Development of the affinity materials for phosphorylated proteins/peptides enrichment in phosphoproteomics analysis

ACS Applied Materials and Interfaces

Volumn 7, Issue 16, 2015, Pages 8377-8392

  Wang, Zhi Gang ^a,b   Lv, Nan ^a,b   Bi, Wen Zhi ^a,b   Zhang, Ji Lin ^a   Ni, Jia Zuan ^a,c  

^a CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c SHENZHEN UNIVERSITY   (China)

Author keywords

affinity materials; development; enrichment; phosphopeptide; phosphoprotein

Indexed keywords

BLAST ENRICHMENT; MASS SPECTROMETRY; PROTEINS;

BIOLOGICAL PROCESS; DEVELOPMENT; FUTURE CHALLENGES; PHOSPHOPEPTIDES; PHOSPHOPROTEIN; PHOSPHORYLATED PROTEINS; PROTEIN PHOSPHORYLATION; SUPPRESSION EFFECTS;

PHOSPHORYLATION;

NANOCOMPOSITE; PHOSPHOPEPTIDE; PHOSPHOPROTEIN;

CHEMISTRY; PHOSPHORYLATION; PROCEDURES; PROTEOMICS;

NANOCOMPOSITES; PHOSPHOPEPTIDES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEOMICS;

EID: 84929459070     PISSN: 19448244     EISSN: 19448252     Source Type: Journal    
DOI: 10.1021/acsami.5b01254     Document Type: Article

References (146)

