Baclofen, a GABABR agonist, ameliorates immune-complex mediated acute lung injury by modulating pro-inflammatory mediators

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  Jin, Shunying ^a   Merchant, Michael L ^a   Ritzenthaler, Jeffrey D ^a   McLeish, Kenneth R ^a,b,c   Lederer, Eleanor D ^a,c   Torres Gonzalez, Edilson ^a   Fraig, Mostafa ^a   Barati, Michelle T ^a   Lentsch, Alex B ^d   Roman, Jesse ^a,c   Klein, Jon B ^a,b,c   Rane, Madhavi J ^a,b  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d UNIVERSITY OF CINCINNATI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; BACLOFEN; I KAPPA B; INTERLEUKIN 1 RECEPTOR ACCESSORY PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; [3 (3,4 DICHLOROBENZYLAMINO)PROPYL](DIETHOXYMETHYL)PHOSPHINIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; ANTIGEN ANTIBODY COMPLEX; AUTACOID; LIPOPOLYSACCHARIDE;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN ANTIBODY COMPLEX; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN TISSUE; IMMUNE COMPLEX DEPOSITION; IMMUNOMODULATION; LUNG ALVEOLUS CELL TYPE 2; LUNG LAVAGE; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RAT; SIGNAL TRANSDUCTION; ANIMAL; BRONCHOALVEOLAR LAVAGE FLUID; CHEMISTRY; DRUG EFFECTS; ENZYME IMMUNOASSAY; LONG EVANS RAT; MATRIX-ASSISTED LASER DESORPTION-IONIZATION MASS SPECTROMETRY; METABOLISM; TOXICITY; WESTERN BLOTTING;

RATTUS;

ACUTE LUNG INJURY; ANIMALS; ANTIGEN-ANTIBODY COMPLEX; APOPTOSIS; BACLOFEN; BLOTTING, WESTERN; BRONCHOALVEOLAR LAVAGE FLUID; GABA-B RECEPTOR AGONISTS; IMMUNOENZYME TECHNIQUES; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MALE; RATS; RATS, LONG-EVANS; RECEPTORS, GABA-B; SIGNAL TRANSDUCTION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84929497406     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0121637     Document Type: Article

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