Genetic Analysis Using an Isogenic Mating Pair of Aspergillus fumigatus Identifies Azole Resistance Genes and Lack of MAT Locus’s Role in Virulence

PLoS Pathogens

Volumn 11, Issue 4, 2015, Pages

  Losada, Liliana ^a   Sugui, Janyce A ^b   Eckhaus, Michael A ^c   Chang, Yun C ^b   Mounaud, Stephanie ^a   Figat, Abigail ^b   Joardar, Vinita ^a   Pakala, Suman B ^a   Pakala, Suchitra ^a   Venepally, Pratap ^a   Fedorova, Natalie ^d   Nierman, William C ^a   Kwon Chung, Kyung J ^b  

^a J CRAIG VENTER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ITRACONAZOLE; POSACONAZOLE; PYRROLE; VORICONAZOLE; ANTIFUNGAL AGENT; FUNGAL PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; METHYLSTEROL MONOOXYGENASE; MIXED FUNCTION OXIDASE; PYRROLE DERIVATIVE; STEROL 14ALPHA DEMETHYLASE; TRIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPERGILLUS FUMIGATUS; AZOLE RESISTANCE; CHROMOSOME SEGREGATION; COMPARATIVE GENOMIC HYBRIDIZATION; DRUG RESISTANCE; FUNGAL STRAIN; FUNGAL VIRULENCE; GENE LOCUS; GENE MUTATION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC RECOMBINATION; GENETIC VARIABILITY; HISTOLOGY; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PHENOTYPE; SINGLE NUCLEOTIDE POLYMORPHISM; ANIMAL; ASPERGILLOSIS; BAGG ALBINO MOUSE; CROSS BREEDING; DRUG EFFECTS; FUNGAL MATING TYPE GENE; GENETICS; ISOLATION AND PURIFICATION; LARVA; METABOLISM; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MOTH; MULTIDRUG RESISTANCE; MUTATION; PATHOGENICITY; PATHOLOGY; SURVIVAL ANALYSIS; VIRULENCE;

ANIMALIA; ASPERGILLUS FUMIGATUS;

ANIMALS; ANTIFUNGAL AGENTS; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; AZOLES; CROSSES, GENETIC; DRUG RESISTANCE, MULTIPLE, FUNGAL; FUNGAL PROTEINS; GENES, MATING TYPE, FUNGAL; GENETIC LOCI; HYDROXYMETHYLGLUTARYL COA REDUCTASES; ITRACONAZOLE; LARVA; MICE, INBRED BALB C; MICROBIAL SENSITIVITY TESTS; MIXED FUNCTION OXYGENASES; MOTHS; MUTATION; STEROL 14-DEMETHYLASE; SURVIVAL ANALYSIS; TRIAZOLES; VIRULENCE; VORICONAZOLE;

EID: 84929470013     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004834     Document Type: Article

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