The role of alveolar epithelial type II-Like cells in uptake of structurally different antigens and in polarisation of local immune responses

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  Akgün, Johnnie ^a   Schabussova, Irma ^a   Schwarzer, Martin ^b   Kozakova, Hana ^b   Kundi, Michael ^c   Wiedermann, Ursula ^a,d  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b INSTITUTE OF MICROBIOLOGY   (Czech Republic)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

6 CARBOXYFLUORESCEIN; ALLERGEN; BET V1 PROTEIN; EPITOPE; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; THYMIC STROMAL LYMPHOPOIETIN; UNCLASSIFIED DRUG; 5,6-DICARBOXYFLUORESCEIN; ANTIGEN; BET V 1 ALLERGEN, BETULA; CYTOKINE; FLUORESCEIN DERIVATIVE; PLANT ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BAGG ALBINO MOUSE; CELL CULTURE; COCULTURE; CONTROLLED STUDY; ELISA KIT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; INTERNALIZATION; LUNG ALVEOLUS EPITHELIUM CELL; LUNG ALVEOLUS EPITHELIUM TYPE 2 LIKE CELL; LYMPHOID TISSUE; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PHENOTYPE; POLARIZATION; PROTEIN TRANSPORT; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SENSITIZATION; STEADY STATE; ANIMAL; CHEMISTRY; CYTOLOGY; EPITHELIUM CELL; HYPERSENSITIVITY; IMMUNE SYSTEM; IMMUNOLOGY; LUNG ALVEOLUS; METABOLISM; RESPIRATORY SYSTEM;

MUS;

ALLERGENS; ANIMALS; ANTIGENS; ANTIGENS, PLANT; CYTOKINES; EPITHELIAL CELLS; EPITOPES; EPITOPES, T-LYMPHOCYTE; FEMALE; FLOW CYTOMETRY; FLUORESCEINS; HYPERSENSITIVITY; IMMUNE SYSTEM; MICE; MICE, INBRED BALB C; PHENOTYPE; PULMONARY ALVEOLI; REAL-TIME POLYMERASE CHAIN REACTION; RESPIRATORY SYSTEM;

EID: 84929484583     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0124777     Document Type: Article

References (37)

