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Volumn 14, Issue 9, 2009, Pages 3754-3779

Nasal delivery of high molecular weight drugs

Author keywords

Macromolecular drugs; Nasal delivery; Peptide; Protein; Vaccine

Indexed keywords

DRUG;

EID: 70349556669     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules14093754     Document Type: Review
Times cited : (189)

References (110)
  • 1
    • 0035130249 scopus 로고    scopus 로고
    • The biopharmaceutical aspects of nasal mucoadhesive drug delivery
    • Ugwoke, M.I.; Verbeke, N.; Kinget, R. The biopharmaceutical aspects of nasal mucoadhesive drug delivery. J. Pharm. Pharmacol. 2001, 53, 3-21.
    • (2001) J. Pharm. Pharmacol. , vol.53 , pp. 3-21
    • Ugwoke, M.I.1    Verbeke, N.2    Kinget, R.3
  • 3
    • 0037107001 scopus 로고    scopus 로고
    • Permeability issues in nasal drug delivery
    • Arora, P.; Sharma, S.; Garg, S. Permeability issues in nasal drug delivery. Drug Discov. Today 2002, 7, 967-975.
    • (2002) Drug Discov. Today , vol.7 , pp. 967-975
    • Arora, P.1    Sharma, S.2    Garg, S.3
  • 4
    • 0027985517 scopus 로고
    • Nasal mucosa as an absorption barrier
    • Cornaz, A.L.; Buri, P. Nasal Mucosa as an Absorption Barrier. Eur. J. Pharm. Biopharm. 1994, 40, 261-270.
    • (1994) Eur. J. Pharm. Biopharm. , vol.40 , pp. 261-270
    • Cornaz, A.L.1    Buri, P.2
  • 5
    • 0035940305 scopus 로고    scopus 로고
    • The Nose and paranasal sinuses physiology and anatomy
    • Jones, N. The Nose and paranasal sinuses physiology and anatomy. Adv. Drug Deliv. Rev. 2001, 57, 5-19.
    • (2001) Adv. Drug Deliv. Rev. , vol.57 , pp. 5-19
    • Jones, N.1
  • 6
    • 0007051450 scopus 로고
    • Gennaro, A.R., Ed.; Mack Publishing Company: Easton, PA, USA; Chapter 95
    • Sciarra, J.J. Remington: The Science and Practice of Pharmacy; Gennaro, A.R., Ed.; Mack Publishing Company: Easton, PA, USA, 1995; Chapter 95, p. 1676.
    • (1995) Remington: The Science and Practice of Pharmacy , pp. 1676
    • Sciarra, J.J.1
  • 7
    • 0031544021 scopus 로고    scopus 로고
    • The deposition of solution-based and suspension-based aerosols from metered dose inhalers in healthy subjects and asthmatic patients
    • Sanders, P.; Washington, N.; Frier, M.; Wilson, C.G.; Feely, L.C.; Washington, C. The deposition of solution-based and suspension-based aerosols from metered dose inhalers in healthy subjects and asthmatic patients. S.T.P. Pharm. Sci. 1997, 7, 300-306.
    • (1997) S.T.P. Pharm. Sci. , vol.7 , pp. 300-306
    • Sanders, P.1    Washington, N.2    Frier, M.3    Wilson, C.G.4    Feely, L.C.5    Washington, C.6
  • 8
    • 0025851808 scopus 로고
    • The nasal mucociliary clearance: Relevance to nasal drug delivery
    • Schipper, N.G.; Verhoef, J.C.; Merkus, F.W. The nasal mucociliary clearance: Relevance to nasal drug delivery. Pharm. Res. 1991, 8, 807-814.
    • (1991) Pharm. Res. , vol.8 , pp. 807-814
    • Schipper, N.G.1    Verhoef, J.C.2    Merkus, F.W.3
  • 9
    • 0141872336 scopus 로고    scopus 로고
    • Peptide and protein drug delivery systems for non-parenteral routes of administration
    • ; Frokjaer, S., Hovgaard, L., Eds.; Taylor & Francis: Philadelphia, PA, USA; Chapter 10
    • Ingemann, M.; Frokjaer, S.; Hovgaard, L.; Brøndsted, H. Peptide and Protein Drug Delivery Systems for Non-Parenteral Routes of Administration. In Pharmaceutical Formulation Development of Peptides and Proteins; Frokjaer, S., Hovgaard, L., Eds.; Taylor & Francis: Philadelphia, PA, USA, 2000; Chapter 10, p.189.
    • (2000) Pharmaceutical Formulation Development of Peptides and Proteins , pp. 189
    • Ingemann, M.1    Frokjaer, S.2    Hovgaard, L.3    Brøndsted, H.4
  • 10
    • 70349500661 scopus 로고    scopus 로고
    • Intranasal drug delivery
    • Rathbone, M.J., Hadgraft, J., Roberts, M.S., Eds.; Marcel Dekker, Inc.: New York, NY, USA; Chapter 61
    • Wermeling, D.P.; Miller, J.L. Intranasal Drug Delivery. In Modified Release Drug Delivery Technology; Rathbone, M.J., Hadgraft, J., Roberts, M.S., Eds.; Marcel Dekker, Inc.: New York, NY, USA, 2002; Chapter 61, p. 727.
    • (2002) Modified Release Drug Delivery Technology , pp. 727
    • Wermeling, D.P.1    Miller, J.L.2
  • 11
    • 0027092943 scopus 로고
    • Effects of enzymatic inhibition and increased paracellular shunting on transport of vasopressin analogues in the rat
    • Ungell, A.L.; Andreasson, A.; Lundin, K.; Utter, L. Effects of enzymatic inhibition and increased paracellular shunting on transport of vasopressin analogues in the rat. J. Pharm. Sci. 1992, 87, 640-645.
    • (1992) J. Pharm. Sci. , vol.87 , pp. 640-645
    • Ungell, A.L.1    Andreasson, A.2    Lundin, K.3    Utter, L.4
  • 12
    • 0024391104 scopus 로고
    • Drug absorption through mucosal membranes: Effect of mucosal route and penetrant hydrophilicity
    • Corbo, D.C.; Liu, J.C.; Chien, Y.W. Drug absorption through mucosal membranes: Effect of mucosal route and penetrant hydrophilicity. Pharm. Res. 1989, 6, 848-852.
