An extended CCR5 ECL2 peptide forms a helix that binds HIV-1 gp120 through non-specific hydrophobic interactions

FEBS Journal

Volumn 282, Issue 10, 2015, Pages 1906-1921

  Abayev, Meital ^a   Moseri, Adi ^a   Tchaicheeyan, Oren ^a,c   Kessler, Naama ^a   Arshava, Boris ^b   Naider, Fred ^b   Scherf, Tali ^a   Anglister, Jacob ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b CITY UNIVERSITY OF NEW YORK   (United States)

^c BAR ILAN UNIVERSITY   (Israel)

Author keywords

CCR5; ECL2; gp120; HIV 1 inhibitors; NMR

Indexed keywords

BOVINE SERUM ALBUMIN; BUFFER; CHEMOKINE RECEPTOR CCR5; EXTRACELLULAR LOOP 2 PEPTIDE; GLYCOPROTEIN GP 120; PEPTIDES AND PROTEINS; UNCLASSIFIED DRUG; CCR5 PROTEIN, HUMAN; PEPTIDE; PROTEIN BINDING;

AMPHIPHILIC HELIX; AQUEOUS SOLUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHEMICAL PHENOMENA; CONTROLLED STUDY; CRYSTAL STRUCTURE; DYNAMICS; HUMAN; HUMAN CELL; HYDROPHOBICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; VIRUS NEUTRALIZATION; ANIMAL; BOVINE; CHEMISTRY; HUMAN IMMUNODEFICIENCY VIRUS 1; METABOLISM; PROTEIN SECONDARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ANIMALS; CATTLE; CRYSTALLOGRAPHY, X-RAY; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, CCR5; SERUM ALBUMIN, BOVINE;

EID: 84929580499     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.13243     Document Type: Article

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