Pulmonary administration of PEGylated polylysine dendrimers: Absorption from the lung versus retention within the lung is highly size-dependent

Molecular Pharmaceutics

Volumn 10, Issue 8, 2013, Pages 2986-2995

  Ryan, Gemma M ^a   Kaminskas, Lisa M ^a   Kelly, Brian D ^b   Owen, David J ^b   McIntosh, Michelle P ^a   Porter, Christopher J H ^a  

^a MONASH UNIVERSITY   (Australia)

^b Starpharma Holdings Limited   (Australia)

Author keywords

dendrimer; drug delivery; lung; metabolism; PEGylation; pharmacokinetics; pulmonary absorption

Indexed keywords

DENDRIMER; MACROGOL; MACROGOL 200; MACROGOL 2300; MACROGOL 570; PEGYLATED POLYLYSINE DENDRIMER; POLYLYSINE; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG ABSORPTION; DRUG ADMINISTRATION ROUTE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG EXCRETION; DRUG HALF LIFE; DRUG INSTILLATION; DRUG METABOLISM; DRUG RETENTION; LUNG; LUNG LAVAGE; LUNG PARENCHYMA; MALE; MAXIMUM PLASMA CONCENTRATION; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION; URINARY EXCRETION;

ABSORPTION; ANIMALS; DENDRIMERS; LUNG; MALE; POLYETHYLENE GLYCOLS; POLYLYSINE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84881363461     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400091n     Document Type: Article

References (38)