    • (1989) Pharm. Res. , vol.6 , pp. 848-852
    • Corbo, D.C.1    Liu, J.C.2    Chien, Y.W.3
  • 13
    • 0023370041 scopus 로고
    • Analysis of structural requirements for the absorption of drugs and macromolecules from the nasal cavity
    • McMartin, C.; Hutchinson, L.E.; Hyde, R.; Peters, G.E. Analysis of structural requirements for the absorption of drugs and macromolecules from the nasal cavity. J. Pharm. Sci. 1987, 76, 535-540.
    • (1987) J. Pharm. Sci. , vol.76 , pp. 535-540
    • McMartin, C.1    Hutchinson, L.E.2    Hyde, R.3    Peters, G.E.4
  • 14
    • 0037817352 scopus 로고    scopus 로고
    • Crossing cellular barriers
    • Tuma, P.L.; Hubbard, L. Transcytosis: Crossing cellular barriers. Physiol. Rev. 2003, 83, 871-932.
    • (2003) Physiol. Rev. , vol.83 , pp. 871-932
    • Tuma, P.L.1    Transcytosis, H.L.2
  • 15
    • 0037459005 scopus 로고    scopus 로고
    • Nasal Drug delivery-possibilities, problems and solutions
    • Illum, L. Nasal Drug delivery-possibilities, problems and solutions. J. Control. Release 2003, 87, 187-198.
    • (2003) J. Control. Release , vol.87 , pp. 187-198
    • Illum, L.1
  • 16
    • 0032484626 scopus 로고    scopus 로고
    • Intranasal drug delivery
    • Hussain, A.A. Intranasal drug delivery. Adv. Drug Deliv. Rev. 1998, 29, 39-49.
    • (1998) Adv. Drug Deliv. Rev. , vol.29 , pp. 39-49
    • Hussain, A.A.1
  • 17
    • 0025153296 scopus 로고
    • Absorption of peptides and proteins from the respiratory tract and the potential for development of locally administered vaccine
    • O'Hagan, D.T.; Illum, L. Absorption of peptides and proteins from the respiratory tract and the potential for development of locally administered vaccine. Crit. Rev. Ther. Drug Carrier Syst. 1990, 7, 35-97.
    • (1990) Crit. Rev. Ther. Drug Carrier Syst. , vol.7 , pp. 35-97
    • O'Hagan, D.T.1    Illum, L.2
  • 18
    • 0028046044 scopus 로고
    • The effect of cyclodextrins on the stability of peptides in nasal enzymic systems
    • Irwin, W.J.; Dwivedi, A.K.; Holbrook, P.A.; Dey, M.J. The Effect of cyclodextrins on the stability of peptides in nasal enzymic systems. Pharm. Res. 1994, 11, 1698-1703.
    • (1994) Pharm. Res. , vol.11 , pp. 1698-1703
    • Irwin, W.J.1    Dwivedi, A.K.2    Holbrook, P.A.3    Dey, M.J.4
  • 20
    • 56649103707 scopus 로고    scopus 로고
    • Formulation for delivery the therapeutics proteins
    • Stolnic, S.; Shakesheff, K. Formulation for delivery the therapeutics proteins. Biotechnol. Lett. 2009, 31, 1-11.
    • (2009) Biotechnol. Lett. , vol.31 , pp. 1-11
    • Stolnic, S.1    Shakesheff, K.2
  • 22
    • 0026586445 scopus 로고
    • Drug metabolism in the nasal mucosa
    • Sarkar, M.A. Drug Metabolism in the nasal mucosa. Pharm. Res. 1992, 9, 1-9.
    • (1992) Pharm. Res. , vol.9 , pp. 1-9
    • Sarkar, M.A.1
  • 23
    • 0033851743 scopus 로고    scopus 로고
    • In vivo studies on nasal preparations of ciprofloxacin hydrochloride
    • Ozsoy, Y.; Tuncel, T.; Can, A.; Akev, N.; Birteksöz, S.; Gerçeker, A. In vivo studies on nasal preparations of ciprofloxacin hydrochloride. Pharmazie 2000, 55, 607-609.
    • (2000) Pharmazie , vol.55 , pp. 607-609
    • Ozsoy, Y.1    Tuncel, T.2    Can, A.3    Akev, N.4    Birteksöz, S.5    Gerçeker, A.6
  • 24
    • 0242288486 scopus 로고    scopus 로고
    • Absorption enhancers for nasal drug delivery
    • Davis, S.S.; Illum, L. Absorption enhancers for nasal drug delivery. Clin. Pharmacokinet. 2003, 42, 1107-1128.
    • (2003) Clin. Pharmacokinet. , vol.42 , pp. 1107-1128
    • Davis, S.S.1    Illum, L.2
  • 25
    • 0035936973 scopus 로고    scopus 로고
    • Preparation of desmopressin-containing liposomes for intranasal delivery
    • Law, S.L.; Huang, K.J.; Chou, H.Y. Preparation of desmopressin-containing liposomes for intranasal delivery. J. Control. Release 2001, 70, 375-382.
    • (2001) J. Control. Release , vol.70 , pp. 375-382
    • Law, S.L.1    Huang, K.J.2    Chou, H.Y.3
  • 26
    • 0034665475 scopus 로고    scopus 로고
    • Lipid emulsions as vehicles for enhanced nasal delivery of insulin
    • Mitra, R.; Pezron, I.; Chu, W.A.; Mitra, A.K. Lipid emulsions as vehicles for enhanced nasal delivery of insulin. Int. J. Pharm. 2000, 205, 127-134.
    • (2000) Int. J. Pharm. , vol.205 , pp. 127-134
    • Mitra, R.1    Pezron, I.2    Chu, W.A.3    Mitra, A.K.4
  • 27
    • 65749099862 scopus 로고    scopus 로고
    • Formulation and characterization of nanoemulsion-based drug delivery system of risperidone
    • Kumar, M.; Pathak, K.; Misra, A. Formulation and characterization of nanoemulsion-based drug delivery system of risperidone. Drug Dev. Ind. Pharm. 2009, 35, 387-395.
