Regulation of calcium reabsorption along the rat nephron: A modeling study

American Journal of Physiology - Renal Physiology

Volumn 308, Issue 6, 2015, Pages F553-F566

  Edwards, Aurélie ^a  

^a SORBONNE UNIVERSITÉ   (France)

Author keywords

Calcium; CaSR; Epithelium; Mathematical model; Transport

Indexed keywords

CALCIUM; CALCIUM SENSING RECEPTOR; FUROSEMIDE; VANILLOID RECEPTOR 5; PARATHYROID HORMONE;

ARTICLE; CALCIUM ABSORPTION; CALCIUM BLOOD LEVEL; CALCIUM EXCRETION; CALCIUM STONE; CONTROLLED STUDY; HENLE LOOP; HYPOPARATHYROIDISM; IN VITRO STUDY; KIDNEY COLLECTING TUBULE; KIDNEY PERFUSION; KIDNEY TUBULE ABSORPTION; MATHEMATICAL MODEL; MEASUREMENT; NEPHRON; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; RISK ASSESSMENT; URINE PH; URINE VOLUME; WATER PERMEABILITY; ANIMAL; BIOLOGICAL MODEL; KIDNEY TUBULE; METABOLISM; PHYSIOLOGY; RAT; URINE;

ANIMALS; CALCIUM; KIDNEY TUBULES; MODELS, BIOLOGICAL; PARATHYROID HORMONE; RATS;

EID: 84929503539     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00577.2014     Document Type: Article

References (64)