1. Li, Y.; Zhang, X. M.; Deng, C. H. Functionalized Magnetic Nanoparticles for Sample Preparation in Proteomics and Peptidomics Analysis Chem. Soc. Rev. 2013, 42, 8517-8539
2. Zhang, Y.; Guo, Y. M.; Xianyu, Y. L.; Chen, W. W.; Zhao, Y. Y.; Jiang, X. Y. Nanomaterials for Ultrasensitive Protein Detection Adv. Mater. 2013, 25, 3802-3819
3. Zhang, L.; Wu, S. B.; Li, C.; Yang, Q. H. Facile Synthesis of Hybrid Hollow Mesoporous Nanospheres with High Content of Interpenetrating Polymers for Size-Selective Peptides/Proteins Erichment Chem. Commun. 2012, 48, 4190-4192
4. Liu, Q.; Shi, J. B.; Sun, J. T.; Wang, T.; Zeng, L. X.; Jiang, G. B. Graphene and Graphene Oxide Sheets Supported on Silica as Versatile and High-Performance Adsorbents for Solid-Phase Extraction Angew. Chem., Int. Ed. 2011, 50, 5913-5917
5. Zhang, Y. T.; Ma, W. F.; Li, D.; Yu, M.; Guo, J.; Wang, C. C. Benzoboroxole-Functionalized Magnetic Core/Shell Microspheres for Highly Specific Enrichment of Glycoproteins under Physiological Conditions Small 2013, 10, 1379-1386
6. Shao, M. F.; Ning, F. Y.; Zhao, J. W.; Wei, M.; Evans, D. G.; Duan, X. Preparation of Fe3O4@SiO2@Layered Double Hydroxide Core-Shell Microspheres for Magnetic Separation of Proteins J. Am. Chem. Soc. 2012, 134, 1071-1077
7. Lampe, P. D.; Lau, A. F. The Effects of Connexin Phosphorylation on Gap Junctional Communication Int. J. Biochem. Cell Biol. 2004, 36, 1171-1186
8. Mayr, B.; Montminy, M. Transcriptional Regulation by The Phosphorylation-Dependent Factor CREB Nat. Rev. Mol. Cell Biol. 2001, 2, 599-609
9. O'Connor, D. S.; Grossman, D.; Plescia, J.; Li, F.; Zhang, H.; Villa, A.; Tognin, S.; Marchisio, P. C.; Altieri, D. C. Regulation of Apoptosis at Cell Division by p34cdc2 Phosphorylation of Survivin Proc. Natl. Acad. Sci. U.S.A. 2000, 97, 13103-13107
10. Roux, P. P.; Thibault, P. The Coming of Age of Phosphoproteomics - from Large Data Sets to Inference of Protein Functions Mol. Cell Proteomics 2013, 12, 3453-3464
11. Mann, M.; Ong, S. E.; Gronborg, M.; Steen, H.; Jensen, O. N.; Pandey, A. Analysis of Protein Phosphorylation Using Mass Spectrometry: Deciphering the Phosphoproteome Trends Biotechnol. 2002, 20, 261-268
12. Beltran, L.; Cutillas, P. R. Advances in Phosphopeptide Enrichment Techniques for Phosphoproteomics Amino Acids 2012, 43, 1009-1024
13. Batalha, I. L.; Lowe, C. R.; Roque, A. C. Platforms for Enrichment of Phosphorylated Proteins and Peptides in Proteomics Trends Biotechnol. 2012, 30, 100-110
14. Moser, K.; White, F. M. Phosphoproteomic Analysis of Rat Liver by High Capacity IMAC and LC-MS/MS J. Proteome Res. 2006, 5, 98-104
15. Tsai, C. F.; Wang, Y. T.; Chen, Y. R.; Lai, C. Y.; Lin, P. Y.; Pan, K. T.; Chen, J. Y.; Khoo, K. H.; Chen, Y. J. Immobilized Metal Affinity Chromatography Revisited: pH/Acid Control Toward High Selectivity in Phosphoproteomics J. Proteome Res. 2008, 7, 4058-4069
16. Fukuda, I.; Hirabayashi-Ishioka, Y.; Sakikawa, I.; Ota, T.; Yokoyama, M.; Uchiumi, T.; Morita, A. Optimization of Enrichment Conditions on TiO2 Chromatography Using Glycerol As an Additive Reagent for Effective Phosphoproteomic Analysis J. Proteome Res. 2013, 12, 5587-5597
17. Leitner, A.; Sturm, M.; Lindner, W. Tools for Analyzing the Phosphoproteome and Other Phosphorylated Biomolecules: A Review Anal. Chim. Acta 2011, 703, 19-30
18. Leitner, A. Phosphopeptide Enrichment Using Metal Oxide Affinity Chromatography Trend Anal. Chem. 2010, 29, 177-185
19. Andersson, L.; Porath, J. Isolation of Phosphoproteins by Immobilized Metal (Fe3+) Affinity Chromatography Anal. Biochem. 1986, 154, 250-254
20. Kinoshita, E.; Kinoshita-Kikuta, E.; Takiyama, K.; Koike, T. Phosphate-Binding Tag, a New Tool to Visualize Phosphorylated Proteins Mol. Cell Proteomics 2006, 5, 749-757
21. Hu, Q.; Hu, S. Q.; Zhang, Z. Y.; Zhou, X. M.; Yang, S. S.; Zhang, Y.; Chen, X. G. Fe3+-Immobilized Nanoparticle-Modified Capillary for Capillary Electrophoretic Separation of Phosphoproteins and Non-phosphoproteins Electrophoresis 2011, 32, 2867-2873
22. Posewitz, M. C.; Tempst, P. Immobilized Gallium(III) Affinity Chromatography of Phosphopeptides Anal. Chem. 1999, 71, 2883-2892
23. Ficarro, S. B.; Adelmant, G.; Tomar, M. N.; Zhang, Y.; Cheng, V. J.; Marto, J. A. Magnetic Bead Processor for Rapid Evaluation and Optimization of Parameters for Phosphopeptide Enrichment Anal. Chem. 2009, 81, 4566-4575
24. Yu, Z. Y.; Han, G. H.; Sun, S. T.; Jiang, X. N.; Chen, R.; Wang, F. J.; Wu, R. A.; Ye, M. L.; Zou, H. F. Preparation of Monodisperse Immobilized Ti4+ Affinity Chromatography Microspheres for Specific Enrichment of Phosphopeptides Anal. Chim. Acta 2009, 636, 34-41