    • (2009) Drug Dev. Ind. Pharm. , vol.35 , pp. 387-395
    • Kumar, M.1    Pathak, K.2    Misra, A.3
  • 28
    • 70349486155 scopus 로고    scopus 로고
    • Ondansetron-loaded biodegradable microspheres as a nasal sustained delivery system: In vitro/in vivo studies
    • doi: 10.1080/10837450903148257
    • Gungor, S.; Okyar, A.; Erturk-Toker, S.; Baktir, G.; Ozsoy, Y. Ondansetron-loaded biodegradable microspheres as a nasal sustained delivery system: In vitro/in vivo studies. Pharm. Dev. Tech. 2009, doi: 10.1080/10837450903148257.
    • (2009) Pharm. Dev. Tech.
    • Gungor, S.1    Okyar, A.2    Erturk-Toker, S.3    Baktir, G.4    Ozsoy, Y.5
  • 30
    • 0034891405 scopus 로고    scopus 로고
    • Transport of nanoparticles accross the rat nasal mucosa
    • Brooking, J.; Davis, S.S.; Illum, L. Transport of nanoparticles accross the rat nasal mucosa. J. Drug Target. 2001, 9, 267-279.
    • (2001) J. Drug Target , vol.9 , pp. 267-279
    • Brooking, J.1    Davis, S.S.2    Illum, L.3
  • 31
    • 0343683341 scopus 로고    scopus 로고
    • Preparation of microspheres by the solvent evaporation technique
    • McGinity, J.W.; O'Donnell, P.B. Preparation of microspheres by the solvent evaporation technique. Adv. Drug Deliv. Rev. 1997, 28, 25-42.
    • (1997) Adv. Drug Deliv. Rev. , vol.28 , pp. 25-42
    • McGinity, J.W.1    O'Donnell, P.B.2
  • 33
    • 22044457597 scopus 로고    scopus 로고
    • Mucoadhesive microspheres for controlled drug delivery
    • Chowdary, K.P.; Rao, Y.S. Mucoadhesive microspheres for controlled drug delivery. Biol. Pharm. Bull. 2004, 27, 1717-1724.
    • (2004) Biol. Pharm. Bull. , vol.27 , pp. 1717-1724
    • Chowdary, K.P.1    Rao, Y.S.2
  • 34
    • 7444268954 scopus 로고    scopus 로고
    • Recent advances on chitosan-based micro- and nanoparticles in drug delivery
    • Agnihotri, S.A.; Mallikarjuna, N.N.; Aminabhavi, T.M. Recent advances on chitosan-based micro- and nanoparticles in drug delivery. J. Control. Release 2004, 100, 5-28.
    • (2004) J. Control. Release , vol.100 , pp. 5-28
    • Agnihotri, S.A.1    Mallikarjuna, N.N.2    Aminabhavi, T.M.3
  • 35
    • 70349497605 scopus 로고    scopus 로고
    • Kumar, M.N.V.R., Ed.; American Scientific Publisher: Stevenson Ranch, CA, USA, Chapter 8
    • Ozsoy Y. In Handbook of Particulate Drug Delivery; Kumar, M.N.V.R., Ed.; American Scientific Publisher: Stevenson Ranch, CA, USA, 2008; Vol.2, Chapter 8, p.143.
    • (2008) Handbook of Particulate Drug Delivery , vol.2 , pp. 143
    • Ozsoy, Y.1
  • 37
    • 60849101842 scopus 로고    scopus 로고
    • Chitosan and its use in design of insulin delivery system
    • Wong, T.W. Chitosan and its use in design of insulin delivery system. Recent Pat. Drug Deliv. Formul. 2009, 3, 8-25.
    • (2009) Recent Pat. Drug Deliv. Formul. , vol.3 , pp. 8-25
    • Wong, T.W.1
  • 39
    • 0030787377 scopus 로고    scopus 로고
    • Chitosans as absorption enhancers for poorly absorbable drugs 2: Mechanism of absorption enhancement
    • Schipper, N.G.; Olsson, S.; Hoogstraate, J.A.; deBoer, A.G.; Varum, K.M.; Artursson, P. Chitosans as absorption enhancers for poorly absorbable drugs 2: Mechanism of absorption enhancement. Pharm. Res. 1997, 74, 923-929.
    • (1997) Pharm. Res. , vol.74 , pp. 923-929
    • Schipper, N.G.1    Olsson, S.2    Hoogstraate, J.A.3    Deboer, A.G.4    Varum, K.M.5    Artursson, P.6
  • 40
    • 0026800237 scopus 로고
    • In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers
    • Lehr, C.M.; Bouwstra, J.A.; Schacht, E.H.; Junginger, H.E. In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers. Int. J. Pharm. 1992, 78, 43-48.
    • (1992) Int. J. Pharm. , vol.78 , pp. 43-48
    • Lehr, C.M.1    Bouwstra, J.A.2    Schacht, E.H.3    Junginger, H.E.4
  • 41
    • 0028071051 scopus 로고
    • Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2)
    • Artursson, P.; Lindmark, T.; Davis, S.S.; Illum, L. Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2). Pharm. Res. 1994, 77, 1358-1361.
    • (1994) Pharm. Res. , vol.77 , pp. 1358-1361
    • Artursson, P.1    Lindmark, T.2    Davis, S.S.3    Illum, L.4
  • 45
    • 0025026181 scopus 로고
    • Nasal administration of insulin using bioadhesive microspheres as a delivery system
    • Farraj, N.F.; Johansen, B.R.; Davis, SS.; Illum, L. Nasal administration of insulin using bioadhesive microspheres as a delivery system. J. Control. Release 1990, 73, 253-261.
