Activation of the bacterial thermosensor DesK involves a serine zipper dimerization motif that is modulated by bilayer thickness

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 20, 2015, Pages 6353-6358

  Cybulski, Larisa Estefanía ^a   Ballering, Joost ^b   Moussatova, Anastassiia ^c   Inda, Maria Eugenia ^a   Vazquez, Daniela B ^a   Wassenaar, Tsjerk A ^d   De Mendoza, Diego ^a   Tieleman, D Peter ^c   Killian, J Antoinette ^b  

^a UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UNIVERSITY OF CALGARY   (Canada)

^d UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Helix helix interaction|; Lipid protein interaction|; Thermosensing|; Transmembrane helix dimerization; Two component system|

Indexed keywords

BACTERIAL PROTEIN; DESK PROTEIN; DIMER; MUTANT PROTEIN; PHOSPHOTRANSFERASE; SERINE; SYNTHETIC PEPTIDE; TRYPTOPHAN; UNCLASSIFIED DRUG; LIPID BILAYER;

ARTICLE; BACTERIAL MEMBRANE; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVATION; FLUORESCENCE; HYDROPHILICITY; IN VIVO STUDY; LIPID BILAYER; MOLECULAR DYNAMICS; MOLECULAR MODEL; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; PROTEIN MOTIF; SIGNAL TRANSDUCTION; THERMORECEPTOR; THICKNESS; CHEMISTRY; GENETICS; PHYSIOLOGY; PROTEIN CONFORMATION; SPECTROFLUOROMETRY; TEMPERATURE SENSE;

BACTERIA (MICROORGANISMS);

AMINO ACID MOTIFS; CIRCULAR DICHROISM; DIMERIZATION; LIPID BILAYERS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PROTEIN CONFORMATION; SERINE; SIGNAL TRANSDUCTION; SPECTROMETRY, FLUORESCENCE; THERMOSENSING;

EID: 84929501009     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1422446112     Document Type: Article

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