1. Patton, J. S.; Fishburn, C. S.; Weers, J. G. The Lungs as a Portal of Entry for Systemic Drug Delivery Proc. Am. Thor. Soc. 2004, 1 (4) 338-344
2. Heinemann, L. The failure of exubera: are we beating a dead horse? J. Diabetes Sci. Technol. 2008, 2 (3) 518-29
3. Patton, J. S. Mechanisms of macromolecule absorption by the lungs Adv. Drug Delivery Rev. 1996, 19 (1) 3-36
4. Stone, K. C.; Mercer, R. R.; Gehr, P.; Stockstill, B.; Crapo, J. D. Allometric relationships of cell numbers and size in the mammalian lung Am. J. Respir. Cell Mol. Biol. 1992, 6 (2) 235-43
5. Rytting, E.; Nguyen, J.; Wang, X.; Kissel, T. Biodegradable polymeric nanocarriers for pulmonary drug delivery Expert Opin. Drug Delivery 2008, 5 (6) 629-639
6. Patton, J. S.; Platz, R. M. (D) Routes of delivery: Case studies: (2) Pulmonary delivery of peptides and proteins for systemic action Adv. Drug Delivery Rev. 1992, 8 (2-3) 179-196
7. A. Steimer, E. H.; Lehr, C.-M. Cell Culture Models of the Respiratory Tract Relevant to Pulmonary Drug Delivery J. Aerosol Med. 2005, 18 (2) 137-182
8. Patton, J. S.; Fishburn, C. S.; Weers, J. G. The Lungs as a Portal of Entry for Systemic Drug Delivery Proc. Am. Thorac. Soc. 2004, 1 (4) 338-344
9. Liu, Y.; Lu, W.-l.; Zhang, X.; Wang, X.-q.; Zhang, H.; Zhang, Q. Pharmacodynamics and pharmacokinetics of recombinant hirudin via four non-parenteral routes Peptides 2005, 26 (3) 423-430
10. Yamamoto, A.; Iseki, T.; Ochi-Sugiyama, M.; Okada, N.; Fujita, T.; Muranishi, S. Absorption of water-soluble compounds with different molecular weights and [Asu1.7]-eel calcitonin from various mucosal administration sites J. Controlled Release 2001, 76 (3) 363-374
11. Edwards, D. A.; Hanes, J.; Caponetti, G.; Hrkach, J.; Ben-Jebria, A.; Eskew, M. L.; Mintzes, J.; Deaver, D.; Lotan, N.; Langer, R. Large Porous Particles for Pulmonary Drug Delivery Science 1997, 276 (5320) 1868-1872
12. Patton, J. S.; Byron, P. R. Inhaling medicines: delivering drugs to the body through the lungs Nat. Rev. Drug Discovery 2007, 6 (1) 67-74
13. Hussain, A.; Arnold, J. J.; Khan, M. A.; Ahsan, F. Absorption enhancers in pulmonary protein delivery J. Controlled Release 2004, 94 (1) 15-24
14. Mark, M. B.; Cory, J. B. Nanoparticle formulations in pulmonary drug delivery Med. Res. Rev. 2009, 196-212
15. Scheuch, G.; Kohlhaeufl, M. J.; Brand, P.; Siekmeier, R. Clinical perspectives on pulmonary systemic and macromolecular delivery Adv. Drug Delivery Rev. 2006, 58 (9-10) 996-1008
16. Quie, P. G. Lung defense against infection J. Pediatrics 1986, 108 (5, Part 2) 813-816
17. Smola, M.; Vandamme, T.; Sokolowski, A. Nanocarriers as pulmonary drug delivery systems to treat and to diagnose respiratory and non respiratory diseases Int. J. Nanomed. 2008, 3 (1) 1-19
18. Zeng, X. M.; Martin, G. P.; Marriott, C. The controlled delivery of drugs to the lung Int. J. Pharmaceutics 1995, 124 (2) 149-164
19. Olsson, B.; Bondesson, E.; Borgström, L.; Edsbäcker, S.; Eirefelt, S.; Ekelund, K.; Gustavsson, L.; Hegelund-Myrbäck, T., Pulmonary Drug Metabolism, Clearance, and Absorption Controlled Pulmonary Drug Delivery; Smyth, H. D. C.; Hickey, A. J., Eds.; Springer: New York: 2011; pp 21-50.
20. Kobayashi, S.; Kondo, S.; Juni, K. Critical factors on pulmonary absorption of peptides and proteins (diffusional barrier and metabolic barrier) Eur. J. Pharm. Sci. 1996, 4 (6) 367-372
21. Chandrasekar, D.; Sistla, R.; Ahmad, F. J.; Khar, R. K.; Diwan, P. V. The development of folate-PAMAM dendrimer conjugates for targeted delivery of anti-arthritic drugs and their pharmacokinetics and biodistribution in arthritic rats Biomaterials 2007, 28 (3) 504-512
