Acid-induced cell injury and death in lung epithelial cells is associated with the activation of mitogen-activated protein kinases

Molecular Medicine Reports

Volumn 8, Issue 2, 2013, Pages 565-570

  Chen, Qiuhua ^a   Huang, Yingzi ^a   Yang, Yi ^a   Qiu, Haibo ^a  

^a MEDICAL SCHOOL OF SOUTHEAST UNIVERSITY   (China)

Author keywords

Acute lung injury; Acute respiratory distress syndrome; Apoptosis; Hydrochloric acid; Mitogen activated protein kinase

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; CASPASE 3; HYDROCHLORIC ACID; INTERLEUKIN 8; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE;

ARTICLE; CELL DAMAGE; CELL DEATH; CELL VIABILITY; CYTOTOXICITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; PH; SUPERNATANT; WESTERN BLOTTING;

APOPTOSIS; CELL DEATH; CELL LINE; CELL SURVIVAL; ENZYME ACTIVATION; GASTRIC ACID; HUMANS; HYDROCHLORIC ACID; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; PNEUMOCYTES; PROTEIN KINASE INHIBITORS; TIME FACTORS;

EID: 84879895009     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2013.1537     Document Type: Article

References (29)

1. Villar J, Blanco J, Añón JM, et al: The ALIEN study: incidence and outcome of acute respiratory distress syndrome in the era of lung protective ventilation. Intensive Care Med 37: 1932-1941, 2011.
2. Phua J, Badia JR, Adhikari NK, et al: Has mortality from acute respiratory distress syndrome decreased over time? A systematic review. Am J Respir Crit Care Med 179: 220-227, 2009.
3. Miwa C, Koyama S, Watanabe Y, Tsubochi H, Endo S, Nokubi M and Kawabata Y: Pathological findings and pulmonary dysfunction after acute respiratory distress syndrome for 5 years. Intern Med 49: 1599-1604, 2010.
4. Segal BH, Davidson BA, Hutson AD, et al: Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice. Am J Physiol Lung Cell Mol Physiol 292: L760-L768, 2007.
5. Reiss LK, Uhlig U and Uhlig S: Models and mechanisms of acute lung injury caused by direct insults. Eur J Cell Biol 91: 590-601, 2012.
6. Marik PE: Aspiration pneumonitis and aspiration pneumonia. N Engl J Med 344: 665-671, 2001.
7. Fielhaber JA, Carroll SF, Dydensborg AB, et al: Inhibition of mammalian target of rapamycin augments lipopolysaccharide-induced lung injury and apoptosis. J Immunol 188: 4535-4542, 2012.
8. Fujita M, Kuwano K, Kunitake R, et al: Endothelial cell apoptosis in lipopolysaccharide-induced lung injury in mice. Int Arch Allergy Immunol 117: 202-208, 1998.
9. Ohwada A, Tsutsumi-Ishii Y, Yoshioka Y, Iwabuchi K, Nagaoka I and Fukuchi Y: Acid exposure potentiates intercellular adhesion molecule-1 and e-cadherin expression on A549 alveolar lining epithelial cells. Exp Lung Res 29: 389-400, 2003.
10. Kou B, Ni J, Vatish M and Singer DR: Xanthine oxidase interaction with vascular endothelial growth factor in human endothelial cell angiogenesis. Microcirculation 15: 251-267, 2008.
11. Vrana JA, Grant S and Dent P: Inhibition of the MAPK pathway abrogates BCL2-mediated survival of leukemia cells after exposure to low-dose ionizing radiation. Radiat Res 151: 559-569, 1999.
12. Mirzoeva OK, Das D, Heiser LM, et al: Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res 69: 565-572, 2009.
13. Cheng Y, Liu X, Zhang S, Lin Y, Yang J and Zhang C: MicroRNA-21 protects against the H2O2-induced injury on cardiac myocytes via its target gene PDCD4. J Mol Cell Cardiol 47: 5-14, 2009.
14. Tai KK, Blondelle SE, Ostresh JM, Houghten RA and Montal M: An N-methyl-D-aspartate receptor channel blocker with neuroprotective activity. Proc Natl Acad Sci USA 13: 3519-3524, 2001.
15. Kasof GM and Gomes BC: Livin, a novel inhibitor of apoptosis protein family member. J Biol Chem 276: 3238-3246, 2001.
16. Lopez AD, Avasarala S, Grewal S, Murali AK and London L: Differential role of the Fas/Fas ligand apoptotic pathway in inflammation and lung fibrosis associated with reovirus 1/L-induced bronchiolitis obliterans organizing pneumonia and acute respiratory distress syndrome. J Immunol 183: 8244-8257, 2009.
17. Guo Q, Jin J, Yuan JX, Zeifman A, Chen J, Shen B and Huang J: VEGF, Bcl-2 and Bad regulated by angiopoietin-1 in oleic acid induced acute lung injury. Biochem Biophys Res Commun 413: 630-636, 2011.
18. Maniatis NA, Sfika A, Nikitopoulou I, et al: Acid-induced acute lung injury in mice is associated with p44/42 and c-Jun N-Terminal kinase activation and requires the function of tumor necrosis factor α receptor I. Shock 38: 381-386, 2012.
19. Zimmermann AM, Roberts KD, Lampland AL, et al: Improved gas exchange and survival after KL-4 surfactant in newborn pigs with severe acute lung injury. Pediatr Pulmonol 45: 782-788, 2010.
20. Kim MN, Lee KE, Hong JY, Heo WI, Kim KW, Kim KE and Sohn MH: Involvement of the MAPK and PI3K pathways in chitinase 3-like 1-regulated hyperoxia-induced airway epithelial cell death. Biochem Biophys Res Commun 421: 790-796, 2012.
21. Roberson EC, Tully JE, Guala AS, et al: Influenza induces endoplasmic reticulum stress, caspase-12-dependent apoptosis, and c-Jun N-terminal kinase-mediated transforming growth factor-β release in lung epithelial cells. Am J Respir Cell Mol Biol 46: 573-581, 2012.
22. Chopra M, Reuben JS and Sharma AC: Acute lung injury: apoptosis and signaling mechanisms. Exp Biol Med (Maywood) 234: 361-371, 2009.
23. Imai Y, Parodo J, Kajikawa O, et al: Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome. JAMA 289: 2104-2112, 2003.
24. Chang L and Karin M: Mammalian MAP kinase signalling cascades. Nature 410: 37-40, 2001.
25. Souza RF, Shewmake K, Terada LS and Spechler SJ: Acid exposure activates the mitogen-activated protein kinase pathways in Barrett's esophagus. Gastroenterology 122: 299-307, 2002.
26. Togbe D, Schnyder-Candrian S, Schnyder B, et al: Toll-like receptor and tumour necrosis factor dependent endotoxin-induced acute lung injury. Int J Exp Pathol 88: 387-391, 2007.
27. Verma G and Datta M: The critical role of JNK in the ER-mitochondrial crosstalk during apoptotic cell death. J Cell Physiol 227: 1791-1795, 2012.
28. Park H, Im JY, Kim J, Choi WS and Kim HS: Effects of apicidin, a histone deacetylase inhibitor, on the regulation of apoptosis in H-ras-transformed breast epithelial cells. Int J Mol Med 21: 325-333, 2008.
29. Goillot E, Raingeaud J, Ranger A, Tepper RI, Davis RJ, Harlow E and Sanchez I: Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway. Proc Natl Acad Sci USA 94: 3302-3307, 1997.