Aspergillus oryzae CsyB catalyzes the condensation of two β-ketoacyl-CoAs to form 3-acetyl-4-hydroxy-6-alkyl-α-pyrone

Journal of Biological Chemistry

Volumn 289, Issue 29, 2014, Pages 19976-19984

  Hashimoto, Makoto ^a   Koen, Tsukasa ^a   Takahashi, Hiroaki ^a   Suda, Chihiro ^a   Kitamoto, Katsuhiko ^b   Fujii, Isao ^a  

^a IWATE MEDICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ASPERGILLUS; CONDENSATION; ESCHERICHIA COLI; PLANTS (BOTANY); STARTERS; SUBSTRATES;

ASPERGILLUS ORYZAE; DEHYDROACETIC ACIDS; FEEDING EXPERIMENTS; IN-VITRO ANALYSIS; POLYKETIDE SYNTHASES; REACTION CATALYZED; SECONDARY METABOLITES; TYPE III POLYKETIDE SYNTHASE;

CATALYSIS;

2 PYRONE DERIVATIVE; 3 ACETYL 4 HYDROXY 6 ALKYL ALPHA PYRONE; 3 BUTANOYL 4 HYDROXY 6 PROPYL ALPHA PYRONE; ACYL COENZYME A; BETA KETOACYL COENZYME A; BETA KETOHEXANOIC ACID; COENZYME A; CYSPYRONE B; DEHYDROACETIC ACID; HEXANOIC ACID DERIVATIVE; N ACETYLCYSTEAMINE THIOESTER; POLYKETIDE SYNTHASE; PYRONE DERIVATIVE; THIOESTER; UNCLASSIFIED DRUG;

ARTICLE; ASPERGILLUS ORYZAE; BIOSYNTHESIS; CATALYSIS; CHEMICAL ANALYSIS; CHEMICAL INTERACTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; CROSS COUPLING REACTION; CYSB GENE; ENZYME SUBSTRATE; FUNGAL GENE; GENE FUNCTION; GENE IDENTIFICATION; GENE INTERACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; MASS SPECTROMETRY; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN INTERACTION;

ASPERGILLUS; ENZYME CATALYSIS; ENZYME MECHANISM; FATTY ACID METABOLISM; NATURAL PRODUCT BIOSYNTHESIS; POLYKETIDE; TYPE III POLYKETIDE SYNTHASE; Α-PYRONE;

ACYL COENZYME A; ASPERGILLUS ORYZAE; CATALYSIS; FUNGAL PROTEINS; GENES, FUNGAL; KINETICS; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; POLYKETIDE SYNTHASES; PYRONES; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 84904490513     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.569095     Document Type: Article

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