25. Zhao, P. X.; Zhao, Y.; Guo, X. F.; Wang, H.; Zhang, H. S. Isolation of Phosphopeptides Using Zirconium-Chlorophosphonazo Chelate-Modified Silica Nanoparticles J. Chromatogr. A 2011, 1218, 2528-2539
26. Han, G. H.; Ye, M. L.; Zou, H. F. Development of Phosphopeptide Enrichment Techniques for Phosphoproteome Analysis Analyst 2008, 133, 1128-1138
27. Zhao, P. X.; Guo, X. F.; Wang, H.; Qi, C. B.; Xia, H. S.; Zhang, H. S. Zirconium Arsenate-Modified Silica Nanoparticles for Specific Capture of Phosphopeptides and Direct Analysis by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Anal. Bioanal. Chem. 2012, 402, 1041-1056
28. Li, X. S.; Xu, L. D.; Zhu, G. T.; Yuan, B. F.; Feng, Y. Q. Zirconium Arsenate-Modified Magnetic Nanoparticles: Preparation, Characterization and Application to the Enrichment of Phosphopeptides Analyst 2012, 137, 959-967
29. Stanghellini, P. L.; Boccaleri, E.; Diana, E.; Alberti, G.; Vivani, R. Vibrational Study of Some Layered Structures Based on Titanium and Zirconium Phosphates Inorg. Chem. 2004, 43, 5698-5703
30. Troup, J. M.; Clearfield, A. On the Mechanism of Ion Exchange in Zirconium Phosphates. 20. Refinement of the Crystal Structure of α-Zirconium Phosphate Inorg. Chem. 1977, 16, 3311-3314
31. Nonglaton, G.; Benitez, I. O.; Guisle, I.; Pipelier, M.; Léger, J.; Dubreuil, D.; Tellier, C.; Talham, D. R.; Bujoli, B. New Approach to Oligonucleotide Microarrays Using Zirconium Phosphonate-Modified Surfaces J. Am. Chem. Soc. 2004, 126, 1497-1502
32. Zhou, H. J.; Xu, S. Y.; Ye, M. L.; Feng, S.; Pan, C. S.; Jiang, X. G.; Li, X.; Han, G. H.; Fu, Y.; Zou, H. F. Zirconium Phosphonate-Modified Porous Silicon for Highly Specific Capture of Phosphopeptides and MALDI-TOF MS Analysis J. Proteome Res. 2006, 5, 2431-2437
33. Wei, J. Y.; Zhang, Y. J.; Wang, J. L.; Tan, F.; Liu, J. F.; Cai, Y.; Qian, X. H. Highly Efficient Enrichment of Phosphopeptides by Magnetic Nanoparticles Coated with Zirconium Phosphonate for Phosphoproteome Analysis Rapid Commun. Mass Spectrom. 2008, 22, 1069-1080
34. Qin, W. J.; Zhang, W. J.; Song, L. N.; Zhang, Y. J.; Qian, X. H. Surface Initiated Atom Transfer Radical Polymerization: Access to Three Dimensional Wavelike Polymer Structure Modified Capillary Columns for Online Phosphopeptide Enrichment Anal. Chem. 2010, 82, 9461-9468
35. Zhao, L.; Qin, H. Q.; Hu, Z. Y.; Zhang, Y.; Wu, R. A.; Zou, H. F. A Poly(ethylene glycol)-Brush Decorated Magnetic Polymer for Highly Specific Enrichment of Phosphopeptides Chem. Sci. 2012, 3, 2828-2838
36. Hucknall, A.; Kim, D.-H.; Rangarajan, S.; Hill, R. T.; Reichert, W. M.; Chilkoti, A. Simple Fabrication of Antibody Microarrays on Nonfouling Polymer Brushes with Femtomolar Sensitivity for Protein Analytes in Serum and Blood Adv. Mater. 2009, 21, 1968-1971
37. Lu, J.; Li, Y.; Deng, C. H. Facile Synthesis of Zirconium Phosphonate-Functionalized Magnetic Mesoporous Silica Microspheres Designed for Highly Selective Enrichment of Phosphopeptides Nanoscale 2011, 3, 1225-1233
38. Wang, P. Y.; Zhao, L.; Wu, R. A.; Zhong, H.; Zou, H. F.; Yang, J.; Yang, Q. H. Phosphonic Acid Functionalized Periodic Mesoporous Organosilicas and Their Potential Applications in Selective Enrichment of Phosphopeptides J. Phys. Chem. C 2009, 113, 1359-1366
39. Zhou, H. J.; Ye, M. L.; Dong, J.; Han, G. H.; Jiang, X. N.; Wu, R. A.; Zou, H. F. Specific Phosphopeptide Enrichment with Immobilized Titanium Ion Affinity Chromatography Adsorbent for Phosphoproteome Analysis J. Proteome Res. 2008, 7, 3957-3967
40. Ma, W. F.; Zhang, Y.; Li, L. L.; Zhang, Y. T.; Yu, M.; Guo, J.; Lu, H. J.; Wang, C. C. Ti4+-Immobilized Magnetic Composite Microspheres for Highly Selective Enrichment of Phosphopeptides Adv. Funct. Mater. 2013, 23, 107-115
41. Shen, F.; Hu, Y. F.; Guan, P.; Ren, X. Q. Ti4+-Phosphate Functionalized Cellulose for Phosphopeptides Enrichment and Its Application in Rice Phosphoproteome Analysis J. Chromatogr. B 2012, 902, 108-115
42. Shen, F.; Hu, Y. F.; Guan, P.; Ren, X. Q. Facile Preparation of Titanium Phosphate-Modified Chitosan for Selective Capture of Phosphopeptides J. Sep. Sci. 2013, 36, 540-547
43. Wang, Z.-G.; Zhang, J.-L.; Sun, D.-H.; Ni, J.-Z. Novel Ti4+-Chelated Magnetic Nanostructured Affinity Microspheres Containing N-methylene Phosphonic Chitosan for Highly Selective Enrichment and Rapid Separation of Phosphopeptides J. Mater. Chem. B 2014, 2, 6886-6892