1. Agus ZS, Chiu PJ, Goldberg M. Regulation of urinary calcium excretion in the rat. Am J Physiol Renal Fluid Electrolyte Physiol 232: F545-F549, 1977.
2. Asplin JR, Mandel NS, Coe FL. Evidence of calcium phosphate super-saturation in the loop of Henle. Am J Physiol Renal Fluid Electrolyte Physiol 270: F604-F613, 1996.
3. Azroyan A, Laghmani K, Mordasini D, Doucet A, Edwards A. Regulation of pendrin by pH: dependence on glycosylation. Biochem J 434: 61-72, 2011.
4. Bai M, Quinn S, Trivedi S, Kifor O, Pearce SH, Pollak MR, Krapcho K, Hebert SC, Brown EM. Expression and characterization of inactivating and activating mutations in the human Ca2+-sensing receptor. J Biol Chem 271: 19537-19545, 1996.
5. Bengele HH, Alexander EA, Lechene CP. Calcium and magnesium transport along the inner medullary collecting duct of the rat. Am J Physiol Renal Fluid Electrolyte Physiol 239: F24-F29, 1980.
6. Bennett KM, Bertram JF, Beeman SC, Gretz N. The emerging role of MRI in quantitative renal glomerular morphology. Am J Physiol Renal Physiol 304: F1252-F1257, 2013.
7. Bindels RJ, Ramakers PL, Dempster JA, Hartog A, Os CH. Role of Na /Ca2+ exchange in transcellular Ca2+transport across primary cultures of rabbit kidney collecting system. Pflügers Arch 420: 566-572, 1992.
8. Bonny O, Edwards A. Calcium reabsorption in the distal tubule: regulation by sodium, pH, and flow. Am J Physiol Renal Physiol 304: F585-F600, 2013.
9. Boros S, Bindels R, Hoenderop J. Active Ca2+ reabsorption in the connecting tubule. Pflügers Arch 458: 99-109, 2009.
10. Bourdeau JE, Burg MB. Voltage dependence of calcium transport in the thick ascending limb of Henle’s loop. Am J Physiol Renal Fluid Electrolyte Physiol 236: F357-F364, 1979.
11. Bourdeau JE, Hellstrom-Stein RJ. Voltage dependent calcium movement across the cortical collecting duct. Am J Physiol Renal Fluid Electrolyte Physiol 242: F285-F292, 1982.
12. Bushinsky DA, Neumann KJ, Asplin J, Krieger NS. Alendronate decreases urine calcium and supersaturation in genetic hypercalciuric rats. Kidney Int 55: 234-243, 1999.
13. Bustamante M, Hasler U, Leroy V, de Seigneux S, Dimitrov M, Mordasini D, Rousselot M, Martin PY, Feraille E. Calcium-sensing receptor attenuates AVP-induced aquaporin-2 expression via a calmodulin-dependent mechanism. J Am Soc Nephrol 19: 109-116, 2008.
14. Capasso G, Geibel PJ, Damiano S, Jaeger P, Richards WG, Geibel JP. The calcium sensing receptor modulates fluid reabsorption and acid secretion in the proximal tubule. Kidney Int 84: 277-284, 2013.
15. Cha SK, Huang C, Ding Y, Qi X, Huang CL, Miller RT. Calcium-sensing receptor decreases cell surface expression of the inwardly rectifying K channel Kir4.1. J Biol Chem 286: 1828-1835, 2011.
16. Clark I, Rivera-Cordero F. Effect of parathyroid function on absorption and excretion of calcium, magnesium and phosphate by rats. Endocrinology 88: 302-308, 1971.
17. De Jesus Ferreira MC, Bailly C. Extracellular Ca2+ decreases chloride reabsorption in rat CTAL by inhibiting cAMP pathway. Am J Physiol Renal Physiol 275: F198-F203, 1998.
18. De Jesus Ferreira MC, Helies-Toussaint C, Imbert-Teboul M, Bailly C, Verbavatz JM, Bellanger AC, Chabardes D.; Co-expression of a Ca2+-inhibitable adenylyl cyclase and of a Ca2+-sensing receptor in the cortical thick ascending limb cell of the rat kidney: inhibition of hormone-dependent cAMP accumulation by extracellular Ca2+. J Biol Chem 273: 15192-15202, 1998.
19. Desfleurs E, Wittner M, Simeone S, Pajaud S, Moine G, Rajerison R, Di Stefano A. Calcium-sensing receptor: regulation of electrolyte transport in the thick ascending limb of Henle’s loop. Kidney Blood Press Res 21: 401-412, 1998.
20. Dimke H, Hoenderop JG, Bindels RJ. Hereditary tubular transport disorders: implications for renal handling of Ca2+and Mg2+. Clin Sci 118: 1-18, 2010.
21. Frick KK, Asplin JR, Favus MJ, Culbertson C, Krieger NS, Bushinsky DA. Increased biological response to 1,25(OH)2D3 in genetic hypercalciuric stone-forming rats. Am J Physiol Renal Physiol 304: F718-F726, 2013.
