Structural basis for the formation of acylalkylpyrones from two β-ketoacyl units by the fungal type III polyketide synthase CsyB

Journal of Biological Chemistry

Volumn 290, Issue 8, 2015, Pages 5214-5225

  Mori, Takahiro ^a   Yang, Dengfeng ^a   Matsui, Takashi ^b   Hashimoto, Makoto ^c   Morita, Hiroyuki ^b   Fujii, Isao ^c   Abe, Ikuro ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

^c IWATE MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ASPERGILLUS;

ASPERGILLUS ORYZAE; STRUCTURAL BASIS; TYPE III POLYKETIDE SYNTHASE;

KETONES;

ACYLALKYLPYRONE DERIVATIVE; BETA KETO ACID; CYSTEINE; HISTIDINE; NUCLEOPHILE; OXOACID; POLYKETIDE; POLYKETIDE SYNTHASE; PROTEIN CSYB; PYRONE DERIVATIVE; THIOESTER; UNCLASSIFIED DRUG; WATER; FUNGAL PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; ASPERGILLUS ORYZAE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYCLIZATION; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HYDROGEN BOND; HYDROPHOBICITY; IN VITRO STUDY; NONHUMAN; NUCLEOPHILICITY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; CHEMISTRY; ENZYMOLOGY; GENETICS; MISSENSE MUTATION; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ASPERGILLUS ORYZAE;

AMINO ACID SUBSTITUTION; ASPERGILLUS ORYZAE; CRYSTALLOGRAPHY, X-RAY; FUNGAL PROTEINS; MUTATION, MISSENSE; POLYKETIDE SYNTHASES; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84929493715     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.626416     Document Type: Article

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