Temperature-sensitive mutants in the influenza A virus RNA polymerase: Alterations in the PA linker reduce nuclear targeting of the PB1-PA dimer and result in viral attenuation

Journal of Virology

Volumn 89, Issue 12, 2015, Pages 6376-6390

  da Costa, Bruno ^a   Sausset, Alix ^a   Munier, Sandie ^b,c,d   Ghounaris, Alexandre ^a   Naffakh, Nadia ^b,c,d   Le Goffic, Ronan ^a   Delmas, Bernard ^a  

^a INRA Institut National de la Recherche Agronomique   (France)

^b Sorbonne Paris Cité   (France)

^c CNRS   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEINS AND BINDING PROTEINS; DIMER; PROTEIN IPO5; RNA DIRECTED RNA POLYMERASE; RNA DIRECTED RNA POLYMERASE PA SUBUNIT; RNA DIRECTED RNA POLYMERASE PB1 SUBUNIT; RNA DIRECTED RNA POLYMERASE PB2 SUBUNIT; UNCLASSIFIED DRUG; INFLUENZA VIRUS POLYMERASE BASIC PROTEIN 1; MUTANT PROTEIN; PA PROTEIN, INFLUENZA VIRUSES; PROTEIN BINDING; VIRUS PROTEIN;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS; CIRCULAR DICHROISM; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BINDING; ENZYME STRUCTURE; FEMALE; INFLUENZA VIRUS A; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN TARGETING; REVERTANT; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS; TEMPERATURE SENSITIVITY; VIROGENESIS; VIRUS ATTENUATION; VIRUS MUTANT; VIRUS REPLICATION; VIRUS TRANSCRIPTION; VIRUS VIRULENCE; ACTIVE TRANSPORT; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CHEMISTRY; GENETIC COMPLEMENTATION; GENETICS; HUMAN; INFLUENZA A VIRUS (H1N1); METABOLISM; PHYSIOLOGY; PROTEIN DOMAIN; RADIATION RESPONSE; TEMPERATURE;

GAUSSIA PRINCEPS (T. SCOTT, 1894); INFLUENZA A VIRUS; MUS; ORTHOMYXOVIRIDAE;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CIRCULAR DICHROISM; FEMALE; GENETIC COMPLEMENTATION TEST; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; MICE, INBRED BALB C; MICE, INBRED C57BL; MUTANT PROTEINS; MUTATION; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, SECONDARY; RNA REPLICASE; TEMPERATURE; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 84929593784     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00589-15     Document Type: Article

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