22. Friedman PA, Gesek FA. Cellular calcium transport in renal epithelia: measurement, mechanisms, and regulation. Physiol Rev 75: 429-471, 1995.
23. Gemba M, Nishimura K. Effects of diuretics on calcium excretion and Ca2+-activated ATPase in rat kidney. Jpn J Pharmacol 27: 205-211, 1977.
24. Gil FZ, Gomes GN, Cavanal MF, Cesar KR. Influence of parathyroid ectomy and calcium on rat renal function. Nephron 83: 59-65, 1999.
25. Greger R, Lang F, Oberleithner H. Distal site of calcium reabsorption in the rat nephron. Pflügers Arch 374: 153-157, 1978.
26. Harris CA, Sutton RA, Dirks JH. Effects of hypercalcemia on calcium and phosphate ultrafilterability and tubular reabsorption in the rat. Am J Physiol Renal Fluid Electrolyte Physiol 233: F201-F206, 1977.
27. Hoenderop JG, Nilius B, Bindels RJ. Calcium absorption across epithelia. Physiol Rev 85: 373-422, 2005.
28. Hoenderop JG, van Leeuwen JP, van der Eerden BC, Kersten FF, van derKemp AW, Merillat AM, Waarsing JH, Rossier BC, Vallon V, Hummler E, Bindels RJ. Renal Ca2+wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5. J Clin Invest 112: 1906-1914, 2003.
29. Houillier P. Mechanisms and regulation of renal magnesium transport. Annu Rev Physiol 76: 411-430, 2014.
30. Huang C, Sindic A, Hill CE, Hujer KM, Chan KW, Sassen M, Wu Z, Kurachi Y, Nielsen S, Romero MF, Miller RT. Interaction of the Ca2+-sensing receptor with the inwardly rectifying potassium channels Kir4.1 and Kir42 results in inhibition of channel function. Am J Physiol Renal Physiol 292: F1073-F1081, 2007.
31. Jamison RL, Frey NR, Lacy FB. Calcium reabsorption in the thin loop of Henle. Am J Physiol 227: 745-751, 1974.
32. Kenny AD. Urinary calcium response to chronic parathyroidectomy in rats. Endocrinology 79: 77-80, 1966.
33. Layton AT. A mathematical model of the urine concentrating mechanism in the rat renal medulla. I. Formulation and base-case results. Am J Physiol Renal Physiol 300: F356-F371, 2011.
34. Le Grimellec C, Roinel N, Morel F, Philippe P, Malorey P.; Simultaneous Mg, Ca, P, K, Na and Cl analysis in rat tubular fluid. II. During acute Mg plasma loading. Pflügers Arch 340: 197-210, 1973.
35. LeGrimellec C, Roinel N, Morel F, Philippe P, Malorey P.; Simulta-neous Mg, Ca, P, K, Na and Cl analysis in rat tubular fluid. III. During acute Ca plasma loading. Pflügers Arch 346: 171-188, 1974.
36. Lee CT, Chen HC, Lai LW, Yong KC, Lien YH. Effects of furosemide on renal calcium handling. Am J Physiol Renal Physiol 293: F1231-F1237, 2007.
37. Li YH, Gregory S. Diffusion of ions in sea water and in deep-sea sediments. Geochim Cosmochim Acta 38: 703-714, 1974.
38. Loffing J, Kaissling B. Sodium and calcium transport pathways along the mammalian distal nephron: from rabbit to human. Am J Physiol Renal Physiol 284: F628-F643, 2003.
39. Loupy A, Ramakrishnan SK, Wootla B, Chambrey R, de la Faille R, Bourgeois S, Bruneval P, Mandet C, Christensen EI, Faure H, Cheval L, Laghmani K, Collet C, Eladari D, Dodd RH, Ruat M, Houillier P. PTH-independent regulation of blood calcium concentration by the calcium-sensing receptor. J Clin Invest 122: 3355-3367, 2012.
40. Magaldi AJ, van Baak AA, Rocha AS. Calcium transport across rat inner medullary collecting duct perfused in vitro. Am J Physiol Renal Fluid Electrolyte Physiol 257: F738-F745, 1989.
41. Mandon B, Siga E, Roinel N, Rouffignac C. Ca2+, Mg2, and K transport in the cortical and medullary thick ascending limb of the rat nephron: influence of transepithelial voltage. Pflügers Arch 424: 558-560, 1993.
42. Moss R, Thomas SR. Hormonal regulation of salt and water excretion: a mathematical model of whole kidney function and pressure natriuresis. Am J Physiol Renal Physiol 306: F224-F248, 2014.
43. Nijenhuis T, Hoenderop JG, van der Kemp AW, Bindels RJ. Localization and regulation of the epithelial Ca2+ channel TRPV6 in the kidney. J Am Soc Nephrol 14: 2731-2740, 2003.
44. Quamme GA, Dirks JH. Intraluminal and contraluminal magnesium on magnesium and calcium transfer in the rat nephron. Am J Physiol Renal Fluid Electrolyte Physiol 238: F187-F198, 1980.