1. Geha RS. Allergy and hypersensitivity. Nature versus nurture in allergy and hypersensitivity. Curr Opin Immunol. 2003; 15: 603-608. PMID: 14630191.
2. Wills-Karp M, Santeliz J, Karp CL. The germless theory of allergic disease: revisiting the hygiene hypothesis. Nat Rev Immunol. 2001; 1: 69-75. PMID: 11905816.
3. Akkoc T, Akdis M, Akdis CA. Update in the mechanisms of allergen-specific immunotheraphy. Allergy Asthma Immunol Res. 2011; 3: 11-20. doi:10.4168/aair.2011.3.1.11 PMID: 21217920.
4. Valenta R, Linhart B, Swoboda I, Niederberger V. Recombinant allergens for allergen-specific immunotherapy: 10 years anniversary of immunotherapy with recombinant allergens. Allergy. 2011; 66: 775- 783. doi:10.1111/j.1398-9995.2011.02565.x PMID: 21352238.
5. Winkler B, Wagner S, Repa A, Eichler HG, Scheiner O, Kraft D, et al. Mucosal tolerance as therapy of type I allergy: intranasal application of recombinant Bet v 1, the major birch pollen allergen, leads to the suppression of allergic immune responses and airway inflammation in sensitized mice. Clin Exp Allergy. 2002; 32: 30-36. PMID: 12002733.
6. Wiedermann U, Jahn-Schmid B, Bohle B, Repa A, Renz H, Kraft D, et al. Suppression of antigen-specific T- and B-cell responses by intranasal or oral administration of recombinant bet v 1, the major birch pollen allergen, in a murine model of type I allergy. J Allergy Clin Immunol. 1999; 103: 1202-1210. PMID: 10359907.
7. Hufnagl K, Winkler B, Focke M, Valenta R, Scheiner O, Renz H, et al. Intranasal tolerance induction with polypeptides derived from 3 noncross-reactive major aeroallergens prevents allergic polysensitization in mice. J Allergy Clin Immunol. 2005; 116: 370-376. PMID: 16083792.
8. Hufnagl K, Focke M, Gruber F, Hufnagl P, Loupal G, Scheiner O, et al. Airway inflammation induced after allergic poly-sensitization can be prevented by mucosal but not by systemic administration of polypeptides. Clin Exp Allergy. 2008; 38: 1192-1202. doi:10.1111/j.1365-2222.2008.02992.x PMID: 18462454.
9. Hammad H, Lambrecht BN. Dendritic cells and airway epithelial cells at the interface between innate and adaptive immune responses. Allergy. 2011; 66: 579-587. doi:10.1111/j.1398-9995.2010.02528.x PMID: 21251015.
10. Vinhas R, Cortes L, Cardoso I, Mendes VM, Manadas B, Todo-Bom A, et al. Pollen proteases compromise the airway epithelial barrier through degradation of transmembrane adhesion proteins and lung bioactive peptides. Allergy. 2011; 66: 1088-1098. doi:10.1111/j.1398-9995.2011.02598.xPMID: 21480927.
11. Fehrenbach H. Alveolar epithelial type II cell: defender of the alveolus revisited. Respir Res 2001; 2: 33-46. PMID: 11686863.
12. Singh G, Katyal SL, Brown WE, Collins DL, Mason RJ. Pulmonary lysozyme-a secretory protein of type II pneumocytes in the rat. Am Rev Respir Dis. 1988; 138: 1261-1267. PMID: 3202483.
13. Strunk RC, Eidlen DM, Mason RJ. Pulmonary alveolar type II epithelial cells synthesize and secrete proteins of the classical and alternative complement pathways. J Clin Invest. 1988; 81: 1419-1426. PMID: 2966814.
14. Kolesar L, Brabcova E, Thorburn E, Sekerkova A, Brabcova I, Jaresova M, et al. Cytokine gene expression profile in monocytic cells after a co-culture with epithelial cells. Immunol Res. 2012; 52: 269-275. doi:10.1007/s12026-012-8338-y PMID: 22528126.
15. Stumbles PA, Strickland DH, Pimm CL, Proksch SF, Marsh AM, McWilliam AS, et al. Regulation of dendritic cell recruitment into resting and inflamed airway epithelium: use of alternative chemokine receptors as a function of inducing stimulus. J Immunol. 2001; 167: 228-234. PMID: 11418653.
16. Adam E, Hansen KK, Astudillo Fernandez O, Coulon L, Bex F, Duhant X, et al. The house dust mite allergen Der p 1, unlike Der p 3, stimulates the expression of interleukin-8 in human airway epithelial cells via a proteinase-activated receptor-2-independent mechanism. J Biol Chem. 2006; 281: 6910-6923. PMID: 16293628.
17. Galligan C, Yoshimura T. Phenotypic and functional changes of cytokine-activated neutrophils. Chem Immunol Allergy. 2003; 83: 24-44. PMID: 12947977.
18. Maurer M, von Stebut E. Macrophage inflammatory protein-1. Int J Biochem Cell Biol. 2004; 36: 1882- 1886. PMID: 15203102.