    • (1990) J. Control. Release , vol.73 , pp. 253-261
    • Farraj, N.F.1    Johansen, B.R.2    Davis, S.S.3    Illum, L.4
  • 46
    • 0025076289 scopus 로고
    • Characterization of degradable starch microspheres as a nasal delivery system for drugs
    • Björk, E.; Edman, P. Characterization of degradable starch microspheres as a nasal delivery system for drugs. Int. J. Pharm. 1990, 62, 187-192.
    • (1990) Int. J. Pharm. , vol.62 , pp. 187-192
    • Björk, E.1    Edman, P.2
  • 47
    • 0026769129 scopus 로고
    • Microspheres as a nasal delivery system for peptide drugs
    • Edman, P.; Björk, E.; Ryden, L. Microspheres as a nasal delivery system for peptide drugs. J. Control. Release 1992, 27, 165-172.
    • (1992) J. Control. Release , vol.27 , pp. 165-172
    • Edman, P.1    Björk, E.2    Ryden, L.3
  • 48
    • 0034657667 scopus 로고    scopus 로고
    • Evaluation of starch-maltodextrin-carbopol 974 P mixtures for the nasal delivery of insulin in rabbits
    • Callens, C.; Remon, J.P. Evaluation of starch-maltodextrin-carbopol 974 P mixtures for the nasal delivery of insulin in rabbits. J. Control. Release 2000, 66, 215-220.
    • (2000) J. Control. Release , vol.66 , pp. 215-220
    • Callens, C.1    Remon, J.P.2
  • 49
    • 0035800249 scopus 로고    scopus 로고
    • Bioadhesive starch microspheres and absorption enhancing agents act synergistically to enhance the nasal absorption of polypeptides
    • Illum, L.; Fisher, A.N.; Jabbal-Gill, I.; Davis, S.S. Bioadhesive starch microspheres and absorption enhancing agents act synergistically to enhance the nasal absorption of polypeptides. Int. J. Pharm. 2001, 222, 109-119.
    • (2001) Int. J. Pharm. , vol.222 , pp. 109-119
    • Illum, L.1    Fisher, A.N.2    Jabbal-Gill, I.3    Davis, S.S.4
  • 50
    • 0037448409 scopus 로고    scopus 로고
    • Influence of multiple nasal administrations of bioadhesive powders on the insulin bioavailability
    • Callens, C.; Pringels, E.; Remon, J.P. Influence of multiple nasal administrations of bioadhesive powders on the insulin bioavailability. Int. J. Pharm. 2003, 250, 415-422.
    • (2003) Int. J. Pharm. , vol.250 , pp. 415-422
    • Callens, C.1    Pringels, E.2    Remon, J.P.3
  • 51
    • 37849026961 scopus 로고    scopus 로고
    • The addition of calcium ions to starch/carbopol mixtures enhances the nasal bioavailability of insulin
    • Pringels, E.; Vervaet, C.; Verbeeck, R.; Foreman, P.; Remon, J.P. The addition of calcium ions to starch/carbopol mixtures enhances the nasal bioavailability of insulin. Eur. J. Pharm. Biopharm. 2008, 68, 201-206.
    • (2008) Eur. J. Pharm. Biopharm. , vol.68 , pp. 201-206
    • Pringels, E.1    Vervaet, C.2    Verbeeck, R.3    Foreman, P.4    Remon, J.P.5
  • 52
    • 43249125970 scopus 로고    scopus 로고
    • Effective insulin delivery using starch nanoparticles as a potential trans-nasal mucoadhesive carrier
    • Jain, A.K.; Khar, R. K.; Ahmed, F. J.; Diwan, P.V. Effective insulin delivery using starch nanoparticles as a potential trans-nasal mucoadhesive carrier. Eur. J. Pharm. Biopharm. 2008, 69, 426-435.
    • (2008) Eur. J. Pharm. Biopharm. , vol.69 , pp. 426-435
    • Jain, A.K.1    Khar, R.K.2    Ahmed, F.J.3    Diwan, P.V.4
  • 53
    • 0029154925 scopus 로고
    • Dextran microspheres as a potential nasal drug delivery system for insulin-in vitro and in vivo properties
    • Pereswetoff-Morath, L.; Edman, P. Dextran microspheres as a potential nasal drug delivery system for insulin-in vitro and in vivo properties. Int. J. Pharm. 1995, 724, 37-44.
    • (1995) Int. J. Pharm. , vol.724 , pp. 37-44
    • Pereswetoff-Morath, L.1    Edman, P.2
  • 56
    • 0033300109 scopus 로고    scopus 로고
    • Development of a freeze-dried formulation of insulin-loaded chitosan nanoparticles intended for nasal administration
    • Fernandez-Urrusuno, R.; Romani, D.; Calvo, P.; Vila-Jato, J.L.; Alonso, M.J. Development of a freeze-dried formulation of insulin-loaded chitosan nanoparticles intended for nasal administration. S.T.P. Pharma. Sci. 1999, 9, 429-436.
    • (1999) S.T.P. Pharma. Sci. , vol.9 , pp. 429-436
    • Fernandez-Urrusuno, R.1    Romani, D.2    Calvo, P.3    Vila-Jato, J.L.4    Alonso, M.J.5
  • 57
    • 11944263459 scopus 로고    scopus 로고
    • Nasal delivery of insulin using chitosan microspheres
    • Varshosaz, J.; Sadrai, H.; Alinagari, R. Nasal delivery of insulin using chitosan microspheres. J. Microencapsul. 2004, 21, 761-774.
    • (2004) J. Microencapsul. , vol.21 , pp. 761-774
    • Varshosaz, J.1    Sadrai, H.2    Alinagari, R.3
  • 58
    • 33750926464 scopus 로고    scopus 로고
    • In vivo evealuation of a nasal insulin delivery system based on thiolated chitosan
    • Krauland, A.H.; Leitner, V.M.; Grabovac, V.; Bernkop-Schnürch, A. In vivo evealuation of a nasal insulin delivery system based on thiolated chitosan. J. Pharm. Sci. 2006, 95, 2463-2472.
