 5, pp. 559-567, 2009.
64. E. Theodoratou, I. Tzoulaki, L. Zgaga, and J. P. A. Ioannidis, "Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials," The British Medical Journal, vol. 348, Article ID g2035, 2014.
65. M. J. Bolland, A. Grey, G. D. Gamble, and I. R. Reid, "The effect of vitamin D supplementation on skeletal, vascular, or cancer outcomes: a trial sequential meta-analysis," The Lancet Diabetes & Endocrinology, vol. 2, no. 4, pp. 307-320, 2014.
66. M. J. Bolland, A. Grey, G. D. Gamble, and I. R. Reid, "Vitamin D supplementation and falls: a trial sequential meta-analysis," The Lancet Diabetes & Endocrinology, vol. 2, no. 7, pp. 573-580, 2014.
67. C. F. Garland, E. D. Gorham, S. B. Mohr, and F. C. Garland, "Vitamin D for cancer prevention: global perspective," Annals of Epidemiology, vol. 19, no. 7, pp. 468-483, 2009.
68. M. Chung, J. Lee, T. Terasawa, J. Lau, and T. A. Trikalinos, "Vitamin D with or without calcium supplementation for prevention of cancer and fractures: an updated meta-analysis for the U.S. Preventive Services Task Force," Annals of Internal Medicine, vol. 155, no. 12, pp. 827-838, 2011.
69. K. D. Cashman, "A review of vitamin D status and CVD," Proceedings of the Nutrition Society, vol. 73, no. 1, pp. 65-72, 2014.
70. M. B. Elamin, N. O. Abu Elnour, K. B. Elamin et al., "Vitamin D and cardiovascular outcomes: a systematic review and metaanalysis," Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 7, pp. 1931-1942, 2011.
71. S. Muldowney and M. Kiely, "Vitamin D and cardiometabolic health: a review of the evidence," Nutrition Research Reviews, vol. 24, no. 1, pp. 1-20, 2011.
72. J. A. Ford, G. S. MacLennan, A. Avenell, M. Bolland, A. Grey, and M. Witham, "Cardiovascular disease and vitamin D supplementation: trial analysis, systematic review, and metaanalysis," The American Journal of Clinical Nutrition, vol. 100, no. 3, pp. 746-755, 2014.
73. V. Kunadian, G. A. Ford, B. Bawamia, W. Qiu, and J. E. Manson, "Vitamin D deficiency and coronary artery disease: a review of the evidence," The American Heart Journal, vol. 167, no. 3, pp. 283-291, 2014.
74. P. Messa, M. Curreri, A. Regalia, and C. M. Alfieri, "Vitamin D and the cardiovascular system: an overview of the recent literature," The American Journal of Cardiovascular Drugs, vol. 14, no. 1, pp. 1-14, 2014.
75. G. Muscogiuri, J. Mitri, C. Mathieu et al., "Mechanisms in endocrinology: vitamin D as a potential contributor in endocrine health and disease," European Journal of Endocrinology, vol. 171, no. 3, pp. R101-R110, 2014.
76. R. Chowdhury, S. Kunutsor, A. Vitezova et al., "Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies," The British Medical Journal, vol. 348, Article ID g1903, 2014.
77. P. Pludowski, M. F. Holick, S. Pilz et al., "Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality - a review of recent evidence," Autoimmunity Reviews, vol. 12, no. 10, pp. 976-989, 2013.
78. N. C. Harvey and C. Cooper, "Vitamin D: some perspective please," The British Medical Journal, vol. 345, no. 7869, Article ID e4695, 2012.
79. T. Richart, Y. Li, and J. A. Staessen, "Renal versus extrarenal activation of vitamin D in relation to atherosclerosis, arterial stiffening, and hypertension," The American Journal of Hyper vol. 20, no. 9, pp. 1007-1015, 2007.
80. K. P. Schlingmann, M. Kaufmann, S. Weber et al., "Mutations in CYP24A1 and idiopathic infantile hypercalcemia," The New England Journal of Medicine, vol. 365, no. 5, pp. 410-421, 2011.
81. K. M. Sanders, A. L. Stuart, E. J. Williamson et al., "Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial," The Journal of the American Medical Association, vol. 303, no. 18, pp. 1815-1822, 2010.
82. K. M. Sanders, G. C. Nicholson, and P. R. Ebeling, "Is high dose vitamin D harmful?" Calcified Tissue International, vol. 92, no. 2, pp. 191-206, 2013.