22. Kaminskas, L. M.; Kelly, B. D.; McLeod, V. M.; Boyd, B. J.; Krippner, G. Y.; Williams, E. D.; Porter, C. J. H. Pharmacokinetics and Tumor Disposition of PEGylated, Methotrexate Conjugated Poly-l-lysine Dendrimers Mol. Pharmaceutics 2009, 6 (4) 1190-1204
23. Kaminskas, L. M.; Boyd, B. J.; Porter, C. J. H. Dendrimer pharmacokinetics: the effect of size, structure and surface characteristics on ADME properties Nanomedicine 2011, 6 (6) 1063-1084
24. Gillies, E. R.; Fréchet, J. M. J. Dendrimers and dendritic polymers in drug delivery Drug Discovery Today 2005, 10 (1) 35-43
25. Dong, Z.; Hamid, K. A.; Gao, Y.; Lin, Y.; Katsumi, H.; Sakane, T.; Yamamoto, A. Polyamidoamine dendrimers can improve the pulmonary absorption of insulin and calcitonin in rats J. Pharm. Sci. 2011, 100 (5) 1866-1878
26. Inapagolla, R.; Guru, B. R.; Kurtoglu, Y. E.; Gao, X.; Lieh-Lai, M.; Bassett, D. J. P.; Kannan, R. M. In vivo efficacy of dendrimer- methylprednisolone conjugate formulation for the treatment of lung inflammation Int. J. Pharmaceutics 2010, 399 (1-2) 140-147
27. Malik, N.; Evagorou, E. G.; Duncan, R. Dendrimer-platinate: a novel approach to cancer chemotherapy Anti-Cancer Drugs 1999, 10 (8) 767-776
28. Kaminskas, L. M.; Boyd, B. J.; Karellas, P.; Krippner, G. Y.; Lessene, R.; Kelly, B.; Porter, C. J. H. The Impact of Molecular Weight and PEG Chain Length on the Systemic Pharmacokinetics of PEGylated Poly l-Lysine Dendrimers Mol. Pharmaceutics 2008, 5 (3) 449-463
29. Kaminskas, L. M.; Kota, J.; McLeod, V. M.; Kelly, B. D.; Karellas, P.; Porter, C. J. H. PEGylation of polylysine dendrimers improves absorption and lymphatic targeting following SC administration in rats J. Controlled Release 2009, 140 (2) 108-116
30. Boyd, B. J.; Kaminskas, L. M.; Karellas, P.; Krippner, G.; Lessene, R.; Porter, C. J. H. Cationic Poly-l-lysine Dendrimers: Pharmacokinetics, Biodistribution, and Evidence for Metabolism and Bioresorption after Intravenous Administration to Rats Mol. Pharmaceutics 2006, 3 (5) 614-627
31. Gillies, E. R.; Dy, E.; Fréchet, J. M. J.; Szoka, F. C. Biological Evaluation of Polyester Dendrimer: Poly(ethylene oxide) "Bow-Tie" Hybrids with Tunable Molecular Weight and Architecture Mol. Pharmaceutics 2005, 2 (2) 129-138
32. Bai, S.; Thomas, C.; Ahsan, F. Dendrimers as a carrier for pulmonary delivery of enoxaparin, a low-molecular weight heparin J. Pharm. Sci. 2007, 96 (8) 2090-2106
33. Bai, S.; Ahsan, F. Synthesis and Evaluation of Pegylated Dendrimeric Nanocarrier for Pulmonary Delivery of Low Molecular Weight Heparin Pharm. Res. 2009, 26 (3) 539-548
34. Fox, M. E.; Guillaudeu, S.; Fréchet, J. M. J.; Jerger, K.; Macaraeg, N.; Szoka, F. C. Synthesis and In Vivo Antitumor Efficacy of PEGylated Poly(l-lysine) Dendrimer-Camptothecin Conjugates Mol. Pharmaceutics 2009, 6 (5) 1562-1572
35. Kaminskas, L. M.; Kelly, B. D.; McLeod, V. M.; Sberna, G.; Owen, D. J.; Boyd, B. J.; Porter, C. J. H. Characterisation and tumour targeting of PEGylated polylysine dendrimers bearing doxorubicin via a pH labile linker J. Controlled Release 2011, 152 (2) 241-248
36. Folkesson, H. G.; Weström, B. R.; Dahlbäck, M.; Lundin, S.; Karlsson, B. W. Passage of Aerosolized BSA and the Nona-peptide dDAVP via the Respiratory Tract in Young and Adult Rats Exp. Lung Res. 1992, 18 (5) 595-614
37. Lee, K. C.; Chae, S. Y.; Kim, T. H.; Lee, S.; Lee, E. S.; Youn, Y. S. Intrapulmonary potential of polyethylene glycol-modified glucagon-like peptide-1s as a type 2 anti-diabetic agent Regul. Pept. 2009, 152 (1-3) 101-107
38. Baginski, L.; Gobbo, O. L.; Tewes, F.; Salomon, J. J.; Healy, A. M.; Bakowsky, U.; Ehrhardt, C. In vitro and in vivo characterisation of PEG-lipid-based micellar complexes of salmon calcitonin for pulmonary delivery Pharm. Res. 2012, 29 (6) 1425-34