    • (2006) J. Pharm. Sci. , vol.95 , pp. 2463-2472
    • Krauland, A.H.1    Leitner, V.M.2    Grabovac, V.3    Bernkop-Schnürch, A.4
  • 59
    • 34447263071 scopus 로고    scopus 로고
    • Chitosan/cyclodextrin nanoparticles as macromolecular drug delivery system
    • Krauland, A.H.; Alonso, M.J. Chitosan/cyclodextrin nanoparticles as macromolecular drug delivery system. Int. J. Pharm. 2007, 340, 134-142.
    • (2007) Int. J. Pharm. , vol.340 , pp. 134-142
    • Krauland, A.H.1    Alonso, M.J.2
  • 60
    • 34250835820 scopus 로고    scopus 로고
    • Chitosan reduced gold nanoparticles as novel carriers for transmucosal delivery of insulin
    • Bhumkar, D.R.; Joshi, H.M.; Sastry, M.; Pokharkar, V.B. Chitosan reduced gold nanoparticles as novel carriers for transmucosal delivery of insulin. Pharm. Res. 2007, 24, 1415-1426.
    • (2007) Pharm. Res. , vol.24 , pp. 1415-1426
    • Bhumkar, D.R.1    Joshi, H.M.2    Sastry, M.3    Pokharkar, V.B.4
  • 61
    • 57349184053 scopus 로고    scopus 로고
    • Chitosan-NAC nanoparticles as a Vehicle for nasal absorption enhancement of insulin
    • Wang, X.; Zheng, C.; Wu, Z.; Teng, D.; Zhang, X.; Wang, Z.; Li, C. Chitosan-NAC nanoparticles as a Vehicle for nasal absorption enhancement of insulin. J. Biomed. Mater. Res. 2009, 88, 150-161.
    • (2009) J. Biomed. Mater. Res. , vol.88 , pp. 150-161
    • Wang, X.1    Zheng, C.2    Wu, Z.3    Teng, D.4    Zhang, X.5    Wang, Z.6    Li, C.7
  • 62
    • 64149091646 scopus 로고    scopus 로고
    • New generation of hybrid poly/oligosaccharide nanoparticles as carriers for the nasal delivery of macromolecules
    • Teijeiro-Osorio, D.; Remunán-López, C.; Alonso, M.J. New generation of hybrid poly/oligosaccharide nanoparticles as carriers for the nasal delivery of macromolecules. Biomacromolecules 2009, 10, 243-249.
    • (2009) Biomacromolecules , vol.10 , pp. 243-249
    • Teijeiro-Osorio, D.1    Remunán-López, C.2    Alonso, M.J.3
  • 63
    • 33744797668 scopus 로고    scopus 로고
    • Aminated gelatin microspheres as a nasal delivery system for peptide drugs: Evaluation of in vitro release and in vivo absorption in rats
    • Wang, J.; Tabata, Y.; Morimoto. K. Aminated gelatin microspheres as a nasal delivery system for peptide drugs: Evaluation of in vitro release and in vivo absorption in rats. J. Control. Release 2006, 113, 31-37.
    • (2006) J. Control. Release , vol.113 , pp. 31-37
    • Wang, J.1    Tabata, Y.2    Morimoto., K.3
  • 64
  • 65
    • 71849101103 scopus 로고    scopus 로고
    • Alternative routes of administration for systemic delivery of protein pharmaceuticals
    • Moeller, E.M.; Jorgensen, L. Alternative routes of administration for systemic delivery of protein pharmaceuticals. Drug Discov. Today Technol. 2008, doi:10.1016-j.ddtec.2008.11.005.
    • (2008) Drug Discov. Today Technol.
    • Moeller, E.M.1    Jorgensen, L.2
  • 66
    • 0028131270 scopus 로고
    • Nasal absorption of desmopressin in rats and sheep. Effect of a bioadhesive microsphere delivery system
    • Critchley, H.; Davis, S.S.; Farraj, N.F.; Illum, L. Nasal absorption of desmopressin in rats and sheep. Effect of a bioadhesive microsphere delivery system. J. Pharm. Pharmacol. 1994, 46, 651-656.
    • (1994) J. Pharm. Pharmacol. , vol.46 , pp. 651-656
    • Critchley, H.1    Davis, S.S.2    Farraj, N.F.3    Illum, L.4
  • 67
    • 67349148276 scopus 로고    scopus 로고
    • Clinical study shows improved absorption of desmopressin with novel formulation
    • Fransén, N.; Bredenberg, S.; Björk, E. Clinical study shows improved absorption of desmopressin with novel formulation. Pharm. Res. 2009, 26, 1618-1625.
    • (2009) Pharm. Res. , vol.26 , pp. 1618-1625
    • Fransén, N.1    Bredenberg, S.2    Björk, E.3
  • 68
    • 0035067784 scopus 로고    scopus 로고
    • Evaluation of gelatin microspheres for nasal and intramuscular administrations of salmon calcitonin
    • Morimoto, K.; Katsumata, H.; Yabuta, T.; Iwanaga, K.; Kakemi, M.; Tabata, Y.; Ikada, Y. Evaluation of gelatin microspheres for nasal and intramuscular administrations of salmon calcitonin. Eur. J. Pharm. Sci. 2001, 13, 179-185.
    • (2001) Eur. J. Pharm. Sci. , vol.13 , pp. 179-185
    • Morimoto, K.1    Katsumata, H.2    Yabuta, T.3    Iwanaga, K.4    Kakemi, M.5    Tabata, Y.6    Ikada, Y.7
  • 69
    • 18844392068 scopus 로고    scopus 로고
    • Effect of chitosan on the intranasal absorption of salmon calcitonin in sheep
    • Hinchcliffe, M.; Jabbal-Gill, I.; Smith, A. Effect of chitosan on the intranasal absorption of salmon calcitonin in sheep. J. Pharm. Pharmacol. 2005, 57, 681-687.
    • (2005) J. Pharm. Pharmacol. , vol.57 , pp. 681-687
    • Hinchcliffe, M.1    Jabbal-Gill, I.2    Smith, A.3
  • 71
    • 0035859976 scopus 로고    scopus 로고
    • Improved nasal bioavailability of elcatonin by insoluble powder formulation
    • Ishikawa, F.; Katsura, M.; Tamai, I.; Tsuji, A. Improved nasal bioavailability of elcatonin by insoluble powder formulation. Int. J. Pharm. 2001, 224, 105-114.