44. Xiong, Z. C.; Zhang, L. Y.; Fang, C. L.; Zhang, Q. Q.; Ji, Y. S.; Zhang, Z.; Zhang, W. B.; Zou, H. F. Ti4+-Immobilized Multilayer Polysaccharide Coated Magnetic Nanoparticles for Highly Selective Enrichment of Phosphopeptides J. Mater. Chem. B 2014, 2, 4473-4480
45. Tsunehiro, M.; Meki, Y.; Matsuoka, K.; Kinoshita-Kikuta, E.; Kinoshita, E.; Koike, T. A Phos-tag-Based Magnetic-Bead Method for Rapid and Selective Separation of Phosphorylated Biomolecules J. Chromatogr. B 2013, 925, 86-94
46. Zhang, L. Y.; Zhao, Q.; Liang, Z.; Yang, K. G.; Sun, L. L.; Zhang, L. H.; Zhang, Y. K. Synthesis of Adenosine Functionalized Metal Immobilized Magnetic Nanoparticles for Highly Selective and Sensitive Enrichment of Phosphopeptides Chem. Commun. 2012, 48, 6274-6276
47. Yan, Y. H.; Zheng, Z. F.; Deng, C. H.; Zhan, X. M.; Yang, P. Y. Facile Synthesis Ti4+-Immobilized Fe3O4@Polydopamine Core-shell Microspheres for Highly Selective Enrichment of Phosphopeptides Chem. Commun. 2013, 49, 5055-5057
48. Yan, Y. H.; Zheng, Z. F.; Deng, C. H.; Li, Y.; Zhang, X. M.; Yang, P. Y. Hydrophilic Polydopamine-Coated Graphene for Metal Ion Immobilization as a Novel Immobilized Metal Ion Affinity Chromatography Platform for Phosphoproteome Analysis Anal. Chem. 2013, 85, 8483-8487
49. Shi, C. Y.; Deng, C. H.; Zou, S. E.; Zhang, X. M. Polydopamine-Coated Eppendorf Tubes for Ti4+ Immobilization for Selective Enrichment of Phosphopeptides Talanta 2014, 127, 88-93
50. Yan, Y. H.; Zheng, Z. F.; Li, Y.; Deng, C. H.; Zhang, X. M. Titanium(IV)-Immobilized Hydrophilic Hierarchically Ordered Macro-/Mesoporous Silica for Fast Enrichment of Phosphopeptides ChemPlusChem. 2014, 79, 662-666
51. Dunn, J. D.; Reid, G. E.; Bruening, M. L. Techniques for Phosphopeptide Enrichment Prior to Analysis by Mass Spectrometry Mass Spectrom. Rev. 2010, 29, 29-54
52. Hasan, N.; Wu, H. F. Highly Selective and Sensitive Enrichment of Phosphopeptides via NiO Nanoparticles Using a Microwave-Assisted Centrifugation on-Particle Ionization/Enrichment Approach in MALDI-MS Anal. Bioanal. Chem. 2011, 400, 3451-3462
53. Chen, W. Y.; Chen, Y. C. Functional Fe3O4@ZnO Magnetic Nanoparticle-Assisted Enrichment and Enzymatic Digestion of Phosphoproteins from Saliva Anal. Bioanal. Chem. 2010, 398, 2049-2057
54. Li, Y.; Liu, Y. C.; Tang, J.; Lin, H. Q.; Yao, N.; Shen, X. Z.; Deng, C. H.; Yang, P. Y.; Zhang, X. M. Fe3O4@Al2O3 Magnetic Core-Shell Microspheres for Rapid and Highly Specific Capture of Phosphopeptides with Mass Spectrometry Analysis J. Chromatogr. A 2007, 1172, 57-71
55. Han, L.; Shan, Z.; Chen, D. H.; Yu, X. J.; Yang, P. Y.; Tu, B.; Zhao, D. Y. Mesoporous Fe2O3 Microspheres: Rapid and Effective Enrichment of Phosphopeptides for MALDI-TOF MS Analysis J. Colloid Interface Sci. 2008, 318, 315-321
56. Li, Y.; Lin, H. Q.; Deng, C. H.; Yang, P. Y.; Zhang, X. M. Highly Selective and Rapid Enrichment of Phosphorylated Peptides Using Gallium Oxide-Coated Magnetic Microspheres for MALDI-TOF-MS and Nano-LC-ESI-MS/MS/MS Analysis Proteomics 2008, 8, 238-249
57. Larsen, M. R.; Thingholm, T. E.; Jensen, O. N.; Roepstorff, P.; Jorgensen, T. J. Highly Selective Enrichment of Phosphorylated Peptides from Peptide Mixtures Using Titanium Dioxide Microcolumns Mol. Cell Proteomics 2005, 4, 873-886
58. Kweon, H. K.; Håkansson, K. Selective Zirconium Dioxide-Based Enrichment of Phosphorylated Peptides for Mass Spectrometric Analysis Anal. Chem. 2006, 78, 1743-1749
59. Sturm, M.; Leitner, A.; Smått, J.-H.; Lindén, M.; Lindner, W. Tin Dioxide Microspheres as a Promising Material for Phosphopeptide Enrichment Prior to Liquid Chromatography-(Tandem) Mass Spectrometry Analysis Adv. Funct. Mater. 2008, 18, 2381-2389
60. Rivera, J. G.; Choi, Y. S.; Vujcic, S.; Wood, T. D.; Colon, L. A. Enrichment/Isolation of Phosphorylated Peptides on Hafnium Oxide Prior to Mass Spectrometric Analysis Analyst 2009, 134, 31-33
61. Ficarro, S. B.; Parikh, J. R.; Blank, N. C.; Marto, J. A. Niobium(V) Oxide (Nb2O5): Application to Phosphoproteomics Anal. Chem. 2008, 80, 4606-4613
62. Qi, D. W.; Lu, J.; Deng, C. H.; Zhang, X. M. Development of Core-Shell Structure Fe3O4@Ta2O5 Microspheres for Selective Enrichment of Phosphopeptides for Mass Spectrometry Analysis J. Chromatogr. A 2009, 1216, 5533-5539
63. Lu, Z. D.; Duan, J. C.; He, L.; Hu, Y. X.; Yin, Y. D. Mesoporous TiO2 Nanocrystal Clusters for Selective Enrichment of Phosphopeptides Anal. Chem. 2010, 82, 7249-7258
64. Lu, Z. D.; Ye, M. M.; Li, N.; Zhong, W. W.; Yin, Y. D. Self-Assembled TiO2 Nanocrystal Clusters for Selective Enrichment of Intact Phosphorylated Proteins Angew. Chem., Int. Ed. 2010, 49, 1862-1866
