HPLC and LC-MS analysis of sinomenine and its application in pharmacokinetic studies in rats

Acta Pharmacologica Sinica

Volumn 31, Issue 11, 2010, Pages 1508-1514

  Long, Li Hong ^a,b,c   Wu, Peng Fei ^a   Chen, Xiang Long ^a   Zhang, Zui ^a   Chen, Yu ^a   Li, Yi Yong ^a   Jin, You ^a   Chen, Jian Guo ^a,b,c   Wang, Fang ^a,b,c  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

electrospray ionization; LC MS MS; pharmacokinetics; sinomenine

Indexed keywords

CHLORAMPHENICOL; HYDROGEN PEROXIDE; SINOMENINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; BRAIN TISSUE; CELL STRAIN; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PLASMA; QUANTITATIVE ANALYSIS; RAT; SINGLE DRUG DOSE; STANDARD; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; BRAIN; CALIBRATION; CELL CULTURE TECHNIQUES; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; HYDROGEN PEROXIDE; MALE; MORPHINANS; NEUROPROTECTIVE AGENTS; OXIDANTS; PC12 CELLS; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TISSUE DISTRIBUTION;

EID: 78149370612     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.122     Document Type: Article

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