    • (2001) Int. J. Pharm. , vol.224 , pp. 105-114
    • Ishikawa, F.1    Katsura, M.2    Tamai, I.3    Tsuji, A.4
  • 72
    • 0028217784 scopus 로고
    • The bioavailability of intranasal salmon calcitonin in healthy volunteers with and without a permeation enhancer
    • Lee, W.A.; Ennis, R.D.; Longenecker, J.P.; Bengtsson, P. The bioavailability of intranasal salmon calcitonin in healthy volunteers with and without a permeation enhancer. Pharm. Res. 1994, 77, 747-750.
    • (1994) Pharm. Res. , vol.77 , pp. 747-750
    • Lee, W.A.1    Ennis, R.D.2    Longenecker, J.P.3    Bengtsson, P.4
  • 74
    • 33749559943 scopus 로고    scopus 로고
    • Improved nasal absorption of salmon calcitonin by powdery formulation with N-acetyl-L-cysteine as a mucolytic agent
    • Matsuyama, T.; Morita, T.; Horikiri, Y.; Yamahara, H.; Yoshino, H. Improved nasal absorption of salmon calcitonin by powdery formulation with N-acetyl-L-cysteine as a mucolytic agent. J. Control. Release 2006, 775, 183-188.
    • (2006) J. Control. Release , vol.775 , pp. 183-188
    • Matsuyama, T.1    Morita, T.2    Horikiri, Y.3    Yamahara, H.4    Yoshino, H.5
  • 75
    • 29244452120 scopus 로고    scopus 로고
    • Enhancement of nasal absorption of large molecular weight compounds by combination of mucolytic agent and nonionic surfactant
    • Matsuyama, T.; Morita, T.; Horikiri, Y.; Yamahara, H.; Yoshino, H. Enhancement of nasal absorption of large molecular weight compounds by combination of mucolytic agent and nonionic surfactant. J. Control. Release 2006, 770, 347-352.
    • (2006) J. Control. Release , vol.770 , pp. 347-352
    • Matsuyama, T.1    Morita, T.2    Horikiri, Y.3    Yamahara, H.4    Yoshino, H.5
  • 76
    • 0026543325 scopus 로고
    • Bioavailability of leuprolide acetate following nasal and inhalation delivery to rats and healthy humans
    • Adjei, A.; Sundberg, D.; Miller, J.; Chun, A. Bioavailability of leuprolide acetate following nasal and inhalation delivery to rats and healthy humans. Pharm. Res. 1992, 9, 244-249.
    • (1992) Pharm. Res. , vol.9 , pp. 244-249
    • Adjei, A.1    Sundberg, D.2    Miller, J.3    Chun, A.4
  • 77
    • 0029556939 scopus 로고
    • Enhanced nasal delivery of luteinizing hormone releasing hormone agonist buserelin by oleic acid solubilized and stabilized in hydroxypropyl-beta- cyclodextrin
    • Abe, K.; Irie, T.; Uekama, K. Enhanced nasal delivery of luteinizing hormone releasing hormone agonist buserelin by oleic acid solubilized and stabilized in hydroxypropyl-beta-cyclodextrin. Chem. Pharm. Bull. 1995, 43, 2232-2237.
    • (1995) Chem. Pharm. Bull. , vol.43 , pp. 2232-2237
    • Abe, K.1    Irie, T.2    Uekama, K.3
  • 78
    • 0034005096 scopus 로고    scopus 로고
    • Novel chitosan-based delivery systems for the nasal administration of a LHRH-analogue
    • Illum, L.; Watts, P.; Fisher, A.N.; Jabbal Gill, I.; Davis, S.S. Novel chitosan-based delivery systems for the nasal administration of a LHRH-analogue. S.T.P. Pharma Sci. 2000, 70, 89-94.
    • (2000) S.T.P. Pharma Sci. , vol.70 , pp. 89-94
    • Illum, L.1    Watts, P.2    Fisher, A.N.3    Jabbal Gill, I.4    Davis, S.S.5
  • 79
    • 0025224846 scopus 로고
    • Investigation of the nasal absorption of biosynthetic human growth hormone in sheep - Use of a bioadhesive microsphere delivery system
    • Illum, L.; Farraj, N.F.; Davis, S.S.; Johansen, B.R.; O'Hagan, D.T. Investigation of the nasal absorption of biosynthetic human growth hormone in sheep - use of a bioadhesive microsphere delivery system. Int. J. Pharm. 1990, 63, 207-211.
    • (1990) Int. J. Pharm. , vol.63 , pp. 207-211
    • Illum, L.1    Farraj, N.F.2    Davis, S.S.3    Johansen, B.R.4    O'Hagan, D.T.5
  • 80
    • 0029959813 scopus 로고    scopus 로고
    • And bioactivity of three different doses of nasal growth hormone (GH) administered to GH-deficient patients: Comparison with intravenous and subcutaneous administration
    • Laursen, T.; Grandjean, B.; Jorgensen, J.O.; Christiansen, J.S. Bioavailability and bioactivity of three different doses of nasal growth hormone (GH) administered to GH-deficient patients: Comparison with intravenous and subcutaneous administration. Eur. J. Endocrinol. 1996, 735, 309-315.
    • (1996) Eur. J. Endocrinol. , vol.735 , pp. 309-315
    • Laursen, T.1    Grandjean, B.2    Jorgensen, J.O.3    Bioavailability, S.C.J.4
  • 81
    • 0028577536 scopus 로고
    • Epithelial transport and bioavailability of intranasally administered human growth hormone formulated with the absorption enhancers idecanoyl-L-alpha-phosphatidylcholine and Alpha-cyclodextrin in rabbits
    • Agerholm, C.; Bastholm, L.; Johansen, P.B.; Nielsen M.H.; Elling, F. Epithelial transport and bioavailability of intranasally administered human growth hormone formulated with the absorption enhancers idecanoyl-L-alpha- phosphatidylcholine and Alpha-cyclodextrin in rabbits. J. Pharm. Sci. 1994, 83, 1706-1711.
