Effects of baclofen on colon inflammation-induced Fos, CGRP and SP expression in spinal cord and brainstem

Brain Research

Volumn 889, Issue 1-2, 2001, Pages 118-130

  Lu, Ying ^a   Westlund, Karin N ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

GABA; Inflammatory bowel disease; Pain; Primary afferent; Viscera

Indexed keywords

ALLYL ISOTHIOCYANATE; BACLOFEN; CALCITONIN GENE RELATED PEPTIDE; PROTEIN FOS; SUBSTANCE P;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLITIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DORSAL RAPHE NUCLEUS; IMMUNOCYTOCHEMISTRY; LOCUS CERULEUS; MALE; NOCICEPTIVE STIMULATION; NONHUMAN; PARABRACHIAL NUCLEUS; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; RAT; SOLITARY TRACT NUCLEUS; SPINAL CORD DORSAL HORN; TISSUE DISTRIBUTION;

ANIMALS; BACLOFEN; BRAIN STEM; CALCITONIN GENE-RELATED PEPTIDE; CELL COUNT; COLITIS; COLON; GABA AGONISTS; GENE EXPRESSION REGULATION; GENES, FOS; IMMUNOHISTOCHEMISTRY; KINETICS; MALE; MEDULLA OBLONGATA; MUSTARD PLANT; NEURONS; PLANT EXTRACTS; PLANT OILS; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; SUBSTANCE P;

EID: 0035910321     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)03124-3     Document Type: Article

References (70)

