Adrenomedullin promotes differentiation of oligodendrocyte precursor cells into myelin-basic-protein expressing oligodendrocytes under pathological conditions in vitro

Stem Cell Research

Volumn 15, Issue 1, 2015, Pages 68-74

  Maki, Takakuni ^a   Takahashi, Yoko ^a,b   Miyamoto, Nobukazu ^a   Liang, Anna C ^a   Ihara, Masafumi ^c   Lo, Eng H ^a   Arai, Ken ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ADRENOMEDULLIN; COBALT CHLORIDE; MYELIN BASIC PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; ADRENOMEDULLIN (22-52); ADRENOMEDULLIN RECEPTOR; PEPTIDE FRAGMENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL HYPOXIA; CELL MATURATION; CONTROLLED STUDY; IN VITRO STUDY; MYELIN SHEATH; NEWBORN; NONHUMAN; OLIGODENDROCYTE PRECURSOR CELL; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; WHITE MATTER; ANIMAL; CELL PROLIFERATION; CELL SURVIVAL; CYTOLOGY; DRUG EFFECTS; METABOLISM; NEURAL STEM CELL; PHOSPHORYLATION; SPRAGUE DAWLEY RAT;

RATTUS;

ADRENOMEDULLIN; ANIMALS; CELL DIFFERENTIATION; CELL HYPOXIA; CELL PROLIFERATION; CELL SURVIVAL; MYELIN BASIC PROTEIN; NEURAL STEM CELLS; OLIGODENDROGLIA; PEPTIDE FRAGMENTS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENOMEDULLIN;

EID: 84929471649     PISSN: 18735061     EISSN: 18767753     Source Type: Journal    
DOI: 10.1016/j.scr.2015.05.001     Document Type: Article

References (45)

