An improved preparation of the activity-based probe JPM-OEt and in situ applications

Synthesis

Volumn , Issue 2, 2005, Pages 240-244

  Chehade, Kareem A H ^a,c   Baruch, Amos ^a,c   Verhelst, Steven H L ^b   Bogyo, Matthew ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Department of Chemical Proteomics ^*  (United States)

Author keywords

Activity based probes; Cysteine proteases; Epoxides; Inhibitors; Medicinal chemistry

Indexed keywords

CELL MEMBRANES; COMPUTATIONAL METHODS; ENZYME INHIBITION; PROBES; STEREOCHEMISTRY; TUMORS;

ACTIVITY-BASED PROBE; ANIMAL MODELS; CELL PERMEABLE CATHESPIN; MULTI-GRAM QUANTITIES;

SYNTHESIS (CHEMICAL);

AMIDE; CATHEPSIN; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; EPOXIDE; N [[3 (ETHOXYCARBONYL)OXIRAN 2 YL]CARBONYL]LEUCYL 3 (4 HYDROXYPHENYL)ETHYLAMIDE; PAPAIN; REAGENT; SUCCINIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ACTIVITY BASED PROBE; ARTICLE; CANCER MODEL; CELL MEMBRANE PERMEABILITY; ENZYME ANALYSIS; MOLECULAR PROBE; PROTEIN FAMILY; STEREOCHEMISTRY; SYNTHESIS;

EID: 13844275008     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-837295     Document Type: Article

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