65. Zhang, L. Y.; Liang, Z.; Yang, K. G.; Xia, S. M.; Wu, Q.; Zhang, L. H.; Zhang, Y. K. Mesoporous TiO2 Aerogel for Selective Enrichment of Phosphopeptides in Rat Liver Mitochondria Anal. Chim. Acta 2012, 729, 26-35
66. Zhang, L. Y.; Xu, J.; Sun, L. L.; Ma, J. F.; Yang, K. G.; Liang, Z.; Zang, L. H.; Zhang, Y. K. Zirconium Oxide Aerogel for Effective Enrichment of Phosphopeptides with High Binding Capacity Anal. Bioanal. Chem. 2011, 399, 3399-3405
67. Zhang, Y. T.; Li, L. L.; Ma, W. F.; Zhang, Y.; Yu, M.; Guo, J.; Lu, H. J.; Wang, C. C. Two-in-One Strategy for Effective Enrichment of Phosphopeptides Using Magnetic Mesoporous γ-Fe2O3 Nanocrystal Clusters ACS Appl. Mater. Interfaces 2013, 5, 614-621
68. Ma, R. N.; Hu, J. J.; Cai, Z. W.; Ju, H. X. Highly Selective Enrichment of Phosphopeptides with High-Index Facets Exposed Octahedral Tin Dioxide Nanoparticles for Mass Spectrometric Analysis Talanta 2014, 119, 452-457
69. Zhong, H. Y.; Xiao, X.; Zheng, S.; Zhang, W. Y.; Ding, M. G.; Jiang, H. Y.; Huang, L. L.; Kang, J. Mass Spectrometric Analysis of Mono- and Multi-Phosphopeptides by Selective Binding with NiZnFe2O4 Magnetic Nanoparticles Nat. Commun. 2013, 4, 1656-1662
70. Yan, J. Y.; Li, X. L.; Cheng, S. Y.; Ke, Y. X.; Liang, X. M. Facile Synthesis of Titania-Zirconia Monodisperse Microspheres and Application for Phosphopeptides Enrichment Chem. Commun. 2009, 2929-2931
71. Li, L. P.; Zheng, T.; Xu, L. N.; Li, Z.; Sun, L. D.; Nie, Z. X.; Bai, Y.; Liu, H. W. SnO2-ZnSn(OH)6: a Novel Binary Affinity Probe for Global Phosphopeptide Detection Chem. Commun. 2013, 49, 1762-1764
72. Guo, J.; Yang, W. L.; Wang, C. C. Magnetic Colloidal Supraparticles: Design, Fabrication and Biomedical Applications Adv. Mater. 2013, 25, 5196-5214
73. Li, W. W.; Deng, Q. L.; Fang, G. Z.; Chen, Y.; Zhan, J.; Wang, S. Facile Synthesis of Fe3O4@TiO2-ZrO2 and Its Application in Phosphopeptide Enrichment J. Mater. Chem. B 2013, 1, 1947-1961
74. Qi, D. W.; Lu, J.; Deng, C. H.; Zhang, X. M. Magnetically Responsive Fe3O4@C@SnO2 Core-Shell Microspheres: Synthesis, Characterization and Application in Phosphoproteomics J. Phys. Chem. C 2009, 113, 15854-15861
75. Ma, W. F.; Zhang, C.; Zhang, Y. T.; Yu, M.; Guo, J.; Zhang, Y.; Lu, H. J.; Wang, C. C. Magnetic MSP@ZrO2 Microspheres with Yolk-Shell Structure: Designed Synthesis and Application in Highly Selective Enrichment of Phosphopeptides Langmuir 2014, 30, 6602-6611
76. Ma, W. F.; Zhang, Y.; Li, L. L.; You, L. J.; Zhang, P.; Zhang, Y. T.; Li, J. M.; Yu, M.; Guo, J.; Lu, H. J.; Wang, C. C. Tailor-Made Magnetic Fe3O4@mTiO2 Microspheres with a Tunable Mesoporous Anatase Shell for Highly Selective and Effective Enrichment of Phosphopeptides ACS Nano 2012, 6, 3179-3188
77. Zhang, Y.; Ma, W. F.; Zhang, C.; Wang, C. C.; Lu, H. J. Titania Composite Microspheres Endowed with a Size-Exclusive Effect Toward the Highly Specific Revelation of Phosphopeptidome ACS Appl. Mater. Interfaces 2014, 6, 6290-6299
78. Cheng, G.; Wang, Z. G.; Liu, Y. L.; Zhang, J. L.; Sun, D. H.; Ni, J. Z. Magnetic Affinity Microspheres with Meso-/Macroporous Shells for Selective Enrichment and Fast Separation of Phosphorylated Biomolecules ACS Appl. Mater. Interfaces 2013, 5, 3182-3190
79. Iijima, S. Helical Microtubules of Graphitic Carbon Nature(London) 1991, 354, 56-58
80. Allen, M. J.; Tung, V. C.; Kaner, R. B. Honeycomb Carbon: A Review of Graphene Chem. Rev. 2010, 110, 132-145
81. Pang, H.; Lu, Q. Y.; Gao, F. Graphene Oxide Induced Growth of One-Dimensional Fusiform Zirconia Nanostructures for Highly Selective Capture of Phosphopeptides Chem. Commun. 2011, 47, 11772-11774
82. Fang, G.; Gao, W.; Deng, Q.; Qian, K.; Han, H.; Wang, S. Highly Selective Capture of Phosphopeptides Using a Nano Titanium Dioxide-Multiwalled Carbon Nanotube Nanocomposite Anal. Biochem. 2012, 423, 210-217
83. Tang, L. A.; Wang, J.; Lim, T. K.; Bi, X.; Lee, W. C.; Lin, Q.; Chang, Y. T.; Lim, C. T.; Loh, K. P. High-Performance Graphene-Titania Platform for Detection of Phosphopeptides in Cancer Cells Anal. Chem. 2012, 84, 6693-6700
84. Yan, Y. H.; Zheng, Z. F.; Deng, C. H.; Zhang, X. M.; Yang, P. Y. Selective Enrichment of Phosphopeptides by Titania Nanoparticles Coated Magnetic Carbon Nanotubes Talanta 2014, 118, 14-20
85. Wang, M. Y.; Deng, C. H.; Li, Y.; Zhang, X. M. Magnetic Binary Metal Oxides Affinity Probe for Highly Selective Enrichment of Phosphopeptides ACS Appl. Mater. Interfaces 2014, 6, 11775-11782