45. Ramakrishnan SK, Loupy A, Edwards A, Bushinsky DA, Houillier P. Genetic hypercalciuric stone-forming rats have a decrease in paracellular permeability to calcium in the cortical thick ascending limb. J Am Soc Nephrol 23: 43A, 2012.
46. Renkema KY, Velic A, Dijkman HB, Verkaart S, van der Kemp AW, Nowik M, Timmermans K, Doucet A, Wagner CA, Bindels RJ, Hoenderop JG. The calcium-sensing receptor promotes urinary acidification to prevent nephrolithiasis. J Am Soc Nephrol 20: 1705-1713,2009.
47. Riccardi D, Brown EM. Physiology and pathophysiology of the calcium-sensing receptor in the kidney. Am J Physiol Renal Physiol 298: F485-F499, 2010.
48. Riccardi D, Hall AE, Chattopadhyay N, Xu JZ, Brown EM, Hebert SC. Localization of the extracellular Ca2+/polyvalent cation-sensing protein in rat kidney. Am J Physiol Renal Physiol 274: F611-F622, 1998.
49. Sammon PJ, Stacey RE, Bronner F. Role of parathyroid hormone in calcium homeostasis and metabolism. Am J Physiol 218: 479-485, 1970.
50. Sands JM, Naruse M, Baum M, Jo I, Hebert SC, Brown EM, Harris HW. Apical extracellular calcium/polyvalent cation-sensing receptor regulates vasopressin-elicited water permeability in rat kidney inner medullary collecting duct. J Clin Invest 99: 1399-1405, 1997.
51. Sutton RA, Dirks JH. The renal excretion of calcium: a review of micropuncture data. Can J Physiol Pharmacol 53: 979-988, 1975.
52. Toka HR, Al-Romaih K, Koshy JM, DiBartolo S, Kos CH, Quinn SJ, Curhan GC, Mount DB, Brown EM, Pollak MR. Deficiency of the calcium-sensing receptor in the kidney causes parathyroid hormone-independent hypocalciuria. J Am Soc Nephrol 23: 1879-1890, 2012.
53. Topala CN, Schoeber JP, Searchfield LE, Riccardi D, Hoenderop JG, Bindels RJ. Activation of the Ca2+-sensing receptor stimulates the activity of the epithelial Ca2+channel TRPV5. Cell Calcium 45: 331-339, 2009.
54. Tournus M, Seguin N, Perthame B, Thomas SR, Edwards A. A model of calcium transport along the rat nephron. Am J Physiol Renal Physiol 305: F979-F994, 2013.
55. Tsuruoka S, Bushinsky DA, Schwartz GJ. Defective renal calcium reabsorption in genetic hypercalciuric rats. Kidney Int 51: 1540-1547, 1997.
56. Urena P, Mannstadt M, Hruby M, Ferreira A, Schmitt F, Silve C, Ardaillou R, Lacour B, Abou-Samra AB, Segre GV, Drueke T. Parathyroidectomy does not prevent the renal PTH//PTHrP receptor down-regulation in uremic rats. Kidney Int 47: 1797-1805, 1995.
57. van Abel M, Hoenderop JG, van der Kemp AW, Friedlaender MM, van Leeuwen JP, Bindels RJ. Coordinated control of renal Ca2 transport proteins by parathyroid hormone. Kidney Int 68: 1708-1721, 2005.
58. van de Stolpe A, Jamison RL. Micropuncture study of the effect of ANP on the papillary collecting duct in the rat. Am J Physiol Renal Fluid Electrolyte Physiol 254: F477-F483, 1988.
59. Wagner CA. The calcium-sensing receptor directly regulates proximal tubular functions. Kidney Int 84: 228-230, 2013.
60. Wang WH, Lu M, Hebert SC. Cytochrome P-450 metabolites mediate extracellular Ca2+-induced inhibition of apical K channels in the TAL. Am J Physiol Cell Physiol 271: C103-C111, 1996.
61. Weinstein AM. A mathematical model of rat ascending Henle limb. III. Tubular function. Am J Physiol Renal Physiol 298: F543-F556, 2010.
62. Wills MR, Lewin MR. Plasma calcium fractions and the protein-binding of calcium in normal subjects and in patients with hypercalcaemia and hypocalcaemia. J Clin Pathol 24: 856-866, 1971.
63. Wittner M, di Stefano A, Wangemann P, Nitschke R, Greger R, Bailly C, Amiel C, Roinel N, de Rouffignac C. Differential effects of ADH on sodium, chloride, potassium, calcium and magnesium transport in cortical and medullary thick ascending limbs of mouse nephron. Pflügers Arch 412: 516-523, 1988.
64. Wittner M, Mandon B, Roinel N, Rouffignac C, Stefano A. Hormonal stimulation of Ca2+and Mg2+transport in the cortical thick ascending limb of Henle’s loop of the mouse: evidence for a change in the paracellular pathway permeability. Pflügers Arch 423: 387-396, 1993.