1. Arai K., Lo E.H. An oligovascular niche: cerebral endothelial cells promote the survival and proliferation of oligodendrocyte precursor cells. J. Neurosci. 2009, 29:4351-4355.
2. Baumann N., Pham-Dinh D. Biology of oligodendrocyte and myelin in the mammalian central nervous system. Physiol. Rev. 2001, 81:871-927.
3. Benowitz L.I., Carmichael S.T. Promoting axonal rewiring to improve outcome after stroke. Neurobiol. Dis. 2010, 37:259-266.
4. Dimou L., Simon C., Kirchhoff F., Takebayashi H., Gotz M. Progeny of Olig2-expressing progenitors in the gray and white matter of the adult mouse cerebral cortex. J. Neurosci. 2008, 28:10434-10442.
5. Emery B. Regulation of oligodendrocyte differentiation and myelination. Science 2010, 330:779-782.
6. Franklin R.J., Ffrench-Constant C. Remyelination in the CNS: from biology to therapy. Nat. Rev. Neurosci. 2008, 9:839-855.
7. Funfschilling U., Supplie L.M., Mahad D., Boretius S., Saab A.S., Edgar J., Brinkmann B.G., Kassmann C.M., Tzvetanova I.D., Mobius W., Diaz F., Meijer D., Suter U., Hamprecht B., Sereda M.W., Moraes C.T., Frahm J., Goebbels S., Nave K.A. Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity. Nature 2012, 485:517-521.
8. Griffiths I., Klugmann M., Anderson T., Yool D., Thomson C., Schwab M.H., Schneider A., Zimmermann F., McCulloch M., Nadon N., Nave K.A. Axonal swellings and degeneration in mice lacking the major proteolipid of myelin. Science 1998, 280:1610-1613.
9. Hinson J.P., Kapas S., Smith D.M. Adrenomedullin, a multifunctional regulatory peptide. Endocr. Rev. 2000, 21:138-167.
10. Hurtado O., Serrano J., Sobrado M., Fernandez A.P., Lizasoain I., Martinez-Murillo R., Moro M.A., Martinez A. Lack of adrenomedullin, but not complement factor H, results in larger infarct size and more extensive brain damage in a focal ischemia model. Neuroscience 2010, 171:885-892.
11. Jiang Q., Zhang Z.G., Chopp M. MRI evaluation of white matter recovery after brain injury. Stroke 2010, 41:S112-S113.
12. Kato J., Tsuruda T., Kita T., Kitamura K., Eto T. Adrenomedullin: a protective factor for blood vessels. Arterioscler. Thromb. Vasc. Biol. 2005, 25:2480-2487.
13. Kitamura K., Kangawa K., Kawamoto M., Ichiki Y., Nakamura S., Matsuo H., Eto T. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem. Biophys. Res. Commun. 1993, 192:553-560.
14. Kotter M.R., Stadelmann C., Hartung H.P. Enhancing remyelination in disease-can we wrap it up?. Brain 2011, 134:1882-1900.
15. Lappe-Siefke C., Goebbels S., Gravel M., Nicksch E., Lee J., Braun P.E., Griffiths I.R., Nave K.A. Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination. Nat. Genet. 2003, 33:366-374.
16. Larrayoz I.M., Ochoa-Callejero L., Garcia-Sanmartin J., Vicario-Abejon C., Martinez A. Role of adrenomedullin in the growth and differentiation of stem and progenitor cells. Int. Rev. Cell Mol. Biol. 2012, 297:175-234.
17. Levine J.M., Reynolds R., Fawcett J.W. The oligodendrocyte precursor cell in health and disease. Trends Neurosci. 2001, 24:39-47.
18. Lopez J., Martinez A. Cell and molecular biology of the multifunctional peptide, adrenomedullin. Int. Rev. Cytol. 2002, 221:1-92.
19. Maki T., Ihara M., Fujita Y., Nambu T., Miyashita K., Yamada M., Washida K., Nishio K., Ito H., Harada H., Yokoi H., Arai H., Itoh H., Nakao K., Takahashi R., Tomimoto H. Angiogenic and vasoprotective effects of adrenomedullin on prevention of cognitive decline after chronic cerebral hypoperfusion in mice. Stroke 2011, 42:1122-1128.
20. Maki T., Ihara M., Fujita Y., Nambu T., Harada H., Ito H., Nakao K., Tomimoto H., Takahashi R. Angiogenic roles of adrenomedullin through vascular endothelial growth factor induction. Neuroreport 2011, 22:442-447.
21. Maki T., Hayakawa K., Pham L.D., Xing C., Lo E.H., Arai K. Biphasic mechanisms of neurovascular unit injury and protection in CNS diseases. CNS Neurol. Disord. Drug Targets 2013, 12:302-315.
22. Martinez-Herrero S., Larrayoz I.M., Ochoa-Callejero L., Garcia-Sanmartin J., Martinez A. Adrenomedullin as a growth and cell fate regulatory factor for adult neural stem cells. Stem Cells Int. 2012, 2012:804717.
23. Mitome-Mishima Y., Miyamoto N., Tanaka R., Shimosawa T., Oishi H., Arai H., Hattori N., Urabe T. Adrenomedullin deficiency and aging exacerbate ischemic white matter injury after prolonged cerebral hypoperfusion in mice. BioMed Res. Int. 2014, 2014:861632.
24. Miyamoto N., Tanaka R., Shimosawa T., Yatomi Y., Fujita T., Hattori N., Urabe T. Protein kinase A-dependent suppression of reactive oxygen species in transient focal ischemia in adrenomedullin-deficient mice. J. Cereb. Blood Flow Metab. 2009, 29:1769-1779.