86. Cheng, G.; Yu, X.; Zhou, M. D.; Zheng, S. Y. Preparation of Magnetic Graphene Composites with Hierarchical Structure for Selective Capture of Phosphopeptides J. Mater. Chem. B 2014, 2, 4711-4719
87. Yan, Y. H.; Sun, X. N.; Deng, C. H.; Li, Y.; Zhang, X. M. Metal Oxide Affinity Chromatography Platform-Polydopamine Coupled Functional Two-Dimensional Titania Graphene Nanohybrid for Phosphoproteome Research Anal. Chem. 2014, 86, 4327-4332
88. Stöber, W.; Fink, A. Controlled Growth of Monodisperse Silica Spheres in the Micron Size Range J. Colloid Interface Sci. 1968, 26, 62-69
89. He, X.-M.; Zhu, G.; Li, X.-S.; Yuan, B.-F.; Shi, Z.; Feng, Y. Q. Rapid Enrichment of Phosphopeptides by SiO2/TiO2 Composite Fibers Analyst 2013, 138, 5495-5502
90. Wu, J. H.; Li, X. S.; Zhao, Y.; Gao, Q.; Guo, L.; Feng, Y. Q. Titania Coated Magnetic Mesoporous Hollow Silica Microspheres: Fabrication and Application to Selective Enrichment of Phosphopeptides Chem. Commun. 2010, 46, 9031-9033
91. Wan, H. H.; Yan, J. Y.; Yu, L.; Zhang, X. L.; Xue, X. Y.; Li, X. L.; Liang, X. M. Zirconia Layer Coated Mesoporous Silica Microspheres Used for Highly Specific Phosphopeptide Enrichment Talanta 2010, 82, 1701-1707
92. Qian, K.; Wan, J. J.; Liu, F.; Girault, H. H.; Liu, B. H.; Yu, C. Z. A Phospho-Directed Macroporous Alumina-Silica Nanoreactor with Multi-Functions ACS Nano 2009, 3, 3656-3662
93. Wan, J. J.; Qian, K.; Qiao, L.; Wang, Y. H.; Kong, J. L.; Yang, P. Y.; Liu, B. H.; Yu, C. Z. TiO2-Modified Macroporous Silica Foams for Advanced Enrichment of Multi-Phosphorylated Peptides Chem.-Eur. J. 2009, 15, 2504-2508
94. Yan, Y. H.; Zhang, X. M.; Deng, C. H. Designed Synthesis of Titania Nanoparticles Coated Hierarchially Ordered Macro/Mesoporous Silica for Selective Enrichment of Phosphopeptides ACS Appl. Mater. Interfaces 2014, 6, 5467-5471
95. Çelikbiçak, Ö.; Atakay, M.; Güler, Ü.; Salih, B. A Novel Tantalum-Based Sol-gel Packed Microextraction Syringe for Highly Specific Enrichment of Phosphopeptides in MALDI-MS Applications Analyst 2013, 138, 4403-4410
96. Tan, Y.; Sui, D.; Wang, W.; Kuo, M. H.; Reid, G. E.; Bruening, M. L. Phosphopeptide Enrichment with TiO2-Modified Membranes and Investigation of Tau Protein Phosphorylation Anal. Chem. 2013, 85, 5699-5706
97. Sandison, M. E.; Jensen, K. T.; Gesellchen, F.; Cooperb, J. M.; Pitt, A. R. Magnetite-Doped Polydimethylsiloxane (PDMS) for Phosphopeptide Enrichment Analyst 2014, 139, 4974-4981
98. Min, Q.; Chen, X.; Zhang, X.; Zhu, J. J. Tailoring of a TiO2 Nanotube Array-Integrated Portable Microdevice for Efficient on-Chip Enrichment and Isotope Labeling of Serum Phosphopeptides Lab Chip 2013, 13, 3853-3861
99. Tsougeni, K.; Zerefos, P.; Tserepi, A.; Vlahou, A.; Garbis, S. D.; Gogolides, E. TiO2-ZrO2 Affinity Chromatography Polymeric Microchip for Phosphopeptide Enrichment and Separation Lab Chip 2011, 11, 3113-3120
100. He, Z. Y.; Zhang, Q. H.; Wang, H. Z.; Li, Y. G. Continuous High-Throughput Phosphopeptide Enrichment Using Microfluidic Channels Modified with Aligned ZnO/TiO2 Nanorod Arrays Biomed. Microdevices 2011, 13, 865-875
101. Kouvonen, P.; Rainio, E. M.; Suni, V.; Koskinen, P.; Corthals, G. L. Enrichment and Sequencing of Phosphopeptides on Indium Tin Oxide Coated Glass Slides Mol. Biosyst. 2011, 7, 1828-1837
102. Lu, J.; Qi, D. W.; Deng, C. H.; Zhang, X. M.; Yang, P. Y. Hydrothermal Synthesis of α-Fe2O3@SnO2 Core-Shell Nanotubes for Highly Selective Enrichment of Phosphopeptides for Mass Spectrometry Analysis Nanoscale 2010, 2, 1892-1900
103. Zhang, Y.; Li, J. H.; Niu, F. G.; Sun, J.; Dou, Y.; Liu, Y. T.; Su, Y. J.; Yang, Y. J. Comparison of A Novel TiO2/Diatomite Composite and Pure TiO2 for the Purification of Phosvitin Phosphopeptides J. Chromatogr. B 2014, 960, 52-58
104. Duan, J. J.; He, X. M.; Zhang, L. N. Magnetic Cellulose-TiO2 Nanocomposite Microspheres for Highly Selective Enrichment of Phosphopeptides Chem. Commun. 2015, 51, 338-341
105. Eichhorn, G. L.; Butzow, J. J. Interactions of Metal Ions with Polynucleotides and Related Compounds. III. Degradation of Polyribonucleotides by Lanthanum Ions Biopolymers 1965, 3, 79-94
106. Persy, V. P.; Behets, G. J.; Broe, M. E. D.; D'Haese, P. C. Management of Hyperphosphatemia in Patients with End-Stage Renal Disease: Focus on Lanthanum Carbonate Int. J. Nephrol. Renovasc. Dis. 2009, 2, 1-8
107. Pink, M.; Verma, N.; Polato, F.; Bonn, G. K.; Baba, H. A.; Rettenmeier, A. W.; Schmitz-Spanke, S. Precipitation by Lanthanum Ions: A Straightforward Approach to Isolating Phosphoproteins J. Proteomics 2011, 75, 375-383