    • (1994) J. Pharm. Sci. , vol.83 , pp. 1706-1711
    • Agerholm, C.1    Bastholm, L.2    Johansen, P.B.3    Nielsen, M.H.4    Elling, F.5
  • 82
    • 0027415975 scopus 로고
    • Intranasal administration of human growth hormone (hGH) in combination with a membrane permeation enhancer in patients with GH deficiency: A pharmacokinetic study
    • Hedin, L.; Olsson, B.; Diczfalusy, M.; Flyg, C.; Petersson, A.S.; Rosberg, S.; Albertsson- Wikland, K. Intranasal administration of human growth hormone (hGH) in combination with a membrane permeation enhancer in patients with GH deficiency: A pharmacokinetic study. J. Clinical Endocrinol. Metab. 1993, 76, 962-967.
    • (1993) J. Clinical Endocrinol. Metab. , vol.76 , pp. 962-967
    • Hedin, L.1    Olsson, B.2    Diczfalusy, M.3    Flyg, C.4    Petersson, A.S.5    Rosberg, S.6    Albertsson-Wikland, K.7
  • 83
    • 7444254865 scopus 로고    scopus 로고
    • Nasal Delivery of human growth hormone: In vitro and in vivo evaluation of a thiomer/glutathione microparticulate delivery system
    • Leitner, V.M.; Guggi, D.; Krauland, A.H.; Bernkop-Schnürch, A. Nasal Delivery of human growth hormone: In vitro and in vivo evaluation of a thiomer/glutathione microparticulate delivery system. J. Control. Release 2004, 700, 87-95.
    • (2004) J. Control. Release , vol.700 , pp. 87-95
    • Leitner, V.M.1    Guggi, D.2    Krauland, A.H.3    Bernkop-Schnürch, A.4
  • 86
    • 27744588682 scopus 로고    scopus 로고
    • Nasal administration of heparin-loaded microspheres based on poly(lactic acid)
    • Yildiz, A.; Okyar, A.; Baktir, G.; Araman, A.; Ozsoy, Y. Nasal administration of heparin-loaded microspheres based on poly(lactic acid). Il Farmaco 2005, 60, 919-924.
    • (2005) Il Farmaco , vol.60 , pp. 919-924
    • Yildiz, A.1    Okyar, A.2    Baktir, G.3    Araman, A.4    Ozsoy, Y.5
  • 87
    • 0035998957 scopus 로고    scopus 로고
    • Nasal administration of low molecular weight heparin
    • Arnold, J.; Ahsan, F.; Meezan, E.; Pillion, D.J. Nasal administration of low molecular weight heparin. J. Pharm. Sci. 2002, 97, 1707-1714.
    • (2002) J. Pharm. Sci. , vol.97 , pp. 1707-1714
    • Arnold, J.1    Ahsan, F.2    Meezan, E.3    Pillion, D.J.4
  • 88
    • 3242673511 scopus 로고    scopus 로고
    • Cyclodextrins in nasal delivery of low-molecular-weight heparins in vivo and in vitro studies
    • Yang, T.; Hussain, A.; Paulson, J.; Abbruscato, T.J.; Ahsan, F. Cyclodextrins in nasal delivery of low-molecular-weight heparins in vivo and in vitro studies. Pharm. Res. 2004, 21, 1127-1136.
    • (2004) Pharm. Res. , vol.21 , pp. 1127-1136
    • Yang, T.1    Hussain, A.2    Paulson, J.3    Abbruscato, T.J.4    Ahsan, F.5
  • 89
    • 1542724890 scopus 로고    scopus 로고
    • Chain length-dependent effects of alkylmaltosides on nasal absorption of enoxaparin
    • Mustafa, F.; Yang, T.; Khan, M.A.; Ahsan, F. Chain length-dependent effects of alkylmaltosides on nasal absorption of enoxaparin. J. Pharm. Sci. 2004, 93, 675-683.
    • (2004) J. Pharm. Sci. , vol.93 , pp. 675-683
    • Mustafa, F.1    Yang, T.2    Khan, M.A.3    Ahsan, F.4
  • 90
    • 1042292671 scopus 로고    scopus 로고
    • Alkanoylsucroses in nasal delivery of low molecular weight heparins: In vivo absorption and reversibility studies in rats
    • Yang, T.; Mustafa, F.; Ahsan, F. Alkanoylsucroses in nasal delivery of low molecular weight heparins: In vivo absorption and reversibility studies in rats. J. Pharm. Pharmacol. 2004, 56, 53-60.
    • (2004) J. Pharm. Pharmacol. , vol.56 , pp. 53-60
    • Yang, T.1    Mustafa, F.2    Ahsan, F.3
  • 91
    • 33750365562 scopus 로고    scopus 로고
    • Positively charged polyethylenimines enhance nasal absorption of the negatively charged drug, low molecular weight heparin
    • Yang, T.; Hussain, A.; Bai, S.; Khalil, I.A.; Harashima, H.; Ahsan, F. Positively charged polyethylenimines enhance nasal absorption of the negatively charged drug, low molecular weight heparin. J. Control. Release 2006, 775, 289-297.
    • (2006) J. Control. Release , vol.775 , pp. 289-297
    • Yang, T.1    Hussain, A.2    Bai, S.3    Khalil, I.A.4    Harashima, H.5    Ahsan, F.6
  • 92
    • 26944447851 scopus 로고    scopus 로고
    • Preparation characterization and nasal delivery of α-cobrotoxin- loaded poly(lactide-co-glycolide)/polyanhydride microspheres
    • Li, Y.; Jiang, H.L.; Zhu, K.J.; Liu, J.H.; Hao, Y.L. Preparation, characterization and nasal delivery of α-cobrotoxin-loaded poly(lactide-co-glycolide)/polyanhydride microspheres. J. Control. Release 2005, 708, 10-20.