25. Miyamoto N., Maki T., Pham L.D., Hayakawa K., Seo J.H., Mandeville E.T., Mandeville J.B., Kim K.W., Lo E.H., Arai K. Oxidative stress interferes with white matter renewal after prolonged cerebral hypoperfusion in mice. Stroke 2013, 44:3516-3521.
26. Miyamoto N., Pham L.D., Hayakawa K., Matsuzaki T., Seo J.H., Magnain C., Ayata C., Kim K.W., Boas D., Lo E.H., Arai K. Age-related decline in oligodendrogenesis retards white matter repair in mice. Stroke 2013, 44:2573-2578.
27. Miyashita K., Itoh H., Arai H., Suganami T., Sawada N., Fukunaga Y., Sone M., Yamahara K., Yurugi-Kobayashi T., Park K., Oyamada N., Sawada N., Taura D., Tsujimoto H., Chao T.H., Tamura N., Mukoyama M., Nakao K. The neuroprotective and vasculo-neuro-regenerative roles of adrenomedullin in ischemic brain and its therapeutic potential. Endocrinology 2006, 147:1642-1653.
28. Nagaya N., Mori H., Murakami S., Kangawa K., Kitamura S. Adrenomedullin: angiogenesis and gene therapy. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2005, 288:R1432-R1437.
29. Nait-Oumesmar B., Picard-Riera N., Kerninon C., Baron-Van Evercooren A. The role of SVZ-derived neural precursors in demyelinating diseases: from animal models to multiple sclerosis. J. Neurol. Sci. 2008, 265:26-31.
30. Paus T., Zijdenbos A., Worsley K., Collins D.L., Blumenthal J., Giedd J.N., Rapoport J.L., Evans A.C. Structural maturation of neural pathways in children and adolescents: in vivo study. Science 1999, 283:1908-1911.
31. Pham L.D., Hayakawa K., Seo J.H., Nguyen M.N., Som A.T., Lee B.J., Guo S., Kim K.W., Lo E.H., Arai K. Crosstalk between oligodendrocytes and cerebral endothelium contributes to vascular remodeling after white matter injury. Glia 2012, 60:875-881.
32. Philips T., Rothstein J.D. Glial cells in amyotrophic lateral sclerosis. Exp. Neurol. 2014, 262:111-120.
33. Savitz S.I., Fisher M. Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials. Ann. Neurol. 2007, 61:396-402.
34. Scholz J., Klein M.C., Behrens T.E., Johansen-Berg H. Training induces changes in white-matter architecture. Nat. Neurosci. 2009, 12:1370-1371.
35. Serrano J., Alonso D., Fernandez A.P., Encinas J.M., Lopez J.C., Castro-Blanco S., Fernandez-Vizarra P., Richart A., Santacana M., Uttenthal L.O., Bentura M.L., Martinez-Murillo R., Martinez A., Cuttitta F., Rodrigo J. Adrenomedullin in the central nervous system. Microsc. Res. Tech. 2002, 57:76-90.
36. Shindo T., Sakurai T., Kamiyoshi A., Ichikawa-Shindo Y., Shimoyama N., Iinuma N., Arai T., Miyagawa S. Regulation of adrenomedullin and its family peptide by RAMP system-lessons from genetically engineered mice. Curr. Protein Pept. Sci. 2013, 14:347-357.
37. Tixier E., Leconte C., Touzani O., Roussel S., Petit E., Bernaudin M. Adrenomedullin protects neurons against oxygen glucose deprivation stress in an autocrine and paracrine manner. J. Neurochem. 2008, 106:1388-1403.
38. Tosto G., Zimmerman M.E., Carmichael O.T., Brickman A.M. Predicting aggressive decline in mild cognitive impairment: the importance of white matter hyperintensities. JAMA Neurol. 2014, 71:872-877.
39. Ueta Y., Kitamura K., Isse T., Shibuya I., Kabashima N., Yamamoto S., Kangawa K., Matsuo H., Eto T., Yamashita H. Adrenomedullin-immunoreactive neurons in the paraventricular and supraoptic nuclei of the rat. Neurosci. Lett. 1995, 202:37-40.
40. Vergano-Vera E., Fernandez A.P., Hurtado-Chong A., Vicario-Abejon C., Martinez A. Lack of adrenomedullin affects growth and differentiation of adult neural stem/progenitor cells. Cell Tissue Res. 2010, 340:1-11.
41. Watanabe K., Takayasu M., Noda A., Hara M., Takagi T., Suzuki Y., Yoshia J. Adrenomedullin reduces ischemic brain injury after transient middle cerebral artery occlusion in rats. Acta Neurochir. 2001, 143:1157-1161.
42. Xia C.F., Yin H., Borlongan C.V., Chao J., Chao L. Adrenomedullin gene delivery protects against cerebral ischemic injury by promoting astrocyte migration and survival. Hum. Gene Ther. 2004, 15:1243-1254.
43. Xia C.F., Yin H., Borlongan C.V., Chao J., Chao L. Postischemic infusion of adrenomedullin protects against ischemic stroke by inhibiting apoptosis and promoting angiogenesis. Exp. Neurol. 2006, 197:521-530.
44. Yang Y., Rosenberg G.A. Blood-brain barrier breakdown in acute and chronic cerebrovascular disease. Stroke 2011, 42:3323-3328.
45. Young K.M., Psachoulia K., Tripathi R.B., Dunn S.J., Cossell L., Attwell D., Tohyama K., Richardson W.D. Oligodendrocyte dynamics in the healthy adult CNS: evidence for myelin remodeling. Neuron 2013, 77:873-885.