108. Guzel, Y.; Rainer, M.; Mirza, M. R.; Messner, C. B.; Bonn, G. K. Highly Selective Recovery of Phosphopeptides Using Trypsin-Assisted Digestion of Precipitated Lanthanide-Phosphoprotein Complexes Analyst 2013, 138, 2897-2905
109. Mirza, M. R.; Rainer, M.; Guzel, Y.; Choudhary, I. M.; Bonn, G. K. A Novel Strategy for Phosphopeptide Enrichment Using Lanthanide Phosphate Co-precipitation Anal. Bioanal. Chem. 2012, 404, 853-862
110. Li, Y.; Qi, D. W.; Deng, C. H.; Yang, P. Y.; Zhang, X. M. Cerium Ion-Chelated Magnetic Silica Microspheres for Enrichment and Direct Determination of Phosphopeptides by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry J. Proteome Res. 2008, 7, 1767-1777
111. Wang, Z.-G.; Cheng, G.; Liu, Y.-L.; Zhang, J.-L.; Sun, D.-H.; Ni, J.-Z. Novel core-shell Ce(IV)-Immobilized Magnetic Polymeric Microspheres for Selective Enrichment and Rapid Separation of Phosphopeptides J. Colloid Interface Sci. 2014, 417, 217-226
112. Bonomi, R.; Scrimin, P.; Mancin, F. Phosphate Diesters Cleavage Mediated by Ce(IV) Complexes Self-Assembled on Gold Nanoparticles Org. Biomol. Chem. 2010, 8, 2622-2626
113. Mirza, M. R.; Rainer, M.; Messner, C. B.; Guezel, Y.; Schemeth, D.; Stasyk, T.; Choudhary, M. I.; Huber, L. A.; Rode, B. M.; Bonn, G. K. A New Type of Metal Chelate Affinity Chromatography Using Trivalent Lanthanide Ions for Phosphopeptide Enrichment Analyst 2013, 138, 2995-3004
114. Jabeen, F.; Hussain, D.; Fatima, B.; Musharraf, S. G.; Huck, C. W.; Bonn, G. K.; Najam-Ul-Haq, M. Silica-Lanthanum Oxide: Pioneer Composite of Rare-Earth Metal Oxide in Selective Phosphopeptides Enrichment Anal. Chem. 2012, 84, 10180-10185
115. Tan, F.; Zhang, Y. J.; Wang, J. L.; Wei, J. Y.; Cai, Y.; Qian, X. H. An Efficient Method for Dephosphorylation of Phosphopeptides by Cerium Oxide J. Mass Spectrom. 2008, 43, 628-632
116. Cheng, G.; Zhang, J. L.; Liu, Y. L.; Sun, D. H.; Ni, J. Z. Synthesis of Novel Fe3O4@SiO2@CeO2 Microspheres with Mesoporous Shell for Phosphopeptide Capturing and Labeling Chem. Commun. 2011, 47, 5732-5734
117. Wang, Z.-G.; Bi, W.-Z.; Ma, S.-C.; Lv, N.; Zhang, J.-L.; Sun, D.-H.; Ni, J.-Z. Facet-Dependent Effect of Well-Defined CeO2 Nanocrystals on the Adsorption and Dephosphorylation of Phosphorylated Molecules Part. Part. Syst. Charact. 2015, 10.1002/ppsc.201400230
118. Cheng, G.; Li, S. M.; Wang, Y.; Wang, Z. G.; Zhang, J. L.; Ni, J. Z. REPO4 (RE=La, Nd, Eu) Affinity Nanorods Modified on a MALDI Plate for Rapid Capture of Target Peptides from Complex Biosamples Chem. Commun. 2013, 49, 8492-8494
119. Cheng, G.; Zhang, J. L.; Liu, Y. L.; Sun, D. H.; Ni, J. Z. Monodisperse REPO4 (RE = Yb, Gd, Y) Hollow Microspheres Covered with Nanothorns as Affinity Probes for Selectively Capturing and Labeling Phosphopeptides Chem.-Eur. J. 2012, 18, 2014-2020
120. Wang, Z. G.; Cheng, G.; Liu, Y. L.; Zhang, J. L.; Sun, D. H.; Ni, J. Z. Fabrication of Novel Hierarchical Structured Fe3O4@LnPO4(Ln=Eu, Tb, Er) Multifunctional Microspheres for Capturing and Labeling Phosphopeptides Small 2012, 8, 3456-3464
121. Cheng, G.; Liu, Y.-L.; Wang, Z.-G.; Li, S.-M.; Zhang, J.-L.; Ni, J.-Z. Yolk-Shell Magnetic Microspheres with Mesoporous Yttrium Phosphate Shells for Selective Capture and Identification of Phosphopeptides J. Mater. Chem. B 2013, 1, 3661-3669
122. Cheng, G.; Wang, Z. G.; Liu, Y. L.; Zhang, J. L.; Sun, D. H.; Ni, J. Z. A Graphene-Based Multifunctional Affinity Probe for Selective Capture and Sequential Identification of Different Biomarkers from Biosamples Chem. Commun. 2012, 48, 10240-10242
123. Cheng, G.; Liu, Y. L.; Zhang, J. L.; Sun, D. H.; Ni, J. Z. Lanthanum Silicate Coated Magnetic Microspheres as a Promising Affinity Material for Phosphopeptide Enrichment and Identification Anal. Bioanal. Chem. 2012, 404, 763-770
124. Wang, Z.-G.; Cheng, G.; Liu, Y.-L.; Zhang, J.-L.; Sun, D.-H.; Ni, J.-Z. Magnetic γ-Fe2O3@REVO4(RE=Sm, Dy, Ho) Affinity Microspheres for Selective Capture, Fast Separation and Easy Identification of Phosphopeptides J. Mater. Chem. B 2013, 1, 1491-1500
125. Wang, Z.-G.; Cheng, G.; Liu, Y.-L.; Zhang, J.-L.; Sun, D.-H.; Ni, J.-Z. Novel 3D Flowerlike Hierarchical γ-Fe2O3@xNH4F·yLuF3 Core-Shell Microspheres Tailor-Made by a Phase Transformation Process for the Capture of Phosphopeptides J. Mater. Chem. B 2013, 1, 4845-4854
126. Li, L.-P.; Liu, J.-Z.; Xu, L.-N.; Li, Z.; Bai, Y.; Xiao, Y.-L.; Liu, H.-W. GdF3 as a Promising Phosphopeptide Affinity Probe and Dephospho-Labelling Media: Experiments and Theoretically Explain Chem. Commun. 2014, 50, 11572-11575