    • (2005) J. Control. Release , vol.708 , pp. 10-20
    • Li, Y.1    Jiang, H.L.2    Zhu, K.J.3    Liu, J.H.4    Hao, Y.L.5
  • 95
    • 28744444699 scopus 로고    scopus 로고
    • Nasal recombinant hirudin-2 delivery: Absorption and its mechanism in vivo and in vitro studies
    • Zhang, Y.; Zhang, Q.; Sun, Y.; Sun, J.; Wang, X.; Chen, M. Nasal recombinant hirudin-2 delivery: absorption and its mechanism in vivo and in vitro studies. Biol. Pharm. Bull. 2005, 28, 2263-2267. (Pubitemid 41757417)
    • (2005) Biological and Pharmaceutical Bulletin , vol.28 , Issue.12 , pp. 2263-2267
    • Zhang, Y.1    Zhang, Q.2    Sun, Y.3    Sun, J.4    Wang, X.5    Chen, M.6
  • 96
    • 0026518527 scopus 로고
    • Tolerability and absorption enhancement of intranasally administered octreotide by sodium taurodihydrofusidate in healthy subjects
    • Kissel, T.; Drewe, J.; Bantle, S.; Rummelt, A.; Beglinger, C. Tolerability and absorption enhancement of intranasally administered octreotide by sodium taurodihydrofusidate in healthy subjects. Pharm. Res. 1992, 9, 52-57.
    • (1992) Pharm. Res. , vol.9 , pp. 52-57
    • Kissel, T.1    Drewe, J.2    Bantle, S.3    Rummelt, A.4    Beglinger, C.5
  • 97
    • 0030576623 scopus 로고    scopus 로고
    • Nasal delivery of octreotide: Absorption enhancement by particulate carrier systems
    • Oechslein, C.R.; Fricker, G.; Kissel, T. Nasal delivery of octreotide: absorption enhancement by particulate carrier systems. Int. J. Pharm. 1996, 739, 25-32.
    • (1996) Int. J. Pharm. , vol.739 , pp. 25-32
    • Oechslein, C.R.1    Fricker, G.2    Kissel, T.3
  • 99
    • 0037157272 scopus 로고    scopus 로고
    • Influence of dose and immunization route on the serum IgG antibody response to BSA loaded PLGA microspheres
    • Gutierro, I.G.; Hernandez, R.M. ; Igartua, M.; Gascon, A. R.; Pedraz, J. L. Influence of dose and immunization route on the serum IgG antibody response to BSA loaded PLGA microspheres. Vaccine 2002, 20, 2181-2190.
    • (2002) Vaccine , vol.20 , pp. 2181-2190
    • Gutierro, I.G.1    Hernandez, R.M.2    Igartua, M.3    Gascon, A.R.4    Pedraz, J.L.5
  • 100
    • 0035940315 scopus 로고    scopus 로고
    • Nasal delivery of epitope based vaccines
    • Olszewska, W.; Steward, M.W. Nasal delivery of epitope based vaccines. Adv. Drug Deliv. Rev. 2001, 57, 161-171.
    • (2001) Adv. Drug Deliv. Rev. , vol.57 , pp. 161-171
    • Olszewska, W.1    Steward, M.W.2
  • 101
    • 34250332586 scopus 로고    scopus 로고
    • Implication of nanoparticles/microparticles in mucosal vaccine delivery
    • Vyas, S.P.; Gupta, P.N. Implication of nanoparticles/microparticles in mucosal vaccine delivery. Expert Rev. Vaccines 2007, 6, 401-418.
    • (2007) Expert Rev. Vaccines , vol.6 , pp. 401-418
    • Vyas, S.P.1    Gupta, P.N.2
  • 102
    • 62849109927 scopus 로고    scopus 로고
    • Pharmaceutical aspects of intranasal delivery of vaccines using particulate systems
    • Sharma, S.; Mukkur, T.K.S.; Benson, H.A.E.; Chen, Y. Pharmaceutical aspects of intranasal delivery of vaccines using particulate systems. J. Pharm. Sci. 2009, 98, 812-843.
    • J. Pharm. Sci. , vol.2009 , Issue.98 , pp. 812-843
    • Sharma, S.1    Mukkur, T.K.S.2    Benson, H.A.E.3    Chen, Y.4
  • 103
    • 35349027729 scopus 로고    scopus 로고
    • Nanoparticles and microparticles as vaccine-delivery systems
    • Singh, M.; Chakrapani, A.; O'Hagan, D. Nanoparticles and microparticles as vaccine-delivery systems. Expert Rev. Vaccines 2007, 6, 797-808.
    • (2007) Expert Rev. Vaccines , vol.6 , pp. 797-808
    • Singh, M.1    Chakrapani, A.2    O'Hagan, D.3
  • 107
    • 31544467293 scopus 로고    scopus 로고
    • Diphtheria toxoid loaded poly-(epsilon- caprolactone) nanoparticles as mucosal vaccine delivery systems
    • Singh, J.; Pandit, S.; Bramwell, V.W.; Alpar, H.O. Diphtheria toxoid loaded poly-(epsilon- caprolactone) nanoparticles as mucosal vaccine delivery systems. Methods 2006, 38, 96-105.
    • (2006) Methods , vol.38 , pp. 96-105
    • Singh, J.1    Pandit, S.2    Bramwell, V.W.3    Alpar, H.O.4
  • 110
    • 0034950338 scopus 로고    scopus 로고
    • Tetanus toxoid loaded nanoparticles from sulfobutylated poly(vinyl alcohol)-graft-poly(lactide-co-glycolide): Evaluation of antibody response after oral and nasal application in mice
    • Jung, T.; Kamm, W.; Breitenbach, A.; Hungerer, K.D.; Hundt, E.; Kissel, T. Tetanus toxoid loaded nanoparticles from sulfobutylated poly(vinyl alcohol)-graft-poly(lactide-co-glycolide): Evaluation of antibody response after oral and nasal application in mice. Pharm. Res. 2001, 18,352-360.
    • (2001) Pharm. Res. , vol.18 , pp. 352-360
    • Jung, T.1    Kamm, W.2    Breitenbach, A.3    Hungerer, K.D.4    Hundt, E.5    Kissel, T.6


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