Inhibition of cathepsin proteases attenuates migration and sensitizes aggressive N-Myc amplified human neuroblastoma cells to doxorubicin

Oncotarget

Volumn 6, Issue 13, 2015, Pages 11175-11190

  Gangoda, Lahiru ^a   Keerthikumar, Shivakumar ^a   Fonseka, Pamali ^a   Edgington, Laura E ^a   Ang, Ching Seng ^b   Ozcitti, Cemil ^a   Bogyo, Matthew ^c   Parker, Belinda S ^a   Mathivanan, Suresh ^a  

^a LA TROBE UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c STANFORD UNIVERSITY   (United States)

Author keywords

Mass spectrometry; N Myc amplification; Neuroblastoma; Proteomics; Secretome

Indexed keywords

CATHEPSIN PROTEASE; CYSTEINE PEPTIDASE; DOXORUBICIN; MYC PROTEIN; PEPTIDASE; PROTEINASE; PROTEOME; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; CATHEPSIN; MESSENGER RNA; PROTEINASE INHIBITOR;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG RESPONSE; ENZYME ACTIVITY; ENZYME ASSAY; HUMAN; HUMAN CELL; MIGRATION INHIBITION; MOLECULAR DYNAMICS; NEUROBLASTOMA CELL LINE; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; ANTAGONISTS AND INHIBITORS; APOPTOSIS; CELL MOTION; CELL PROLIFERATION; DRUG EFFECTS; DRUG RESISTANCE; GENE EXPRESSION REGULATION; GENETICS; LIQUID CHROMATOGRAPHY; METABOLISM; NEUROBLASTOMA; PATHOLOGY; PROTEOMICS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TANDEM MASS SPECTROMETRY; TUMOR CELL CULTURE; WESTERN BLOTTING; WOUND HEALING;

ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; BLOTTING, WESTERN; CATHEPSINS; CELL MOVEMENT; CELL PROLIFERATION; CHROMATOGRAPHY, LIQUID; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEUROBLASTOMA; PROTEASE INHIBITORS; PROTEOMICS; PROTO-ONCOGENE PROTEINS C-MYC; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TANDEM MASS SPECTROMETRY; TUMOR CELLS, CULTURED; WOUND HEALING;

EID: 84929629269     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3579     Document Type: Article

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