Cloning and structure-function analyses of quinolone- and acridone-producing novel type III polyketide synthases from citrus microcarpa

Journal of Biological Chemistry

Volumn 288, Issue 40, 2013, Pages 28845-28858

  Mori, Takahiro ^a   Shimokawa, Yoshihiko ^a   Matsui, Takashi ^b   Kinjo, Keishi ^a   Kato, Ryohei ^c,f   Noguchi, Hiroshi ^d   Sugio, Shigetoshi ^c   Morita, Hiroyuki ^b   Abe, Ikuro ^a,e  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

^c MITSUBISHI CHEMICAL CORPORATION   (Japan)

^d UNIVERSITY OF SHIZUOKA   (Japan)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^f MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID BIOSYNTHESIS; FUNCTION ANALYSIS; MOLECULAR BASIS; POLYKETIDE SYNTHASES; POLYKETIDES; QUINOLONES; SINGLE PRODUCT; STRUCTURE-FUNCTION ANALYSIS;

BIOCHEMISTRY; KETONES; METABOLITES; NITROGEN COMPOUNDS; SCAFFOLDS;

ALKALOIDS;

4 COUMAROYL COENZYME A; 4 HYDROXY N METHYLQUINOLONE; ACRIDONE DERIVATIVE; ACRIDONE SYNTHASE; ALKALOID DERIVATIVE; AMINO ACID; BENZOPHENONE; BENZOYL COENZYME A; BENZYLIDENEACETONE; CHALCONE; CHALCONE SYNTHASE; COENZYME A; DIKETIDE QUINOLONE; HEXANOYL COENZYME A; MALONYL COENZYME A; N METHYLANTHRANILOYL COENZYME A; NARINGENIN; PHLOROGLUCINOL; POLYKETIDE; POLYKETIDE SYNTHASE; QUINOLONE; QUINOLONE SYNTHASE; SYNTHETASE; TYPE III POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG; VEGETABLE PROTEIN;

AEGLE MARMELOS; ALFALFA; AMINO ACID SEQUENCE; ARTICLE; CALAMONDIN; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME MODIFICATION; ENZYME SPECIFICITY; ENZYME SYNTHESIS; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

BIOSYNTHESIS; CLONING; ENZYMES; POLYKETIDES; STRUCTURAL BIOLOGY;

ACRIDONES; ACYLTRANSFERASES; AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITRUS; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTANT PROTEINS; PHYLOGENY; QUINOLONES; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, PROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84885111664     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.493155     Document Type: Article

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