127. Messner, C. B.; Mirza, M. R.; Rainer, M.; Lutz, O. M. D.; Güzel, Y.; Hofer, T. S.; Huck, C. W.; Rode, B. M.; Bonn, G. K. Selective Enrichment of Phosphopeptides by a Metal-Organic Framework Anal. Methods 2013, 5, 2379-2383
128. Wang, F. Q.; Shi, Z. H.; Hu, F.; Xia, Z. R.; Wang, L. Tuning of Ti-Doped Mesoporous Silica for Highly Efficient Enrichment of Phosphopeptides in Human Placenta Mitochondria Anal. Bioanal. Chem. 2012, 405, 1683-1693
129. Xu, B.; Zhou, L. P.; Wang, F. J.; Qin, H. Q.; Zhu, J.; Zou, H. F. Selective Capture of Phosphopeptides by the Hierarchical Ti-aluminophosphate-5 Molecular Sieves Chem. Commun. 2011, 48, 1802-1804
130. Gu, Z. Y.; Yang, C. X.; Chang, N.; Yan, X. P. Metal-Organic Frameworks for Analytical Chemistry: from Sample Collection to Chromatographic Separation Acc. Chem. Res. 2012, 45, 734-745
131. Saeed, A.; Maya, F.; Xiao, D. J.; Najam-ul-Haq, M.; Svec, F.; Britt, D. K. Growth of a Highly Porous Coordination Polymer on a Macroporous Polymer Monolith Support for Enhanced Immobilized Metal Ion Affinity Chromatographic Enrichment of Phosphopeptides Adv. Funct. Mater. 2014, 24, 5790-5797
132. Zhao, M.; Deng, C. H.; Zhang, X. M. Designed Synthesis of Hydrophilic Core-shell-shell Structured Magnetic Metal-Organic Framework as a Novel Immobilized Metal Ion Affinity Platform for Phosphoproteome Research Chem. Commun. 2014, 50, 6228-6231
133. Kailasa, S. K.; Wu, H.-F. Rapid enrichment of Phosphopeptides by BaTiO3 Nanoparticles after Microwave-Assisted Tryptic Digest of Phosphoproteins, and Their Identification by MALDI-MS Microchim. Acta 2012, 179, 83-90
134. Xu, S.; Whitin, J. C.; Yu, T. T.-S.; Zhou, H.; Sun, D.; Sue, H.-J.; Zou, H.; Cohen, H. J.; Zare, R. N. Capture of Phosphopeptides Using α-Zirconium Phosphate Nanoplatelets Anal. Chem. 2008, 80, 5542-5549
135. Mamone, G.; Picariello, G.; Ferranti, P.; Addeo, F. Hydroxyapatite Affinity Chromatography for the Highly Selective Enrichment of Mono- and Multi-Phosphorylated Peptides in Phosphoproteome Analysis Proteomics 2010, 10, 380-393
136. Hargrove, A. E.; Nieto, S.; Zhang, T.; Sessler, J. L.; Anslyn, E. V. Artificial Receptors for the Recognition of Phosphorylated Molecules Chem. Rev. 2011, 111, 6603-6782
137. Zhang, Y.; Wang, H. J.; Lu, H. J. Sequential Selective Enrichment of Phosphopeptides and Glycopeptides Using Amine-Functionalized Magnetic Nanoparticles Mol. Biosyst. 2013, 9, 492-500
138. Fischnaller, M.; Bakry, R.; Vallant, R. M.; Huber, L. A.; Bonn, G. K. C60-Fullerene Bound Silica for the Preconcentration and the Fractionation of Multiphosphorylated Peptides Anal. Chim. Acta 2013, 761, 92-101
139. Atakay, M.; Celikbicak, O.; Salih, B. Amine-Functionalized Sol-Gel-Based Lab-in-a-Pipet-Tip Approach for the Fast Enrichment and Specific Purification of Phosphopeptides in MALDI-MS Applications Anal. Chem. 2012, 84, 2713-2720
140. Chen, C. T.; Wang, L. Y.; Ho, Y. P. Use of Polyethylenimine-Modified Magnetic Nanoparticles for Highly Specific Enrichment of Phosphopeptides for Mass Spectrometric Analysis Anal. Bioanal. Chem. 2011, 399, 2795-2806
141. Woods, A. S.; Ferre, S. Amazing Stability of the Arginine-Phosphate Electrostatic Interaction J. Proteome Res. 2005, 4, 1397-1402
142. Chang, C.-K.; Wu, C.-C.; Wang, Y.-S.; Chang, H.-C. Selective Extraction and Enrichment of Multiphosphorylated Peptides Using Polyarginine-Coated Diamond Nanoparticles Anal. Chem. 2008, 80, 3791-3797
143. Xu, L.-N.; Li, L.-P.; Jin, L.; Bai, Y.; Liu, H.-W. Guanidyl-Functionalized Graphene as a Bi-function Adsorbent for Selective Enrichment of Phosphopeptides Chem. Commun. 2014, 50, 10963-10966
144. Xiong, Z. C.; Chen, Y. J.; Zhang, L. Y.; Ren, J.; Zhang, Q. Q.; Ye, M. L.; Zhang, W. B.; Zou, H. F. Facile Synthesis of Guanidyl-Functionalized Magnetic Polymer Microspheres for Tunable and Specific Capture of Global Phosphopeptides or Only Multiphosphopeptides ACS Appl. Mater. Interfaces 2014, 6, 22743-22750
145. Deng, Q. L.; Wu, J. H.; Chen, Y.; Zhang, Z. J.; Wang, Y.; Fang, G. Z.; Wang, S.; Zhang, Y. K. Guanidinium Functionalized Superparamagnetic Silica Spheres for Selective Enrichment of Phosphopeptides and Intact Phosphoproteins from Complex Mixtures J. Mater. Chem. B 2014, 2, 1048-1058
146. Lee, C. W.; Ferreon, J. C.; Ferreon, A. C.; Arai, M.; Wright, P. E. Graded Enhancement of p53 Binding to CREB-binding Protein (CBP) by Multisite Phosphorylation Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 19290-19295