83. P. Welsh and N. Sattar, "Vitamin D and chronic disease prevention," The British Medical Journal, vol. 348, Article ID g2280, 2014.
84. S. Yusuf, G. Dagenais, J. Pogue, J. Bosch, and P. Sleight, "Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators," The New England Journal of Medicine, vol. 342, no. 3, pp. 154-160, 2000.
85. B. K. Dunn, E. S. Richmond, L. M. Minasian, A. M. Ryan, and L. G. Ford, "A nutrient approach to prostate cancer prevention: the selenium and vitamin E cancer prevention trial (SELECT)," Nutrition and Cancer, vol. 62, no. 7, pp. 896-918, 2010.
86. J. E. Rossouw, G. L. Anderson, R. L. Prentice et al., "Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women's health initiative randomized controlled trial," The Journal of the American Medical Association, vol. 288, no. 3, pp. 321-333, 2002.
87. K. Muse, "After the Women's Health initiative-what to tell our patients," Southern Medical Journal, vol. 95, no. 9, pp. 957-959, 2002.
88. O. S. Miettinen, "The clinical trial as a paradigm for epidemiologic research," Journal of Clinical Epidemiology, vol. 42, no. 6, pp. 491-498, 1989.
89. K. J. Rothman, S. Greenland, and T. L. Lash, Modern Epidemiology, Lippincott Williams & Wilkins, Philadelphia, Pa, USA, 2008.
90. P. Lips, T. Duong, A. Oleksik et al., "A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: baseline data from the multiple outcomes of raloxifene evaluation clinical trial," Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 3, pp. 1212-1221, 2001.
91. E. Hyppönen and C. Power, "Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors," The American Journal of Clinical Nutrition, vol. 85, no. 3, pp. 860-868, 2007.
92. T. Hagenau, R. Vest, T. N. Gissel et al., "Global vitamin D levels in relation to age, gender, skin pigmentation and latitude: an ecologic meta-regression analysis," Osteoporosis International, vol. 20, no. 1, pp. 133-140, 2009.
93. P. Lips, "Vitamin D status and nutrition in Europe and Asia," Journal of Steroid Biochemistryand Molecular Biology, vol. 103, no. 3-5, pp. 620-625, 2007.
94. I. S. Fetahu, J. Hobaus, and E. Kallay, "Vitamin D and the epigenome," Frontiers in Physiology, vol. 5, article 164, 2014.
95. K. M. Flegal, B. I. Graubard, D. F. Williamson, and R. S. Cooper, "Reverse causation and illness-related weight loss in observational studies of body weight and mortality," The American Journal of Epidemiology, vol. 173, no. 1, pp. 1-9, 2011.
96. P. Autier, M. Boniol, C. Pizot, and P. Mullie, "Vitamin D status and ill health: a systematic review," The Lancet Diabetes & Endocrinology, vol. 2, no. 1, pp. 76-89, 2014.
97. R. Gama, J. L. Waldron, H. L. Ashby et al., "Hypovitaminosis D and disease: consequence rather than cause?" The British Medical Journal, vol. 345, no. 7872, Article ID e5706, 2012.
98. M. Bochud, "On the use of Mendelian randomization to infer causality in observational epidemiology," European Heart Journal, vol. 29, no. 20, pp. 2456-2457, 2008.
99. M. Bochud and V. Rousson, "Usefulness of Mendelian randomization in observational epidemiology," International Journal of Environmental Research and Public Health, vol. 7, no. 3, pp. 711-728, 2010.
100. S. K. Kunutsor, S. Burgess, P. B. Munroe, and H. Khan, "Vitamin D and high blood pressure: causal association or epiphenomenon?" European Journal of Epidemiology, vol. 29, no. 1, pp. 1-14, 2014.
101. K. S. Vimaleswaran, A. Cavadino, D. J. Berry et al., "Association of vitamin D status with arterial blood pressure and hypertension risk: a Mendelian randomisation study," The Lancet Diabetes & Endocrinology, vol. 2, no. 9, pp. 719-729, 2014.
102. Z. Ye, S. J. Sharp, S. Burgess et al., "Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a mendelian randomisation study," The Lancet Diabetes & Endocrinology, vol. 3, no. 1, pp. 35-42, 2015.
103. A. M. Rose, "Vitamin D testing: clinical and laboratory considerations," Medical Laboratory Observer, vol. 45, no. 5, pp. 8-14, 2013.
104. A. Prentice, G. R. Goldberg, and I. Schoenmakers, "Vitamin D across the lifecycle: physiology and biomarkers," The American Journal of Clinical Nutrition, vol. 88, no. 2, pp. 500S-506S, 2008.