1. Differential contribution of the two phases of the formalin test to the pattern of c-fos expression in the rat spinal cord: Studies with remifentanil and lidocaine
2. A method for studying pain arising from the urinary bladder in conscious, freely-moving rats
3. Activation by cutaneous or visceral noxious stimulation of spinal neurons projecting to the medullary dorsal reticular nucleus in the rat: A c-fos study
4. Sites of renal pain processing in the rat spinal cord-c-fos study using a percutaneous method to perform ureteral obstruction
5. Organization of the efferent projections from the spinal cervical enlargement to the parabrachial area and periaqueductal gray: A PHA-L study in the rat
6. Distribution and structure of vagal afferent intraganglionic laminar endings (IGLEs) in the rat gastrointestinal tract
7. Further evidence for the involvement of the spinoparabrachial pathway in nociceptive processes - A c-FOS study in the rat
8. Tachykinins: Central and peripheral effects
9. Electrical stimulation of visceral afferent pathways in the pelvic nerve increases c-fos in the rat lumborsacral spinal cord
10. Increased c-fos expression in spinal neurons after irritation of the lower urinary tract in the rat
11. The effect of glutamate antagonists on c-fos expression induced in spinal neurons by irritation of the lower urinary tract
12. Induction of c-fos expression in spinal neurons by nociceptive and nonnociceptive stimulation of LUT
13. Contribution of C-fiber afferent nerves and autonomic pathways in the urinary bladder to spinal c-fos expression induced by bladder irritation
14. Cyclophosphamide cystitis as a model of visceral pain in rats. A survey of hindbrain structures involved in visceroception and nociception using the expression of c-Fos and Krox-24 proteins
15. Cyclophosphamide cystitis as a model of visceral pain in rats: Minor effects at mesodiencephalic levels as revealed by the expression of c-fos, with a note on Krox-24
16. GABA receptor multiplicity. Visualization of different receptor types in the mammalian CNS
17. B receptor site distribution in the rat central nervous system
18. The contribution of GABAB receptor-mediated events to inflammatory pain processing: Carrageenan oedema and associated spinal c-Fos expression in the rat
19. Involvement of the spinoparabrachial pathway in inflammatory nociceptine processes - A c-fos protein study in the awake rat
20. Enhanced pressor response to GABA in the nucleus tractus solitarii of the spontaneously hypertensive rat
21. Complex changes of GABAA and GABAB receptor binding in the spinal cord dorsal horn following peripheral inflammation orneurectomy
22. Pharmacological studies of nociceptive systems using the c-Fos immunohistochemical technique: An indicator of noxiously activated spinal neurons
23. Common patterns of increased and decreased fos expression in midbrain and pons evoked by noxious deep somatic and noxious visceral manipulations in the rat
24. Activation of the c-fos proto-oncogene in the spinal cord following noxious stimulation of the urinary bladder
25. Effects of spinal cord stimulation on touch-evoked allodynia involve GABAergic mechanisms. An experimental study in the mononeuropathic rat
26. Spinal cord stimulation attenuates augmented dorsal horn release of excitatory amino acid in mononeuropathy via a GABAergic mechanism
27. B and adenosine receptor activation
28. Differential c-fos-like protein expression in mechanically versus chemically induced visceral nociception
29. Intrathecal baclofen and muscimol, but not midazolam, are antinociceptive using the rat-formalin model
30. Regulation of neurokinin-1 receptor expression by GABA(B) receptor agonists
31. Topographic organization of spinal and trigeminal somatosensery pathways to the rat parabrachial and Kolliker-Fuse nuclei
32. Inhibition of noxious stimulus-evoked pain behaviors and neuronal fos-like immunoreactivity in the spinal cord of the rat by supraspinal morphine
33. Inhibitory neurotransmitters and nociception: Role of GABA and glycine
34. Morphine or U-50, 488 suppresses Fos protein-like immunoreactivity in the spinal cord and nucleus tractus solitarii evoked by a noxious visceral stimulus in the rat
35. Inducible and constitutive transcription factors in the mammalian nervous system: Control of gen expression by Jun. Fos and Krox, and CREB/ATF proteins
36. Responses of neurons in caudal solitary nucleus of female rats to stimulation of vagina, cervix, uterine horn and colon
37. Role of NMDA and AMPA glutamatergic transmission in spinal c-fos expression after urinary tract irritation
38. Spinal and hindbrain structures involved in visceroception and visceronociception as revealed by the expression of Fos, Jun and Krox-24 proteins
39. Cyclophosphamide cystitis as a model of visceral pain in rats: Model elaboration and spinal structures involved as revealed by the expression of c-Fos and Krox-24 protein
40. Peptides and the primary afferent nociceptor
41. Spinal c-fos expression is differentially induced by brief or persistent noxious stimulation
42. Basal and touch-evoked fos-like immunoreactivity during experimental inflammation in the rat
43. Chronic (-)baclofen or CGP 36742 alters GABAB receptor sensitivity in rat brain and spinal cord
44. Proximal colon distention increases Fos expression in the lumbosacral spinal cord and activates sacral parasympathetic NADPHd-positive neurons in rats
45. The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat
46. Spinal and trigeminal projections to the nucleus of the solitary tract: A possible substrate for somatovisceral and viscerovisceral reflex activation
47. Pharmacological approaches other than opioids in chronic non-cancer pain management
48. The location and morphology of preganglionic neurons and the distribution of visceral afferents from the rat pelvic nerve: A horseradish peroxidase study
49. A hypertensive response to baclofen in the nucleus tractus solitarii in rats
50. Induction and suppression of immediate-early genes in the rat brain by a selective alpha-2-adrenoceptor agonist and antagonist following noxious peripheral stimulation
51. Calcitonin gene-related peptide in viscerosensitive response to colorectal distension in rats
52. Expression of Fos immunoreactivity in the rat supraspinal regions following noxious visceral stimulation
53. Opposite influences of different adrenoceptors on baclofen-induced antinociception in mice
54. Adenosine inhibits action potential-dependent release of calcitonin gene-related peptide- and substance P-like immunoreactivities from primary afferents in rat spinal cord
55. GABAergic mechanisms in antinociception
56. Evidence for the involvement of descending noradrenergic pathways in the antinociceptive effect of baclofen
57. Involvement of GABAB receptors in the antinociception induced by baclofen in the formalin test
58. Spinal cord and trigeminal projections to the pontine parabrachial region in the rat as demonstrated with Phaseolus vulgaris leucoagglutinin
59. Endogenous GABA acts on GABAB receptors in nucleus tractus solitarius to increase blood pressure
60. Hypertension inhibits noxious-evoked c-fos expression in the rat spinal cord
61. Opiates modify induction of c-fos proto-oncogene in the spinal cord of the rat following noxious stimulation
62. Fos-like proteins in the lumbosacral spinal cord following noxious and non-noxious colorectal distention in the rat
63. Differential expression of c-fos and c-jun in two regions of the rat spinal cord following noxious colorectal distention
64. Noxious distention of viscera results in differential c-Fos expression in second order sensory neurons receiving 'sympathetic' or 'parasympathetic' input
65. Attenuation of c-fos expression in the rat lumbosacral spinal cord by morphine or tramadol following noxious colorectal distention
66. Noxious colorectal distention induced-c-Fos protein in limbic brain structures in the rat
67. Differential c-fos expression in the nucleus of the solitary tract and spinal cord following noxious gastric distention in the rat
68. Alterations in spinal cord Fos protein expression induced by bladder stimulation following cystitis
69. Association of spinal lamina I projections with brainstem catecholamine neurons in the monkey