19. Reibman J, Hsu Y, Chen LC, Bleck B, Gordon T. Airway epithelial cells release MIP-3alpha/CCL20 in response to cytokines and ambient particulate matter. Am J Respir Cell Mol Biol. 2003; 28: 648-654. PMID: 12760962.
20. Sauty A, Dziejman M, Taha RA, Iarossi AS, Neote K, Garcia-Zepeda EA, et al. The T cell-specific CXC chemokines IP-10, Mig, and I-TAC are expressed by activated human bronchial epithelial cells. J Immunol. 1999; 162: 3549-3558. PMID: 10092813.
21. Schabussova I, Ul-Haq O, Hoflehner E, Akgun J, Wagner A, Loupal G, et al. Oesophagostomum dentatum extract modulates T cell-dependent immune responses to bystander antigens and prevents the development of allergy in mice. PLoS One. 2013; 8: e67544. doi:10.1371/journal.pone.0067544 PMID: 23844022.
22. Driscoll B, Kikuchi A, Lau AN, Lee J, Reddy R, Jesudason E, et al. Isolation and characterization of distal lung progenitor cells. Methods Mol Biol. 2012; 879: 109-122. doi:10.1007/978-1-61779-815-3-7 PMID: 22610556.
23. Ozsoy Y, Gungor S, Cevher E. Nasal delivery of high molecular weight drugs. Molecules. 2009; 14: 3754-3779. doi:10.3390/molecules14093754 PMID: 19783956.
24. Ryan GM, Kaminskas LM, Kelly BD, Owen DJ, McIntosh MP, Porter CJ. Pulmonary administration of PEGylated polylysine dendrimers: Absorption from the lung versus retention within the lung is highly size-dependent. Mol Pharm. 2013; 10: 2986-2995. doi:10.1021/mp400091n PMID: 23750747.
25. Vermaelen KY, Carro-Muino I, Lambrecht BN, Pauwels RA. Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes. J Exp Med. 2001; 193: 51-60. PMID: 11136820.
26. Bozza S, Gaziano R, Spreca A, Bacci A, Montagnoli C, di Francesco P, et al. Dendritic cells transport conidia and hyphae of Aspergillus fumigatus from the airways to the draining lymph nodes and initiate disparate Th responses to the fungus. J Immunol. 2002; 168: 1362-1371. PMID: 11801677.
27. Lombry C, Bosquillon C, Preat V, Vanbever R. Confocal imaging of rat lungs following intratracheal delivery of dry powders or solutions of fluorescent probes. J Control Release. 2002; 83: 331-341. PMID: 12387942.
28. Salik E, Tyorkin M, Mohan S, George I, Becker K, Oei E, et al. Antigen trafficking and accessory cell function in respiratory epithelial cells. Am J Respir Cell Mol Biol. 1999; 21: 365-379. PMID: 10460754.
29. Schmiedl A, Luhrmann A, Pabst R, Koslowski R. Increased surfactant protein a and d expression in acute ovalbumin-induced allergic airway inflammation in brown norway rats. Int Arch Allergy Immunol. 2009; 148: 118-126. doi:10.1159/000155742 PMID: 18802356.
30. Campbell L, Hollins AJ, Al-Eid A, Newman GR, von Ruhland C, Gumbleton M. Caveolin-1 expression and caveolae biogenesis during cell transdifferentiation in lung alveolar epithelial primary cultures. Biochem Biophys Res Commun. 1999; 262: 744-751. PMID: 10471396.
31. Danto SI, Shannon JM, Borok Z, Zabski SM, Crandall ED. Reversible transdifferentiation of alveolar epithelial cells. Am J Respir Cell Mol Biol. 1995; 12: 497-502. PMID: 7742013.
32. Lambrecht BN, Hammad H. Biology of lung dendritic cells at the origin of asthma. Immunity. 2009; 31: 412-424. doi:10.1016/j.immuni.2009.08.008 PMID: 19766084.
33. Golias J, Schwarzer M, Wallner M, Kverka M, Kozakova H, Srutkova D, et al. Heat-induced structural changes affect OVA-antigen processing and reduce allergic response in mouse model of food allergy. PLoS One. 2012; 7: e37156. doi:10.1371/journal.pone.0037156 PMID: 22629361.
34. Akdis CA, Blesken T, Wymann D, Akdis M, Blaser K. Differential regulation of human T cell cytokine patterns and IgE and IgG4 responses by conformational antigen variants. Eur J Immunol. 1998; 28: 914-925. PMID: 9541587.
35. Becker S, Quay J, Koren HS, Haskill JS. Constitutive and stimulated MCP-1, GRO alpha, beta, and gamma expression in human airway epithelium and bronchoalveolar macrophages. Am J Physiol. 1994; 266: L278-L286. PMID: 8166297.
36. Olszewska-Pazdrak B, Casola A, Saito T, Alam R, Crowe SE, Mei F, et al. Cell-specific expression of RANTES, MCP-1, and MIP-1alpha by lower airway epithelial cells and eosinophils infected with respiratory syncytial virus. J Virol. 1998; 72: 4756-4764. PMID: 9573240.
37. Striz I, Slavcev A, Kalanin J, Jaresova M, Rennard SI. Cell-cell contacts with epithelial cells modulate the phenotype of human macrophages. Inflammation. 2001; 25: 241-246. PMID: 11580100.