105. I. Tzoulaki, K. C. Siontis, E. Evangelou, and J. P. A. Ioannidis, "Bias in associations of emerging biomarkers with cardiovascular disease," JAMA Internal Medicine, vol. 173, no. 8, pp. 664-671, 2013.
106. C. J. L. Farrell, S. Martin, B. McWhinney, I. Straub, P. Williams, and M. Herrmann, "State-of-the-art vitamin D assays: a comparison of automated immunoassays with liquid chromatography-tandem mass spectrometry methods," Clinical Chemistry, vol. 58, no. 3, pp. 531-542, 2012.
107. B. W. Hollis, "Assessment of circulating 25(OH)D and 1,25(OH)2D: emergence as clinically important diagnostic tools," Nutrition Reviews, vol. 65, no. 8, part 2, pp. S87-S90, 2007.
108. S. J. Bruce, B. Rochat, A. Béguin et al., "Analysis and quantification of vitamin D metabolites in serum by ultra-performance liquid chromatography coupled to tandem mass spectrometry and high-resolution mass spectrometry-a method comparison and validation," Rapid Communications in Mass Spectrometry, vol. 27, no. 1, pp. 200-206, 2013.
109. E. Giovannucci, "Strengths and limitations of current epidemiologic studies: vitamin D as a modifier of colon and prostate cancer risk," Nutrition Reviews, vol. 65, no. 8, part 2, pp. S77-S79, 2007.
110. F. R. Greer, "25-Hydroxyvitamin D: functional outcomes in infants and young children," The American Journal of Clinical Nutrition, vol. 88, no. 2, pp. 529S-533S, 2008.
111. C. J. E. Lamberg-Allardt and H. T. Viljakainen, "25-Hydroxyvitamin D and functional outcomes in adolescents," The American Journal of Clinical Nutrition, vol. 88, no. 2, pp. 534S-536S, 2008.
112. B. Dawson-Hughes, "Serum 25-hydroxyvitamin D and functional outcomes in the elderly," The American Journal of Clinical Nutrition, vol. 88, no. 2, pp. 537S-540S, 2008.
113. J. E. Manson, S. S. Bassuk, I.-M. Lee et al., "The VITamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease," Contemporary Clinical Trials, vol. 33, no. 1, pp. 159-171, 2012.
114. S. Pilz, K. Kienreich, A. Tomaschitz et al., "Vitamin D and cardiovascular disease: update and outlook," Scandinavian Journal of Clinical and Laboratory Investigation Supplements, vol. 243, pp. 83-91, 2012.
115. S. Pilz, F. Rutters, and J. M. Dekker, "Disease prevention: vitamin D trials," Science, vol. 338, no. 6109, p. 883, 2012.
116. K. Michaëlsson, "The puzzling world of vitamin D insufficiency," The Lancet Diabetes & Endocrinology, vol. 2, no. 4, pp. 269-270, 2014.
117. "Vitamin D: chasing a myth?" The Lancet Diabetes & Endocrinology, vol. 2, no. 1, p. 1, 2014.
118. V. Prasad, A. Cifu, and J. P. A. Ioannidis, "Reversals of established medical practices: evidence to abandon ship," The Journal of the American Medical Association, vol. 307, no. 1, pp. 37-38, 2012.
119. I. Guessous and M. Bochud, "Reply to the letter to the editor 'Vitamin D deficiency and cardiovascular disease' by Ahmed et al," Swiss Medical Weekly, vol. 143, Article ID w13822, 2013.
120. J. P. A. Ioannidis, "Biomarker failures," Clinical Chemistry, vol. 59, no. 1, pp. 202-204, 2013.
121. K. Kupferschmidt, "Uncertain verdict as vitamin D goes on trial," Science, vol. 337, no. 6101, pp. 1476-1478, 2012.
122. N. Sattar, P. Welsh, M. Panarelli, and N. G. Forouhi, "Increasing requests for vitamin D measurement: costly, confusing, and without credibility," The Lancet, vol. 379, no. 9811, pp. 95-96, 2012.
123. R. H. Fletcher, "Review: vitamin D3 supplementation may reduce mortality in adults; vitamin D2 does not," Annals of Internal Medicine, vol. 161, no. 2, article JC5, 2014.
124. I. R. Reid, M. J. Bolland, and A. Grey, "Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis," The Lancet, vol. 383, no. 9912, pp. 146-155, 2014.